EP1545608A4 - Ch1-deletierte säugetier-mimetikörper, zusammensetzungen, verfahren und anwendungen - Google Patents
Ch1-deletierte säugetier-mimetikörper, zusammensetzungen, verfahren und anwendungenInfo
- Publication number
- EP1545608A4 EP1545608A4 EP03742272A EP03742272A EP1545608A4 EP 1545608 A4 EP1545608 A4 EP 1545608A4 EP 03742272 A EP03742272 A EP 03742272A EP 03742272 A EP03742272 A EP 03742272A EP 1545608 A4 EP1545608 A4 EP 1545608A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- mammalian
- compositions
- methods
- deleted mimetibodies
- mimetibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39243102P | 2002-06-28 | 2002-06-28 | |
US392431P | 2002-06-28 | ||
PCT/US2003/020347 WO2004002417A2 (en) | 2002-06-28 | 2003-06-27 | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1545608A2 EP1545608A2 (de) | 2005-06-29 |
EP1545608A4 true EP1545608A4 (de) | 2006-09-13 |
Family
ID=30000868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03742272A Withdrawn EP1545608A4 (de) | 2002-06-28 | 2003-06-27 | Ch1-deletierte säugetier-mimetikörper, zusammensetzungen, verfahren und anwendungen |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1545608A4 (de) |
JP (1) | JP2006504406A (de) |
CN (1) | CN1735433A (de) |
AU (1) | AU2003280130B2 (de) |
CA (1) | CA2490409A1 (de) |
WO (1) | WO2004002417A2 (de) |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
CN1810832B (zh) | 1998-10-23 | 2012-12-12 | 麒麟-安姆根有限公司 | 与MPl受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽 |
AU2003222069A1 (en) * | 2002-03-29 | 2003-10-20 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
CA2490411A1 (en) * | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
UA89481C2 (uk) * | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування |
AU2004316266A1 (en) * | 2003-09-30 | 2005-09-09 | Centocor, Inc. | Human hinge core mimetibodies, compositions, methods and uses |
MXPA06011425A (es) * | 2004-03-31 | 2007-03-12 | Johnson & Johnson | Memiticuerpos de peptido-1 similar a glucagon de humano, composiciones, metodos y usos. |
WO2007081302A2 (en) * | 2005-03-28 | 2007-07-19 | Centocor, Inc. | Human glp-1 mimetibodies, compositions, methods and uses |
AU2005289685B2 (en) | 2004-09-24 | 2009-07-16 | Amgen Inc. | Modified Fc molecules |
JP2008537874A (ja) * | 2004-09-27 | 2008-10-02 | セントカー・インコーポレーテツド | sRAGEミメティボディ、組成物、方法および使用 |
EA200700944A1 (ru) * | 2004-10-25 | 2008-04-28 | Сентокор, Инк. | Миметические антитела, связывающие меланокортиновый рецептор, композиции, способы и применение |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
EP2007602A4 (de) * | 2006-03-31 | 2010-09-22 | Centocor Ortho Biotech Inc | Humane mimetische epo-hinge-core-mimetikörper, zusammensetzungen, verfahren und verwendung zur prävention oder behandlung von glukoseintoleranzbedingten erkrankungen oder mit nierenkrankheit assoziierter anämie |
US7943310B2 (en) | 2006-08-30 | 2011-05-17 | Centocor Ortho Biotech Inc. | Methods for assessing response to therapy in subjects having ulcerative colitis |
WO2008079976A2 (en) * | 2006-12-21 | 2008-07-03 | Centocor, Inc. | Dimeric high affinity egfr constructs and uses thereof |
US8536113B2 (en) | 2006-12-21 | 2013-09-17 | Janssen Biotech, Inc. | EGFR binding peptides and uses thereof |
US8834920B2 (en) | 2006-12-21 | 2014-09-16 | Alza Corporation | Liposome composition for targeting egfr receptor |
WO2008092209A1 (en) * | 2007-02-01 | 2008-08-07 | Arana Therapeutics Limited | Protein construct with improved properties |
US8383114B2 (en) | 2007-09-27 | 2013-02-26 | Amgen Inc. | Pharmaceutical formulations |
