EP0928155A1 - Systeme de controle pour la prise reguliere d'un medicament - Google Patents

Systeme de controle pour la prise reguliere d'un medicament

Info

Publication number
EP0928155A1
EP0928155A1 EP97936601A EP97936601A EP0928155A1 EP 0928155 A1 EP0928155 A1 EP 0928155A1 EP 97936601 A EP97936601 A EP 97936601A EP 97936601 A EP97936601 A EP 97936601A EP 0928155 A1 EP0928155 A1 EP 0928155A1
Authority
EP
European Patent Office
Prior art keywords
control system
detection device
substance
detection
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97936601A
Other languages
German (de)
English (en)
Inventor
Hans-Georg Batz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Publication of EP0928155A1 publication Critical patent/EP0928155A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/681—Wristwatch-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to a control system for monitoring the regular intake of a drug in a patient and a pharmaceutical dosage form for such a control system.
  • the invention proposes a control system which, as coordinated system components, comprises a dosage form of the medicament and a detection device for the non-invasive detection of a substance contained in the dosage form (hereinafter "detection substance") in the patient's body.
  • detection substance a substance contained in the dosage form
  • the detection device is designed for the reagent-free direct measurement of a measured variable correlating with the presence of the detection substance in the patient's body.
  • the detection substance can be formed by the medicament itself, ie the therapeutically active substance. This is however, limited to cases in which the active substance is non-invasively detectable. Almost all chemotherapeutic agents have characteristic IR bands that can be used for a determination. Examples include: antibiotics such as tetracyclines, nitrofurones and nalidixic acid, the tuberculosis agents rifampicin and isonicotinic acid hydrazide, the antimalarial agent chloroquine, but also anticoagulants such as maramar and cardiovascular agents such as nitroglycerin and digoxin, which enable non-invasive detection.
  • antibiotics such as tetracyclines, nitrofurones and nalidixic acid
  • the antimalarial agent chloroquine but also anticoagulants such as maramar and cardiovascular agents such as nitroglycerin and digoxin
  • the typical IR bands are overlaid by the bands of the body's own substances.
  • a preferred embodiment of the invention in which the non-invasively detectable substance contained in the dosage form is a non-toxic marking substance different from the medicament (active substance).
  • the marking substance is specifically chosen so that it does not impair the pharmaceutical effectiveness of the active pharmaceutical ingredient on the one hand and also does not cause any negative effects in the patient's body (preferably it behaves inertly in the body) and on the other hand its presence in the patient's body is easily detectable. It is possible to optimize the labeling substance, particularly from the point of view of easy detection.
  • a toxic activity which is harmful to the body can, if necessary, be eliminated by encapsulation or incorporation into a macromolecular protective molecule structure, in particular a protective molecule from the group of the Dendri ere or Fullvalene.
  • a macromolecular protective molecule structure in particular a protective molecule from the group of the Dendri ere or Fullvalene.
  • the invention is explained in more detail below with the use of a separate marking substance. However, this is not intended to limit the generality - for cases in which the active substance itself has the properties of a suitable detection substance.
  • Very different physically measurable quantities can serve as a measurement quantity. Examples are the intensity, the frequency or the phase position of an electromagnetic radiation (in particular of light in the IR range or also in the visible range), the intensity, frequency or phase position of a sound signal or the intensity or polarity of a magnetic field. It is crucial that the measured variable is influenced in a measurable manner by the presence of the marker substance in the patient's body, so that a change in the concentration of the marker substance associated with the use of the medicament can be detected with the aid of the measured variable by the detection device. Such a measured variable is referred to below as "parameter” in accordance with a term commonly used in the English language (“quantifiable parameter").
  • the detection device preferably has means for determining the change in the parameter over time.
  • Such electronic means for differentiating or for forming difference quotients from a measurement signal are known.
  • An increase or decrease in the parameter measurement signal is preferably used as an indication of the intake of the medicament, ie an output signal corresponding to the "detection" of the labeling substance is generated when the parameter rameter measurement signal with a minimum change rate predetermined as a limit value increases or decreases.
