EP2207493A1 - Dispositif de signalisation pour des instruments électrochirurgicaux et adaptateur pour la connexion d'un instrument électrochirugical - Google Patents
Dispositif de signalisation pour des instruments électrochirurgicaux et adaptateur pour la connexion d'un instrument électrochirugicalInfo
- Publication number
- EP2207493A1 EP2207493A1 EP08870927A EP08870927A EP2207493A1 EP 2207493 A1 EP2207493 A1 EP 2207493A1 EP 08870927 A EP08870927 A EP 08870927A EP 08870927 A EP08870927 A EP 08870927A EP 2207493 A1 EP2207493 A1 EP 2207493A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- display device
- electrosurgical instrument
- adapter
- voltage
- instrument
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/30—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1402—Probes for open surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/0091—Handpieces of the surgical instrument or device
- A61B2018/00916—Handpieces of the surgical instrument or device with means for switching or controlling the main function of the instrument or device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/30—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
- A61B2090/309—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure using white LEDs
Definitions
- the invention relates to an electrosurgical instrument comprising at least one display device for displaying at least one status information of a control unit and an adapter for connecting an electrosurgical instrument.
- Electrosurgical instruments have been used for many years in high frequency surgery (RF surgery) to coagulate or even cut biological tissue.
- RF surgery high frequency surgery
- a high-frequency current is passed through the tissue to be treated, so that this changes due to protein coagulation and dehydration.
- the tissue contracts in such a way that the vessels are closed and bleeding is stopped.
- the tissue is completely severable while avoiding heavy bleeding, both with the help of high-frequency current, as well as by mechanical means.
- Electrosurgical procedures can be performed with monopolar and bipolar instruments.
- the current path usually leads from the electrosurgical instrument via the tissue to be treated to a neutral electrode.
- bipolar instruments may be used, which are formed with two mutually electrically isolated sections. The current path in this case extends from a first section of the electrosurgical instrument via the tissue to be treated to a second section of the electrosurgical instrument.
- the electrosurgical instrument should be intuitive to use and should contain all the necessary information be easily available.
- this information includes status information provided, for example, by an RF generator.
- DE 36 27 221 Al shows a handle for an electrosurgical instrument having a power control and an optical power indicator.
- This power indicator on the handle indicates information about the power delivered, such as the presence of high or low voltage.
- a handle for an electrosurgical instrument which is characterized in that the electrode-side end of the handle, a light exit opening is provided, which is fed by a located in the RF generator cold light generator.
- the light source serves to illuminate the surgical field better.
- DE 199 43 792 A1 discloses an electrosurgical instrument in which the handle arranged thereon has a display device which makes it possible to read operation-specific information, for example the operating mode of the electrosurgical instrument.
- an electrosurgical instrument comprising at least one display device for displaying at least one status information of a control unit, wherein the display device is arranged on the electrosurgical instrument and oriented in the distal direction, that the display device in an active state, an operating field of electrosurgical instrument illuminates.
- the display device may be a single light emitting diode or an array or matrix of light emitting diodes. These are preferably active elements which indicate at least one status of a control unit and / or of the HF generator and / or of the electrosurgical instrument itself.
- an active state of the display device may be defined as the state in which the display device is illuminated.
- the active state of the display device preferably correlates with an active state of the electrosurgical instrument in which it is immediately ready for operation, for example a current is present for carrying out a coagulation process.
- the advantage of the present invention is therefore that the display is not only used to provide the user of the device or the electrosurgical instrument information about its status, but at the same time fulfills a lighting function, which in the actual intervention by means of the electrosurgical Instrument is helpful.
- the electrosurgical instrument includes a handle, wherein the at least one display device is disposed at a distal end of the handle. That is, the display device is arranged so that it radiates in the direction of the actual tool head of the electrosurgical instrument and thus illuminates the area where the electrosurgical instrument is to be used.
- the electrosurgical instrument described has particular advantages in a hand-held instrument.
- the display device is designed to emit colored light. The different hues can either be used to indicate different status information or to identify different electrosurgical instruments.
- the hue of the display device of the electrosurgical instrument could correspond to a hue on the RF generator to indicate that, among a variety of electrosurgical instruments, the present one is active, or that an RF voltage is applied to the present electrosurgical instrument.
- the at least one status information indicates a concern of a voltage on the electrosurgical instrument and / or a power indication and / or an operation mode of the control unit.
