EP2195718A1 - Temperature control device - Google Patents

Temperature control device

Info

Publication number
EP2195718A1
EP2195718A1 EP08801557A EP08801557A EP2195718A1 EP 2195718 A1 EP2195718 A1 EP 2195718A1 EP 08801557 A EP08801557 A EP 08801557A EP 08801557 A EP08801557 A EP 08801557A EP 2195718 A1 EP2195718 A1 EP 2195718A1
Authority
EP
European Patent Office
Prior art keywords
tempering device
wall section
solution container
tempering
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08801557A
Other languages
German (de)
French (fr)
Other versions
EP2195718B1 (en
Inventor
Benjamin Böbst
Frank Boettger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Original Assignee
Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotheker Vetter and Company Arzneimittel GmbH Ravensburg filed Critical Apotheker Vetter and Company Arzneimittel GmbH Ravensburg
Publication of EP2195718A1 publication Critical patent/EP2195718A1/en
Application granted granted Critical
Publication of EP2195718B1 publication Critical patent/EP2195718B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/16—Holders for containers
    • A61J1/165—Cooled holders, e.g. for medications, insulin, blood, plasma

Definitions

  • the invention relates to a tempering device according to the preamble of claim 1.
  • Temperature control of the type discussed here are known. They are used in particular for pharmaceutical solution containers in which, in particular for preparing for sterile filtration, solutions are mixed or solids are dissolved in solvents, preferably in water.
  • the temperature of the solution in the pharmaceutical solution container is of particular importance, since it influences, for example, the solubility of solids in a solvent. The temperature may also affect the stability of the ingredients found in the solution.
  • the dissolution of solids in solvents and the mixing of solutions is carried out in solution containers in the form of pressure vessels or boilers. A temperature of the solution is carried out by double-jacketed solution container.
  • Such solution containers have two wall regions arranged concentrically with one another, wherein the solution to be mixed or the solvent intended for dissolving a solid can be introduced into the space delimited by the first wall region.
  • a medium suitable for tempering is introduced, the temperature of which is preferably regulated by means of a thermostat.
  • the temperature of the temperature-controlled medium is transferred via the first wall region to the medium in the solution container.
  • Such double-jacketed pharmaceutical solutions sungs have the disadvantage that they are very expensive and therefore very expensive to manufacture.
  • Another disadvantage of such solution containers is their time-consuming cleaning. Incidentally, there is the risk that the temperature-controlled medium arranged between the first and the second wall region comes into contact with the pharmaceutical solution. In any case, contamination of the pharmaceutical solution in the solution container can not be completely ruled out.
  • the object of the invention is therefore to provide a tempering device for a pharmaceutical solution container, which avoids the disadvantages mentioned above.
  • a tempering device for pharmaceutical solution container which has the features mentioned in claim 1.
  • the tempering device has at least one wall section into which a heatable medium can be introduced. It is characterized by the fact that it can be attached to the outside of the solution container and removed from it again.
  • This embodiment of a tempering device offers the advantage that in the production of pharmaceutical solution containers which require a tempering device, the production costs can be substantially reduced, since the enormous production costs of the double casing are eliminated.
  • the tempering device proposed here can be used advantageously in conventional pharmaceutical solution containers of various sizes and shapes. It is conceivable, for example, to place it like a jacket around the solution container and to remove it again from the solution container after completion of the tempering process.
  • the tempering device can also be designed as disposable tempering device for use in sterile rooms. By eliminating the double coating of a pharmaceutical solution container also its weight is considerably reduced.
  • a tempering device which is characterized in that it has at least one inlet and at least one outlet.
  • the at least one inlet and the at least one outlet open into the at least one wall section, into which the temperature-controllable medium, referred to below as medium only, can be introduced.
  • a medium can thus be introduced into the wall section via the inlet and led out again via the outlet.
  • a tempering device which is characterized in that the tempering device has a thermostat.
  • the medium which can be introduced into the at least one wall section of the tempering device can be heated or cooled to a specific temperature.
  • a tempering device which is characterized in that at least the at least one wall portion comprises a temperature-resistant material or consists of this. This advantageous embodiment ensures that even with strong heating or cooling of the medium located in the wall section, the temperature control is not damaged.
  • a tempering device is also preferred, which can be attached to the pharmaceutical solution container with at least one belt and / or with at least one hook-and-loop fastener. In this way, the tempering can be very easily attached to a conventional solution container and removed again.
  • the tempering device can also be fastened in various other ways to a pharmaceutical solution container by simple means.
  • the temperature device has an overpressure device by means of which, in particular, the at least one wall section of the tempering device can be adapted to the solution container.
  • the overpressure device When the overpressure device is actuated, the inner diameter of the tempering device, which finally adapts to the circumference of the pharmaceutical solution container, changes so that the tempering device bears firmly against the solution container.
  • a tempering device which is characterized in that water, alcohol and / or silicone oil can be used as heatable medium.
  • water, alcohol and / or silicone oil can be used as heatable medium.
  • a tempering device is preferred in which at least the at least one wall section is flexible. Due to the flexibility of the tempering device, at least in some areas, it is advantageously possible to use this for differently shaped solution containers. It is also conceivable to provide a prefilled tempering device, which is connected via a corresponding connection only with a thermostat or the like. that must be. In particular, it can be provided that the tempering device has flexible plastic or at least partially consists of this. The use of flexible plastic offers the advantage that the tempering device on the one hand is flexible in use and on the other hand favorable in the manufacturing process.
  • a tempering device which is characterized in that the at least one wall section for the realization of channels is rib-shaped.
  • a serpentine formed channel is provided, which is flowed through by a medium.
  • a tempering device is also preferred, which is characterized in that an inner side of the tempering device resting against the solution container has a smooth surface. Due to this advantageous embodiment, a particularly good heat transfer from the tempering device to the pharmaceutical solution container is possible.
  • a tempering device that is Y-sterilizable and / or steam-sterilizable is particularly preferred. This advantageous embodiment makes it possible to use the tempering several times, for example for use in sterile rooms.
  • a tempering device in which a plurality of inlets and outlets are provided.
  • the multiple inlets and outlets preferably cooperate with a plurality of separate wall sections.
  • a circulation of the medium is effected in the at least one wall section. It is provided that the medium flows from the inlet of the at least one wall section to its outlet and thus a circulation in the wall section is effected.
  • a plurality of mutually separate wall sections are provided which serve to receive a temperature-controlled medium. It is also conceivable to introduce different temperable media into the separate wall sections. In each of the wall sections, a separate circulation of the medium to be tempered is preferably effected.
  • a tempering device which is characterized in that its applied to the solution container inside consists of a thermally conductive material or is coated with such a material nem. Furthermore, the outside of the inner side, that is, the side of the tempering device facing away from the solution container, preferably consists of an insulating material or is coated with such a material.
  • This embodiment has the advantage that on the one hand little heat is released to the environment of the tempering and on the other hand there is a good heat transfer between the tempering and the pharmaceutical solution container.
  • a tempering device is preferred in which the at least one wall section is designed to be multi-layered.
  • a layer arranged parallel to it can be provided, into which, for example, compressed air for realizing an overpressure device can be introduced.
  • Figure 1 is a schematic representation of a tempering device for pharmaceutical solution containers
  • Figure 2 shows an embodiment of a tempering
  • Figure 3 is a schematic representation of a tempering in plan view.
  • FIG. 1 shows a perspective view of a tempering device 1 for pharmaceutical solution containers with at least one wall section 3 into which a heatable medium can be introduced.
  • the at least one wall section 3 here extends over the entire surface of the tempering device 1. However, it can also be provided that the wall section 3 extends only in a region of the tempering device 1.
  • the tempering device 1 has at least one inlet 5 and at least one outlet 7, which are in fluid communication with the at least one wall section 3.