EP3381445B1 (de) | 2007-11-15 | 2023-10-25 | Amgen Inc. | Wässrige antikörperformulierung mit stabilisierung durch antioxidantien zur parenteralen verabreichung |
US9175078B2 (en) | 2008-01-25 | 2015-11-03 | Amgen Inc. | Ferroportin antibodies and methods of use |
ES2487846T3 (es) | 2008-05-01 | 2014-08-25 | Amgen, Inc. | Anticuerpos anti-hepcindina y métodos de uso |
DK2329259T3 (en) | 2008-08-29 | 2016-05-09 | Janssen Biotech Inc | MARKERS AND PROCEDURES FOR ASSESSING AND TREATING ULCERATIVE COLITIS AND RELATED DISEASES USING A 20-GEN PANEL |
US20120052066A1 (en) | 2008-11-07 | 2012-03-01 | Cesar Calderon | Markers and methods for assessing and treating lupus patients susceptible to photoprovocation |
WO2010056981A2 (en) | 2008-11-13 | 2010-05-20 | Massachusetts General Hospital | Methods and compositions for regulating iron homeostasis by modulation bmp-6 |
WO2011050333A1 (en) | 2009-10-23 | 2011-04-28 | Amgen Inc. | Vial adapter and system |
AU2010322202B2 (en) | 2009-11-17 | 2015-01-22 | Janssen Biotech Inc. | Display of disulfide linked dimeric proteins on filamentous phage |
MY159680A (en) | 2009-11-17 | 2017-01-13 | Janssen Biotech Inc | Improved bacterial membrane protein secrection |
WO2011103164A1 (en) | 2010-02-18 | 2011-08-25 | Centocor Ortho Biotech Inc. | Monkey homolog of human interferon omega |
EP2558482B1 (de) | 2010-04-16 | 2017-09-27 | Janssen Biotech, Inc. | Genetisch veränderte cysteinproteasen aus pflanzen und ihre verwendung |
ES2545411T5 (es) | 2010-06-07 | 2024-04-05 | Amgen Inc | Dispositivo de administración de fármaco |
EP2621950A4 (de) | 2010-09-27 | 2015-09-02 | Janssen Biotech Inc | Antikörper zur bindung von humanem kollagen ii |
MX341790B (es) | 2011-03-31 | 2016-09-02 | Amgen Inc | Adaptador de viales y sistema. |
AU2012245231B2 (en) | 2011-04-20 | 2016-10-13 | Amgen Inc. | Autoinjector apparatus |
CN103930142B (zh) | 2011-10-14 | 2016-12-14 | 安姆根有限公司 | 注射器和装配方法 |
SI3081249T1 (sl) | 2012-11-21 | 2021-03-31 | Amgen Inc. | Naprava za dajanje zdravila |
CA2904725C (en) | 2013-03-15 | 2022-04-12 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
JP6768501B2 (ja) | 2013-03-15 | 2020-10-14 | アムゲン・インコーポレーテッド | 薬物カセット、自動注入機、および自動注入機システム |
NZ729747A (en) * | 2013-03-15 | 2020-03-27 | Omeros Corp | Methods of generating bioactive peptide-bearing antibodies and compositions comprising the same |
DK2968503T3 (en) | 2013-03-15 | 2018-12-03 | Intrinsic Lifesciences Llc | ANTI-HEPCIDIN ANTIBODIES AND APPLICATIONS THEREOF |
WO2014149357A1 (en) | 2013-03-22 | 2014-09-25 | Amgen Inc. | Injector and method of assembly |
PL3060275T3 (pl) | 2013-10-24 | 2019-12-31 | Amgen Inc. | Wstrzykiwacz i sposób montażu |
EP3060281B1 (de) | 2013-10-24 | 2019-01-30 | Amgen Inc. | Arzneimittelabgabesystem mit temperaturempfindlicher steuerung |
WO2015119906A1 (en) | 2014-02-05 | 2015-08-13 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
AU2015256082C1 (en) | 2014-05-07 | 2020-09-10 | Amgen Inc. | Autoinjector with shock reducing elements |
CN112237662B (zh) | 2014-06-03 | 2022-10-21 | 安姆根有限公司 | 药物递送***和使用方法 |
NZ730186A (en) | 2014-09-22 | 2020-04-24 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
AU2015332557B2 (en) | 2014-10-14 | 2020-05-14 | Amgen Inc. | Drug injection device with visual and audio indicators |
ES2785311T3 (es) | 2014-12-19 | 2020-10-06 | Amgen Inc | Dispositivo de administración de fármacos con botón móvil o campo de interfaz de usuario |
JP6716566B2 (ja) | 2014-12-19 | 2020-07-01 | アムジエン・インコーポレーテツド | 近接センサ付き薬物送達装置 |
CA2976935C (en) | 2015-02-17 | 2020-03-10 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
