DK1194528T3 - Monoklonalt antistof mod faktor VII, hvilket antistof selv ved forekomst i molært overskud kun delvist inaktiverer faktor VII, samt fremgangsmåde til produktion af et sådant antistof - Google Patents

Monoklonalt antistof mod faktor VII, hvilket antistof selv ved forekomst i molært overskud kun delvist inaktiverer faktor VII, samt fremgangsmåde til produktion af et sådant antistof

Info

Publication number
DK1194528T3
DK1194528T3 DK00949329T DK00949329T DK1194528T3 DK 1194528 T3 DK1194528 T3 DK 1194528T3 DK 00949329 T DK00949329 T DK 00949329T DK 00949329 T DK00949329 T DK 00949329T DK 1194528 T3 DK1194528 T3 DK 1194528T3
Authority
DK
Denmark
Prior art keywords
ligands
factor
molar excess
factor viii
complex
Prior art date
Application number
DK00949329T
Other languages
English (en)
Inventor
Marc G Jacquemin
Jean-Marie R Saint-Remy
Original Assignee
D Collen Res Foundation Vzw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9916450.1A external-priority patent/GB9916450D0/en
Application filed by D Collen Res Foundation Vzw filed Critical D Collen Res Foundation Vzw
Application granted granted Critical
Publication of DK1194528T3 publication Critical patent/DK1194528T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK00949329T 1999-07-14 2000-07-13 Monoklonalt antistof mod faktor VII, hvilket antistof selv ved forekomst i molært overskud kun delvist inaktiverer faktor VII, samt fremgangsmåde til produktion af et sådant antistof DK1194528T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14389199P 1999-07-14 1999-07-14
GBGB9916450.1A GB9916450D0 (en) 1999-07-14 1999-07-14 Ligands for use in therapeutic compounds for the treatment of hemostasis disorders
PCT/EP2000/006677 WO2001004269A1 (en) 1999-07-14 2000-07-13 Ligands for use in therapeutic compositions for the treatment of hemostasis disorders

Publications (1)

Publication Number Publication Date
DK1194528T3 true DK1194528T3 (da) 2007-07-09

Family

ID=26315767

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00949329T DK1194528T3 (da) 1999-07-14 2000-07-13 Monoklonalt antistof mod faktor VII, hvilket antistof selv ved forekomst i molært overskud kun delvist inaktiverer faktor VII, samt fremgangsmåde til produktion af et sådant antistof

Country Status (11)

Country Link
EP (1) EP1194528B1 (da)
JP (2) JP4297207B2 (da)
AT (1) ATE356201T1 (da)
AU (1) AU781638B2 (da)
CA (1) CA2381125C (da)
CY (1) CY1107638T1 (da)
DE (1) DE60033814T2 (da)
DK (1) DK1194528T3 (da)
ES (1) ES2283308T3 (da)
PT (1) PT1194528E (da)
WO (1) WO2001004269A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7829085B2 (en) 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
EP1222929B8 (en) 2001-01-11 2010-07-07 Life Sciences Research Partners VZW Method and pharmaceutical composition for preventing and/or treating systemic inflammatory response syndrome
AU2002313194B9 (en) * 2001-06-12 2008-06-05 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Human-type anti-blood coagulation factor VIII antibody
EP1388544A1 (en) 2002-07-31 2004-02-11 D. Collen Research Foundation vzw Anti-idiotypic antibodies against factor VIII inhibitor and uses thereof
JP4422430B2 (ja) 2003-05-14 2010-02-24 帝國製薬株式会社 エストロゲン及び／又はプロゲストゲン含有外用貼付剤
AU2004264265C1 (en) * 2003-08-14 2012-06-28 Thrombogenics Nv Antibodies against factor VIII with modified glycosylation in the variable region
ATE509957T1 (de) * 2005-07-29 2011-06-15 Life Sciences Res Partners Vzw An die a2-domäne bindende, humane inhibitorische anti-faktor-viii-antikörper
FR2892724B1 (fr) 2005-11-02 2008-01-04 Lab Francais Du Fractionnement Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii.
FR2897868B1 (fr) * 2006-02-24 2012-08-31 Lab Francais Du Fractionnement Anticorps anti-idiotypiques neutralisant l'activite inhibitrice d'un anticorps inhibiteur dirige contre le domaine c1 du facteur viii.
CA2767612A1 (en) 2009-07-10 2011-01-13 Thrombogenics Nv Variants of plasminogen and plasmin
EP2480249B1 (en) 2009-08-28 2015-01-28 ThromboGenics N.V. Plasmin for the treatment of filtration failure after trabeculectomy
ES2583082T3 (es) 2011-01-05 2016-09-19 Thrombogenics N.V. Variantes de plasminógeno y plasmina
RU2604810C2 (ru) 2011-08-12 2016-12-10 Тромбодженикс Н.В. Варианты плазминогена и плазмина
EP2785739B1 (en) 2011-12-01 2017-03-15 ThromboGenics N.V. Improving trabeculectomy outcome
KR101395736B1 (ko) * 2012-07-10 2014-05-16 아주대학교산학협력단 인간 혈액응고인자 ⅷ 도메인 특이적 항체 및 이의 제조방법
WO2017153567A1 (en) 2016-03-10 2017-09-14 Thrombogenics Nv Posterior ocular fibrosis inhibition by antagonizing placental growth factor
CA3062238A1 (en) * 2017-05-11 2018-11-15 Vib Vzw Glycosylation of variable immunoglobulin domains

