EP0975672A4 - Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniers - Google Patents
Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniersInfo
- Publication number
- EP0975672A4 EP0975672A4 EP98910277A EP98910277A EP0975672A4 EP 0975672 A4 EP0975672 A4 EP 0975672A4 EP 98910277 A EP98910277 A EP 98910277A EP 98910277 A EP98910277 A EP 98910277A EP 0975672 A4 EP0975672 A4 EP 0975672A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- blood coagulation
- antibodies
- native human
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/814,806 US5986065A (en) | 1997-03-10 | 1997-03-10 | Antibodies for inhibiting blood coagulation and methods of use thereof |
US814806 | 1997-03-10 | ||
PCT/US1998/004644 WO1998040408A1 (fr) | 1997-03-10 | 1998-03-10 | Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniers |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0975672A1 EP0975672A1 (fr) | 2000-02-02 |
EP0975672A4 true EP0975672A4 (fr) | 2005-02-02 |
EP0975672B1 EP0975672B1 (fr) | 2012-01-11 |
Family
ID=25216046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98910277A Expired - Lifetime EP0975672B1 (fr) | 1997-03-10 | 1998-03-10 | Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniers |
Country Status (13)
Country | Link |
---|---|
US (5) | US5986065A (fr) |
EP (1) | EP0975672B1 (fr) |
JP (2) | JP4281852B2 (fr) |
KR (2) | KR20060015702A (fr) |
CN (2) | CN101298479A (fr) |
AT (1) | ATE540976T1 (fr) |
AU (1) | AU745506B2 (fr) |
CA (1) | CA2283746C (fr) |
DK (1) | DK0975672T3 (fr) |
ES (1) | ES2380452T3 (fr) |
HK (1) | HK1029123A1 (fr) |
PT (1) | PT975672E (fr) |
WO (1) | WO1998040408A1 (fr) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7749498B2 (en) * | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US20030109680A1 (en) * | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US20060235209A9 (en) * | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
US20040229282A1 (en) * | 1997-03-10 | 2004-11-18 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
WO2000018398A1 (fr) | 1998-09-25 | 2000-04-06 | Sunol Molecular Corporation | Composes pharmaceutiquement actifs, et methodes d'utilisation correspondantes |
US7764130B2 (en) * | 1999-01-22 | 2010-07-27 | Multigig Inc. | Electronic circuitry |
US6398772B1 (en) * | 1999-03-26 | 2002-06-04 | Coraje, Inc. | Method and apparatus for emergency treatment of patients experiencing a thrombotic vascular occlusion |
US6924359B1 (en) | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
MXPA02003278A (es) * | 1999-10-01 | 2002-09-02 | Chugai Pharmaceutical Co Ltd | Prevencion y tratamiento de enfermedades relacionadas con la coagulacion sanguinea. |
CA2387857A1 (fr) | 1999-10-27 | 2001-05-03 | Sunol Molecular Corporation | Antagonistes de facteur tissulaire et leurs procedes d'utilisation |
EP1829535A3 (fr) * | 1999-10-27 | 2007-10-24 | Tanox, Inc. | Antagonistes de facteur de tissus et leurs procédés d'utilisation |
US6703494B2 (en) | 2000-03-16 | 2004-03-09 | Genentech, Inc. | Anti-tissue factor antibodies with enhanced anticoagulant potency |
CA2402596A1 (fr) * | 2000-03-16 | 2001-09-27 | Genentech, Inc. | Anticorps de facteur anti-tissulaire a pouvoir anticoagulant ameliore |
US20030211094A1 (en) * | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
US7160540B2 (en) * | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
WO2002059268A2 (fr) * | 2001-01-23 | 2002-08-01 | Saint Louis University | Facteur ixa et son interaction avec le facteur viiia, et methodes s'y rapportant |
US20030143225A1 (en) * | 2001-03-08 | 2003-07-31 | Genentech, Inc. | Combinations of anti-tissue factor antibodies and anticoagulant and/or antiplatelet agents |