ES2905870T3 (es) | 2015-02-27 | 2022-04-12 | Amgen Inc | Dispositivo de suministro de fármacos que tiene un mecanismo de protección de aguja con un umbral de resistencia ajustable al movimiento de la protección de aguja |
WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
WO2017100501A1 (en) | 2015-12-09 | 2017-06-15 | Amgen Inc. | Auto-injector with signaling cap |
WO2017120178A1 (en) | 2016-01-06 | 2017-07-13 | Amgen Inc. | Auto-injector with signaling electronics |
EP3429663B1 (de) | 2016-03-15 | 2020-07-15 | Amgen Inc. | Verringerung der wahrscheinlichkeit auf glasbruch in arzneimittelabgabevorrichtungen |
WO2017189089A1 (en) | 2016-04-29 | 2017-11-02 | Amgen Inc. | Drug delivery device with messaging label |
WO2017192287A1 (en) | 2016-05-02 | 2017-11-09 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
MX2018013616A (es) | 2016-05-13 | 2019-02-21 | Amgen Inc | Montaje de cubierta protectora de vial. |
US11238150B2 (en) | 2016-05-16 | 2022-02-01 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
WO2017209899A1 (en) | 2016-06-03 | 2017-12-07 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
WO2018004842A1 (en) | 2016-07-01 | 2018-01-04 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
EP3532127A1 (de) | 2016-10-25 | 2019-09-04 | Amgen Inc. | Injektor am körper |
AU2018210301A1 (en) | 2017-01-17 | 2019-08-01 | Amgen Inc. | Injection devices and related methods of use and assembly |
MX2019009755A (es) | 2017-02-17 | 2019-10-07 | Amgen Inc | Mecanismo de insercion para dispositivo de suministro de farmacos. |
WO2018151890A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Drug delivery device with sterile fluid flowpath and related method of assembly |
EP3592403A1 (de) | 2017-03-06 | 2020-01-15 | Amgen Inc. | Wirkstofffreisetzungsvorrichtung mit aktivierungsverhinderungsfunktion |
IL268478B2 (en) | 2017-03-07 | 2023-10-01 | Amgen Inc | Inserting a needle using super pressure |
IL268386B2 (en) | 2017-03-09 | 2023-11-01 | Amgen Inc | Insertion mechanism for a drug delivery device |
CN110446499A (zh) | 2017-03-20 | 2019-11-12 | 豪夫迈·罗氏有限公司 | 一种体外糖基工程化红细胞生成刺激蛋白的方法 |
EP4241807A3 (de) | 2017-03-28 | 2023-10-11 | Amgen Inc. | Kolbenstange und spritzenanordnungssystem und verfahren |
AU2018280054B2 (en) | 2017-06-08 | 2023-07-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
AU2018282077B2 (en) | 2017-06-08 | 2023-11-23 | Amgen Inc. | Torque driven drug delivery device |
US11541183B2 (en) | 2017-06-22 | 2023-01-03 | Amgen Inc. | Device activation impact/shock reduction |
JP7475860B2 (ja) | 2017-06-23 | 2024-04-30 | アムジエン・インコーポレーテツド | スイッチアセンブリにより起動されるキャップを含む電子薬物送達デバイス |
ES2972207T3 (es) | 2017-07-14 | 2024-06-11 | Amgen Inc | Sistema de inserción-retracción de agujas con sistema de resorte de torsión doble |
MA49626A (fr) | 2017-07-21 | 2020-05-27 | Amgen Inc | Élément d'étanchéité perméable aux gaz pour récipient à médicament et procédés d'assemblage |
EP4085942A1 (de) | 2017-07-25 | 2022-11-09 | Amgen Inc. | Arzneimittelabgabevorrichtung mit getriebemodul und verwandtes verfahren zur montage |
EP3658206A1 (de) | 2017-07-25 | 2020-06-03 | Amgen Inc. | Arzneimittelabgabevorrichtung mit behälterzugangssystem und zugehörigem verfahren zur montage |
EP3664863A2 (de) | 2017-08-09 | 2020-06-17 | Amgen Inc. | Hydraulisch-pneumatisches druckkammer-arzneimittelabgabesystem |
EP3668567A1 (de) | 2017-08-18 | 2020-06-24 | Amgen Inc. | Am körper tragbarer injektor mit sterilem klebepflaster |
US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
WO2019070472A1 (en) | 2017-10-04 | 2019-04-11 | Amgen Inc. | FLOW ADAPTER FOR MEDICATION DELIVERY DEVICE |
IL272636B1 (en) | 2017-10-06 | 2024-06-01 | Amgen Inc | Drug delivery device with combination assembly and related assembly method |