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA24512A1 (fr) * 1996-01-17 1998-12-31 Univ Vermont And State Agrienl Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose

Also Published As

Publication number Publication date
CA2381125C (en) 2013-04-23
CA2381125A1 (en) 2001-01-18
EP1194528A1 (en) 2002-04-10
DE60033814D1 (de) 2007-04-19
CY1107638T1 (el) 2013-04-18
ES2283308T3 (es) 2007-11-01
JP4297225B2 (ja) 2009-07-15
AU781638B2 (en) 2005-06-02
ATE356201T1 (de) 2007-03-15
JP4297207B2 (ja) 2009-07-15
PT1194528E (pt) 2007-05-31
EP1194528B1 (en) 2007-03-07
WO2001004269A1 (en) 2001-01-18
DE60033814T2 (de) 2007-11-08
JP2008295455A (ja) 2008-12-11
JP2003504045A (ja) 2003-02-04
AU6273000A (en) 2001-01-30

Similar Documents

Publication Publication Date Title
CY1107638T1 (el) Μονοκλωνο αντισωμα του παραγοντα viii που ακομη και οταν υπαρχει σε μοριακη περισσεια αδρανοποιει τον παραγοντα viii μονο εν μερει και μια μεθοδος παραγωγης ενος τετοιου αντισωματος
HK1068798A1 (en) Antibodies for inhibiting blood coagulation and methods of use thereof
WO2010065077A3 (en) Antagonists of il-6 to prevent or treat thrombosis
LU93265I2 (fr) Eftrénonacog alfa ou un produit biosimilaire conformément à l'article 10(4) de la directive 2001/83/CE, tel que protégé par le brevet de base
ATE540976T1 (de) Antikörper zur inhibierung der blutgerinnung und verfahren zur deren verwendung
DE69932084D1 (de) Antikörperfragmente zur lokalen Behandlung von Augenerkrankungen
WO2002060955A3 (en) Modified antibodies and methods of use
ATE434447T1 (de) Zusammensetzungen und verfahren zur erzeugung von gefässeokklusion
EP2228389A3 (en) Antibodies against vascular endothelial growth factor 2
CY1108566T1 (el) Ανοσολογικος ελεγχος των επιπεδων του b-αμυλοειδους in vivo
PT833911E (pt) Anticorpos anti-factor tecidular enxertados com cdr e metodos para a sua utilizacao
CN110325211A (zh) 采用抗因子XI/XIa抗体治疗的方法
WO1999008109A3 (en) Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma
PT1214600E (pt) Determinacao de proteinas de ligacao a adrenomedulina
WO2003093313A3 (en) Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein
WO2002074251A3 (en) Monoclonal antibody therapy for pancreas cancer
Hansen et al. Target-mediated clearance and bio-distribution of a monoclonal antibody against the Kunitz–type protease inhibitor 2 domain of tissue factor pathway inhibitor
HUP0301804A2 (hu) Antitrombotikus ágensek
Gorkun et al. Interactions mediated by the N-terminus of fibrinogen's Bβ chain
EP1334983A3 (de) Inhibitorischer, monoklonaler Antikörper gegen die den Blutgerinnungsfaktor VII akitivierende Protease
Astermark et al. Antibodies to factor VIIa in patients with haemophilia and high‐responding inhibitors
DE59909356D1 (de) Pharmazeutische präparation, enthaltend einen rezeptor-antagonisten zur behandlung von blutgerinnungsstörungen
ATE374180T1 (de) N-acylpyrrolidin-2-ylalkylbenzamidin-derivate als inhibitoren von factor xa
DE60128084D1 (de) Verwendung von inaktives cln2 proenzym zur behandlung von lincl
DE60020970D1 (de) Monoklonaler antikörper mit selektiver bindung an vgf und verwendung zur behandlung von vgf-erkrankungen