  • a temperature-controlled medium such as water and / or alcohol and / or silicone oil can be introduced into the wall section 3.
  • the tempering device 1 preferably interacts with a thermostat, not shown here, which regulates the temperature of the heatable medium located in the wall section 3.
  • At least the at least one wall section 3 of the tempering device 1 preferably has a temperature-resistant material or consists of it, so that damage to the tempering device 1 is prevented at a temperature of the medium located in the wall section 3 to very high or even very low temperatures.
  • FIG. 1 makes it clear that the at least one wall section 3 is rib-shaped.
  • the ribs are connected to each other in a serpentine manner such that a channel 9 is formed in the wall section 3, which extends from the inlet 5 to the outlet 7.
  • a medium which enters the at least one wall section 3 via the inlet 5 is guided in the channel 9 in the direction of the arrows 11 and then led out of the wall section 3 via the outlet 7.
  • the medium preferably passes from the outlet 7 to the temperature controller, not shown here, in particular to a thermostat. This results in a cycle of the temperature-controlled medium from the thermostat to the wall section 3 via the inlet 5 and via the outlet 7 back to the thermostat.
  • the medium circulates in the wall section 3, the thermostat ensuring that the medium has a desired temperature.
  • the channel 9 in the at least one wall section 3 can be realized in various ways and have different shapes or courses in the wall section 3.
  • the serpentine shape of the channel 9 may be, for example edgewise with respect to a solution container or even horizontally.
  • the tempering device 1 has a plurality of wall sections 3, in each of which a channel 9 is formed.
  • the temperature control device 1 has a plurality of channels 9 arranged separately from one another, each having its own inlet 5 and its own outlet 7.
  • each wall section 3 is a separate circuit of temperature-controlled medium available.
  • wall sections 3 which each have an inlet and an outlet and thus their own circuit, prevents a medium on its way through a wall section 3 changes its temperature too much. This may be the case in particular if the path through the wall section is too long.
  • a plurality of wall sections 3 are provided, in which the medium has to travel a shorter distance until it arrives again at the thermostat.
  • the tempering device 1 can also have sensors which measure the temperature of the medium located in the wall section 3 at any location in the tempering device 1 or also outside thereof.
  • FIG. 2 shows an embodiment of a tempering device 1.
  • the same parts are provided with the same reference numerals, so that reference is made to the description of FIG.
  • FIG. 1 shows a solution container 13, which is surrounded by a tempering device 1.
  • the solution container 13 is preferably used for mixing solutions or for dissolving solids in solvents such as water.
  • the resulting pharmaceutical solution should also be storable in the solution container 13 at a certain temperature.
  • the temperature control device 1 proposed here is advantageously suitable.
  • the tempering device 1 is preferably flexible, for example, made of a flexible plastic and can be flexibly adapted to different shapes and sizes of solution containers 13.
  • the tempering device 1 can be attached to the solution container 13 in various ways.
  • the tempering device 1 is fastened by means of a belt 15 to the solution container 13.
  • the belt 15 may be incorporated into the temperature control device 1 and is preferably provided with a hook and loop fastener, not shown here, which allows a particularly simple attachment of the temperature control device 1 to the solution container 13.
  • a hook and loop fastener can also be provided directly on the tempering 1 without belt.
  • the belt 15 shown here is purely exemplary, a fastening device for the temperature control device 1 proposed here can be realized in various ways. It is crucial that the temperature control device 1 can be attached in a simple manner to a solution container 13 and easily removed again from the solution container 13. It is also possible to provide an overpressure device, not shown here, for realizing a fastening device which changes the shape of the tempering device 1 in such a way that it adapts to the shape and / or the size of any solution container. This will be discussed later in more detail.
  • the tempering 1 is preferably made flexible, in particular, it has a flexible plastic or at least partially made of this.
  • This embodiment of the tempering device 1 also allows particularly flexible adaptation to a wide variety of solution containers. It is understood that the present invention is not limited to the tempering device 1 shown here, but this may also be arbitrarily formed in their shape and size.
  • the tempering device 1 can here be arranged around a solution container 13 virtually like a jacket and can be fastened thereto by means of a suitable fastening device. It is also conceivable, however, a closed embodiment of the temperature control device 1, so that it is überstülpbar example of a solution container.
  • the inside of the tempering device 1 resting against the solution container 13 preferably has a smooth surface at least in the area of the at least one wall section 3, so that a particularly large contact surface of the tempering device 1 results on the solution container 13, whereby the temperature transfer from the at least one wall section 3 on the solution container 13 is particularly good.
  • the tempering device 1 is preferably designed such that it is ⁇ -sterilizable and / or steam-sterilizable, this advantageously makes it possible to adjust the temperature.
  • rier driving 1 in particular to use in a sterile environment several times.
  • the inner side of the tempering device 1 lying against the solution container 13 at least in the region of the at least one wall section 3 consists of a thermally conductive material or is coated with such a material.
  • the temperature transition between the tempering device 1 and the solution container 13 can be substantially improved.
  • the outer side of the tempering device 1 facing away from the inner side and facing away from the solution container 13 is made of an insulating material or coated with such a material.
  • the temperature control of the pharmaceutical solution contained in the solution container 13 is further improved in that a temperature compensation between the temperature-controlled medium in the wall section 3 and the environment is reduced.
  • FIG. 3 shows a schematic illustration of a further embodiment of a tempering device 1 in plan view. Identical parts are provided with the same reference numerals, so that reference is made to the description of the preceding figures.
  • FIG. 3 shows a tempering device 1, in which the at least one wall section 3 is designed in multiple layers.
  • at least one channel 17 is formed by the multi-layered design of the wall section 3, into which a medium can be introduced.
  • the channel 17 preferably has an access, not shown here.
  • the at least one channel 17 can be provided to record, for example, compressed air for the realization of a pressure device 19.
  • the overpressure device 19 can be realized in such a way that compressed air can be introduced into a plurality of channels 17 formed by a multi-layered design of the tempering device 1. If the tempering device 1 is to be attached to a solution container 13, compressed air can be introduced into the channels 17 via the access, whereby the channels 17 expand and the tempering device 1 becomes smaller in its inner diameter. In the event that the temperature control device 1 is no longer needed, the air from the channels 17 can be left out again. The inner diameter of the tempering device 17 thus increases and the tempering device can be removed from the solution container 13.
  • the overpressure device 19 can also be realized by another suitable medium which can be introduced into the channel 17.
  • the temperature control device 1 is preferably ⁇ -sterilizable and / or steam-sterilizable. However, it can also be provided to provide the tempering device 1 as disposable tempering device, which is disposed of after a single use to ensure the sterility of a sterile room.
  • the tempering device 1 can be pre-filled, so that only a corresponding temperature control device must be connected to the inlet or to the outlet in order to make the temperature control device 1 operational.
  • the tempering device 1 can be made in various shapes and sizes be. As already stated, it is also conceivable to provide a plurality of separately arranged wall sections 3 with separate inlets and outlets.
  • the tempering device 1 proposed here has the advantage that a conventional solution container 13 can be stored in a temperature-controlled manner without double wrapping of a wide variety of shapes and sizes, without requiring a complicated double-jacket solution container.
  • the temperature control device 1 proposed here can be produced particularly inexpensively. Contamination of the present in the solution container 13 pharmaceutical medium with the temperature controlled in the tempering device 1 is excluded by the here proposed separately from the solution tank 13 running tempering device 1 otherwise. Furthermore, the complex purification process of the known double-chamber solution container is completely eliminated.
  • the tempering device 1 can be easily attached to a solution container 13 in an advantageous manner and can easily be removed again from the solution container 13 after the tempering process has ended.

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention relates to a temperature control device (1) for pharmaceutical solution containers (13), comprising at least one wall section (3), into which a temperature-controlled medium can be introduced. The device is characterised in that it can be attached to and detached from the exterior of the solution container (13).