  • the invention is suitable for a wide variety of pharmaceutical dosage forms. It is of particular importance for oral administration (tablets, capsules and the like), but it can also be used for other dosage forms, such as suppositories or injections, insofar as monitoring of the regular administration of the medication is necessary. Of course, the marking substance must be brought into a galenical form suitable for the respective dosage form.
  • the invention can have different mechanisms of action, i.e. on the basis of very different interactions between the marking substance and the detection device. Some preferred examples are explained below.
  • the marking substance has dye properties, preferably in the IR region of the light spectrum.
  • a detection device tuned to this radiates light of the appropriate wavelength through the skin into the patient's body and measures the light emerging from the body after interaction with the constituents contained therein (and thus also with the marking substance).
  • the system components are expediently coordinated with one another in such a way that a possible high intensity of the incident light lies in a spectral range in which the marking substance has an absorption maximum.
  • This wavelength is preferably chosen so that it is outside the absorption maxima of optically absorbing substances contained in the patient's body (in particular in his skin) in high concentration Substances lie, especially outside the absorption bands of water and hemoglobin.
  • the light is usually irradiated in several wavelengths and the spectral dependence of the measured parameter of the light is used to detect the substance sought.
  • the spectral dependence of the measured parameter of the light is used to detect the substance sought.
  • several wavelengths are used in order to detect the marking substance spectroscopically.
  • a particularly suitable mechanism of action is based on the use of a fluorescent dye as a labeling substance, the detection device being designed for in vivo detection of the fluorescence. For this purpose, it radiates light, the wavelength of which corresponds to the absorption wavelength of the fluorescent dye, into the patient's body. Lasers are particularly suitable as the light source for this. The resulting fluorescence radiation is detected in a wavelength-selective manner. Fluorescent dyes are preferably used which emit in the long-wave range of visible light and in the near infrared. Wavelengths are particularly preferred. lengths between about 600 nm and about 800 nm. Despite the low intensity of the emitted fluorescent light, this action mechanism proves to be particularly suitable for the purposes of the invention, because the superimposition of the useful signal with interference signals is relatively small and therefore a good comparison with other methods Signal / noise ratio results.
  • Suitable labeling substances can be, for example, molecules that have been developed as marker molecules for diagnostic purposes. Examples include:
  • Fluorescent labeling substances in particular fluorescein and fluorescent metal complex compounds, as are mentioned in WO 96/03410.
  • Absorption or fluorescent dyes for example according to EP-B-0567 622.
  • ferromagnetic microparticles the magnetic effect of which can be detected through the skin, can also be used as the marking substance.
  • Electromagnetic radiation with a wavelength outside the spectrum of light can also be used as a probe for detecting the presence of a labeling substance in the patient's body.
  • substances with diode properties can in particular be used as the marking substance. Details of this are described in WO 92/15 013.
  • the marking substance has a pn junction which causes a diode behavior, ie in the electric field the substance is conductive in one field direction, while it has a high resistance in the other field direction.
  • Such semiconductor diodes can be manufactured in micro-miniaturized form so that they act as marking sub- are generally suitable in a medication.
  • the detection is carried out by influencing a high-frequency signal, preferably in the MHz range, as explained in the aforementioned WO 92/15 013.
  • Fig. 2 is a block diagram of a detection device and an external interrogation unit and
  • Fig. 3 is a graphical representation of a spectrum in an embodiment of the invention.
  • the control system consists of a pharmaceutical dosage form 1 (here a tablet) which contains a marking substance symbolically identified by an asterisk and a detection device 2 which, in the preferred embodiment shown, is designed as a wristwatch worn by the patient 3.
  • a detection device which is usually in the form of a device worn on the body, fulfills its control function in an inconspicuous manner that is not burdensome for the patient.
  • the control device should be so small and light that it can be carried easily.
