EP1670422A4 - Identification of kinase inhibitors - Google Patents

Identification of kinase inhibitors

Info

Publication number
EP1670422A4
EP1670422A4 EP03752561A EP03752561A EP1670422A4 EP 1670422 A4 EP1670422 A4 EP 1670422A4 EP 03752561 A EP03752561 A EP 03752561A EP 03752561 A EP03752561 A EP 03752561A EP 1670422 A4 EP1670422 A4 EP 1670422A4
Authority
EP
European Patent Office
Prior art keywords
identification
kinase inhibitors
kinase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03752561A
Other languages
German (de)
French (fr)
Other versions
EP1670422A2 (en
Inventor
John C Prescott
Andrew Braisted
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of EP1670422A2 publication Critical patent/EP1670422A2/en
Publication of EP1670422A4 publication Critical patent/EP1670422A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
EP03752561A 2003-09-17 2003-09-17 Identification of kinase inhibitors Withdrawn EP1670422A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/029870 WO2005034840A2 (en) 2003-09-17 2003-09-17 Identification of kinase inhibitors

Publications (2)

Publication Number Publication Date
EP1670422A2 EP1670422A2 (en) 2006-06-21
EP1670422A4 true EP1670422A4 (en) 2007-08-01

Family

ID=34434214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03752561A Withdrawn EP1670422A4 (en) 2003-09-17 2003-09-17 Identification of kinase inhibitors

Country Status (4)

Country Link
EP (1) EP1670422A4 (en)
AU (1) AU2003270848A1 (en)
CA (1) CA2539064A1 (en)
WO (1) WO2005034840A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
MX2009003793A (en) 2006-10-09 2009-12-14 Takeda Pharmaceutical Kinase inhibitors.
IN2012DN02534A (en) * 2009-09-16 2015-08-28 Avila Therapeutics Inc
BR112012015721A2 (en) 2009-12-30 2017-09-26 Avila Therapeutics Inc covalent ligand-driven protein modification
PT2580322T (en) 2010-06-09 2018-03-01 Dana Farber Cancer Inst Inc A mek 1 mutation conferring resistance to raf and mek inhibitors
GB201614152D0 (en) 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
US20220265669A1 (en) * 2019-02-25 2022-08-25 Albert Einstein College Of Medicine Compounds useful for inhibiting raf dimers
CN116434828B (en) * 2023-04-17 2024-03-26 深圳新锐基因科技有限公司 Method and device for introducing dynamic disulfide bonds of protein molecules based on computational structure biology

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042773A2 (en) * 2000-11-21 2002-05-30 Sunesis Pharmaceuticals, Inc. An extended tethering approach for rapid identification of ligands
WO2003014308A2 (en) * 2001-08-07 2003-02-20 Sunesis Pharmaceuticals, Inc. Cysteine mutants and methods for detecting ligand binding to biological molecules
WO2003081210A2 (en) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042773A2 (en) * 2000-11-21 2002-05-30 Sunesis Pharmaceuticals, Inc. An extended tethering approach for rapid identification of ligands
WO2003014308A2 (en) * 2001-08-07 2003-02-20 Sunesis Pharmaceuticals, Inc. Cysteine mutants and methods for detecting ligand binding to biological molecules
WO2003081210A2 (en) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ERLANSON DANIEL A ET AL: "MAKING DRUGS ON PROTEINS: SITE-DIRECTED LIGAND DISCOVERY FOR FRAGMENT-BASED LEAD ASSEMBLY", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 8, no. 4, August 2004 (2004-08-01), pages 399 - 406, XP009072514, ISSN: 1367-5931 *
MALY D J ET AL: "Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 14 MAR 2000 UNITED STATES, vol. 97, no. 6, 14 March 2000 (2000-03-14), pages 2419 - 2424, XP002199108, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2005034840A8 (en) 2006-04-20
WO2005034840A2 (en) 2005-04-21
EP1670422A2 (en) 2006-06-21
AU2003270848A1 (en) 2005-04-27
CA2539064A1 (en) 2005-04-21
WO2005034840A3 (en) 2006-10-05

Similar Documents

Publication Publication Date Title
IL173381A0 (en) 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
PL373649A1 (en) Kinase inhibitors
SI1569907T1 (en) Nicotinamide-based kinase inhibitors
AU2003271566A8 (en) Pyrrolopyrazines as kinase inhibitors
AP2048A (en) Diazepinoindole derivatives as kinase inhibitors
AU2003299651A8 (en) Tyrosine kinase inhibitors
IL175568A0 (en) Azole-based kinase inhibitors
IL173200A0 (en) Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
IL172132A0 (en) Thienopyridone derivatives as kinase inhibitors
IL173380A0 (en) Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors
IL208520A0 (en) Akt protein kinase inhibitors
HK1072545A1 (en) Novel inhibitors of kinases
IL165515A0 (en) Bisindolyl-maleimid derivatives as kinase inhibitors
EP1558609A4 (en) Kinase inhibitors
AU2003298942A8 (en) Tyrosine kinase inhibitors
HK1071758A1 (en) Pyrazolopyridines as cyclin dependent kinase inhibitors
IL183276A0 (en) Kinase inhibitors
EP1534268A4 (en) Tyrosine kinase inhibitors
AU2003275282A8 (en) Novel tyrosine kinase inhibitors
HK1100141A1 (en) Kinase inhibitors
PL378116A1 (en) Heterocyclic kinase inhibitors
EP1651599A4 (en) Tyrosine kinase inhibitors
EP1496897A4 (en) Tyrosine kinase inhibitors
EP1670422A4 (en) Identification of kinase inhibitors
EP1569907A4 (en) Nicotinamide-based kinase inhibitors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060413

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

PUAK Availability of information related to the publication of the international search report

Free format text: ORIGINAL CODE: 0009015

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/68 20060101ALI20061115BHEP

Ipc: C12N 9/99 20060101AFI20061115BHEP

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20070704

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/566 20060101ALI20070628BHEP

Ipc: C12Q 1/48 20060101AFI20070628BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20071003