Description

Temperiereinrichtunq Temperiereinrichtunq
Beschreibungdescription
Die Erfindung betrifft eine Temperiereinrichtung gemäß Oberbegriff des Anspruchs 1.The invention relates to a tempering device according to the preamble of claim 1.
Temperiereinrichtungen der hier angesprochenen Art sind bekannt. Sie werden insbesondere für pharmazeutische Lösungsbehälter eingesetzt, in denen, insbesondere zur Vorbereitung auf die Sterilfittra- tion, Lösungen gemischt oder Feststoffe in Lösungsmitteln, vorzugsweise in Wasser, gelöst werden. Die Temperatur der in dem pharmazeutischen Lösungsbehälter befindlichen Lösung ist dabei von besonderer Bedeutung, da sie beispielsweise die Löslichkeit von Feststoffen in einem Lösungsmittel beeinflusst. Die Temperatur kann auch die Stabilität der in der Lösung vorkommenden Inhaltsstoffe beeinflussen. Das Auflösen von Feststoffen in Lösungsmitteln sowie das Durchmischen von Lösungen wird in Lösungsbehältern in Form von Druckbehältern oder Kesseln durchgeführt. Eine Temperierung der Lösung erfolgt dabei durch doppelummantelte Lösungsbehälter. Derartige Lösungsbehälter weisen zwei konzentrisch zueinander angeordnete Wandbereiche auf, wobei in den durch den ersten Wand- bereich begrenzten Raum die zu mischende Lösung beziehungsweise das zur Lösung eines Feststoffs gedachte Lösungsmittel einbringbar ist. In dem durch den zweiten Wandbereich begrenzten Raum wird ein zur Temperierung geeignetes Medium eingebracht, dessen Temperatur vorzugsweise mittels eines Thermostats geregelt wird. Die Temperatur des temperierbaren Mediums wird über den ersten Wandbereich an das in dem Lösungsbehälter befindliche Medium übertragen. Derartige doppelummantelte pharmazeutische Lö- sungsbehälter haben den Nachteil, dass sie sehr aufwändig und damit sehr kostspielig in ihrer Herstellung sind. Ein weiter Nachteil derartiger Lösungsbehälter ist deren aufwändige Reinigung. Im Übrigen besteht die Gefahr, dass das zwischen dem ersten und dem zweiten Wandbereich angeordnete temperierbare Medium in Kontakt mit der pharmazeutischen Lösung kommt. Eine Kontaminierung der pharmazeutischen Lösung in dem Lösungsbehälter kann jedenfalls nicht vollständig ausgeschlossen werden.Temperature control of the type discussed here are known. They are used in particular for pharmaceutical solution containers in which, in particular for preparing for sterile filtration, solutions are mixed or solids are dissolved in solvents, preferably in water. The temperature of the solution in the pharmaceutical solution container is of particular importance, since it influences, for example, the solubility of solids in a solvent. The temperature may also affect the stability of the ingredients found in the solution. The dissolution of solids in solvents and the mixing of solutions is carried out in solution containers in the form of pressure vessels or boilers. A temperature of the solution is carried out by double-jacketed solution container. Such solution containers have two wall regions arranged concentrically with one another, wherein the solution to be mixed or the solvent intended for dissolving a solid can be introduced into the space delimited by the first wall region. In the space bounded by the second wall region, a medium suitable for tempering is introduced, the temperature of which is preferably regulated by means of a thermostat. The temperature of the temperature-controlled medium is transferred via the first wall region to the medium in the solution container. Such double-jacketed pharmaceutical solutions sungsbehälter have the disadvantage that they are very expensive and therefore very expensive to manufacture. Another disadvantage of such solution containers is their time-consuming cleaning. Incidentally, there is the risk that the temperature-controlled medium arranged between the first and the second wall region comes into contact with the pharmaceutical solution. In any case, contamination of the pharmaceutical solution in the solution container can not be completely ruled out.
Aufgabe der Erfindung ist es daher, eine Temperiereinrichtung für einen pharmazeutischen Lösungsbehälter zu schaffen, welche die oben genannten Nachteile vermeidet.The object of the invention is therefore to provide a tempering device for a pharmaceutical solution container, which avoids the disadvantages mentioned above.
Zur Lösung dieser Aufgabe wird eine Temperiereinrichtung für pharmazeutische Lösungsbehälter vorgeschlagen, welche die in Anspruch 1 genannten Merkmale aufweist. Die Temperiereinrichtung weist wenigstens einen Wandabschnitt auf, in den ein temperierbares Medium einbringbar ist. Sie zeichnet sich dadurch aus, dass sie außen an dem Lösungsbehälter anbringbar und von diesem wieder entfernbar ist. Diese Ausgestaltung einer Temperiereinrichtung bietet den Vorteil, dass bei der Herstellung von pharmazeutischen Lö- sungsbehältern, die eine Temperiereinrichtung benötigen, die Herstellungskosten wesentlich reduziert werden können, da der enorme Fertigungsaufwand der Doppelummantelung entfällt. Die hier vorgeschlagene Temperiereinrichtung kann in vorteilhafter Weise bei herkömmlichen pharmazeutischen Lösungsbehältern verschiedenster Größe und Form eingesetzt werden. Denkbar ist es beispielsweise, sie wie einen Mantel um den Lösungsbehälter zu legen und nach Beendigung des Temperiervorgangs wieder von dem Lösungsbehälter zu entfernen. Dadurch, dass das temperierbare Medium in we- nigstens einem Wandabschnitt vorgesehen ist, ist eine Kontamination mit der in dem Lösungsbehälter befindlichen Lösung ausgeschlossen. Die Temperiereinrichtung kann zur Anwendung in sterilen Räumen auch als Einwegtemperiereinrichtung ausgebildet sein. Durch den Wegfall der Doppelummantelung eines pharmazeutischen Lösungsbehälters wird zudem dessen Gewicht beträchtlich reduziert.To solve this problem, a tempering device for pharmaceutical solution container is proposed, which has the features mentioned in claim 1. The tempering device has at least one wall section into which a heatable medium can be introduced. It is characterized by the fact that it can be attached to the outside of the solution container and removed from it again. This embodiment of a tempering device offers the advantage that in the production of pharmaceutical solution containers which require a tempering device, the production costs can be substantially reduced, since the enormous production costs of the double casing are eliminated. The tempering device proposed here can be used advantageously in conventional pharmaceutical solution containers of various sizes and shapes. It is conceivable, for example, to place it like a jacket around the solution container and to remove it again from the solution container after completion of the tempering process. Because the temperature-controlled medium in is provided at least one wall portion, contamination with the solution in the solution container is excluded. The tempering device can also be designed as disposable tempering device for use in sterile rooms. By eliminating the double coating of a pharmaceutical solution container also its weight is considerably reduced.
Besonders bevorzugt wird eine Temperiereinrichtung, die sich dadurch auszeichnet, dass sie wenigstens einen Einlass und wenigs- tens einen Auslass aufweist. Der wenigstens eine Einlass und der wenigstens eine Auslass münden dabei in den wenigstens einen Wandabschnitt, in den das temperierbare Medium, im Folgenden nur noch Medium genannt, einbringbar ist. Über den Einlass kann ein Medium somit in den Wandabschnitt eingebracht und über den Aus- lass wieder herausgeführt werden.Particularly preferred is a tempering device, which is characterized in that it has at least one inlet and at least one outlet. The at least one inlet and the at least one outlet open into the at least one wall section, into which the temperature-controllable medium, referred to below as medium only, can be introduced. A medium can thus be introduced into the wall section via the inlet and led out again via the outlet.
Weiterhin bevorzugt wird eine Temperiereinrichtung, die sich dadurch auszeichnet, dass die Temperiereinrichtung einen Thermostat aufweist. Mittels des Thermostats kann das in den wenigstens einen Wandabschnitt der Temperiereinrichtung einbringbare Medium auf eine bestimmte Temperatur erwärmt oder abgekühlt werden.Further preferred is a tempering device, which is characterized in that the tempering device has a thermostat. By means of the thermostat, the medium which can be introduced into the at least one wall section of the tempering device can be heated or cooled to a specific temperature.
