EP1530479A2 - Medicaments, complements alimentaires et additifs pour produit alimentaire pour animaux - Google Patents

Medicaments, complements alimentaires et additifs pour produit alimentaire pour animaux

Info

Publication number
EP1530479A2
EP1530479A2 EP03792330A EP03792330A EP1530479A2 EP 1530479 A2 EP1530479 A2 EP 1530479A2 EP 03792330 A EP03792330 A EP 03792330A EP 03792330 A EP03792330 A EP 03792330A EP 1530479 A2 EP1530479 A2 EP 1530479A2
Authority
EP
European Patent Office
Prior art keywords
medicament
feed additive
additive according
food supplement
prebiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03792330A
Other languages
German (de)
English (en)
Inventor
Wilhelm Berkulin
Ivo Pischel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Finzelberg GmbH and Co KG
Original Assignee
Finzelberg GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Finzelberg GmbH and Co KG filed Critical Finzelberg GmbH and Co KG
Priority to EP03792330A priority Critical patent/EP1530479A2/fr
Publication of EP1530479A2 publication Critical patent/EP1530479A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/20—Feeding-stuffs specially adapted for particular animals for horses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a pharmaceutical, a food supplement and a feed additive.
  • Prebiotics are non-digestible food components that have a beneficial effect on the growth and activity of individual or a limited number of (positive) intestinal bacteria and thus improve human or animal health.
  • Prebiotics change the intestinal microflora by influencing the intestinal milieu, not by oral bacteria.
  • Prebiotics are neither hydrolyzed nor absorbed in the upper area of the margin-intestinal tract. They are available in the large intestine as a fermentable substrate or as a growth substance for individual bacterial strains. These bacterial strains include Lactobacillii, Bifidobacteria and Eubacteria, which have health-promoting properties.
  • prebiotics In contrast to fiber such as starch, hemicelluloses, pectin and plant gums, prebiotics have a specificity for health-promoting bacteria, while common dietary fibers can also promote growth and metabolic activity of potentially harmful germs.
  • Typical prebiotics are fructooligosaccharides such as inulin and oligofructose, some synthetic galactose-containing oiigosaccharides and soybean oiigosaccharides.
  • Inulin consists of a mixture of different fructose chains, the shorter chain fraction is called oligofructose. Inulin occurs in over 36,000 plant species, some of which are also used for human consumption. For example, chicory contains 15 to 20% inulin and oligofructose, garlic 9 to 16%, wheat 1 to 4%, Jerusalem artichoke 16 to 20%, leek 3 to 10%, rye 0.5 to 1 %, in asparagus 1 to 30%, in onions 2 to 6% and in bananas 0.3 to 0.7%.
  • inulin is obtained commercially from chicory roots.
  • Other commercially available fructooligosaccharides are enzymatically synthesized from sucrose.
  • Inulin is glucose-free and indigestible in the human small intestine.
  • fructooligosaccharides are fermented microbially to short-chain fatty acids, especially to acetate, propionate, butyrate and L-lactic acid.
  • inulin is used for solid and liquid preparations in order to influence viscosity, freezing point, liquid content, color and emulsifiability of foods as well as gel formation and yellowing.
  • Inulin is very hygroscopic.
  • the hygroscopicity has the disadvantage that the preparation, for example a beverage powder, clumps after a short time.
  • the object of the present invention was to provide a more manageable inulin without losing its health-promoting properties.
  • the invention therefore relates, on the one hand, to a dietary supplement or pharmaceutical containing antioxidants of plant origin and prebiotics.
  • the prebiotics used according to the invention can be poly- or oligosaccharides which are of vegetable, synthetic and / or fermentative origin. Particularly preferred prebiotics are selected from the group consisting of fructooligosaccharides, inulin, oligofructose, galactooligosaccharides, transgalactosyloligosaccharides (TOS), lactulose, lactosucrose, glucooligosaccharides (GOS), xylooligosaccharide / Ixomaccharide (XOSaccharide), gentosolcharide (XOSaccharide), gentosolcharide (XOSaccharide), and XOS oligosaccharide (XOSaccharide) maltooligosaccharides.
  • the antioxidants used according to the invention are of vegetable origin, and preferably components of plant extracts from grape seeds and extracts from lamiaceae, in particular rosemary.
  • the antioxidants used according to the invention preferably originate from the substance classes of proanthocyanidins, anthocyanins, polyphenols, phenolic acids, flavonoids, protease inhibitors, sulfides, carotenoids, ascorbates, lignans, quinones and / or selenium compounds. Mixtures can also be used.
  • the agent according to the invention preferably contains about 5 to 20% by weight of antioxidants and 75 to 90% by weight of prebiotics.
  • the ratio of the weights of antioxidants to prebiotics is preferably between 1:20 and 1: 3, preferably between 1:15 and 1: 5, even more preferably between 1:12 and 1: 8.
  • the product according to the invention is preferably free from probiotics, in particular probiotic bacterial strains, since these can negatively influence the shelf life of the product.
  • the agent according to the invention can contain further substances, in particular from the group of pharmaceutical formulation auxiliaries and / or biologically active substances.
  • Typical formulation auxiliaries are, for example, silicon dioxide, dicalci umphosphate, maltodextrin, cellulose derivatives such as microcrystalline cellulose (MCC), etc.
  • Typical other active substances are plant substances without an antioxidative and / or prebiotic effect, for example substances with an anti-inflammatory effect such as ginger and cardamon extract or oil, as well as medicinal and silica.
  • the preparation is obtained by a special manufacturing process (cf. WO 03/09515, with priority among others EP 02 000 740.7).
  • the prebiotic is spray-dried, while the antioxidants and optionally formulation aids are added in dry form.
  • the prebiotic is coated with a layer of the antioxidants.
  • the agent according to the invention is suitable both for the therapy of gastrointestinal complaints, in particular inflammatory processes, such as e.g. Colitis, Crohn's disease, ulcerative colitis, etc., as well as a prophylactic agent, and can e.g. as a food supplement or in the veterinary field as a feed additive, and here, for example, in horses for the treatment and prevention of colic, in the rearing of calves and piglets for the prevention of diarrhea.
  • gastrointestinal complaints in particular inflammatory processes, such as e.g. Colitis, Crohn's disease, ulcerative colitis, etc.
  • a prophylactic agent can e.g. as a food supplement or in the veterinary field as a feed additive, and here, for example, in horses for the treatment and prevention of colic, in the rearing of calves and piglets for the prevention of diarrhea.
  • Another object of the invention is a composition containing inulin and components of plant extracts from grape seeds and / or rosemary, optionally together with the above-mentioned probiotic components or the other substances, in particular in connection with ginger extract or healing earth.
  • the dry product can be filled into hard gelatin capsules as a food supplement.
  • Example 1 80 kg of dry product from Example 1 are mixed with 20 kg of rosemary extract and mixed with 10% silicified microcrystalline ceilulose (MCC) ProSolv ® , compacted. The granulate is filled into hard gelatin capsules and marketed as a dietary supplement.
  • MCC microcrystalline ceilulose
  • inulin spray solution with 42% dry matter 300 kg are spray dried at 210 ° C air inlet temperature and 40 bar nozzle pressure.
  • 12.6 kg of grape seed extract, 6.3 kg of rosemary extract and 126 kg of silica are powdered into the dryer.
  • 259 kg of dry product are obtained.
  • 247 kg of dry product are mixed with 2.5 kg of ginger extract and 0.5 kg of caramon oil.
  • the end product is used as a feed additive in horses for the prevention and treatment of colic.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des médicaments, des compléments alimentaires et des additifs pour produit alimentaire pour animaux qui renferment des agents antioxydants d'origine végétale et des prébiotiques.
EP03792330A 2002-08-16 2003-08-15 Medicaments, complements alimentaires et additifs pour produit alimentaire pour animaux Withdrawn EP1530479A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP03792330A EP1530479A2 (fr) 2002-08-16 2003-08-15 Medicaments, complements alimentaires et additifs pour produit alimentaire pour animaux