  • the essential components of the detection device 2 are shown in the form of a block diagram in FIG. It contains irradiation and detection means 4 and 5, for example in the form of light-emitting diodes and semiconductor light receivers.
  • the signals of the detection means are transmitted through a measuring and evaluation circuit 6 (for example processed by means of one of the methods described in the cited publications) into data on the presence of the marking substance in the body of the patient 3.
  • a time measuring device 9 is provided in order to query the measuring time and also to store it in the memory 8.
  • the detection device can be constructed relatively simply because no absolute concentration has to be determined. It is sufficient to demonstrate the increase in the concentration of the labeling substance associated with the drug intake. This can be done in terms of measurement technology, for example by means of a threshold value or (preferably) by determining the change in the parameter over time (i.e. formation of the first derivative of the measurement signal). Complex calibration procedures are not necessary.
  • the data stored in the memory 8 can be further processed in the usual manner by the microprocessor-controlled measuring and evaluation unit.
  • this can contain a program by which control measurements are initiated at certain predetermined times (for example once a day) in order to check whether the Patient has taken the medication and therefore evidence of the medication is possible.
  • the program can also provide that in the event of a negative result of the check, a warning signal is generated by which an acoustic signal generator 11 is activated in order to inform the patient of the medication being taken.
  • This can be varied in different ways. For example, it can be provided to remind the patient of the medication in each case by a tone without prior checking and to check the ingestion within a defined period afterwards by detecting the marking substance with the aid of the detection device 2.
  • the data on the detection of the marking substance and on the measuring times are transmitted from the detection device 2 to an external interrogation unit 12.
  • This external interrogation unit can be with the patient himself or with the doctor.
  • the same or different query units can also be available to the doctor and the patient.
  • the detection device 2 and the interrogation unit 12 should be designed such that the patient cannot delete or manipulate the data on the detection of the marking substance.
  • the data is transmitted wirelessly from the detection device 2 to the external interrogation unit 12, the detection device 2 having a transmitter 13 and the interrogation unit 12 having a receiver 14, and the transmission being carried out, for example, with infrared rays or with FM radio signals .
  • a data interface for wired transmission can also be provided on the detection device 2, to which the external interrogation unit 12 is connected from time to time by means of a cable.
  • the Fluorescence of this fluorescent dye was measured in vivo in the ears of the mice.
  • the excitation was carried out using a helium-neon laser with a power of approximately 1.5 mW and a wavelength of 632.8 nm.
  • the fluorescent radiation was recorded with a fiber optic on the ear of the mice and focused on the emission monochromator of a fluorescence spectrometer.
  • the resulting spectrum normalized to the maximum value, is shown in FIG. 3, the intensity I (in each case based on the maximum value) being plotted against the wavelength in nm.
  • the measurement curve 16 shows the result of the in vivo measurements on the ear (measurement points as triangles).
  • the measurement curve 17 shows the results of an in vitro measurement of the spectrum of the dye, likewise normalized to the maximum value, using the same spectrometer. It can be seen that the in vivo measurement agrees very well with the in vitro measurement. From this it can be concluded that it is possible to reliably detect changes in the concentration of a physiologically harmless dye in vivo at a suitable wavelength (in particular in the range of the maximum of the emission spectrum) using relatively simple means.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un système de contrôle pour la prise régulière d'un médicament chez un patient. Ce système présente, comme constituants adaptés l'un à l'autre, une forme de préparation (1) du médicament et un appareil de détection (2) pour la détection non invasive d'une substance à détecter contenue dans la forme de préparation dans le corps du patient (3). L'appareil de détection (2) est conçu pour la mesure directe, sans réactifs, d'un paramètre physiquement mesurable associé à la présence de la substance à détecter dans le corps du patient.
EP97936601A 1996-08-16 1997-08-01 Systeme de controle pour la prise reguliere d'un medicament Withdrawn EP0928155A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19633025 1996-08-16
DE19633025 1996-08-16
PCT/DE1997/001653 WO1998007364A1 (fr) 1996-08-16 1997-08-01 Systeme de controle pour la prise reguliere d'un medicament