WO2019074579A1 (en) | 2017-10-09 | 2019-04-18 | Amgen Inc. | DRUG DELIVERY DEVICE COMPRISING A DRIVE ASSEMBLY AND ASSEMBLY METHOD THEREOF |
EP3703778A1 (de) | 2017-11-03 | 2020-09-09 | Amgen Inc. | System und ansätze zum sterilisieren einer arzneimittelabgabevorrichtung |
WO2019089178A1 (en) | 2017-11-06 | 2019-05-09 | Amgen Inc. | Drug delivery device with placement and flow sensing |
WO2019090303A1 (en) | 2017-11-06 | 2019-05-09 | Amgen Inc. | Fill-finish assemblies and related methods |
SG11202002966QA (en) | 2017-11-10 | 2020-05-28 | Amgen Inc | Plungers for drug delivery devices |
IL273638B1 (en) | 2017-11-16 | 2024-06-01 | Amgen Inc | Door lock mechanism for drug delivery device |
SG11202002772VA (en) | 2017-11-16 | 2020-04-29 | Amgen Inc | Autoinjector with stall and end point detection |
US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
US12042645B2 (en) | 2018-07-24 | 2024-07-23 | Amgen Inc. | Delivery devices for administering drugs |
WO2020023220A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with tacky skin attachment portion and related method of preparation |
WO2020023336A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
MX2021000749A (es) | 2018-07-24 | 2021-03-29 | Amgen Inc | Dispositivos de suministro para administrar farmacos. |
WO2020028009A1 (en) | 2018-07-31 | 2020-02-06 | Amgen Inc. | Fluid path assembly for a drug delivery device |
US20210346601A1 (en) | 2018-09-24 | 2021-11-11 | Amgen Inc. | Interventional dosing systems and methods |
CA3110371A1 (en) | 2018-09-28 | 2020-04-02 | Amgen Inc. | Muscle wire escapement activation assembly for a drug delivery device |
EP3860685A1 (de) | 2018-10-02 | 2021-08-11 | Amgen Inc. | Injektionssysteme zur wirkstoffabgabe mit übertragung der inneren kraft |
EP3860686A1 (de) | 2018-10-05 | 2021-08-11 | Amgen Inc. | Medikamentenabgabevorrichtung mit dosisindikator |
CA3109988A1 (en) | 2018-10-15 | 2020-04-23 | Amgen Inc. | Platform assembly process for drug delivery device |
MA53912A (fr) | 2018-10-15 | 2022-01-19 | Amgen Inc | Dispositif d'administration de médicament comprenant un mécanisme d'amortissement |
TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
CA3113076A1 (en) | 2018-11-01 | 2020-05-07 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
US11213620B2 (en) | 2018-11-01 | 2022-01-04 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
MX2021012557A (es) | 2019-04-24 | 2021-11-12 | Amgen Inc | Conjuntos y metodos de verificacion de esterilizacion de jeringuillas. |
MX2022002149A (es) | 2019-08-23 | 2022-03-17 | Amgen Inc | Dispositivo de suministro de farmacos con componentes de acoplamiento de capuchon de aguja configurable y metodos relacionados. |
US20240208680A1 (en) | 2021-05-21 | 2024-06-27 | Amgen Inc. | Method of optimizing a filling recipe for a drug container |
WO2024094457A1 (en) | 2022-11-02 | 2024-05-10 | F. Hoffmann-La Roche Ag | Method for producing glycoprotein compositions |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5608035A (en) * | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
WO2000024782A2 (en) * | 1998-10-23 | 2000-05-04 | Amgen Inc. | Modified peptides, comprising an fc domain, as therapeutic agents |
US20020012989A1 (en) * | 1993-02-01 | 2002-01-31 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
WO2002046227A2 (en) * | 2000-12-07 | 2002-06-13 | Eli Lilly And Company | Glp-1 fusion proteins |
WO2002046238A2 (en) * | 2000-12-05 | 2002-06-13 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