Auch bevorzugt wird eine Temperiereinrichtung, die sich dadurch auszeichnet, dass zumindest der wenigstens eine Wandabschnitt ein temperaturbeständiges Material aufweist oder aus diesem besteht. Durch diese vorteilhafte Ausgestaltung ist gewährleistet, dass selbst bei starker Erhitzung oder Abkühlung des in dem Wandabschnitt befindlichen Mediums die Temperiereinrichtung nicht beschädigt wird. Es wird auch eine Temperiereinrichtung bevorzugt, die mit wenigstens einem Gurt und/oder mit wenigstens einem Klettverschluss an dem pharmazeutischen Lösungsbehälter befestigbar ist. Auf diese Weise kann die Temperiereinrichtung sehr einfach an einem her- kömmlichen Lösungsbehälter befestigt und wieder entfernt werden. Die Temperiereinrichtung kann aber auch auf verschiedene andere Art und Weise an einem pharmazeutischen Lösungsbehälter mit einfachen Mitteln befestigt werden. Insbesondere kann vorgesehen sein, dass die Temperatureinrichtung eine Überdruckeinrichtung aufweist, mittels derer insbesondere der wenigstens eine Wandabschnitt der Temperiereinrichtung an den Lösungsbehälter anpassbar ist. Bei Betätigung der Überdruckeinrichtung verändert sich der Innendurchmesser der Temperiereinrichtung, die sich schließlich so an den Umfang des pharmazeutischen Lösungsbehälters anpasst, dass die Temperiereinrichtung fest an dem Lösungsbehälter anliegt.Also preferred is a tempering device, which is characterized in that at least the at least one wall portion comprises a temperature-resistant material or consists of this. This advantageous embodiment ensures that even with strong heating or cooling of the medium located in the wall section, the temperature control is not damaged. A tempering device is also preferred, which can be attached to the pharmaceutical solution container with at least one belt and / or with at least one hook-and-loop fastener. In this way, the tempering can be very easily attached to a conventional solution container and removed again. However, the tempering device can also be fastened in various other ways to a pharmaceutical solution container by simple means. In particular, it can be provided that the temperature device has an overpressure device by means of which, in particular, the at least one wall section of the tempering device can be adapted to the solution container. When the overpressure device is actuated, the inner diameter of the tempering device, which finally adapts to the circumference of the pharmaceutical solution container, changes so that the tempering device bears firmly against the solution container.
Außerdem wird eine Temperiereinrichtung bevorzugt, die sich dadurch auszeichnet, dass als temperierbares Medium Wasser, Alkohol und/oder Silikonöl verwendbar sind. Für ein bestimmtes Medium ist es dann lediglich notwendig, die Temperiereinrichtung so auszu- führen, dass sie in ihren Eigenschaften stabil hinsichtlich des verwendeten Mediums ist.In addition, a tempering device is preferred, which is characterized in that water, alcohol and / or silicone oil can be used as heatable medium. For a specific medium, it is then only necessary to carry out the tempering device in such a way that its properties are stable with regard to the medium used.
Auch wird eine Temperiereinrichtung bevorzugt, bei der zumindest der wenigstens eine Wandabschnitt flexibel ausgebildet ist. Durch die zumindest bereichsweise Flexibilität der Temperiereinrichtung ist es in vorteilhafter Weise möglich, diese für verschieden geformte Lösungsbehälter einzusetzen. Auch ist es denkbar, eine vorgefüllte Temperiereinrichtung vorzusehen, die über einen entsprechenden Anschluss nur noch mit einem Thermostat oder dergleichen verbun- den werden muss. Insbesondere kann vorgesehen sein, dass die Temperiereinrichtung flexiblen Kunststoff aufweist oder zumindest bereichsweise aus diesem besteht. Die Verwendung von flexiblem Kunststoff bietet den Vorteil, dass die Temperiereinrichtung einer- seits flexibel in der Anwendung und andererseits günstig im Herstellungsverfahren ist.Also, a tempering device is preferred in which at least the at least one wall section is flexible. Due to the flexibility of the tempering device, at least in some areas, it is advantageously possible to use this for differently shaped solution containers. It is also conceivable to provide a prefilled tempering device, which is connected via a corresponding connection only with a thermostat or the like. that must be. In particular, it can be provided that the tempering device has flexible plastic or at least partially consists of this. The use of flexible plastic offers the advantage that the tempering device on the one hand is flexible in use and on the other hand favorable in the manufacturing process.
Weiterhin bevorzugt wird eine Temperiereinrichtung, die sich dadurch auszeichnet, dass der wenigstens eine Wandabschnitt zur Realisierung von Kanälen rippenförmig ausgebildet ist. Insbesondere ist ein schlangenlinienförmig ausgebildeter Kanal vorgesehen, der von einem Medium durchströmt wird.Further preferred is a tempering device, which is characterized in that the at least one wall section for the realization of channels is rib-shaped. In particular, a serpentine formed channel is provided, which is flowed through by a medium.
Auch wird eine Temperiereinrichtung bevorzugt, die sich dadurch auszeichnet, dass eine an dem Lösungsbehälter anliegende Innenseite der Temperiereinrichtung eine glatte Oberfläche aufweist. Durch diese vorteilhafte Ausgestaltung ist eine besonders gute Wärmeübertragung von der Temperiereinrichtung zu dem pharmazeutischen Lösungsbehälter möglich.A tempering device is also preferred, which is characterized in that an inner side of the tempering device resting against the solution container has a smooth surface. Due to this advantageous embodiment, a particularly good heat transfer from the tempering device to the pharmaceutical solution container is possible.
Besonders bevorzugt wird außerdem eine Temperiereinrichtung, die Y-sterilisierbar und/oder dampfsterilisierbar ist. Diese vorteilhafte Ausgestaltung ermöglicht es, die Temperiereinrichtung beispielsweise für die Anwendung in sterilen Räumen mehrmals zu verwenden.In addition, a tempering device that is Y-sterilizable and / or steam-sterilizable is particularly preferred. This advantageous embodiment makes it possible to use the tempering several times, for example for use in sterile rooms.
Auch wird eine Temperiereinrichtung bevorzugt, bei der mehrere Ein- und Auslässe vorgesehen sind. Die mehreren Ein- und Auslässe wirken dabei vorzugsweise mit mehreren voneinander getrennten Wandabschnitten zusammen. Bei einer weiteren bevorzugten Temperiereinrichtung wird in dem wenigstens einen Wandabschnitt eine Zirkulation des Mediums bewirkt. Dabei ist vorgesehen, dass das Medium von dem Einlass des wenigstens einen Wandabschnitts zu dessen Auslass strömt und so eine Zirkulation in dem Wandabschnitt bewirkt wird. Vorzugsweise sind mehrere voneinander getrennte Wandabschnitte vorgesehen, die zur Aufnahme eines temperierbaren Mediums dienen. Es ist auch denkbar, in die getrennten Wandabschnitte unterschiedliche temperierbare Medien einzubringen. In jedem der Wandabschnitte wird vorzugsweise eine eigene Zirkulation des zu temperierenden Mediums bewirkt.Also, a tempering device is preferred in which a plurality of inlets and outlets are provided. The multiple inlets and outlets preferably cooperate with a plurality of separate wall sections. In a further preferred tempering device, a circulation of the medium is effected in the at least one wall section. It is provided that the medium flows from the inlet of the at least one wall section to its outlet and thus a circulation in the wall section is effected. Preferably, a plurality of mutually separate wall sections are provided which serve to receive a temperature-controlled medium. It is also conceivable to introduce different temperable media into the separate wall sections. In each of the wall sections, a separate circulation of the medium to be tempered is preferably effected.
