EP1985550A1 - Unité d'emballage pour médicament et son procédé de fabrication - Google Patents

Unité d'emballage pour médicament et son procédé de fabrication Download PDF

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Publication number
EP1985550A1
EP1985550A1 EP07008654A EP07008654A EP1985550A1 EP 1985550 A1 EP1985550 A1 EP 1985550A1 EP 07008654 A EP07008654 A EP 07008654A EP 07008654 A EP07008654 A EP 07008654A EP 1985550 A1 EP1985550 A1 EP 1985550A1
Authority
EP
European Patent Office
Prior art keywords
packaging
recesses
receiving frame
sections
sealing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07008654A
Other languages
German (de)
English (en)
Inventor
Siegfried Drost
Günter Felk
Georg Pfau
Hans-Werner Bongers-Ambrosius
Heino Dr. Prinz
Richard Mertens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uhlmann Pac Systeme GmbH and Co KG
Original Assignee
Uhlmann Pac Systeme GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uhlmann Pac Systeme GmbH and Co KG filed Critical Uhlmann Pac Systeme GmbH and Co KG
Priority to EP07008654A priority Critical patent/EP1985550A1/fr
Publication of EP1985550A1 publication Critical patent/EP1985550A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
    • B65B9/02—Enclosing successive articles, or quantities of material between opposed webs
    • B65B9/04—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material
    • B65B9/045—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material for single articles, e.g. tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D73/00—Packages comprising articles attached to cards, sheets or webs
    • B65D73/0042—Packages comprising articles attached to cards, sheets or webs the articles being retained within a window, hole or other cut-out portion of a single card
    • B65D73/005—Packages comprising articles attached to cards, sheets or webs the articles being retained within a window, hole or other cut-out portion of a single card by means of separate fixing elements, e.g. clips, clamps, bands
    • B65D73/0057—Packages comprising articles attached to cards, sheets or webs the articles being retained within a window, hole or other cut-out portion of a single card by means of separate fixing elements, e.g. clips, clamps, bands by means of a preformed enclosure, e.g. a bulb
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Definitions