Publications (1)

Publication Number Publication Date
EP0928155A1 true EP0928155A1 (fr) 1999-07-14

Family

ID=7802787

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97936601A Withdrawn EP0928155A1 (fr) 1996-08-16 1997-08-01 Systeme de controle pour la prise reguliere d'un medicament

Country Status (5)

Country Link
US (1) US6081734A (fr)
EP (1) EP0928155A1 (fr)
JP (1) JP2000516504A (fr)
DE (1) DE19780856D2 (fr)
WO (1) WO1998007364A1 (fr)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6138010A (en) * 1997-05-08 2000-10-24 Motorola, Inc. Multimode communication device and method for operating a multimode communication device
US6299374B1 (en) 2000-03-09 2001-10-09 David Naor Instruments for producing edible colored indicia on food substrates and medicaments
EP1802258A4 (fr) 2004-09-13 2015-09-23 Chrono Therapeutics Inc Administration de medicament transdermique biosynchrone
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP1889198B1 (fr) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Systeme pharma-informatique
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
US8730031B2 (en) 2005-04-28 2014-05-20 Proteus Digital Health, Inc. Communication system using an implantable device
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
EP1920418A4 (fr) 2005-09-01 2010-12-29 Proteus Biomedical Inc Systeme de communications sans fil implantable
DE102005056310B4 (de) * 2005-11-25 2017-02-02 Drägerwerk AG & Co. KGaA Verfahren und Vorrichtung zur Überwachung von Infusionen
EP3367386A1 (fr) 2006-05-02 2018-08-29 Proteus Digital Health, Inc. Régimes thérapeutiques personnalisés de patients
CN100500092C (zh) * 2006-06-16 2009-06-17 周常安 具有可变结构的血液生理信号检测装置
EP2087589B1 (fr) 2006-10-17 2011-11-23 Proteus Biomedical, Inc. Oscillateur basse tension pour dispositifs médicaux
JP5916277B2 (ja) 2006-10-25 2016-05-11 プロテウス デジタル ヘルス， インコーポレイテッド 摂取可能な制御活性化識別子
US8718193B2 (en) 2006-11-20 2014-05-06 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
CN101686800A (zh) 2007-02-01 2010-03-31 普罗秋斯生物医学公司 可摄入事件标记器***
EP2111661B1 (fr) 2007-02-14 2017-04-12 Proteus Digital Health, Inc. Source d'énergie intégrée au corps ayant une électrode de zone de surface supérieure
WO2008112577A1 (fr) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. Dispositif dans le corps ayant un émetteur multidirectionnel
EP2063771A1 (fr) 2007-03-09 2009-06-03 Proteus Biomedical, Inc. Dispositif organique à antenne déployable
US8115618B2 (en) 2007-05-24 2012-02-14 Proteus Biomedical, Inc. RFID antenna for in-body device
EP4011289A1 (fr) 2007-09-25 2022-06-15 Otsuka Pharmaceutical Co., Ltd. Dispositif intra-corporel à amplification de signal de dipôle virtuel
ES2840773T3 (es) 2008-03-05 2021-07-07 Otsuka Pharma Co Ltd Sistemas y marcadores de eventos ingeribles de comunicación multimodo
CN102159134B (zh) 2008-07-08 2015-05-27 普罗透斯数字保健公司 可摄取事件标记数据框架
US8540633B2 (en) 2008-08-13 2013-09-24 Proteus Digital Health, Inc. Identifier circuits for generating unique identifiable indicators and techniques for producing same
JP2010091318A (ja) * 2008-10-06 2010-04-22 Seiko Epson Corp 生体内薬剤濃度分布測定装置およびこれに用いる波長可変フィルタ、生体内薬剤濃度分布測定方法
WO2010057049A2 (fr) 2008-11-13 2010-05-20 Proteus Biomedical, Inc. Système d'activation thérapeutique pouvant être ingéré et procédé
US8055334B2 (en) 2008-12-11 2011-11-08 Proteus Biomedical, Inc. Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same
TWI503101B (zh) 2008-12-15 2015-10-11 Proteus Digital Health Inc 與身體有關的接收器及其方法
US9659423B2 (en) 2008-12-15 2017-05-23 Proteus Digital Health, Inc. Personal authentication apparatus system and method
US9439566B2 (en) 2008-12-15 2016-09-13 Proteus Digital Health, Inc. Re-wearable wireless device
CA2750158A1 (fr) 2009-01-06 2010-07-15 Proteus Biomedical, Inc. Retroaction biologique liee a l'ingestion et methode de traitement medical personnalisee et systeme
CN102365084B (zh) 2009-01-06 2014-04-30 普罗秋斯数字健康公司 药剂递送***
GB2480965B (en) 2009-03-25 2014-10-08 Proteus Digital Health Inc Probablistic pharmacokinetic and pharmacodynamic modeling
EA201190281A1 (ru) 2009-04-28 2012-04-30 Протиус Байомедикал, Инк. Высоконадежные проглатываемые отметчики режима и способы их применения
US9149423B2 (en) 2009-05-12 2015-10-06 Proteus Digital Health, Inc. Ingestible event markers comprising an ingestible component
US8558563B2 (en) 2009-08-21 2013-10-15 Proteus Digital Health, Inc. Apparatus and method for measuring biochemical parameters