- a voltage on the electrosurgical instrument and / or a power indication and / or an operation mode of the control unit.
- it makes sense to indicate the presence of a voltage when a distinction has to be made between a plurality of instruments which are partly or all connected to the same HF generator. Even if only a single electrosurgical instrument is used, it may be useful to particularly mark the active state of the electrosurgical instrument to avoid erroneous operation.
- the color indication can visualize a current intensity and / or a voltage and / or a frequency and / or a particular frequency pattern. For example, it has been found that coagulation of tissue requires a different voltage pattern (first mode of operation) than the voltage pattern used to cut through a corresponding tissue (second mode of operation). The color coding could therefore serve to distinguish the modes of operation.
- the display device is coupled into a supply voltage of the electrosurgical instrument.
- the display device can thus be partially or fully fed by the supply voltage, which is present for example for a coagulation process on the electrosurgical instrument.
- the object is achieved by an adapter for connecting an electrosurgical instrument, wherein the adapter comprises:
- At least one supply line for providing a supply voltage for the electrosurgical instrument; and a display device connected to the at least one supply line.
- the adapter to which the corresponding electrosurgical instrument is connected comprises a display device which identifies the corresponding instrument or adapter.
- the indicator on the adapter may also serve to provide status information to the user of the electrosurgical instrument.
- the adapter may be, for example, the end of a supply cable of the electrosurgical instrument, the adapter preferably comprising a plurality of terminals for connecting the instrument.
- the adapter may include controls.
- the at least one supply line is designed to provide an HF voltage. That is, the adapter provides the supply voltage for the electrosurgical instrument and is preferably electrically connected to the RF generator.
- the display device is designed to display an applied voltage, in particular an HF voltage.
- the status information displayed by the display device may indicate whether the connected electrosurgical instrument or adapter is active, i. is supplied with a corresponding voltage.
- FIG. 1 is a schematic representation of a bipolar electrosurgical instrument
- FIG. 2 shows relevant components for controlling the electrosurgical instrument of FIG. 1;
- FIG. 3 shows the electrical connections between a bipolar electrosurgical instrument and an HF generator
- FIG. 4 is a circuit diagram of a first display device
- FIG. 5 is a circuit diagram of a second display device
- FIG. 6 is a circuit diagram of a third display device
- FIG. 7 shows the electrical wiring between a monopolar electrosurgical instrument and an HF generator.
- FIG. 7 shows the electrical wiring between a monopolar electrosurgical instrument and an HF generator.
- Fig. 1 shows an electrosurgical instrument 10, which is composed of a handle 12 and a bipolar instrument head 14.
- the handle 12 has an elongated shape, at the distal end of which the bipolar instrument head 14 attaches to perform a surgical procedure.
- the instrument head 14 has a first electrode 16 and a second electrode 16 'against which a voltage for coagulation or for cutting tissue is applied.
- the electrosurgical instrument 10 further includes a display device 50 at the distal end of the handle 12 that is configured to illuminate the bipolar instrument head 14 and a distal surgical field.
- the display device 50 is configured to display at least one status information. In the present case, the display device 50 indicates whether a voltage is applied to the electrodes 16, 16 '.
- the electrosurgical system according to the invention can be roughly divided into the following four components (see FIG.
- the system includes the control unit 40 which acts on the RF generator 20 to provide a corresponding output.
- the system has an input device, in particular a foot switch 30.
- a specific operation mode can be set on a specific instrument 10.
- the footswitch 30 can also be used to select from a plurality of instruments 10 connected to the RF generator 20 that are then supplied with a corresponding RF voltage.
- the display device 50 serves to provide information about the control unit 40, the RF generator 20 or the electrosurgical instrument 10.
- the display device 50 can according to the invention indicate an activation state of the electrosurgical instrument 10.
- FIG. 3 shows a first embodiment in which the display device 50 is arranged on a bipolar electrosurgical instrument 10. In such a constellation, there are usually two direct electrical lines between the RF generator 20 and the electrosurgical instrument 10. In the embodiment shown in FIG. 3, these are the RF lines 41, 41 '.
- the display device 50 may be composed of a first light-emitting diode 54 and a second light-emitting diode 54 ', wherein the light-emitting diodes 54, 54' are respectively connected in parallel to the electrodes 16, 16 'of the bipolar instrument head 14 on the first RF Line 41 and the second RF line 41 'are arranged.
