EP2352591A4 - MICROCAPILLARY CRYSTALLIZATION SYSTEM OF NANOVOLUME TYPE - Google Patents
MICROCAPILLARY CRYSTALLIZATION SYSTEM OF NANOVOLUME TYPEInfo
- Publication number
- EP2352591A4 EP2352591A4 EP09763807A EP09763807A EP2352591A4 EP 2352591 A4 EP2352591 A4 EP 2352591A4 EP 09763807 A EP09763807 A EP 09763807A EP 09763807 A EP09763807 A EP 09763807A EP 2352591 A4 EP2352591 A4 EP 2352591A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nanovolume
- microcapillary
- crystallization system
- crystallization
- nanovolume microcapillary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
- B01F25/23—Mixing by intersecting jets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/06—Crystallising dishes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Metallurgy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Peptides Or Proteins (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6153608P | 2008-06-13 | 2008-06-13 | |
PCT/US2009/047414 WO2009152520A2 (en) | 2008-06-13 | 2009-06-15 | Nanovolume microcapillary crystallization system |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2352591A2 EP2352591A2 (en) | 2011-08-10 |
EP2352591A4 true EP2352591A4 (en) | 2013-01-23 |
Family
ID=41417428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09763807A Withdrawn EP2352591A4 (en) | 2008-06-13 | 2009-06-15 | MICROCAPILLARY CRYSTALLIZATION SYSTEM OF NANOVOLUME TYPE |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2352591A4 (ja) |
JP (2) | JP2011525166A (ja) |
WO (1) | WO2009152520A2 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
WO2011120024A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet generation for droplet-based assays |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
GB0907504D0 (en) * | 2009-04-30 | 2009-06-10 | Imp Innovations Ltd | Method of producing crystalline protein |
CN113856235A (zh) * | 2021-09-29 | 2021-12-31 | 浙江大华技术股份有限公司 | 降温结晶控制方法、装置、电子设备和*** |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004104228A1 (en) * | 2002-10-04 | 2004-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
WO2008000276A2 (en) * | 2006-06-28 | 2008-01-03 | Microlytic Aps | A device and a method for promoting crystallisation |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585070A (en) * | 1994-04-29 | 1996-12-17 | Phoenix International Life Sciences Inc. | Method for extraction, extraction cartridge and automated extraction processing system |
EP2309130B1 (en) * | 1999-06-28 | 2016-08-10 | California Institute of Technology | Microfabricated elastomeric valve and pump systems |
US7459022B2 (en) * | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
JP4855680B2 (ja) * | 2002-05-09 | 2012-01-18 | ザ・ユニバーシティ・オブ・シカゴ | 圧力駆動プラグによる輸送と反応のための装置および方法 |
WO2004035751A2 (en) * | 2002-10-18 | 2004-04-29 | The Regents Of The University Of California | Methods for crystallographic structure determination employing hydrogen exchange analysis |
CN101914803B (zh) * | 2004-01-25 | 2012-07-04 | 弗卢丁公司 | 晶体形成设备与***以及制造和使用该晶体形成设备与***的方法 |
US9477233B2 (en) * | 2004-07-02 | 2016-10-25 | The University Of Chicago | Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets |
US7655470B2 (en) * | 2004-10-29 | 2010-02-02 | University Of Chicago | Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems |
US20060027780A1 (en) * | 2004-07-12 | 2006-02-09 | Decode Biostructures, Inc. | Crystallization solutions |
JP2008538077A (ja) * | 2005-03-16 | 2008-10-09 | ユニバーシティ オブ シカゴ | マイクロフルイディックシステム |
-
2009
- 2009-06-15 EP EP09763807A patent/EP2352591A4/en not_active Withdrawn
- 2009-06-15 JP JP2011513753A patent/JP2011525166A/ja active Pending
- 2009-06-15 WO PCT/US2009/047414 patent/WO2009152520A2/en active Application Filing
-
2014
- 2014-05-07 JP JP2014095618A patent/JP2014240343A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004104228A1 (en) * | 2002-10-04 | 2004-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
WO2008000276A2 (en) * | 2006-06-28 | 2008-01-03 | Microlytic Aps | A device and a method for promoting crystallisation |
Non-Patent Citations (2)
Title |
---|
KAOUTHAR DHOUIB ET AL: "Microfluidic chips for the crystallization of biomacromolecules by counter-diffusion and on-chip crystal X-ray analysis", LAB ON A CHIP, vol. 9, no. 10, 1 January 2009 (2009-01-01), pages 1412, XP055046156, ISSN: 1473-0197, DOI: 10.1039/b819362b * |
LOUNACI ET AL: "Microfluidic device for protein crystallization under controlled humidity", MICROELECTRONIC ENGINEERING, ELSEVIER PUBLISHERS BV., AMSTERDAM, NL, vol. 84, no. 5-8, 6 May 2007 (2007-05-06), pages 1758 - 1761, XP022062111, ISSN: 0167-9317, DOI: 10.1016/J.MEE.2007.01.269 * |
Also Published As
Publication number | Publication date |
---|---|
EP2352591A2 (en) | 2011-08-10 |
WO2009152520A3 (en) | 2010-02-18 |
JP2014240343A (ja) | 2014-12-25 |
JP2011525166A (ja) | 2011-09-15 |
WO2009152520A2 (en) | 2009-12-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20110420 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: EMERALD BIOSTRUCTURES INC. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20130102 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 1/30 20060101ALI20121218BHEP Ipc: B01L 3/06 20060101AFI20121218BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20170103 |