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP02018416 2002-08-16
EP02018416 2002-08-16
EP03792330A EP1530479A2 (fr) 2002-08-16 2003-08-15 Medicaments, complements alimentaires et additifs pour produit alimentaire pour animaux
PCT/EP2003/009068 WO2004017979A2 (fr) 2002-08-16 2003-08-15 Medicaments, complements alimentaires et additifs pour produit alimentaire pour animaux

Publications (1)

Publication Number Publication Date
EP1530479A2 true EP1530479A2 (fr) 2005-05-18

Family

ID=31896834

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03792330A Withdrawn EP1530479A2 (fr) 2002-08-16 2003-08-15 Medicaments, complements alimentaires et additifs pour produit alimentaire pour animaux

Country Status (4)

Country Link
EP (1) EP1530479A2 (fr)
AU (1) AU2003266285A1 (fr)
PL (1) PL373549A1 (fr)
WO (1) WO2004017979A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060105063A1 (en) * 2004-11-18 2006-05-18 Kent Hann Synergic combination of compositions containing aloe vera isolates and their therapeutic application
EP1887017A1 (fr) * 2006-08-09 2008-02-13 Friesland Brands B.V. Carbohydrates prébiotiques
RU2473680C2 (ru) * 2011-03-17 2013-01-27 Общество с ограниченной ответственностью "Альбит" Селенсодержащий комплекс микроэлементов
ITMI20130476A1 (it) * 2013-03-28 2014-09-29 Novintethical Pharma Sagl Composizioni per il trattamento di disturbi gastro-intestinali a base di complessi di tannini con proteine
MX2017002447A (es) 2014-09-30 2017-05-23 Kimberly Clark Co Papel tisu crepado prebiotico.
AU2014407509B2 (en) 2014-09-30 2020-09-03 Kimberly-Clark Worldwide, Inc. Synergistic prebiotic composition
IT201600115007A1 (it) * 2016-11-15 2018-05-15 Frabes S P A Composizioni alimentari, loro usi e procedimenti per la loro preparazione

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614501A (en) * 1994-07-21 1997-03-25 The University Of Montana Compositions and methods for animal husbandry and for treating gastrointestinal disorders
FI107014B (fi) * 1997-07-25 2001-05-31 Oriola Oy Terveysravintovalmiste
US20010041187A1 (en) * 1998-10-20 2001-11-15 Carl W Hastings Performance-enhancing dietary supplement
RU2161894C1 (ru) * 1999-08-10 2001-01-20 НИФ "Ультрасан" Лечебно-профилактическая композиция
US20010046523A1 (en) * 2000-02-25 2001-11-29 Thomas Newmark Ginger-based herbal composition for promoting health and methods of using same
GB0027761D0 (en) * 2000-11-14 2000-12-27 Nestle Sa Nutritional composition for an immune condition
DE20202562U1 (de) * 2002-02-19 2002-05-23 Orthomol Pharmazeutische Vertr Mikronährstoffkombinationsprodukt mit Pro- und Prebiotika

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2004017979A2 *

Also Published As

Publication number Publication date
WO2004017979A2 (fr) 2004-03-04
WO2004017979A3 (fr) 2004-04-22
AU2003266285A1 (en) 2004-03-11
AU2003266285A8 (en) 2004-03-11
PL373549A1 (en) 2005-09-05

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