EP0975672A4 - Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniers - Google Patents

Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniers

Info

Publication number
EP0975672A4
EP0975672A4 EP98910277A EP98910277A EP0975672A4 EP 0975672 A4 EP0975672 A4 EP 0975672A4 EP 98910277 A EP98910277 A EP 98910277A EP 98910277 A EP98910277 A EP 98910277A EP 0975672 A4 EP0975672 A4 EP 0975672A4
Authority
EP
European Patent Office
Prior art keywords
methods
blood coagulation
antibodies
native human
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98910277A
Other languages
German (de)
English (en)
Other versions
EP0975672A1 (fr
EP0975672B1 (fr
Inventor
Hing C Wong
Jin-An Jiao
Esperanza Liliana Nieves
Lawrence Luepschen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Sunol Molecular Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunol Molecular Corp filed Critical Sunol Molecular Corp
Publication of EP0975672A1 publication Critical patent/EP0975672A1/fr
Publication of EP0975672A4 publication Critical patent/EP0975672A4/fr
Application granted granted Critical
Publication of EP0975672B1 publication Critical patent/EP0975672B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP98910277A 1997-03-10 1998-03-10 Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniers Expired - Lifetime EP0975672B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/814,806 US5986065A (en) 1997-03-10 1997-03-10 Antibodies for inhibiting blood coagulation and methods of use thereof
US814806 1997-03-10
PCT/US1998/004644 WO1998040408A1 (fr) 1997-03-10 1998-03-10 Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniers

Publications (3)

Publication Number Publication Date
EP0975672A1 EP0975672A1 (fr) 2000-02-02
EP0975672A4 true EP0975672A4 (fr) 2005-02-02
EP0975672B1 EP0975672B1 (fr) 2012-01-11

Family

ID=25216046

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98910277A Expired - Lifetime EP0975672B1 (fr) 1997-03-10 1998-03-10 Anticorps permettant d'inhiber la coagulation sanguine et procedes d'utilisation de ces derniers

Country Status (13)

Country Link
US (5) US5986065A (fr)
EP (1) EP0975672B1 (fr)
JP (2) JP4281852B2 (fr)
KR (2) KR20060015702A (fr)
CN (2) CN101298479A (fr)
AT (1) ATE540976T1 (fr)
AU (1) AU745506B2 (fr)
CA (1) CA2283746C (fr)
DK (1) DK0975672T3 (fr)
ES (1) ES2380452T3 (fr)
HK (1) HK1029123A1 (fr)
PT (1) PT975672E (fr)
WO (1) WO1998040408A1 (fr)

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US5986065A (en) * 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US20030109680A1 (en) * 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US20060235209A9 (en) * 1997-03-10 2006-10-19 Jin-An Jiao Use of anti-tissue factor antibodies for treating thromboses
US20040229282A1 (en) * 1997-03-10 2004-11-18 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
WO2000018398A1 (fr) 1998-09-25 2000-04-06 Sunol Molecular Corporation Composes pharmaceutiquement actifs, et methodes d'utilisation correspondantes
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US6924359B1 (en) 1999-07-01 2005-08-02 Yale University Neovascular-targeted immunoconjugates
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US6703494B2 (en) 2000-03-16 2004-03-09 Genentech, Inc. Anti-tissue factor antibodies with enhanced anticoagulant potency
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US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
ES2527102T3 (es) * 2003-06-19 2015-01-20 Genentech, Inc. Composiciones y métodos para el tratamiento de trastornos relacionados con la coagulación
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US20080254043A1 (en) * 2005-02-07 2008-10-16 Chugai Seiyaku Kabushiki Kaisha National University Corporation Hamamatsu Drug For Treating Ischemic Disease
CA2626100A1 (fr) * 2005-10-21 2007-08-30 Genentech, Inc. Traitement pour complications de grossesse liees a un syndrome des antiphospholipides
WO2008030260A2 (fr) * 2005-12-22 2008-03-13 Genentech, Inc. Traitement des infections virales de la variole au moyen d'un inhibiteur de facteur tissulaire
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
CN101717447B (zh) * 2009-12-17 2012-06-27 山西省生物研究所 一种抗人重组组织因子单克隆抗体的制备方法
PT2582728T (pt) 2010-06-15 2017-11-23 Genmab As Conjugados fármaco-anticorpo humano contra fator tecidual
US8722044B2 (en) 2011-03-15 2014-05-13 Janssen Biotech, Inc. Human tissue factor antibody and uses thereof
JP6590803B2 (ja) * 2013-11-21 2019-10-16 ゲンマブ エー／エス 抗体−薬物コンジュゲート凍結乾燥製剤
KR20160136279A (ko) 2014-02-03 2016-11-29 국립연구개발법인 고쿠리츠간켄큐센터 항-조직 인자 모노클로널 항체
EP3595615B1 (fr) 2017-03-14 2024-01-10 The University Of Melbourne Traitement de la gingivite
CN110133303B (zh) * 2019-05-13 2023-04-07 深圳优迪生物技术有限公司 凝血酶原时间测定试剂及其应用
CA3173263A1 (fr) * 2020-03-30 2021-10-07 Yasuhiro Matsumura Conjugue anticorps-medicament
WO2022087405A1 (fr) * 2020-10-23 2022-04-28 The Regents Of The University Of Michigan Compositions et procédés se rapportant à l'identification et au traitement d'états immunothrombotiques

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CAULFIELD M J ET AL: "A pathogenic monoclonal antibody, G8, is characteristic of antierythrocyte autoantibodies from Coombs'-positive NZB mice.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 APR 1992, vol. 148, no. 7, 1 April 1992 (1992-04-01), pages 2068 - 2073, ISSN: 0022-1767 *
DATABASE EMBL [online] 21 October 1991 (1991-10-21), "G8 (ANTI-MRBC) V(L), J(L)", XP002305737, retrieved from EBI accession no. EM_PRO:MMG8LC Database accession no. MMG8LC *
FIORE M M ET AL: "AN UNUSUAL ANTIBODY THAT BLOCKS TISSUE FACTOR/FACTOR VIIA FUNCTION BY INHIBITING CLEAVAGE ONLY OF MACROMOLECULAR SUBSTRATES", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 80, no. 12, December 1992 (1992-12-01), pages 3127 - 3134, XP002910920, ISSN: 0006-4971 *

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AU6455998A (en) 1998-09-29
ATE540976T1 (de) 2012-01-15
EP0975672A1 (fr) 2000-02-02
ES2380452T3 (es) 2012-05-11
KR20060015702A (ko) 2006-02-17
US5986065A (en) 1999-11-16
US6555319B2 (en) 2003-04-29
DK0975672T3 (da) 2012-02-27
US7824677B2 (en) 2010-11-02
EP0975672B1 (fr) 2012-01-11
US20030082636A1 (en) 2003-05-01
PT975672E (pt) 2012-02-15
CA2283746C (fr) 2017-01-17
KR100585473B1 (ko) 2006-06-02
JP2009022275A (ja) 2009-02-05
JP2001516214A (ja) 2001-09-25
CN101298479A (zh) 2008-11-05
HK1029123A1 (en) 2001-03-23
WO1998040408A1 (fr) 1998-09-17
CA2283746A1 (fr) 1998-09-17
US20050271664A1 (en) 2005-12-08
CN1252810A (zh) 2000-05-10
JP4281852B2 (ja) 2009-06-17
CN100383163C (zh) 2008-04-23
AU745506B2 (en) 2002-03-21
US20090041766A1 (en) 2009-02-12
KR20000075734A (ko) 2000-12-26
US20020168357A1 (en) 2002-11-14

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