Weiterhin wird eine Temperiereinrichtung bevorzugt, die sich dadurch auszeichnet, dass ihre an dem Lösungsbehälter anliegende Innenseite aus einem wärmeleitenden Material besteht oder mit ei- nem solchen Material beschichtet ist. Ferner besteht die der Innenseite gegenüberliegende, also die dem Lösungsbehälter abgewandte Außenseite der Temperiereinrichtung vorzugsweise aus einem isolierenden Material oder ist mit einem solchen Material beschichtet. Diese Ausgestaltung bietet den Vorteil, dass einerseits wenig Wärme an die Umgebung der Temperiereinrichtung abgegeben wird und andererseits ein guter Wärmeübergang zwischen der Temperiereinrichtung und dem pharmazeutischem Lösungsbehälter besteht.Furthermore, a tempering device is preferred, which is characterized in that its applied to the solution container inside consists of a thermally conductive material or is coated with such a material nem. Furthermore, the outside of the inner side, that is, the side of the tempering device facing away from the solution container, preferably consists of an insulating material or is coated with such a material. This embodiment has the advantage that on the one hand little heat is released to the environment of the tempering and on the other hand there is a good heat transfer between the tempering and the pharmaceutical solution container.
Schließlich wird eine Temperiereinrichtung bevorzugt, bei welcher der wenigstens eine Wandabschnitt mehrlagig ausgebildet ist. So kann beispielsweise in einem ein Medium aufweisenden Wandabschnitt eine parallel dazu angeordnete Lage vorgesehen sein, in die beispielsweise Druckluft zur Realisierung einer Überdruckeinrichtung einbringbar ist. Die Erfindung wird im Folgenden anhand von Zeichnung näher erläutert. Es zeigen:Finally, a tempering device is preferred in which the at least one wall section is designed to be multi-layered. For example, in a wall section having a medium, a layer arranged parallel to it can be provided, into which, for example, compressed air for realizing an overpressure device can be introduced. The invention will be explained in more detail below with reference to the drawing. Show it:
Figur 1 eine schematische Darstellung einer Temperiereinrichtung für pharmazeutische Lösungsbehälter;Figure 1 is a schematic representation of a tempering device for pharmaceutical solution containers;
Figur 2 ein Ausführungsbeispiel einer Temperiereinrichtung, undFigure 2 shows an embodiment of a tempering, and
Figur 3 eine schematische Darstellung einer Temperiereinrichtung in Draufsicht.Figure 3 is a schematic representation of a tempering in plan view.
Figur 1 zeigt eine perspektivische Darstellung einer Temperierein- richtung 1 für pharmazeutische Lösungsbehälter mit wenigstens einem Wandabschnitt 3, in den ein temperierbares Medium einbringbar ist.FIG. 1 shows a perspective view of a tempering device 1 for pharmaceutical solution containers with at least one wall section 3 into which a heatable medium can be introduced.
Der wenigstens eine Wandabschnitt 3 erstreckt sich hier über die gesamte Fläche der Temperiereinrichtung 1. Es kann aber auch vor- gesehen sein, dass sich der Wandabschnitt 3 lediglich in einem Bereich der Temperiereinrichtung 1 erstreckt. Die Temperiereinrichtung 1 weist wenigstens einen Einlass 5 und wenigstens einen Auslass 7 auf, die mit dem wenigstens einen Wandabschnitt 3 in Fluidverbin- dung stehen.The at least one wall section 3 here extends over the entire surface of the tempering device 1. However, it can also be provided that the wall section 3 extends only in a region of the tempering device 1. The tempering device 1 has at least one inlet 5 and at least one outlet 7, which are in fluid communication with the at least one wall section 3.
Durch den Einlass 5 kann ein temperierbares Medium, wie beispielsweise Wasser und/oder Alkohol und/oder Silikonöl in den Wandabschnitt 3 eingebracht werden. Die Temperiereinrichtung 1 wirkt vorzugsweise mit einem hier nicht dargestellten Thermostat zusammen, der die Temperatur des in dem Wandabschnitt 3 befind- liehen temperierbaren Mediums regelt. Zumindest der wenigstens eine Wandabschnitt 3 der Temperiereinrichtung 1 weist vorzugsweise ein temperaturbeständiges Material auf oder besteht aus diesem, sodass eine Beschädigung der Temperiereinrichtung 1 bei einer Temperierung des in dem Wandab- schnitt 3 befindlichen Mediums auf sehr hohe oder auch auf sehr niedrige Temperaturen ausgeschlossen ist.Through the inlet 5, a temperature-controlled medium, such as water and / or alcohol and / or silicone oil can be introduced into the wall section 3. The tempering device 1 preferably interacts with a thermostat, not shown here, which regulates the temperature of the heatable medium located in the wall section 3. At least the at least one wall section 3 of the tempering device 1 preferably has a temperature-resistant material or consists of it, so that damage to the tempering device 1 is prevented at a temperature of the medium located in the wall section 3 to very high or even very low temperatures.
Figur 1 macht deutlich, dass der wenigstens eine Wandabschnitt 3 rippenförmig ausgebildet ist. In der hier dargestellten Temperiereinrichtung 1 sind die Rippen so schlangenlinienförmig miteinander ver- bunden, dass ein Kanal 9 in dem Wandabschnitt 3 ausgebildet wird, der von dem Einlass 5 zu dem Auslass 7 reicht. Ein Medium, das über den Einlass 5 in den wenigstens einen Wandabschnitt 3 gelangt, wird in dem Kanal 9 in Richtung der Pfeile 11 geleitet und anschließend über den Auslass 7 aus dem Wandabschnitt 3 hinaus geleitet.FIG. 1 makes it clear that the at least one wall section 3 is rib-shaped. In the tempering device 1 shown here, the ribs are connected to each other in a serpentine manner such that a channel 9 is formed in the wall section 3, which extends from the inlet 5 to the outlet 7. A medium which enters the at least one wall section 3 via the inlet 5 is guided in the channel 9 in the direction of the arrows 11 and then led out of the wall section 3 via the outlet 7.
Das Medium gelangt von dem Auslass 7 vorzugsweise zu dem hier nicht dargestellten Temperaturregler, insbesondere zu einem Thermostat. Es entsteht somit ein Kreislauf des temperierbaren Mediums von dem Thermostat zu dem Wandabschnitt 3 über den Einlass 5 und über den Auslass 7 zurück zu dem Thermostat. Das Medium zirkuliert in dem Wandabschnitt 3, wobei der Thermostat dafür sorgt, dass das Medium eine gewünschte Temperatur aufweist.The medium preferably passes from the outlet 7 to the temperature controller, not shown here, in particular to a thermostat. This results in a cycle of the temperature-controlled medium from the thermostat to the wall section 3 via the inlet 5 and via the outlet 7 back to the thermostat. The medium circulates in the wall section 3, the thermostat ensuring that the medium has a desired temperature.
Der Kanal 9 in dem wenigstens einen Wandabschnitt 3 kann auf verschiedene Art und Weise realisiert werden und unterschiedliche Formen beziehungsweise Verläufe in dem Wandabschnitt 3 aufweisen. Die Schlangenlinienform des Kanals 9 kann beispielsweise hochkant bezüglich eines Lösungsbehälters oder auch waagrecht dazu verlaufen.The channel 9 in the at least one wall section 3 can be realized in various ways and have different shapes or courses in the wall section 3. The serpentine shape of the channel 9 may be, for example edgewise with respect to a solution container or even horizontally.
Vorzugsweise weist die Temperiereinrichtung 1 mehrere Wandabschnitte 3 auf, in denen jeweils ein Kanal 9 ausgebildet ist. Die Tem- periereinrichtung 1 weist auf diese Weise mehrere getrennt von einander angeordnete Kanäle 9 aus, die jeweils über einen eigenen Einlass 5 und einen eigenen Auslass 7 verfügen. Somit ist in jedem Wandabschnitt 3 ein eigener Kreislauf von temperierbarem Medium vorhanden.Preferably, the tempering device 1 has a plurality of wall sections 3, in each of which a channel 9 is formed. In this way, the temperature control device 1 has a plurality of channels 9 arranged separately from one another, each having its own inlet 5 and its own outlet 7. Thus, in each wall section 3 is a separate circuit of temperature-controlled medium available.
