EP2352591A4 - Nanovolume microcapillary crystallization system - Google Patents

Nanovolume microcapillary crystallization system

Info

Publication number
EP2352591A4
EP2352591A4 EP09763807A EP09763807A EP2352591A4 EP 2352591 A4 EP2352591 A4 EP 2352591A4 EP 09763807 A EP09763807 A EP 09763807A EP 09763807 A EP09763807 A EP 09763807A EP 2352591 A4 EP2352591 A4 EP 2352591A4
Authority
EP
European Patent Office
Prior art keywords
nanovolume
microcapillary
crystallization system
crystallization
nanovolume microcapillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09763807A
Other languages
German (de)
French (fr)
Other versions
EP2352591A2 (en
Inventor
Cory Gerdts
Mark Elliott
Peter Nollert-Von-Specht
Lansing J Stewart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emerald Biostructures Inc
Original Assignee
Emerald Biostructures Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emerald Biostructures Inc filed Critical Emerald Biostructures Inc
Publication of EP2352591A2 publication Critical patent/EP2352591A2/en
Publication of EP2352591A4 publication Critical patent/EP2352591A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/06—Crystallising dishes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Metallurgy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Peptides Or Proteins (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP09763807A 2008-06-13 2009-06-15 Nanovolume microcapillary crystallization system Withdrawn EP2352591A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6153608P 2008-06-13 2008-06-13
PCT/US2009/047414 WO2009152520A2 (en) 2008-06-13 2009-06-15 Nanovolume microcapillary crystallization system

Publications (2)

Publication Number Publication Date
EP2352591A2 EP2352591A2 (en) 2011-08-10
EP2352591A4 true EP2352591A4 (en) 2013-01-23

Family

ID=41417428

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09763807A Withdrawn EP2352591A4 (en) 2008-06-13 2009-06-15 Nanovolume microcapillary crystallization system

Country Status (3)

Country Link
EP (1) EP2352591A4 (en)
JP (2) JP2011525166A (en)
WO (1) WO2009152520A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
GB0907504D0 (en) * 2009-04-30 2009-06-10 Imp Innovations Ltd Method of producing crystalline protein
CN113856235A (en) * 2021-09-29 2021-12-31 浙江大华技术股份有限公司 Cooling crystallization control method, device, electronic equipment and system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004104228A1 (en) * 2002-10-04 2004-12-02 California Institute Of Technology Microfluidic protein crystallography
WO2008000276A2 (en) * 2006-06-28 2008-01-03 Microlytic Aps A device and a method for promoting crystallisation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585070A (en) * 1994-04-29 1996-12-17 Phoenix International Life Sciences Inc. Method for extraction, extraction cartridge and automated extraction processing system
EP2309130B1 (en) * 1999-06-28 2016-08-10 California Institute of Technology Microfabricated elastomeric valve and pump systems
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
JP4855680B2 (en) * 2002-05-09 2012-01-18 ザ・ユニバーシティ・オブ・シカゴ Apparatus and method for transport and reaction by pressure driven plug
WO2004035751A2 (en) * 2002-10-18 2004-04-29 The Regents Of The University Of California Methods for crystallographic structure determination employing hydrogen exchange analysis
CN101914803B (en) * 2004-01-25 2012-07-04 弗卢丁公司 Crystal forming devices and systems and methods for making and using the same
US9477233B2 (en) * 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US20060027780A1 (en) * 2004-07-12 2006-02-09 Decode Biostructures, Inc. Crystallization solutions
JP2008538077A (en) * 2005-03-16 2008-10-09 ユニバーシティ オブ シカゴ Micro fluidic system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004104228A1 (en) * 2002-10-04 2004-12-02 California Institute Of Technology Microfluidic protein crystallography
WO2008000276A2 (en) * 2006-06-28 2008-01-03 Microlytic Aps A device and a method for promoting crystallisation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAOUTHAR DHOUIB ET AL: "Microfluidic chips for the crystallization of biomacromolecules by counter-diffusion and on-chip crystal X-ray analysis", LAB ON A CHIP, vol. 9, no. 10, 1 January 2009 (2009-01-01), pages 1412, XP055046156, ISSN: 1473-0197, DOI: 10.1039/b819362b *
LOUNACI ET AL: "Microfluidic device for protein crystallization under controlled humidity", MICROELECTRONIC ENGINEERING, ELSEVIER PUBLISHERS BV., AMSTERDAM, NL, vol. 84, no. 5-8, 6 May 2007 (2007-05-06), pages 1758 - 1761, XP022062111, ISSN: 0167-9317, DOI: 10.1016/J.MEE.2007.01.269 *

Also Published As

Publication number Publication date
EP2352591A2 (en) 2011-08-10
WO2009152520A3 (en) 2010-02-18
JP2014240343A (en) 2014-12-25
JP2011525166A (en) 2011-09-15
WO2009152520A2 (en) 2009-12-17

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Legal Events

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Effective date: 20110420

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DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: EMERALD BIOSTRUCTURES INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20130102

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 1/30 20060101ALI20121218BHEP

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