- the supply lines of the electrosurgical instrument 10 supply power to the display device 50.
- resistors 52, 52 ' regulate the voltage supplied to the display device 50 comprising the two light-emitting diodes 54, 54'.
- a first and a second light-emitting diode string thus results in a series circuit comprising a resistor 52 or 52 ', a light emitting diode 54 or 54' and a protective diode 53 or 53 '.
- the protective diodes 53, 53 ' are arranged and designed such that in the first light-emitting diode string an electric current in a first flow direction and in the second an electric current in a second, the first opposite flow direction is allowed.
- FIG. 6 shows an inductive coupling of the display device 50 in the supply circuit of the bipolar instrument head 14.
- the first RF line includes a first induction coil 57 which is magnetically coupled to a second induction coil 57 '.
- the induced energy at the second induction coil 57 ' is used to drive another light emitting diode 54 ", preceded by a resistor 52'".
- the display device 50 according to the invention can also be used in monopolar electrosurgical instruments 10.
- Fig. 7 shows a corresponding arrangement.
- the monopolar instrument is usually supplied directly with the voltage of the HF generator 20 via a first HF line 41.
- a second RF line 41 ' contacts a neutral electrode 1, which is in direct contact with the patient.
- a further line 41 has to be provided which supplies the display device.
- the display device 50 is fed by the supply voltage for the electrosurgical instrument the display device 50 can be dispensed with the RF line 41 ".
- the display device 50 described above can also be integrated according to the invention into an adapter to which an electrosurgical instrument 10 can be connected.
- the handle 12 of the electrosurgical instrument 10 can be plugged onto corresponding terminals of the adapter.
- the display device also utilizes the supply voltage of the electrosurgical instrument 10 to operate the associated light emitting diodes 54, 54 ', 54 "or a corresponding incandescent lamp 56.
- the circuits of Figures 4-6 can be suitably adapted for use in the adapter ,
- the display device 50 of the adapter is supplied with chromatic light waves via an optical waveguide extending alongside the supply lines for the instrument 10.
- the HF generator 12 may be adapted such that, in the case of the application of a voltage to the adapter and thus also to the attached electrosurgical instrument 10, the display device 50 is supplied with correspondingly colored light.
- the RF generator 20 and the control unit be configured such that light waves for a specific adapter are only provided among a plurality of adapters connected to the HF generator 20 if current is present at the corresponding supply voltage.
- a predefined light color of the display device 50 may correspond to a light color on the HF generator 20 in order to indicate that voltage is applied precisely to this adapter.
- the light-emitting diodes 54, 54 ', 54 may be adapted such that they emit a colored light that, for example, corresponds to a display color of a display on the HF generator 20.
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Otolaryngology (AREA)
- Plasma & Fusion (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pathology (AREA)
- Surgical Instruments (AREA)
Abstract
L'invention concerne un instrument électrochirurgical comportant un dispositif d'affichage pour l'affichage d'au moins une information d'état d'une unité de commande, le dispositif d'affichage étant disposé sur l'instrument électrochirurgical et orienté dans sa direction distale de manière à éclairer, à l'état actif, un champ opératoire de l'instrument électrochirurgical. Du fait de cette utilisation, le dispositif d'affichage remplit une fonction double; il fournit d'une part des informations et simplifie d'autre part l'intervention médicale par éclairage du champ opératoire.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007053336A DE102007053336A1 (de) | 2007-11-08 | 2007-11-08 | Signaleinrichtung für elektrochirurgische Instrumente, Adapter zum Anschluss eines elektrochirurgischen Instruments |
