EP1940517A2 - Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal dryness - Google Patents

Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal dryness

Info

Publication number
EP1940517A2
EP1940517A2 EP06805796A EP06805796A EP1940517A2 EP 1940517 A2 EP1940517 A2 EP 1940517A2 EP 06805796 A EP06805796 A EP 06805796A EP 06805796 A EP06805796 A EP 06805796A EP 1940517 A2 EP1940517 A2 EP 1940517A2
Authority
EP
European Patent Office
Prior art keywords
compositions
vaginal
colostrum
hyaluronic acid
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06805796A
Other languages
German (de)
French (fr)
Inventor
Rosa Maria Gobbi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
YOU Biomedical Research Srl
Original Assignee
YOU Biomedical Research Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by YOU Biomedical Research Srl filed Critical YOU Biomedical Research Srl
Publication of EP1940517A2 publication Critical patent/EP1940517A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Definitions

  • the present invention relates to vaginal compositions comprising colostrum and hyaluronic acid, useful for the treatment of vaginal dryness in menopause.
  • Vaginal dryness is one of the consequences of the decrease in estrogen levels in menopause.
  • the fall in circulating estrogen level involves in fact the thinning of the vaginal walls, with reduction of elasticity and decrease in the natural secretion and lubrication, which makes sexual intercourse difficult and painful.
  • Vaginal dryness is usually treated with the replacement therapy comprising estrogens, which however involves well known side effects (slight increase in the number of breast tumours, slight increase in stroke cases, risk of "stimulation" of endometrious with possible “hyperplasia”, increase in the risk of thrombotic phenomena).
  • vaginal topical compositions comprising colostrum exert a beneficial action on vaginal epithelium, increasing its elasticity and promoting mucosal secretion.
  • the present invention relates to fluid compositions in the form of vaginal creams, gel, solutions, ovules, suppositories, capsules or washes containing colostrum and hyaluronic acid, useful for the treatment of vaginal dryness in menopause.
  • the present invention also relates to the use of colostrum and hyaluronic acid for the treatment of vaginal dryness associated to postmenopausal syndrome.
  • colostrum can derive from any mammal, preferably of equine, bovine, ovine origin, and it will be present in the compositions of the invention in percentages ranging from 5 to 0%.
  • hyaluronic acid will be present in the compositions of the invention in percentages ranging from 0.1 to 2%.
  • the compositions of the present invention will also contain soy isoflavones. Soy isoflavones are phytoestrogens that have been used for a long time in replacement therapy.
  • soy isoflavones can be selected from genistein, daidzein, glycitein and their glycosides genistin, daidzin and glycitin, and they will be present in percentages ranging preferably from 0.01 to 5% by weight.
  • compositions of the present invention will also contain vegetable extracts from plants which exert a complementary or anyway useful activity for the purposes of the invention, for example estrogenic, anti-inflammatory, antifungal, antibacterial, re-epithelizing, hydrating, decongesting, microcirculation-improving, protective, antioxidant, refreshing activities and the like.
  • Examples of said plants are coconut palm ⁇ Elaeis guineensis), aloe ⁇ Aloe barbadensis), cypress (Cupressus saffirvirens), maca (Lepidium meyeni ⁇ ), minth ⁇ Mentha piperita), thyme ⁇ Thymus vulgaris), vervain ⁇ Lippia citriodora), oreganon ⁇ Origanum vulgare), and plants of the Citrus genus.
  • compositions of the present invention proved to exert a synergetic activity: in fact they exert a surprisingly higher action than that obtained from the sum of the activity of the single active components.
  • compositions of the present invention will be formulated in the form of vaginal gel, creams, solutions, ovules, suppositories, capsules and washes, using techniques and conventional excipients well-known in the pharmaceutical technique, such as diluents, disintegrants, moisturizers and lubricants.
  • a preferred formulation is that in cream.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to vaginal compositions containing colostrum and hyaluronic acid, more particularly fluid compositions in the form of vaginal creams, gel, solutions, ovules, suppositories, capsules or washes, useful for the treatment of vaginal dryness in menopause.