Die Ausbildung von mehreren Wandabschnitten 3, die jeweils über einen Einlass und einen Auslass und somit über einen eigenen Kreislauf verfügen, verhindert, dass ein Medium auf seinem Weg durch einen Wandabschnitt 3 seine Temperatur zu stark verändert. Dies kann insbesondere dann der Fall sein, wenn der Weg durch den Wandabschnitt zu lang ist. Vorzugsweise sind daher mehrere Wandabschnitte 3 vorgesehen, in denen das Medium eine kürzere Strecke zurücklegen muss, bis es wieder bei dem Thermostat ankommt.The formation of several wall sections 3, which each have an inlet and an outlet and thus their own circuit, prevents a medium on its way through a wall section 3 changes its temperature too much. This may be the case in particular if the path through the wall section is too long. Preferably, therefore, a plurality of wall sections 3 are provided, in which the medium has to travel a shorter distance until it arrives again at the thermostat.
Auch kann vorgesehen sein, mehrere Wandabschnitte 3 auszubil- den, in denen unterschiedliche Medien eingebracht werden. Die Temperiereinrichtung 1 kann auch Sensoren aufweisen, welche die Temperatur des in dem Wandabschnitt 3 befindlichen Mediums an einem beliebigen Ort in der Temperiereinrichtung 1 oder auch außerhalb dieser messen.It can also be provided to form a plurality of wall sections 3, in which different media are introduced. The tempering device 1 can also have sensors which measure the temperature of the medium located in the wall section 3 at any location in the tempering device 1 or also outside thereof.
Figur 2 zeigt eine Ausführungsform einer Temperiereinrichtung 1. Gleiche Teile sind mit gleichen Bezugszeichen versehen, sodass insofern auf die Beschreibung zu Figur 1 verwiesen wird. Figur 1 zeigt einen Lösungsbehälter 13, der von einer Temperiereinrichtung 1 umgeben ist. Der Lösungsbehälter 13 dient vorzugsweise zum Mischen von Lösungen oder zum Lösen von Feststoffen in Lösungsmitteln wie beispielsweise Wasser. Die resultierende pharma- zeutische Lösung soll in dem Lösungsbehälter 13 ferner mit einer bestimmten Temperatur lagerbar sein. Hierzu eignet sich die hier vorgeschlagene Temperiereinrichtung 1 in vorteilhafter Weise.FIG. 2 shows an embodiment of a tempering device 1. The same parts are provided with the same reference numerals, so that reference is made to the description of FIG. FIG. 1 shows a solution container 13, which is surrounded by a tempering device 1. The solution container 13 is preferably used for mixing solutions or for dissolving solids in solvents such as water. The resulting pharmaceutical solution should also be storable in the solution container 13 at a certain temperature. For this purpose, the temperature control device 1 proposed here is advantageously suitable.
Die Temperiereinrichtung 1 ist vorzugweise flexibel, beispielsweise aus einem flexiblen Kunststoff ausgeführt und lässt sich so an ver- schiedene Formen und Größen von Lösungsbehältern 13 flexibel anpassen.The tempering device 1 is preferably flexible, for example, made of a flexible plastic and can be flexibly adapted to different shapes and sizes of solution containers 13.
Die Temperiereinrichtung 1 kann auf verschiedene Art und Weise an dem Lösungsbehälter 13 befestigt werden. Bei der hier dargestellten Ausführungsform ist die Temperiereinrichtung 1 mittels eines Gurts 15 an den Lösungsbehälter 13 befestigt. Der Gurt 15 kann in die Temperiereinrichtung 1 eingearbeitet sein und ist vorzugsweise mit einem hier nicht dargestellten Klettverschluss versehen, der eine besonders einfache Befestigung der Temperiereinrichtung 1 an dem Lösungsbehälter 13 ermöglicht.The tempering device 1 can be attached to the solution container 13 in various ways. In the embodiment shown here, the tempering device 1 is fastened by means of a belt 15 to the solution container 13. The belt 15 may be incorporated into the temperature control device 1 and is preferably provided with a hook and loop fastener, not shown here, which allows a particularly simple attachment of the temperature control device 1 to the solution container 13.
Ein Klettverschluss kann auch direkt an der Temperiereinrichtung 1 ohne Gurt vorgesehen sein. Der hier dargestellte Gurt 15 ist rein beispielhaft, eine Befestigungseinrichtung für die hier vorgeschlagene Temperiereinrichtung 1 ist auf verschiedene Art und Weise realisierbar. Entscheidend ist, dass die Temperiereinrichtung 1 auf einfache Art und Weise an einem Lösungsbehälter 13 befestigbar und von dem Lösungsbehälter 13 einfach wieder entfernbar ist. Es kann auch eine hier nicht dargestellte Überdruckeinrichtung zur Realisierung einer Befestigungseinrichtung vorgesehen sein, welche die Form der Temperiereinrichtung 1 derart verändert, dass sie sich an die Form und/oder die Größe eines beliebigen Lösungsbehälters anpasst. Hierauf wird später noch näher eingegangen werden.A hook and loop fastener can also be provided directly on the tempering 1 without belt. The belt 15 shown here is purely exemplary, a fastening device for the temperature control device 1 proposed here can be realized in various ways. It is crucial that the temperature control device 1 can be attached in a simple manner to a solution container 13 and easily removed again from the solution container 13. It is also possible to provide an overpressure device, not shown here, for realizing a fastening device which changes the shape of the tempering device 1 in such a way that it adapts to the shape and / or the size of any solution container. This will be discussed later in more detail.
Figur 2 macht deutlich, dass, wie bereits oben ausgeführt wurde, die Temperiereinrichtung 1 vorzugsweise flexibel ausgeführt ist, insbesondere weist sie einen flexiblen Kunststoff auf oder besteht zumindest bereichsweise aus diesem. Auch diese Ausgestaltung der Tem- periereinrichtung 1 ermöglicht eine besonders flexible Anpassung an unterschiedlichste Lösungsbehälter. Es versteht sich, dass die vorliegende Erfindung nicht auf die hier dargestellte Temperiereinrichtung 1 beschränkt ist, sondern diese in ihrer Form und Größe ebenfalls beliebig ausgebildet sein kann. Die Temperiereinrichtung 1 ist hier um einen Lösungsbehälter 13 herum quasi wie ein Mantel anor- denbar und mittels einer geeigneten Befestigungseinrichtung an diesem befestigbar. Denkbar ist jedoch auch eine geschlossene Ausführungsform der Temperiereinrichtung 1 , sodass diese beispielsweise über einen Lösungsbehälter überstülpbar ist.Figure 2 makes it clear that, as already stated above, the tempering 1 is preferably made flexible, in particular, it has a flexible plastic or at least partially made of this. This embodiment of the tempering device 1 also allows particularly flexible adaptation to a wide variety of solution containers. It is understood that the present invention is not limited to the tempering device 1 shown here, but this may also be arbitrarily formed in their shape and size. The tempering device 1 can here be arranged around a solution container 13 virtually like a jacket and can be fastened thereto by means of a suitable fastening device. It is also conceivable, however, a closed embodiment of the temperature control device 1, so that it is überstülpbar example of a solution container.
Die an dem Lösungsbehälter 13 anliegende Innenseite der Temperiereinrichtung 1 weist vorzugsweise eine glatte Oberfläche zumindest im Bereich des wenigstens einen Wandabschnitts 3 auf, sodass sich eine besonders große Anlagefläche der Temperiereinrichtung 1 an dem Lösungsbehälter 13 ergibt, wodurch die Temperaturübertra- gung von dem wenigstens einen Wandabschnitt 3 auf den Lösungsbehälter 13 besonders gut ist. Die Temperiereinrichtung 1 ist vorzugsweise so ausgeführt, dass sie γ-sterilisierbar und/oder dampf- sterilisierbar ist, dies ermöglicht es in vorteilhafter Weise, die Tempe- riereinrichtung 1 , insbesondere in einer sterilen Umgebung mehrmals zu verwenden.The inside of the tempering device 1 resting against the solution container 13 preferably has a smooth surface at least in the area of the at least one wall section 3, so that a particularly large contact surface of the tempering device 1 results on the solution container 13, whereby the temperature transfer from the at least one wall section 3 on the solution container 13 is particularly good. The tempering device 1 is preferably designed such that it is γ-sterilizable and / or steam-sterilizable, this advantageously makes it possible to adjust the temperature. riereinrichtung 1, in particular to use in a sterile environment several times.