PCT/EP2008/008737 WO2009089855A1 (fr) | 2007-11-08 | 2008-10-15 | Dispositif de signalisation pour des instruments électrochirurgicaux et adaptateur pour la connexion d'un instrument électrochirugical |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2207493A1 true EP2207493A1 (fr) | 2010-07-21 |
Family
ID=40344642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08870927A Withdrawn EP2207493A1 (fr) | 2007-11-08 | 2008-10-15 | Dispositif de signalisation pour des instruments électrochirurgicaux et adaptateur pour la connexion d'un instrument électrochirugical |
Country Status (6)
Country | Link |
---|---|
US (1) | US20100268221A1 (fr) |
EP (1) | EP2207493A1 (fr) |
JP (1) | JP2011502596A (fr) |
CN (1) | CN101854879A (fr) |
DE (1) | DE102007053336A1 (fr) |
WO (1) | WO2009089855A1 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009018107A1 (de) * | 2009-04-20 | 2010-10-21 | Erbe Elektromedizin Gmbh | Elektrochirurgisches Gerät |
DE102009018100A1 (de) * | 2009-04-20 | 2010-10-21 | Erbe Elektromedizin Gmbh | Elektrochirurgisches Gerät |
US9072523B2 (en) | 2010-11-05 | 2015-07-07 | Ethicon Endo-Surgery, Inc. | Medical device with feature for sterile acceptance of non-sterile reusable component |
US9039720B2 (en) | 2010-11-05 | 2015-05-26 | Ethicon Endo-Surgery, Inc. | Surgical instrument with ratcheting rotatable shaft |
US9782215B2 (en) | 2010-11-05 | 2017-10-10 | Ethicon Endo-Surgery, Llc | Surgical instrument with ultrasonic transducer having integral switches |
US9597143B2 (en) | 2010-11-05 | 2017-03-21 | Ethicon Endo-Surgery, Llc | Sterile medical instrument charging device |
US9247986B2 (en) | 2010-11-05 | 2016-02-02 | Ethicon Endo-Surgery, Llc | Surgical instrument with ultrasonic transducer having integral switches |
US9421062B2 (en) | 2010-11-05 | 2016-08-23 | Ethicon Endo-Surgery, Llc | Surgical instrument shaft with resiliently biased coupling to handpiece |
US9000720B2 (en) | 2010-11-05 | 2015-04-07 | Ethicon Endo-Surgery, Inc. | Medical device packaging with charging interface |
US9649150B2 (en) | 2010-11-05 | 2017-05-16 | Ethicon Endo-Surgery, Llc | Selective activation of electronic components in medical device |
US9011471B2 (en) | 2010-11-05 | 2015-04-21 | Ethicon Endo-Surgery, Inc. | Surgical instrument with pivoting coupling to modular shaft and end effector |
US10660695B2 (en) | 2010-11-05 | 2020-05-26 | Ethicon Llc | Sterile medical instrument charging device |
US9510895B2 (en) | 2010-11-05 | 2016-12-06 | Ethicon Endo-Surgery, Llc | Surgical instrument with modular shaft and end effector |
US10959769B2 (en) | 2010-11-05 | 2021-03-30 | Ethicon Llc | Surgical instrument with slip ring assembly to power ultrasonic transducer |
US9782214B2 (en) | 2010-11-05 | 2017-10-10 | Ethicon Llc | Surgical instrument with sensor and powered control |
US20120116265A1 (en) | 2010-11-05 | 2012-05-10 | Houser Kevin L | Surgical instrument with charging devices |
US9017851B2 (en) | 2010-11-05 | 2015-04-28 | Ethicon Endo-Surgery, Inc. | Sterile housing for non-sterile medical device component |
US10085792B2 (en) | 2010-11-05 | 2018-10-02 | Ethicon Llc | Surgical instrument with motorized attachment feature |
US9526921B2 (en) * | 2010-11-05 | 2016-12-27 | Ethicon Endo-Surgery, Llc | User feedback through end effector of surgical instrument |
US10881448B2 (en) | 2010-11-05 | 2021-01-05 | Ethicon Llc | Cam driven coupling between ultrasonic transducer and waveguide in surgical instrument |
US20120116381A1 (en) | 2010-11-05 | 2012-05-10 | Houser Kevin L | Surgical instrument with charging station and wireless communication |