Description

COMPOSITIONS COMPRISING COLOSTRUM AND HYALURONIC ACID FOR THE TREATMENT OF VAGINAL DRYNESS
Summary of the invention
The present invention relates to vaginal compositions comprising colostrum and hyaluronic acid, useful for the treatment of vaginal dryness in menopause. Technical background
Vaginal dryness is one of the consequences of the decrease in estrogen levels in menopause. The fall in circulating estrogen level involves in fact the thinning of the vaginal walls, with reduction of elasticity and decrease in the natural secretion and lubrication, which makes sexual intercourse difficult and painful. Vaginal dryness is usually treated with the replacement therapy comprising estrogens, which however involves well known side effects (slight increase in the number of breast tumours, slight increase in stroke cases, risk of "stimulation" of endometrious with possible "hyperplasia", increase in the risk of thrombotic phenomena). It has now been found that vaginal topical compositions comprising colostrum exert a beneficial action on vaginal epithelium, increasing its elasticity and promoting mucosal secretion.
Disclosure of the invention
Therefore, the present invention relates to fluid compositions in the form of vaginal creams, gel, solutions, ovules, suppositories, capsules or washes containing colostrum and hyaluronic acid, useful for the treatment of vaginal dryness in menopause.
The present invention also relates to the use of colostrum and hyaluronic acid for the treatment of vaginal dryness associated to postmenopausal syndrome. According to the present invention, colostrum can derive from any mammal, preferably of equine, bovine, ovine origin, and it will be present in the compositions of the invention in percentages ranging from 5 to 0%. According to the present invention, hyaluronic acid will be present in the compositions of the invention in percentages ranging from 0.1 to 2%. According to a preferred aspect of the present invention, the compositions of the present invention will also contain soy isoflavones. Soy isoflavones are phytoestrogens that have been used for a long time in replacement therapy. It is in fact known that Asian women, thanks to a diet rich in phytoestrogens, have markedly fewer postmenopausal symptoms than Western women. According to the present invention, soy isoflavones can be selected from genistein, daidzein, glycitein and their glycosides genistin, daidzin and glycitin, and they will be present in percentages ranging preferably from 0.01 to 5% by weight.
According to a preferred aspect, the compositions of the present invention will also contain vegetable extracts from plants which exert a complementary or anyway useful activity for the purposes of the invention, for example estrogenic, anti-inflammatory, antifungal, antibacterial, re-epithelizing, hydrating, decongesting, microcirculation-improving, protective, antioxidant, refreshing activities and the like. Examples of said plants are coconut palm {Elaeis guineensis), aloe {Aloe barbadensis), cypress (Cupressus semprevirens), maca (Lepidium meyeniϊ), minth {Mentha piperita), thyme {Thymus vulgaris), vervain {Lippia citriodora), oreganon {Origanum vulgare), and plants of the Citrus genus.
The compositions of the present invention proved to exert a synergetic activity: in fact they exert a surprisingly higher action than that obtained from the sum of the activity of the single active components.
The compositions of the present invention will be formulated in the form of vaginal gel, creams, solutions, ovules, suppositories, capsules and washes, using techniques and conventional excipients well-known in the pharmaceutical technique, such as diluents, disintegrants, moisturizers and lubricants. According to the present invention, a preferred formulation is that in cream.
An example of formulation according to the invention is reported below:
Example - Vaginal cream

