EP1940517A2 - Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal dryness - Google Patents
Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal drynessInfo
- Publication number
- EP1940517A2 EP1940517A2 EP06805796A EP06805796A EP1940517A2 EP 1940517 A2 EP1940517 A2 EP 1940517A2 EP 06805796 A EP06805796 A EP 06805796A EP 06805796 A EP06805796 A EP 06805796A EP 1940517 A2 EP1940517 A2 EP 1940517A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- vaginal
- colostrum
- hyaluronic acid
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
Definitions
- the present invention relates to vaginal compositions comprising colostrum and hyaluronic acid, useful for the treatment of vaginal dryness in menopause.
- Vaginal dryness is one of the consequences of the decrease in estrogen levels in menopause.
- the fall in circulating estrogen level involves in fact the thinning of the vaginal walls, with reduction of elasticity and decrease in the natural secretion and lubrication, which makes sexual intercourse difficult and painful.
- Vaginal dryness is usually treated with the replacement therapy comprising estrogens, which however involves well known side effects (slight increase in the number of breast tumours, slight increase in stroke cases, risk of "stimulation" of endometrious with possible “hyperplasia”, increase in the risk of thrombotic phenomena).
- vaginal topical compositions comprising colostrum exert a beneficial action on vaginal epithelium, increasing its elasticity and promoting mucosal secretion.
- the present invention relates to fluid compositions in the form of vaginal creams, gel, solutions, ovules, suppositories, capsules or washes containing colostrum and hyaluronic acid, useful for the treatment of vaginal dryness in menopause.
- the present invention also relates to the use of colostrum and hyaluronic acid for the treatment of vaginal dryness associated to postmenopausal syndrome.
- colostrum can derive from any mammal, preferably of equine, bovine, ovine origin, and it will be present in the compositions of the invention in percentages ranging from 5 to 0%.
- hyaluronic acid will be present in the compositions of the invention in percentages ranging from 0.1 to 2%.
- the compositions of the present invention will also contain soy isoflavones. Soy isoflavones are phytoestrogens that have been used for a long time in replacement therapy.
- soy isoflavones can be selected from genistein, daidzein, glycitein and their glycosides genistin, daidzin and glycitin, and they will be present in percentages ranging preferably from 0.01 to 5% by weight.
- compositions of the present invention will also contain vegetable extracts from plants which exert a complementary or anyway useful activity for the purposes of the invention, for example estrogenic, anti-inflammatory, antifungal, antibacterial, re-epithelizing, hydrating, decongesting, microcirculation-improving, protective, antioxidant, refreshing activities and the like.
- Examples of said plants are coconut palm ⁇ Elaeis guineensis), aloe ⁇ Aloe barbadensis), cypress (Cupressus saffirvirens), maca (Lepidium meyeni ⁇ ), minth ⁇ Mentha piperita), thyme ⁇ Thymus vulgaris), vervain ⁇ Lippia citriodora), oreganon ⁇ Origanum vulgare), and plants of the Citrus genus.
- compositions of the present invention proved to exert a synergetic activity: in fact they exert a surprisingly higher action than that obtained from the sum of the activity of the single active components.
- compositions of the present invention will be formulated in the form of vaginal gel, creams, solutions, ovules, suppositories, capsules and washes, using techniques and conventional excipients well-known in the pharmaceutical technique, such as diluents, disintegrants, moisturizers and lubricants.
- a preferred formulation is that in cream.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001777A ITMI20051777A1 (it) | 2005-09-23 | 2005-09-23 | Composizioni a base di colostro per il trattamento della secchezza vaginale |
PCT/EP2006/009183 WO2007039124A2 (en) | 2005-09-23 | 2006-09-21 | Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal dryness |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1940517A2 true EP1940517A2 (en) | 2008-07-09 |
Family
ID=37890564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06805796A Withdrawn EP1940517A2 (en) | 2005-09-23 | 2006-09-21 | Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal dryness |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1940517A2 (it) |
IT (1) | ITMI20051777A1 (it) |
WO (1) | WO2007039124A2 (it) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2773277C (en) | 2008-09-12 | 2019-03-26 | Nanoko A/S | Colostrum composition |
IT1396425B1 (it) * | 2009-09-24 | 2012-11-23 | You Biomedical Res Srl | Composizioni per il trattamento della secchezza vaginale e delle infezioni vaginali ricorrenti |
CN102239922A (zh) * | 2010-05-13 | 2011-11-16 | 江苏星驰生物科技有限公司 | 一种牛初乳配方粉 |
IT1401351B1 (it) * | 2010-07-28 | 2013-07-18 | Galsor S R L | Composizione farmaceutica a base di una o più frazioni di acido ialuronico o suoi sali in associazione con un inibitore della ialuronidasi e suoi usi in campo medico |
IT1405998B1 (it) * | 2010-12-09 | 2014-02-06 | Bionest Ltd | Gel polifunzionale contro la secchezza vaginale ad effetto diretto e ritardato |
ITMI20112438A1 (it) * | 2011-12-30 | 2013-07-01 | Bionest Ltd | Formulazioni iniettabili di citochine, fattori di crescita, fattori chemiotattici, fattori di stimolazione staminale e rna per la rigenerazione del derma |
CN112088010A (zh) * | 2018-05-04 | 2020-12-15 | 宝洁公司 | 用于治疗***干燥的组合物和方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5953425A (ja) * | 1982-09-22 | 1984-03-28 | Meiji Milk Prod Co Ltd | 「ちつ」 |
US6251436B1 (en) * | 1995-09-29 | 2001-06-26 | L.A.M. Pharmaceutical Corporation | Drug preparations for treating sexual dysfunction |
CN1175401A (zh) * | 1996-09-03 | 1998-03-11 | 深圳市龙岗区新业有限公司 | 护肤用sod精华素及其专用调理液 |
ITMI20030195A1 (it) * | 2003-02-06 | 2004-08-07 | Bsd Bioscience Dev Snc Di O Mini C E Zucc | Formulazioni topiche contenenti principi attivi naturali adatte alla prevenzione e cura dei processi infiammatori delle mucose |
AU2004228759B2 (en) * | 2003-04-09 | 2010-04-08 | Dolhay Klinika Egeszsegugyi Kft. | Sexual hygienic composition |
-
2005
- 2005-09-23 IT IT001777A patent/ITMI20051777A1/it unknown
-
2006
- 2006-09-21 WO PCT/EP2006/009183 patent/WO2007039124A2/en active Application Filing
- 2006-09-21 EP EP06805796A patent/EP1940517A2/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO2007039124A2 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007039124A2 (en) | 2007-04-12 |
ITMI20051777A1 (it) | 2007-03-24 |
WO2007039124A3 (en) | 2007-06-28 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 20080416 |
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AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
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17Q | First examination report despatched |
Effective date: 20090409 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20091020 |