JPWO2002078738A1 (ja) * | 2001-03-26 | 2004-10-07 | 鈴木 宏治 | 血液レオロジー改善剤 |
TWI338009B (en) * | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
US20030190705A1 (en) * | 2001-10-29 | 2003-10-09 | Sunol Molecular Corporation | Method of humanizing immune system molecules |
US20040126856A1 (en) * | 2002-01-23 | 2004-07-01 | Bajaj Paul S. | Factor ixa: factor Vllla interaction and methods therefor |
CN1646162A (zh) * | 2002-02-22 | 2005-07-27 | 普罗菲医疗公司 | 组织因子的抑制剂或拮抗剂的用途 |
US20090011991A1 (en) * | 2002-03-08 | 2009-01-08 | Emory University | Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis |
AU2003220091B2 (en) * | 2002-03-08 | 2006-02-16 | Emory University | Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis |
US6706068B2 (en) | 2002-04-23 | 2004-03-16 | Bret A. Ferree | Artificial disc replacements with natural kinematics |
UA81114C2 (en) * | 2002-05-01 | 2007-12-10 | Schering Ag | Novel antibodies to tissue factor as anticoagulants |
US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
US20050106139A1 (en) * | 2002-10-31 | 2005-05-19 | Ivan Svendsen | Humanized tissue factor antibodies |
US7425328B2 (en) * | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
CA2527621A1 (fr) * | 2003-05-30 | 2004-12-23 | Centocor, Inc. | Procede pour inhiber la croissance tumorale avec des anticorps a facteurs anti-tissulaires |
US7605235B2 (en) | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
ES2527102T3 (es) * | 2003-06-19 | 2015-01-20 | Genentech, Inc. | Composiciones y métodos para el tratamiento de trastornos relacionados con la coagulación |
WO2005025623A2 (fr) * | 2003-07-28 | 2005-03-24 | Emory University | Conjugues compose cytotoxique-proteine utilises en tant que suppresseurs de croissance tumorale et d'angiogenese |
WO2005020927A2 (fr) * | 2003-08-29 | 2005-03-10 | Centocor, Inc. | Procede permettant de stimuler la survie d'un greffon a l'aide d'anticorps anti-facteur tissulaire |
US8048101B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
US8052669B2 (en) | 2004-02-25 | 2011-11-08 | Femasys Inc. | Methods and devices for delivery of compositions to conduits |
US9238127B2 (en) | 2004-02-25 | 2016-01-19 | Femasys Inc. | Methods and devices for delivering to conduit |
US8048086B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
WO2005118646A2 (fr) * | 2004-04-26 | 2005-12-15 | Centocor, Inc. | Selection dirigee vers des epitopes, d'anticorps antifacteur de tissu murin |
US7514539B2 (en) * | 2004-04-26 | 2009-04-07 | Centocor, Inc. | Epitope directed selection of antibodies to murine tissue factor |
AU2005260004A1 (en) | 2004-06-25 | 2006-01-12 | Altor Bioscience Corporation | Production of tissue factor in plants |
ES2352204T3 (es) | 2004-10-19 | 2011-02-16 | Lonza Ag | Método de síntesis peptídica en fase sólida. |
EP1676574A3 (fr) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Procédé favorisant la survie des tissus ou cellules griffées |
US20080254043A1 (en) * | 2005-02-07 | 2008-10-16 | Chugai Seiyaku Kabushiki Kaisha National University Corporation Hamamatsu | Drug For Treating Ischemic Disease |
CA2626100A1 (fr) * | 2005-10-21 | 2007-08-30 | Genentech, Inc. | Traitement pour complications de grossesse liees a un syndrome des antiphospholipides |
WO2008030260A2 (fr) * | 2005-12-22 | 2008-03-13 | Genentech, Inc. | Traitement des infections virales de la variole au moyen d'un inhibiteur de facteur tissulaire |
US9554826B2 (en) | 2008-10-03 | 2017-01-31 | Femasys, Inc. | Contrast agent injection system for sonographic imaging |
US10070888B2 (en) | 2008-10-03 | 2018-09-11 | Femasys, Inc. | Methods and devices for sonographic imaging |
UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
CN101717447B (zh) * | 2009-12-17 | 2012-06-27 | 山西省生物研究所 | 一种抗人重组组织因子单克隆抗体的制备方法 |
PT2582728T (pt) | 2010-06-15 | 2017-11-23 | Genmab As | Conjugados fármaco-anticorpo humano contra fator tecidual |
US8722044B2 (en) | 2011-03-15 | 2014-05-13 | Janssen Biotech, Inc. | Human tissue factor antibody and uses thereof |
JP6590803B2 (ja) * | 2013-11-21 | 2019-10-16 | ゲンマブ エー/エス | 抗体−薬物コンジュゲート凍結乾燥製剤 |
KR20160136279A (ko) | 2014-02-03 | 2016-11-29 | 국립연구개발법인 고쿠리츠간켄큐센터 | 항-조직 인자 모노클로널 항체 |
EP3595615B1 (fr) | 2017-03-14 | 2024-01-10 | The University Of Melbourne | Traitement de la gingivite |
CN110133303B (zh) * | 2019-05-13 | 2023-04-07 | 深圳优迪生物技术有限公司 | 凝血酶原时间测定试剂及其应用 |
CA3173263A1 (fr) * | 2020-03-30 | 2021-10-07 | Yasuhiro Matsumura | Conjugue anticorps-medicament |
WO2022087405A1 (fr) * | 2020-10-23 | 2022-04-28 | The Regents Of The University Of Michigan | Compositions et procédés se rapportant à l'identification et au traitement d'états immunothrombotiques |
Citations (4)
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EP0420937A1 (fr) * | 1988-06-21 | 1991-04-10 | Genentech Inc | Compositions therapeutiques pour le traitement de l'infarctus du myocarde. |
WO1994005328A1 (fr) * | 1992-08-28 | 1994-03-17 | The Scripps Research Institute | Inhibitions des metastases tumorales par neutralisation de la fonction de la thromboplastine tissulaire |
US5437864A (en) * | 1987-03-31 | 1995-08-01 | The Scripps Research Institute | Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor |
WO1996040921A1 (fr) * | 1995-06-07 | 1996-12-19 | Ortho Farmaceutical Corporation | Anticorps contre la thromboplastine tissulaire comportant des regions de determination complementaire greffees et leurs methodes d'utilisation |
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US5986065A (en) * | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
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CA2387857A1 (fr) | 1999-10-27 | 2001-05-03 | Sunol Molecular Corporation | Antagonistes de facteur tissulaire et leurs procedes d'utilisation |
US20020025508A1 (en) * | 2000-01-06 | 2002-02-28 | Katja Fechteler | Process for finding a protease inhibitor |
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US6703494B2 (en) * | 2000-03-16 | 2004-03-09 | Genentech, Inc. | Anti-tissue factor antibodies with enhanced anticoagulant potency |
CA2402596A1 (fr) | 2000-03-16 | 2001-09-27 | Genentech, Inc. | Anticorps de facteur anti-tissulaire a pouvoir anticoagulant ameliore |
WO2002101019A2 (fr) * | 2001-06-13 | 2002-12-19 | Genentech, Inc. | Procedes de mise en culture de cellules animales et production de polypeptides dans des cellules animales |
CA2460917A1 (fr) | 2001-10-02 | 2003-04-10 | Novo Nordisk A/S | Anticorps du facteur tissulaire humain |
TWI338009B (en) | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
ES2527102T3 (es) * | 2003-06-19 | 2015-01-20 | Genentech, Inc. | Composiciones y métodos para el tratamiento de trastornos relacionados con la coagulación |
-
1997
- 1997-03-10 US US08/814,806 patent/US5986065A/en not_active Expired - Lifetime
-
1998
- 1998-03-10 CN CNA200810082354XA patent/CN101298479A/zh active Pending
- 1998-03-10 AU AU64559/98A patent/AU745506B2/en not_active Expired
- 1998-03-10 PT PT98910277T patent/PT975672E/pt unknown
- 1998-03-10 KR KR1020067002062A patent/KR20060015702A/ko not_active Application Discontinuation
- 1998-03-10 KR KR1019997007803A patent/KR100585473B1/ko not_active IP Right Cessation
- 1998-03-10 DK DK98910277.7T patent/DK0975672T3/da active