WO2003084477A2 (en) * | 2002-03-29 | 2003-10-16 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4309989A (en) | 1976-02-09 | 1982-01-12 | The Curators Of The University Of Missouri | Topical application of medication by ultrasound with coupling agent |
FR2374910A1 (fr) | 1976-10-23 | 1978-07-21 | Choay Sa | Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations |
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
US5149636A (en) | 1982-03-15 | 1992-09-22 | Trustees Of Columbia University In The City Of New York | Method for introducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products |
US5169762A (en) | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
SE448277B (sv) | 1985-04-12 | 1987-02-09 | Draco Ab | Indikeringsanordning vid en doseringsanordning for lekemedel |
US4740587A (en) | 1985-07-18 | 1988-04-26 | The Salk Institute For Biological Studies | Inhibin and method of purifying same |
US4721672A (en) | 1985-08-28 | 1988-01-26 | President And Fellows Of Harvard College | CDNA and gene for human angiogenin (angiogenesis factor) and methods of expression |
US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4737578A (en) | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
SE453566B (sv) | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
US4767402A (en) | 1986-07-08 | 1988-08-30 | Massachusetts Institute Of Technology | Ultrasound enhancement of transdermal drug delivery |
NL8720442A (nl) | 1986-08-18 | 1989-04-03 | Clinical Technologies Ass | Afgeefsystemen voor farmacologische agentia. |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
EP0279582A3 (de) | 1987-02-17 | 1989-10-18 | Pharming B.V. | DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten |
JP2647427B2 (ja) | 1987-04-24 | 1997-08-27 | 帝人株式会社 | 被検者の病態の判定のための検出方法、モノクロ−ナル抗体および検出キット |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
US5231166A (en) | 1988-10-25 | 1993-07-27 | Takeda Chemical Industries, Ltd. | Endothelin |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5266491A (en) | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
EP0486526B2 (de) | 1989-08-07 | 2001-03-07 | Peptech Limited | Bindeligande für tumornekrosisfaktor |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5210026A (en) | 1990-08-20 | 1993-05-11 | American Cyanamid Company | Human mk gene and method of expression |
GB9022648D0 (en) | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
US5268465A (en) | 1991-01-18 | 1993-12-07 | The Johns Hopkins University | Purification and molecular cloning of nitric oxide synthase |
US5404871A (en) | 1991-03-05 | 1995-04-11 | Aradigm | Delivery of aerosol medications for inspiration |
WO1992016221A1 (en) | 1991-03-15 | 1992-10-01 | Synergen, Inc. | Pegylation of polypeptides |
IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
ATE359842T1 (de) | 1991-07-02 | 2007-05-15 | Nektar Therapeutics | Abgabevorrichtung für nebelförmige medikamente |
US5976835A (en) | 1992-03-19 | 1999-11-02 | The Rockefeller University | Nucleic acids encoding receptor recognition factor Stat1α and Stat1β, and methods of use thereof |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
US5315000A (en) | 1992-05-14 | 1994-05-24 | Children's Hospital Medical Center | Gene encoding for a L5/3 growth factor and its CDNA |
AU4829593A (en) | 1992-09-23 | 1994-04-12 | Fisons Plc | Inhalation device |
WO1994008552A2 (en) | 1992-10-19 | 1994-04-28 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5643252A (en) | 1992-10-28 | 1997-07-01 | Venisect, Inc. | Laser perforator |
US6143289A (en) | 1992-12-09 | 2000-11-07 | Indiana University Foundation | Compositions of myeloid-cell-suppressive chemokines |