  • the invention relates to a packaging unit for pharmaceuticals, with which for a plurality of days at different times of the day various drugs can be provided, and to a method for their preparation.
  • a blister pack is described in which the drug stations are arranged in a divided by weekdays and intake times matrix with seven rows and at least three columns.
  • the individual drug stations are designed as trough-shaped depressions of a thin plastic layer, and all tablets, which are provided for a time of administration, are taken together in such a depression. All drug stations are covered with a blister foil and the sections for the individual intake times are each separated with perforations, so that a simple separation of individual intake sections for certain times of day and certain days of the week is possible.
  • a method for producing such a packaging unit for the weekly medication needs of a patient is for example off DE 10 2004 020 510 A1 known.
  • Strip-shaped, wound into rolls Vorratsblisterverpackungen containing the individual drugs moved at different output stations on the above-described packaging unit in the transverse direction and pushed by plungers from the strip-shaped supply blister pack in the trough-shaped recesses of the packaging unit before the trained as a weekly blister packaging unit integral with a Sealing film is sealed.
  • the above-mentioned packaging unit and the associated filling method have some disadvantages. Particularly serious is that certain tablets may not be stored together in a receptacle, as they influence each other. An inclusion of certain drug combinations in the above mentioned Packaging unit is therefore not possible from the outset.
  • the filling process is relatively cumbersome and also critical from a contamination point of view, since during the ejection process of the tablets by means of the plunger an amount of tablet dust is generated, which deposits on the plungers and in the trough-shaped depressions.
  • the present invention is therefore an object of the invention to provide a packaging unit for pharmaceuticals, which includes the need for a patient for a longer period of time, in which all possible drug combinations can be used and which is easily prepared with the exclusion of contamination risk, and a corresponding Process for their preparation. This object is solved by the features of claim 1 or claim 9.
  • the pharmaceutical packaging unit has a receiving frame in which a plurality of recesses arranged in a pattern are arranged.
  • it has a plurality of separated, inserted into the recesses and fixed therein packaging sections, each packaging section having a bottom layer with at least one recess, which serves to receive a drug, and a sealing film for closing the recess.
  • an order of delivery times arranged packaging unit for drugs created with any number of different drugs can be stored without having to fear drug interactions during storage or contamination of the drug.
  • the packaging unit preferably has a cover film, which is arranged above the receiving frame and the sealing films.
  • the cover sheet may serve to secure the packaging sections in the recesses but is commonly used to simultaneously peel off all the sealing films of a desired portion of the packaging unit.
  • the cover film is adhesively bonded both to edge regions of the sealing films and to webs of the receiving frame, wherein the adhesive force of the cover film on the sealing films is greater than the adhesive force of the sealing films at the edges of the recesses of the soil layers.
  • the receiving frame is preferably subdivided by means of perforations into subregions, wherein the cover film should also have perforations which correspond to the perforations of the receiving frame.
  • the packaging sections must be secured in the recesses by mechanical fastening means such as lugs, by gluing, welding or sealing, in order to avoid unintentional withdrawal of the packaging sections from the recesses.
  • a method for producing the pharmaceutical packaging unit according to the invention comprises the following steps: producing a receiving frame in which a plurality of recesses arranged in a pattern are arranged; Producing a plurality of separated packaging sections, each packaging section having a bottom layer with at least one depression serving to receive a drug and a sealing film for closing the depression; and inserting the separated packaging sections into the recesses and securing them therein.
  • a packaging unit according to the invention for pharmaceuticals is produced in a particularly simple manner, the method providing only a single filling of a blister pack with medicaments.
  • the tablets contained in the strip-shaped supply blister packs do not have to be removed again from the supply blister packaging during the filling of the packaging unit according to the invention in an intermediate step.
  • the forming of the plurality of separated packaging sections comprises the steps of: forming a longitudinally and transversely extending bottom sheet, thereby forming a plurality of depressions; Delivering drugs to the wells; Closing the wells by means of a sealing foil adhered to lands of the bottom sheet between the wells; and cutting the packaging web produced thereby into separated packaging sections.
  • a particularly simple way of cutting the packaging web into separated packaging sections comprises the following steps: cutting the packaging web in the longitudinal direction by means of a longitudinal cutter; Winding the longitudinal strips of the packaging web to Roll; and unwinding the rolls and cutting the longitudinal strips in the transverse direction by means of a cross cutter.
  • the insertion of the packaging sections in the recesses takes place advantageously by means of a movable suction or gripping device.
  • the suction or gripping device is preferably monitored by means of a camera.
  • Fig. 1 shows a schematic plan view of an example of a packaging unit according to the invention 1.
  • the packaging unit 1 comprises a plurality of segments 3, each of which is associated with a particular time of day of a particular day of the week and can accommodate several drugs stored separately from each other.
  • the segments 3 are arranged in rows and columns and preferably separated by perforations 2, wherein in the illustrated embodiment, the first line 4, for example, for the weekday "Monday”, the second line 5 for the day of the week "Tuesday", etc.
  • each segment 3 comprises four packaging sections 10, which in turn are arranged symmetrically in rows and columns within the segments 3, so that a uniform pattern of the packaging sections 10 results over the entire length and width of the packaging unit 1.
  • the packaging sections 10 are inserted into recesses 12 of a receiving frame 11 and fixed there.
  • a packaging section 10 has a plurality of recesses in the longitudinal and / or transverse direction, in each of which identical tablets are stored. This can speed up the manufacturing process of the packaging unit 1 in particularly frequently used tablets by e.g. a packaging section 10 formed as a strip is inserted as a whole in the receiving frame 11.
  • An irregular arrangement of the packaging sections 10 (eg in a circular arrangement) is also conceivable, as is the configuration of the packaging sections 10 in various sizes or shapes or any modification of the number of days for which drugs are received in the packaging unit 1.
  • a particular form of the embodiment of the packaging unit 1 could be a monthly blister, preferably if only one administration time is to be considered daily.
  • Fig. 2 is a section of a packaging unit 1 according to the invention with two juxtaposed packing sections 10 within a segment 3 in cross-sectional view.
  • the receiving frame 11 is preferably made of plastic or cardboard, and the individual packaging sections 10 are inserted into the recesses 12 in the receiving frame 11 and anchored there via mechanical fasteners 14 such as lugs, for example, embrace the lower surface of the receiving frame 11 at the edge of the recesses 12. Thereby, a mechanical attachment of the packaging sections 10 in the receiving frame 11 is ensured, which exerted an upward Pressure withstands.