US9381058B2 (en) | 2010-11-05 | 2016-07-05 | Ethicon Endo-Surgery, Llc | Recharge system for medical devices |
US9089338B2 (en) | 2010-11-05 | 2015-07-28 | Ethicon Endo-Surgery, Inc. | Medical device packaging with window for insertion of reusable component |
US9161803B2 (en) | 2010-11-05 | 2015-10-20 | Ethicon Endo-Surgery, Inc. | Motor driven electrosurgical device with mechanical and electrical feedback |
US9017849B2 (en) | 2010-11-05 | 2015-04-28 | Ethicon Endo-Surgery, Inc. | Power source management for medical device |
US9375255B2 (en) | 2010-11-05 | 2016-06-28 | Ethicon Endo-Surgery, Llc | Surgical instrument handpiece with resiliently biased coupling to modular shaft and end effector |
JP2014204794A (ja) | 2013-04-11 | 2014-10-30 | 株式会社デンソー | 身体支持追従装置用状態表示装置及び身体支持追従装置 |
US10136938B2 (en) | 2014-10-29 | 2018-11-27 | Ethicon Llc | Electrosurgical instrument with sensor |
DE102015203617A1 (de) * | 2015-02-27 | 2016-09-01 | Olympus Winter & Ibe Gmbh | Beleuchtungselement zur Verwendung in einem elektrochirurgischen System und/oder einem elektrochirurgischen Instrument |
US11135032B2 (en) | 2016-04-04 | 2021-10-05 | Gyrus Acmi, Inc. | Electrosurgical illuminating instrument |
JP2019528897A (ja) * | 2016-09-16 | 2019-10-17 | インブイティ・インコーポレイテッドInvuity, Inc. | 電気外科照明のための方法及び装置 |
DE102017112562A1 (de) * | 2017-06-07 | 2018-12-13 | Olympus Winter & Ibe Gmbh | Medizinisches System, Kopplungsvorrichtung für ein medizinisches System und Verfahren zum Betreiben eines medizinischen Systems |
WO2019071269A2 (fr) | 2017-10-06 | 2019-04-11 | Powell Charles Lee | Système et procédé pour traiter une apnée du sommeil obstructive |
Citations (1)
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US5342356A (en) * | 1992-12-02 | 1994-08-30 | Ellman Alan G | Electrical coupling unit for electrosurgery |
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US3804096A (en) * | 1972-11-30 | 1974-04-16 | Dentsply Int Inc | Electrosurgical device |
US3807404A (en) * | 1973-03-12 | 1974-04-30 | Whaledent Inc | Probe unit for electro-surgical device |
DE3627221A1 (de) | 1986-01-15 | 1988-02-18 | Siemens Ag | Hf-chirurgiegeraet mit leistungssteuerung vom chirurgie-handgriff aus |
US4856514A (en) * | 1987-07-23 | 1989-08-15 | Medi-Tech, Inc. | Control apparatus for a lighted, hand held, surgical electrode holder |
DE4012545C2 (de) | 1990-04-19 | 1995-08-24 | Hagen Uwe | Chirurgie-Handgriff mit einer Aufnahme für eine aktive Elektrode |
JP4636683B2 (ja) * | 1997-10-10 | 2011-02-23 | ボストン サイエンティフィック リミテッド | 軟組織凝固プローブ |
DE19943792C2 (de) | 1999-09-13 | 2003-07-31 | Erbe Elektromedizin | Hochfrequenz-Chirurgiergerät und Hochfrequenzchirurgie-Anordnung |
WO2004054626A2 (fr) * | 2002-12-13 | 2004-07-01 | Gmp Surgical Solutions, Inc. | Bistouri cauterisant lumineux |
US20070049927A1 (en) * | 2005-08-31 | 2007-03-01 | Saltzman Darin J | Electrosurgical pencil with a light |
DE102005048383B4 (de) * | 2005-10-10 | 2010-12-16 | Zdenka Von Tulechov | Tragbares Epilationsgerät |
-
2007
- 2007-11-08 DE DE102007053336A patent/DE102007053336A1/de not_active Withdrawn
-
2008
- 2008-10-15 CN CN200880115335A patent/CN101854879A/zh active Pending
- 2008-10-15 WO PCT/EP2008/008737 patent/WO2009089855A1/fr active Application Filing
- 2008-10-15 EP EP08870927A patent/EP2207493A1/fr not_active Withdrawn
- 2008-10-15 US US12/741,659 patent/US20100268221A1/en not_active Abandoned
- 2008-10-15 JP JP2010532463A patent/JP2011502596A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US5342356A (en) * | 1992-12-02 | 1994-08-30 | Ellman Alan G | Electrical coupling unit for electrosurgery |
Also Published As
Publication number | Publication date |
---|---|
DE102007053336A1 (de) | 2009-05-20 |
CN101854879A (zh) | 2010-10-06 |
WO2009089855A1 (fr) | 2009-07-23 |
US20100268221A1 (en) | 2010-10-21 |
JP2011502596A (ja) | 2011-01-27 |
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