US5849695A (en) | 1993-01-13 | 1998-12-15 | The Regents Of The University Of California | Parathyroid hormone analogues useful for treatment of osteoporosis and disorders of calcium meatabolism in mammals |
WO1994016970A1 (en) | 1993-01-19 | 1994-08-04 | Glaxo Group Limited | Device |
JP3824633B2 (ja) | 1993-02-12 | 2006-09-20 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・リランド・スタンフォード・ジュニアー・ユニバーシティ | 標的遺伝子の調節的転写および他の生物学的結果 |
US5514670A (en) | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
US6190655B1 (en) | 1993-12-03 | 2001-02-20 | Immunex Corporation | Methods of using Flt-3 ligand for exogenous gene transfer |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US5786331A (en) | 1994-02-02 | 1998-07-28 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US5880096A (en) | 1994-02-02 | 1999-03-09 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
US6174995B1 (en) | 1994-08-23 | 2001-01-16 | Haodong Li | Human chemokines, CKβ4 and CKβ10/MCP-4 |
EP0741144B1 (de) | 1994-11-11 | 2002-07-24 | Noboru Kaneko | Monoklonaler antikörper gegen antiannexin-v, verfahren zu seiner herstellung und seiner verwendung |
US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
US6284535B1 (en) | 1995-09-07 | 2001-09-04 | The Trustees Of Columbia University In The City Of New York | Splice variants of the heregulin gene, nARIA and uses thereof |
GB9526100D0 (en) | 1995-12-20 | 1996-02-21 | Intersurgical Ltd | Nebulizer |
EA001016B1 (ru) | 1996-01-03 | 2000-08-28 | Глаксо Груп Лимитед | Ингаляционное устройство |
US5700774A (en) | 1996-03-26 | 1997-12-23 | Genetics Institute, Inc. | Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same |
IL118003A0 (en) | 1996-04-23 | 1996-08-04 | Yeda Res & Dev | Novel vip fragments and pharmaceutical compositions comprising them |
US6271347B1 (en) | 1996-04-26 | 2001-08-07 | Merck & Co., Inc. | Eosinophil eotaxin receptor |
WO1997046668A1 (fr) | 1996-06-07 | 1997-12-11 | Takeda Chemical Industries, Ltd. | Peptide, procede de production et mode d'utilisation correspondants |
DK0857718T3 (da) | 1996-06-10 | 2002-12-16 | Sucampo Ag | Endothelinantagonist |
US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
WO1998009940A1 (en) | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
US6030780A (en) | 1996-10-15 | 2000-02-29 | The Rockefeller University | Purified Stat proteins and methods of purifying thereof |
WO1998021234A2 (en) | 1996-11-15 | 1998-05-22 | Genentech, Inc. | Purification of neurotrophins |
AU5588598A (en) | 1996-11-19 | 1998-06-10 | Georgetown University | Heregulin antagonists and methods for their use |
US5948892A (en) | 1996-12-16 | 1999-09-07 | Amgen Inc. | Analogs of macrophage stimulating protein |
US5879681A (en) | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
US6136558A (en) | 1997-02-10 | 2000-10-24 | Genentech, Inc. | Heregulin variants |
US5921447A (en) | 1997-02-13 | 1999-07-13 | Glaxo Wellcome Inc. | Flow-through metered aerosol dispensing apparatus and method of use thereof |
IT1292017B1 (it) | 1997-05-28 | 1999-01-25 | Dompe Spa | Composizioni farmaceutiche contenenti la proteina stimolante i macrofagi per il trattamento di patologie del sistema nervoso |
IL120943A (en) | 1997-05-29 | 2004-03-28 | Univ Ben Gurion | A system for administering drugs through the skin |
US6265535B1 (en) | 1997-05-30 | 2001-07-24 | The Trustees Of The University Of Pennsylvania | Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses |
AR016551A1 (es) | 1997-07-30 | 2001-07-25 | Smithkline Beecham Corp | Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos |
US6180084B1 (en) * | 1998-08-25 | 2001-01-30 | The Burnham Institute | NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same |