  • the attachment of the packaging sections 10 in the recesses 12 of the receiving frame 11 can be done by any suitable mechanical means.
  • retaining lugs which engage in corresponding grooves on the inside of the recesses 12 of the receiving frame 11.
  • a lid formed identically to the take-up frame 11 may be laid or folded from above with corresponding recesses (not shown) from above onto the take-up frame 11 and the packaging sections 10, which serves to secure the wrapping sections 10.
  • the individual packaging sections 10 are formed from a bottom layer 16 into each of which a large depression for receiving a drug is formed.
  • the bottom layer 16 is preferably made of transparent or optionally colored PVC film, of polypropylene or of an aluminum composite layer.
  • the individual packaging sections 10 and the receiving frame 11 may also have a greater height or smaller width.
  • the webs 18 of the receiving frame, which limit the recesses 12, may also have respective planar projections 19 in their middle region, as in FIG Fig. 3 is shown.
  • Each packaging section 10 is closed with a sealing film 21, which is adhesively bonded to the sections of the bottom layer 16 projecting laterally from the recesses 12.
  • Suitable sealing foil 21 are, for example, aluminum foils, paper-laminated foils or polypropylene foils. It is particularly preferred that the sealing film 21 can be relatively easily detached from this adhesive compound (peelable film), which can be achieved by a suitable choice of the heat-sealing lacquer.
  • the sealing film 21 has no perforation in the covering area of the depression, so that a secure and permanent closure of the drug is ensured until use.
  • an identification code may be applied to the sealing film 21, e.g. imprinted, with which the contents of the packaging section 10 can be properly identified.
  • the cover sheet 23 is preferably an aluminum foil provided with polyethylene Aluminum foil, plastic film, etc. If the individual packaging sections 10 project only slightly beyond the surface of the receiving frame 11, the cover film 23 can be sealed directly onto the straight webs 18 and the edge regions of the sealing films 21. For a larger projection, the embodiment of Fig. 3 be advantageous with the flat projections 19 on the webs 18.
  • the cover sheet 23 also preferably has a perforation 24 in the region of the perforation 2 of the receiving frame 11.
  • the adhesive force of the cover film 23 on the sealing films 21 is preferably greater than the adhesive force of the sealing films 21 at the edges of the recesses of the bottom layers 16. This achieves that when the cover film 23 is pulled off the webs 18 of the mounting frame 11, the sealing films 21 simultaneously detach from the packaging sections 10 and thus be able to access all drugs that are intended for a single administration time at once.
  • the cover film is tearproof and, on the other hand, the packaging sections 10 are fastened in the recesses 12 almost inextricably.
  • mechanical fastening, welding, gluing or sealing of the edge regions of the bottom layer 16 to the receiving frame 11 can also be used.
  • the cover film 23 may additionally be labeled with a list of the medicaments contained in each of the packaging sections 10. Likewise it is conceivable, an additional Provide hinged lid on which information about the medicines are printed.
  • FIG Fig. 4 A flowchart of a preferred method for producing the packaging unit according to the invention is shown in FIG Fig. 4 shown.
  • the receiving frame 11 is prepared, wherein the grid described above with the recesses 12 and preferably with perforations 2 between the different segments 3 is provided for the different intake times (step 30).
  • each packing section 10 serves to receive a medicament and comprises a bottom layer 16 with at least one depression in which the medicament is received, and a sealing film 21 for closing the depression.
  • a preferred method for producing the separated packaging sections 10 consists of several steps, which are described below.
  • recesses for receiving the drugs are formed in a bottom sheet that extends widely in the longitudinal and transverse directions (step 34).
  • the bottom sheet is unwound from a roll, heated in a heating station and provided in a subsequent forming station with the wells.
  • the cavities are filled with medicaments (step 36) and preferably a filling control with coupled product ejection.
  • the depressions are sealed by means of a sealing foil 21 which is adhered to webs 18 of the bottom web between the depressions (step 38).
  • the sealing film 21 is unwound from a roll, applied in a sealing station on the webs 18 of the bottom sheet between the wells and then cooled in a cooling station.
  • the cutting of the packaging web into separated packaging sections initially comprises cutting the packaging web in the longitudinal direction by means of a longitudinal cutter (step 42).
  • the packaging web is cut in the running direction of the packaging web.
  • the cut is preferably carried out in each case with a circular blade on a shaft. This shaft is usually below the packaging web.
  • Above the packaging web is a shaft with one round disk per circular blade.
  • the cut surface is between Round knives and the round disc formed. Hold-down press the packaging web from above against the guide to achieve a straight cut.
  • the slitter is usually driven by a motor via a toothed belt.
  • step 44 longitudinal strips of the packaging web are produced, which are then wound up into rolls (step 44).
  • step 46 the longitudinal strips, which may also have a plurality of depressions in the transverse direction, are unwound from the roll and cut transversely by means of a cross cutter, whereby the separated packaging sections 10 already described above are produced.
  • the structure of the cross cutter may correspond to the structure of the slitter.
  • FIG Fig. 5 An example of a transversely movable suction device 49 is shown in FIG Fig. 5 shown.
  • a vertically movable suction arm 50 which is controlled by a control device (not shown), provided to receive a separated packaging section 10 and insert into the respective desired recess 12 in the receiving frame 11.
  • a control device not shown
  • a movement in the transverse direction along a rail 52 is conceivable, but also any other guided movement, which can be controlled by the control device, can be used here.
  • suction arms 50 it is also possible to use a plurality of suction arms 50 in parallel, which are actuated separately in order to simultaneously insert a plurality of packaging sections 10 into the recesses 12.
  • the transport of the receiving frame 11 is preferably clocked, wherein the filling of the packaging unit 1 with the separated packaging sections 10 is line-wise.
  • a simultaneous filling of several rows or segments 3 can also take place.
  • the suction arms 50 are also movable along the running direction of the packaging unit.
  • a camera installed in the area of the suction device 49 and preferably moved along 54 is used to monitor the suction and, if necessary, to monitor the correct storage of the packaging sections 10 in the recesses 12 of the receiving frame 11. It is also possible during application of the packaging sections 10 before the first sealing process applied to the sealing films 21, for example by printing Identification code by means of a code reader (not shown) to check. Thus, the correct content of the entire packaging unit 1 can be checked in a simple manner.
  • a cover sheet 23 is applied to the receiving frame 11 and the sealing films 21 (step 56), which may have perforations 24.
  • a pharmaceutical packaging unit is easily provided in which the need of a patient for medicines for several days is sorted by intake times, the individual tablets are always safely packed in the separated packaging sections 10 and thus both a contamination of the tablets is avoided a safe manufacturing process is ensured.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP07008654A 2007-04-27 2007-04-27 Unité d'emballage pour médicament et son procédé de fabrication Withdrawn EP1985550A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07008654A EP1985550A1 (fr) 2007-04-27 2007-04-27 Unité d'emballage pour médicament et son procédé de fabrication