Vorzugsweise ist vorgesehen, dass die an dem Lösungsbehälter 13 anliegende Innenseite der Temperiereinrichtung 1 zumindest im Be- reich des wenigstens einen Wandabschnitts 3 aus einem wärmeleitenden Material besteht oder mit einem solchen Material beschichtet ist. Auf diese Weise kann der Temperaturübergang zwischen der Temperiereinrichtung 1 und dem Lösungsbehälter 13 wesentlich verbessert werden. Es kann auch vorgesehen sein, die der Innensei- te gegenüberliegende, dem Lösungsbehälter 13 abgewandte Außenseite der Temperiereinrichtung 1 aus einem isolierenden Material herzustellen oder mit einem solchen Material zu beschichten. Die Temperierung der in dem Lösungsbehälter 13 befindlichen pharmazeutischen Lösung wird dadurch noch verbessert, dass ein Tempe- raturausgleich zwischen dem in dem Wandabschnitt 3 befindlichen temperierten Medium und der Umgebung vermindert wird.It is preferably provided that the inner side of the tempering device 1 lying against the solution container 13 at least in the region of the at least one wall section 3 consists of a thermally conductive material or is coated with such a material. In this way, the temperature transition between the tempering device 1 and the solution container 13 can be substantially improved. It can also be provided that the outer side of the tempering device 1 facing away from the inner side and facing away from the solution container 13 is made of an insulating material or coated with such a material. The temperature control of the pharmaceutical solution contained in the solution container 13 is further improved in that a temperature compensation between the temperature-controlled medium in the wall section 3 and the environment is reduced.
Figur 3 zeigt eine schematische Darstellung einer weiteren Ausführungsform einer Temperiereinrichtung 1 in Draufsicht. Gleiche Teile sind mit gleichen Bezugszeichen versehen, sodass insofern auf die Beschreibung zu den vorangegangenen Figuren verwiesen wird.FIG. 3 shows a schematic illustration of a further embodiment of a tempering device 1 in plan view. Identical parts are provided with the same reference numerals, so that reference is made to the description of the preceding figures.
Figur 3 zeigt eine Temperiereinrichtung 1 , bei welcher der wenigstens einen Wandabschnitt 3 mehrlagig ausgebildet ist. Insbesondere ist vorgesehen, dass durch die mehrlagige Ausbildung des Wandabschnitts 3 wenigstens ein Kanal 17 ausgebildet wird, in den ein Me- dium einbringbar ist. Der Kanal 17 weist vorzugsweise einen hier nicht dargestellten Zugang auf. Der wenigstens eine Kanal 17 kann dafür vorgesehen sein, beispielsweise Druckluft zur Realisierung einer Überdruckeinrichtung 19 aufzunehmen.FIG. 3 shows a tempering device 1, in which the at least one wall section 3 is designed in multiple layers. In particular, it is provided that at least one channel 17 is formed by the multi-layered design of the wall section 3, into which a medium can be introduced. The channel 17 preferably has an access, not shown here. The at least one channel 17 can be provided to record, for example, compressed air for the realization of a pressure device 19.
Die Überdruckeinrichtung 19 kann derart realisiert sein, dass in mehrere durch eine mehrlagige Ausgestaltung der Temperiereinrichtung 1 gebildete Kanäle 17 Druckluft einbringbar ist. Wenn die Temperiereinrichtung 1 an einem Lösungsbehälter 13 befestigt werden soll, kann in die Kanäle 17 über den Zugang Druckluft eingebracht werden, wodurch sich die Kanäle 17 aufweiten und die Temperiereinrichtung 1 in ihrem Innendurchmesser kleiner wird. Für den Fall, dass die Temperiereinrichtung 1 nicht mehr benötigt wird, kann die Luft aus den Kanälen 17 wieder ausgelassen werden. Der Innendurchmesser der Temperiereinrichtung 17 vergrößert sich so und die Temperiereinrichtung kann von dem Lösungsbehälter 13 entfernt werden. Die Überdruckeinrichtung 19 kann aber auch durch ein an- deres in den Kanal 17 einbringbares geeignetes Medium realisiert werden.The overpressure device 19 can be realized in such a way that compressed air can be introduced into a plurality of channels 17 formed by a multi-layered design of the tempering device 1. If the tempering device 1 is to be attached to a solution container 13, compressed air can be introduced into the channels 17 via the access, whereby the channels 17 expand and the tempering device 1 becomes smaller in its inner diameter. In the event that the temperature control device 1 is no longer needed, the air from the channels 17 can be left out again. The inner diameter of the tempering device 17 thus increases and the tempering device can be removed from the solution container 13. However, the overpressure device 19 can also be realized by another suitable medium which can be introduced into the channel 17.
Für den Einsatz in sterilen Räumen ist die Temperiereinrichtung 1 vorzugsweise γ-sterilisierbar und/oder dampfsterilisierbar ausgeführt. Es kann aber auch vorgesehen sein, die Temperiereinrichtung 1 als Einwegtemperiereinrichtung vorzusehen, die nach einer einmaligen Benutzung entsorgt wird, um die Sterilität eines sterilen Raums zu gewährleisten.For use in sterile rooms, the temperature control device 1 is preferably γ-sterilizable and / or steam-sterilizable. However, it can also be provided to provide the tempering device 1 as disposable tempering device, which is disposed of after a single use to ensure the sterility of a sterile room.
Die Temperiereinrichtung 1 kann vorgefüllt sein, sodass also lediglich eine entsprechende Temperaturregeleinrichtung an den Einlass beziehungsweise an den Auslass angeschlossen werden muss, um die Temperiereinrichtung 1 einsatzfähig zu machen. Die Temperiereinrichtung 1 kann in verschiedenen Formen und Größen ausgeführt sein. Wie bereits ausgeführt wurde, ist es auch denkbar, mehrere getrennt voneinander angeordnete Wandabschnitte 3 mit separaten Ein- und Auslässen zu versehen.The tempering device 1 can be pre-filled, so that only a corresponding temperature control device must be connected to the inlet or to the outlet in order to make the temperature control device 1 operational. The tempering device 1 can be made in various shapes and sizes be. As already stated, it is also conceivable to provide a plurality of separately arranged wall sections 3 with separate inlets and outlets.
Die hier vorgeschlagene Temperiereinrichtung 1 bietet den Vorteil, dass ein herkömmlicher Lösungsbehälter 13 ohne Doppelummante- lung unterschiedlichster Form und Größe temperierbar lagerbar ist, ohne dafür einen aufwändig herzustellenden Doppelmantellösungs- behälter zu benötigen. Darüber hinaus ist die hier vorgeschlagene Temperiereinrichtung 1 besonders kostengünstig herstellbar. Eine Kontamination des in dem Lösungsbehälter 13 befindlichen pharmazeutischen Mediums mit dem in der Temperiereinrichtung 1 befindlichen temperierbaren Medium ist durch die hier vorgeschlagene getrennt von dem Lösungsbehälter 13 ausgeführte Temperiereinrichtung 1 im Übrigen ausgeschlossen. Ferner entfällt der aufwändige Reinigungsprozess der bekannten Doppelkammerlösungsbehälter vollständig.The tempering device 1 proposed here has the advantage that a conventional solution container 13 can be stored in a temperature-controlled manner without double wrapping of a wide variety of shapes and sizes, without requiring a complicated double-jacket solution container. In addition, the temperature control device 1 proposed here can be produced particularly inexpensively. Contamination of the present in the solution container 13 pharmaceutical medium with the temperature controlled in the tempering device 1 is excluded by the here proposed separately from the solution tank 13 running tempering device 1 otherwise. Furthermore, the complex purification process of the known double-chamber solution container is completely eliminated.
Die Temperiereinrichtung 1 ist in vorteilhafter Weise an einem Lösungsbehälter 13 einfach anbringbar und nach Beendigung des Temperiervorgangs einfach wieder von dem Lösungsbehälter 13 ab- nehmbar. The tempering device 1 can be easily attached to a solution container 13 in an advantageous manner and can easily be removed again from the solution container 13 after the tempering process has ended.