-
2003
- 2003-06-27 EP EP03742272A patent/EP1545608A4/de not_active Withdrawn
- 2003-06-27 WO PCT/US2003/020347 patent/WO2004002417A2/en active Application Filing
- 2003-06-27 JP JP2004517981A patent/JP2006504406A/ja active Pending
- 2003-06-27 CA CA002490409A patent/CA2490409A1/en not_active Abandoned
- 2003-06-27 AU AU2003280130A patent/AU2003280130B2/en not_active Ceased
- 2003-06-30 CN CNA038201100A patent/CN1735433A/zh active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020012989A1 (en) * | 1993-02-01 | 2002-01-31 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
US5608035A (en) * | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
WO2000024782A2 (en) * | 1998-10-23 | 2000-05-04 | Amgen Inc. | Modified peptides, comprising an fc domain, as therapeutic agents |
WO2002046238A2 (en) * | 2000-12-05 | 2002-06-13 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
WO2002046227A2 (en) * | 2000-12-07 | 2002-06-13 | Eli Lilly And Company | Glp-1 fusion proteins |
WO2003084477A2 (en) * | 2002-03-29 | 2003-10-16 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
Non-Patent Citations (14)
Title |
---|
BES CEDRIC ET AL: "Efficient CD4 binding and immunosuppressive properties of the 13B8.2 monoclonal antibody are displayed by its CDR-H1-derived peptide CB1", FEBS LETTERS, vol. 508, no. 1, 9 November 2001 (2001-11-09), pages 67 - 74, XP004322279, ISSN: 0014-5793 * |
CASARES SOFIA ET AL: "Foreign peptides expressed in engineered chimeric self molecules", BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS INTERCEPT LTD. {A}, P. O. BOX 716, ANDOVER SP10 1YG, ENGLAND SERIES : BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS (ISSN 0264-8725), 1998, pages 159 - 198, XP009069478, ISSN: 1-898298-54-8 * |
HAYDEN M S ET AL: "Antibody engineering", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, vol. 9, no. 2, April 1997 (1997-04-01), pages 201 - 212, XP004327252, ISSN: 0952-7915 * |
HAYDEN M S ET AL: "SINGLE-CHAIN MONO- AND BISPECIFIC ANTIBODY DERIVATIVES WITH NOVEL BIOLOGICAL PROPERTIES AND ANTITUMOUR ACTIVITY FROM A COS CELL TRANSIENT EXPRESSION SYSTEM", THERAPEUTIC IMMUNOLOGY, BLACKWELL SCIENTIFIC PUBL. LONDON, GB, vol. 1, no. 1, January 1994 (1994-01-01), pages 3 - 15, XP009023719, ISSN: 0967-0149 * |
HUFTON-SE ET AL: "Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 475, no. 3, 23 June 2000 (2000-06-23), pages 225 - 231, XP004337267, ISSN: 0014-5793 * |
IGARASHI T ET AL: "Structure of a mouse immunoglobulin G that lacks the entire CH1 domain: protein sequencing and small-angle X-ray scattering studies.", BIOCHEMISTRY. 19 JUN 1990, vol. 29, no. 24, 19 June 1990 (1990-06-19), pages 5727 - 5733, XP002389674, ISSN: 0006-2960 * |
JACOBIN MARIE-JOSEE ET AL: "Human IgG monoclonal anti-alphaIIbbeta3-binding fragments derived from immunized donors using phage display.", JOURNAL OF IMMUNOLOGY, vol. 168, no. 4, 15 February 2002 (2002-02-15), pages 2035 - 2045, XP002389673, ISSN: 0022-1767 * |
LAMBERT MIREILLE ET AL: "Immobilized dimers of N-cadherin-Fc chimera mimic cadherin-mediated cell contact formation: Contribution of both outside-in and inside-out signals", JOURNAL OF CELL SCIENCE, vol. 113, no. 12, June 2000 (2000-06-01), pages 2207 - 2219, XP002389675, ISSN: 0021-9533 * |
LIVNAH O ET AL: "FUNCTIONAL MIMICRY OF A PROTEIN HORMONE BY A PEPTIDE AGONIST: THE EPO RECEPTOR COMPLEX AT 2.8 AA", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 273, 26 July 1996 (1996-07-26), pages 464 - 471, XP002021035, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.273.5274.464 * |