Claims

1. Vaginal compositions containing colostrum and hyaluronic acid for the treatment of vaginal dryness in menopause.
2. Compositions as claimed in claim 1, in which colostrum derives from any mammal, preferably of equine, bovine, ovine origin.
3. Compositions as claimed in claim 1 e 2, containing colostrum in percentages ranging from 5 to 30%.
4. Compositions as claimed in claim 1 e 2, containing hyaluronic acid in percentages ranging from 0.1 to 2%.
5. Compositions according to the above claims, further containing soy isoflavones.
6. Compositions according to the above claims, further containing vegetable extracts from plants selected from the group consisting of Elaeis guineensis, Aloe barbadensis, Cupressus semprevirens, Mentha piperita, Thymus vulgaris, Lippia citriodora, Origanum vulgare, and plants of the Citrus genus.
7. Compositions as claimed in any one of the above claims, in the form of vaginal creams, gel, solutions, ovules, suppositories, capsules or washes.
8. Compositions as claimed in claim 6, in the form of creams.
9. The use of colostrum for the preparation of compositions vaginal for the treatment of vaginal dryness in menopause.
EP06805796A 2005-09-23 2006-09-21 Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal dryness Withdrawn EP1940517A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001777A ITMI20051777A1 (en) 2005-09-23 2005-09-23 COLOSSUS-BASED COMPOSITIONS FOR VAGINAL DRYING TREATMENT
PCT/EP2006/009183 WO2007039124A2 (en) 2005-09-23 2006-09-21 Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal dryness

Publications (1)

Publication Number Publication Date
EP1940517A2 true EP1940517A2 (en) 2008-07-09

Family

ID=37890564

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06805796A Withdrawn EP1940517A2 (en) 2005-09-23 2006-09-21 Compositions comprising colostrum and hyaluronic acid for the treatment of vaginal dryness

Country Status (3)

Country Link
EP (1) EP1940517A2 (en)
IT (1) ITMI20051777A1 (en)
WO (1) WO2007039124A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2773277C (en) 2008-09-12 2019-03-26 Nanoko A/S Colostrum composition
IT1396425B1 (en) * 2009-09-24 2012-11-23 You Biomedical Res Srl COMPOSITIONS FOR THE TREATMENT OF VAGINAL DRYNESS AND RECURRENT VAGINAL INFECTIONS
CN102239922A (en) * 2010-05-13 2011-11-16 江苏星驰生物科技有限公司 Colostrum formula powder
IT1401351B1 (en) * 2010-07-28 2013-07-18 Galsor S R L PHARMACEUTICAL COMPOSITION BASED ON ONE OR MORE HYALURONIC ACID FRACTIONS OR ITS SALTS ASSOCIATED WITH AN INHIBITOR OF IALURONIDASI AND ITS USES IN MEDICAL FIELD
IT1405998B1 (en) * 2010-12-09 2014-02-06 Bionest Ltd MULTIPURPOSE GEL AGAINST THE VAGINAL DRYNESS WITH A DIRECT AND DELAYED EFFECT
ITMI20112438A1 (en) * 2011-12-30 2013-07-01 Bionest Ltd INJECTABLE FORMULATIONS OF CYTOKINES, GROWTH FACTORS, CHEMOTACTIC FACTORS, STAMINAL STIMULATION FATORS AND RNA FOR DERMA REGENERATION
CN112088010A (en) * 2018-05-04 2020-12-15 宝洁公司 Compositions and methods for treating vaginal dryness

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953425A (en) * 1982-09-22 1984-03-28 Meiji Milk Prod Co Ltd Vaginal lubricant
US6251436B1 (en) * 1995-09-29 2001-06-26 L.A.M. Pharmaceutical Corporation Drug preparations for treating sexual dysfunction
CN1175401A (en) * 1996-09-03 1998-03-11 深圳市龙岗区新业有限公司 SOD essence for skin care and special conditioning liquid thereof
ITMI20030195A1 (en) * 2003-02-06 2004-08-07 Bsd Bioscience Dev Snc Di O Mini C E Zucc TOPICAL FORMULATIONS CONTAINING NATURAL ACTIVE INGREDIENTS SUITABLE FOR THE PREVENTION AND TREATMENT OF MAMMOSE INFLAMMATORY PROCESSES
AU2004228759B2 (en) * 2003-04-09 2010-04-08 Dolhay Klinika Egeszsegugyi Kft. Sexual hygienic composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2007039124A2 *

Also Published As

Publication number Publication date
WO2007039124A2 (en) 2007-04-12
ITMI20051777A1 (en) 2007-03-24
WO2007039124A3 (en) 2007-06-28

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