- 1998-03-10 WO PCT/US1998/004644 patent/WO1998040408A1/fr not_active Application Discontinuation
- 1998-03-10 AT AT98910277T patent/ATE540976T1/de active
- 1998-03-10 ES ES98910277T patent/ES2380452T3/es not_active Expired - Lifetime
- 1998-03-10 EP EP98910277A patent/EP0975672B1/fr not_active Expired - Lifetime
- 1998-03-10 CN CNB988041693A patent/CN100383163C/zh not_active Expired - Lifetime
- 1998-03-10 CA CA2283746A patent/CA2283746C/fr not_active Expired - Lifetime
- 1998-03-10 JP JP53970398A patent/JP4281852B2/ja not_active Expired - Lifetime
-
1999
- 1999-04-16 US US09/293,854 patent/US6555319B2/en not_active Expired - Lifetime
-
2000
- 2000-11-10 HK HK00107170A patent/HK1029123A1/xx not_active IP Right Cessation
-
2002
- 2002-11-12 US US10/293,417 patent/US20030082636A1/en not_active Abandoned
-
2005
- 2005-03-22 US US11/087,528 patent/US20050271664A1/en not_active Abandoned
-
2008
- 2008-06-10 US US12/136,718 patent/US7824677B2/en not_active Expired - Fee Related
- 2008-06-18 JP JP2008159661A patent/JP2009022275A/ja active Pending
Patent Citations (4)
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US5437864A (en) * | 1987-03-31 | 1995-08-01 | The Scripps Research Institute | Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor |
EP0420937A1 (fr) * | 1988-06-21 | 1991-04-10 | Genentech Inc | Compositions therapeutiques pour le traitement de l'infarctus du myocarde. |
WO1994005328A1 (fr) * | 1992-08-28 | 1994-03-17 | The Scripps Research Institute | Inhibitions des metastases tumorales par neutralisation de la fonction de la thromboplastine tissulaire |
WO1996040921A1 (fr) * | 1995-06-07 | 1996-12-19 | Ortho Farmaceutical Corporation | Anticorps contre la thromboplastine tissulaire comportant des regions de determination complementaire greffees et leurs methodes d'utilisation |
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CAULFIELD M J ET AL: "A pathogenic monoclonal antibody, G8, is characteristic of antierythrocyte autoantibodies from Coombs'-positive NZB mice.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 APR 1992, vol. 148, no. 7, 1 April 1992 (1992-04-01), pages 2068 - 2073, ISSN: 0022-1767 * |
DATABASE EMBL [online] 21 October 1991 (1991-10-21), "G8 (ANTI-MRBC) V(L), J(L)", XP002305737, retrieved from EBI accession no. EM_PRO:MMG8LC Database accession no. MMG8LC * |
FIORE M M ET AL: "AN UNUSUAL ANTIBODY THAT BLOCKS TISSUE FACTOR/FACTOR VIIA FUNCTION BY INHIBITING CLEAVAGE ONLY OF MACROMOLECULAR SUBSTRATES", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 80, no. 12, December 1992 (1992-12-01), pages 3127 - 3134, XP002910920, ISSN: 0006-4971 * |
Also Published As
Publication number | Publication date |
---|---|
AU6455998A (en) | 1998-09-29 |
ATE540976T1 (de) | 2012-01-15 |
EP0975672A1 (fr) | 2000-02-02 |
ES2380452T3 (es) | 2012-05-11 |
KR20060015702A (ko) | 2006-02-17 |
US5986065A (en) | 1999-11-16 |
US6555319B2 (en) | 2003-04-29 |
DK0975672T3 (da) | 2012-02-27 |
US7824677B2 (en) | 2010-11-02 |
EP0975672B1 (fr) | 2012-01-11 |
US20030082636A1 (en) | 2003-05-01 |
PT975672E (pt) | 2012-02-15 |
CA2283746C (fr) | 2017-01-17 |
KR100585473B1 (ko) | 2006-06-02 |
JP2009022275A (ja) | 2009-02-05 |
JP2001516214A (ja) | 2001-09-25 |
CN101298479A (zh) | 2008-11-05 |
HK1029123A1 (en) | 2001-03-23 |
WO1998040408A1 (fr) | 1998-09-17 |
CA2283746A1 (fr) | 1998-09-17 |
US20050271664A1 (en) | 2005-12-08 |
CN1252810A (zh) | 2000-05-10 |
JP4281852B2 (ja) | 2009-06-17 |
CN100383163C (zh) | 2008-04-23 |
AU745506B2 (en) | 2002-03-21 |
US20090041766A1 (en) | 2009-02-12 |
KR20000075734A (ko) | 2000-12-26 |
US20020168357A1 (en) | 2002-11-14 |
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