MONNET CELINE ET AL: "Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 6, 5 February 1999 (1999-02-05), pages 3789 - 3796, XP002283342, ISSN: 0021-9258 * |
SAGOT MARIE-ASTRID ET AL: "A monoclonal antibody directed against the neurokinin-1 receptor contains a peptide sequence with similar hydropathy and functional properties to substance P, the natural ligand for the receptor", MOLECULAR IMMUNOLOGY, vol. 37, no. 8, June 2000 (2000-06-01), pages 423 - 433, XP002389672, ISSN: 0161-5890 * |
See also references of WO2004002417A2 * |
WELLS J A: "HORMONE MIMICRY", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 273, 26 July 1996 (1996-07-26), pages 449/450, XP000999487, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.273.5274.449 * |
WRIGHTON N C ET AL: "Small peptides as potent mimetics of the protein hormone erythropoietin", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, no. 273, 1 July 1996 (1996-07-01), pages 458 - 463, XP002074894, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.273.5274.458 * |
Also Published As
Publication number | Publication date |
---|---|
CA2490409A1 (en) | 2004-01-08 |
AU2003280130B2 (en) | 2009-06-11 |
AU2003280130A1 (en) | 2004-01-19 |
WO2004002417A2 (en) | 2004-01-08 |
EP1545608A2 (de) | 2005-06-29 |
CN1735433A (zh) | 2006-02-15 |
JP2006504406A (ja) | 2006-02-09 |
WO2004002417A3 (en) | 2004-11-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1545608A4 (de) | Ch1-deletierte säugetier-mimetikörper, zusammensetzungen, verfahren und anwendungen | |
WO2004002424A8 (en) | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses | |
AU2003222069A8 (en) | Mammalian cdr mimetibodies, compositions, methods and uses | |
EP1572079A3 (de) | Säugetier-cdr-mimetikörper, zusammensetzungen, verfahren und anwendungszwecke | |
EP1542699A4 (de) | Verbindungen, zusammensetzungen und diese verwendende verfahren | |
AU2003251858A1 (en) | Microbubble compositions, and methods for preparing and using same | |
AU2003262747A8 (en) | Compounds, compositions, and methods | |
EP1503993A4 (de) | Verbindungen, verfahren und zusammensetzungen | |
AU2003236527A8 (en) | Compounds, compositions, and methods | |
AU2003265242A8 (en) | Compounds, compositions, and methods | |
HK1070656A1 (en) | Compounds, compositions, and methods | |
AU2003270015A8 (en) | Compounds, compositions, and methods | |
AU2003299612A8 (en) | Compounds, compositions and methods | |
IL167936A0 (en) | Compounds, compositions,and methods | |
AU2003286474A8 (en) | Compositions, solutions, and methods used for transplantation | |
AU2003290507A8 (en) | Compounds, compositions and methods | |
EP1711527A4 (de) | Hla-dr-spezifische antikörper, zusammensetzungen und verfahren | |
AU2003277079A8 (en) | Compounds, compositions, and methods | |
AU2003237332A8 (en) | Anti-relp fusion antibodies, compositions, methods and uses | |
AU2003293765A1 (en) | Novel skin lightening agents, compositions and methods | |
AU2003300031A8 (en) | Compounds, compositions, and methods | |
AU2003267169A8 (en) | Compounds, compositions and methods | |
AU2002952442A0 (en) | Probiotic Compositions, Combinations and Related Methods | |
AU2003239594A8 (en) | Bryostatins, bryopyrans and polyketides: compositions and methods | |
AU2002323480A1 (en) | Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20050127 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20060810 |
|
17Q | First examination report despatched |
Effective date: 20080225 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: CENTOCOR ORTHO BIOTECH INC. |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: JANSSEN BIOTECH, INC. |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20120508 |