Claims

Ansprüche claims
1. Temperiereinrichtung (1) für pharmazeutische Lösungsbehälter (13), mit wenigstens einem Wandabschnitt (3), in den ein temperierbares Medium einbringbar ist, dadurch gekennzeichnet, dass sie außen an dem Lösungsbehälter (13) anbringbar und von diesem wieder entfernbar ist.1. tempering device (1) for pharmaceutical solution container (13), with at least one wall section (3) into which a temperature-adjustable medium can be introduced, characterized in that it is attachable to the outside of the solution container (13) and removable from this again.
2 . Temperiereinrichtung nach Anspruch 1 , dadurch gekennzeichnet, dass sie wenigstens einen Einlass (5) und wenigstens einen Auslass (7) aufweist, die in den wenigstens einen Wandabschnitt (3) münden.2. Tempering device according to claim 1, characterized in that it comprises at least one inlet (5) and at least one outlet (7), which open into the at least one wall section (3).
3. Temperiereinrichtung nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass sie einen Thermostaten aufweist.3. tempering device according to claim 1 or 2, characterized in that it comprises a thermostat.
4. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass zumindest der wenigstens eine Wandabschnitt (3) ein temperaturbeständiges Material aufweist oder aus diesem besteht.4. Tempering device according to one of the preceding claims, characterized in that at least the at least one wall section (3) comprises a temperature-resistant material or consists of this.
5. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass sie mit wenigstens einem Gurt (15) und/oder wenigstens einem Klettverschluss an dem Lösungs- behälter (13) anbringbar ist.5. Tempering device according to one of the preceding claims, characterized in that it can be attached to the solution container (13) with at least one belt (15) and / or at least one hook-and-loop fastener.
6. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass sie eine Überdruckeinrichtung (19) aufweist, mittels derer der wenigstens eine Wandabschnitt (3) an den Lösungsbehälter (13) anpassbar ist. 6. tempering device according to one of the preceding claims, characterized in that it comprises an overpressure device (19), by means of which the at least one wall section (3) to the solution container (13) is adaptable.
7. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass als temperierbares Medium Wasser und/oder Alkohol und/oder Silikonöl verwendbar sind.7. Tempering device according to one of the preceding claims, characterized in that as temperature-controlled medium water and / or alcohol and / or silicone oil are used.
8. Temperiereinrichtung nach einem der vorhergehenden Ansprü- che, dadurch gekennzeichnet, dass zumindest der wenigstens eine8. Tempering device according to one of the preceding claims, characterized in that at least the at least one
Wandabschnitt (3) flexibel ist.Wall section (3) is flexible.
9. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass sie flexiblen Kunststoff aufweist oder zumindest bereichsweise aus diesem besteht.9. tempering device according to one of the preceding claims, characterized in that it comprises flexible plastic or at least partially consists of this.
10. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass der wenigstens eine Wandabschnitt (3) zur Realisierung von Kanälen (9) rippenförmig ausgebildet ist.10. tempering device according to one of the preceding claims, characterized in that the at least one wall section (3) for the realization of channels (9) is rib-shaped.
11. Temperiereinrichtung nach einem der vorhergehenden Ansprü- che, dadurch gekennzeichnet, dass eine an dem Lösungsbehälter11. Tempering device according to one of the preceding claims, characterized in that one of the solution container
(13) anliegende Innenseite der Temperiereinrichtung (1) eine glatte Oberfläche aufweist.(13) adjacent inside of the tempering (1) has a smooth surface.
12. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass sie γ-sterilisierbar und/oder dampfsterilisierbar ist.12. Tempering device according to one of the preceding claims, characterized in that it is γ-sterilizable and / or steam sterilizable.
13. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass mehrere Ein- und Auslässe (5,7) vorgesehen sind. 13. Tempering device according to one of the preceding claims, characterized in that a plurality of inlets and outlets (5,7) are provided.
14. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass in dem wenigstens einen Wandabschnitt (3) eine Zirkulation des temperierbaren Mediums bewirkt wird.14. Tempering device according to one of the preceding claims, characterized in that in the at least one wall section (3) a circulation of the temperature-controlled medium is effected.
15. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass ihre an dem Lösungsbehälter (13) anliegende Innenseite aus einem Wärme leitenden Material besteht oder mit einem solchen Material beschichtet ist, und dass die der Innenseite gegenüberliegende, dem Lösungsbehälter (13) ab- gewandte Außenseite, aus einem isolierenden Material besteht oder mit einem solchen Material beschichtet ist.15. Tempering device according to one of the preceding claims, characterized in that its on the solution container (13) adjacent the inner side consists of a heat-conducting material or coated with such a material, and that the inner side opposite, the solution container (13) off facing outside, consists of an insulating material or coated with such a material.
16. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, gekennzeichnet durch mehrere von einander getrennte Wandabschnitte (3), die zur Aufnahme eines temperierbaren Medi- ums dienen.16. Tempering device according to one of the preceding claims, characterized by a plurality of mutually separate wall sections (3), which serve for receiving a temperature-controlled medium.
17. Temperiereinrichtung nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass der wenigstens eine Wandabschnitt (3) mehrlagig ausgebildet ist. 17. Tempering device according to one of the preceding claims, characterized in that the at least one wall section (3) is formed in multiple layers.
EP08801557A 2007-08-28 2008-08-09 Temperature control device Active EP2195718B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007040487A DE102007040487A1 (en) 2007-08-28 2007-08-28 tempering
PCT/EP2008/006593 WO2009030343A1 (en) 2007-08-28 2008-08-09 Temperature control device

Publications (2)

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EP2195718A1 true EP2195718A1 (en) 2010-06-16
EP2195718B1 EP2195718B1 (en) 2012-10-31

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EP08801557A Active EP2195718B1 (en) 2007-08-28 2008-08-09 Temperature control device

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US (1) US20100206888A1 (en)
EP (1) EP2195718B1 (en)
JP (1) JP5453265B2 (en)
CA (1) CA2697715A1 (en)
DE (1) DE102007040487A1 (en)
ES (1) ES2397137T3 (en)
PT (1) PT2195718E (en)
WO (1) WO2009030343A1 (en)

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JP2013180030A (en) * 2012-03-01 2013-09-12 Medikit Kk Medical instrument warmer

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Also Published As

Publication number Publication date
PT2195718E (en) 2013-01-23
CA2697715A1 (en) 2009-03-12
JP2011500107A (en) 2011-01-06
DE102007040487A1 (en) 2009-03-05
JP5453265B2 (en) 2014-03-26
EP2195718B1 (en) 2012-10-31
US20100206888A1 (en) 2010-08-19
ES2397137T3 (en) 2013-03-05
WO2009030343A1 (en) 2009-03-12

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