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07008654A EP1985550A1 (fr) 2007-04-27 2007-04-27 Unité d'emballage pour médicament et son procédé de fabrication

Publications (1)

Publication Number Publication Date
EP1985550A1 true EP1985550A1 (fr) 2008-10-29

Family

ID=38564331

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07008654A Withdrawn EP1985550A1 (fr) 2007-04-27 2007-04-27 Unité d'emballage pour médicament et son procédé de fabrication

Country Status (1)

Country Link
EP (1) EP1985550A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2923966A1 (fr) * 2014-03-28 2015-09-30 The Challenge Printing Company Emballage pour des produits pharmaceutiques comprenant des contraceptifs
US20180319519A1 (en) * 2015-08-25 2018-11-08 Bayer Pharma Aktiengesellschaft Blister packaging
CN114348308A (zh) * 2021-12-17 2022-04-15 唐科华 一种消化内科圆形药片保存装置

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362000A (en) * 1978-05-30 1982-12-07 Sterling Drug Inc. Process and platform apparatus for producing packaging element
EP0852208A1 (fr) * 1995-07-20 1998-07-08 Eli Lilly Japan K.K. Boite pour comprimes
US20030183551A1 (en) * 2002-04-01 2003-10-02 Hulick Martin E. Medicant package
GB2389355A (en) * 2003-06-28 2003-12-10 Donald Aslett Dispensing pack having compartments
US20040093835A1 (en) * 2002-11-18 2004-05-20 Todd Siegel Systems and methods for forming blister packages with support members for pharmaceutical product packaging
WO2005109948A2 (fr) * 2004-04-24 2005-11-17 Inrange Systems, Inc. Support universel a medicaments

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362000A (en) * 1978-05-30 1982-12-07 Sterling Drug Inc. Process and platform apparatus for producing packaging element
EP0852208A1 (fr) * 1995-07-20 1998-07-08 Eli Lilly Japan K.K. Boite pour comprimes
US20030183551A1 (en) * 2002-04-01 2003-10-02 Hulick Martin E. Medicant package
US20040093835A1 (en) * 2002-11-18 2004-05-20 Todd Siegel Systems and methods for forming blister packages with support members for pharmaceutical product packaging
GB2389355A (en) * 2003-06-28 2003-12-10 Donald Aslett Dispensing pack having compartments
WO2005109948A2 (fr) * 2004-04-24 2005-11-17 Inrange Systems, Inc. Support universel a medicaments

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2923966A1 (fr) * 2014-03-28 2015-09-30 The Challenge Printing Company Emballage pour des produits pharmaceutiques comprenant des contraceptifs
US20180319519A1 (en) * 2015-08-25 2018-11-08 Bayer Pharma Aktiengesellschaft Blister packaging
US10889393B2 (en) * 2015-08-25 2021-01-12 Bayer Pharma Aktiengesellschaft Macro blister packaging
CN114348308A (zh) * 2021-12-17 2022-04-15 唐科华 一种消化内科圆形药片保存装置
CN114348308B (zh) * 2021-12-17 2023-11-24 浙江浩宇电力设备有限公司 一种消化内科圆形药片保存装置

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