EP2473095B1 (fr) 2009-09-03 2014-11-12 Evonik Röhm GmbH Forme pharmaceutique orale comprenant au moins un agent biologiquement actif, des substances auxiliaires de formulation et des particules magnetisables
TWI517050B (zh) 2009-11-04 2016-01-11 普羅托斯數位健康公司 供應鏈管理之系統
UA109424C2 (uk) 2009-12-02 2015-08-25 Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки
CA2788336C (fr) 2010-02-01 2018-05-01 Proteus Digital Health, Inc. Systeme de rassemblement de donnees
US9597487B2 (en) 2010-04-07 2017-03-21 Proteus Digital Health, Inc. Miniature ingestible device
TWI557672B (zh) 2010-05-19 2016-11-11 波提亞斯數位康健公司 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置
EP2642983A4 (fr) 2010-11-22 2014-03-12 Proteus Digital Health Inc Dispositif ingérable avec produit pharmaceutique
EP2683291B1 (fr) 2011-03-11 2019-07-31 Proteus Digital Health, Inc. Dispositif associé au corps d'une personne pouvant être porté ayant des diverses configurations physiques
US20130017259A1 (en) 2011-07-06 2013-01-17 The Parkinson's Institute Compositions and Methods for Treatment of Symptoms in Parkinson's Disease Patients
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
WO2015112603A1 (fr) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Produit ingérable pouvant être mâché et système de communication associé
KR101898964B1 (ko) 2011-07-21 2018-09-14 프로테우스 디지털 헬스, 인코포레이티드 모바일 통신 장치, 시스템, 및 방법
US9235683B2 (en) 2011-11-09 2016-01-12 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
EP2874886B1 (fr) 2012-07-23 2023-12-20 Otsuka Pharmaceutical Co., Ltd. Techniques de fabrication de marqueurs d'événements ingérables comprenant un constituant ingérable
MX340182B (es) 2012-10-18 2016-06-28 Proteus Digital Health Inc Aparato, sistema, y metodo para optimizar adaptativamente la disipacion de energia y la energia de difusion en una fuente de energia para un dispositivo de comunicacion.
US20140154813A1 (en) * 2012-11-30 2014-06-05 Sicpa Holding Sa Marking of material, marked material and process of authentication or dilution determination
TWI659994B (zh) 2013-01-29 2019-05-21 美商普羅托斯數位健康公司 高度可膨脹之聚合型薄膜及包含彼之組成物
WO2014151929A1 (fr) 2013-03-15 2014-09-25 Proteus Digital Health, Inc. Appareil, système et procédé d'authentification personnelle
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
EP3005281A4 (fr) 2013-06-04 2017-06-28 Proteus Digital Health, Inc. Système, appareil et procédés de collecte de données et d'évaluation de résultats
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
EP3047618B1 (fr) 2013-09-20 2023-11-08 Otsuka Pharmaceutical Co., Ltd. Procédés, dispositifs et systèmes de réception et de décodage de signal en présence de bruit à l'aide de tranches et d'une distorsion
US9577864B2 (en) 2013-09-24 2017-02-21 Proteus Digital Health, Inc. Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
DE102013113234A1 (de) 2013-11-29 2015-06-03 Deutsche Telekom Ag Medikamentenbox
US10213586B2 (en) 2015-01-28 2019-02-26 Chrono Therapeutics Inc. Drug delivery methods and systems
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
MX2019000888A (es) 2016-07-22 2019-06-03 Proteus Digital Health Inc Percepcion y deteccion electromagnetica de marcadores de evento ingeribles.
IL265827B2 (en) 2016-10-26 2023-03-01 Proteus Digital Health Inc Methods for producing capsules with ingestible event markers
WO2018129304A1 (fr) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Dispositifs et methodes d'administration transdermique de medicament
US10978203B2 (en) * 2017-06-20 2021-04-13 International Business Machines Corporation Power-efficient health affliction classification
AU2019279884A1 (en) 2018-05-29 2020-12-10 Morningside Venture Investments Limited Drug delivery methods and systems

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2257356A1 (de) * 1972-11-20 1974-05-30 Wolfgang Dr Med Wagner Verwendung von druck- und wellenuebertragungsvorrichtungen insbesondere piezoelektrischer art und formverbesserung bei einrichtungen zur kontrollierten arzneiverabreichung durch den mund (perorale medikationskontrolle)
JPS63252239A (ja) * 1987-04-09 1988-10-19 Sumitomo Electric Ind Ltd 反射型オキシメ−タ
JPH06103257B2 (ja) 1988-12-19 1994-12-14 大塚電子株式会社 光散乱を用いた物質の吸光係数測定方法および装置
US5187672A (en) 1989-02-06 1993-02-16 Nim Incorporated Phase modulation spectroscopic system
US5028787A (en) * 1989-01-19 1991-07-02 Futrex, Inc. Non-invasive measurement of blood glucose
DE3940260A1 (de) * 1989-03-04 1990-09-13 Werner Weitschies Verfahren zur bestimmung des aufenthaltsortes und der bewegung von objekten durch ihre markierung als magnetisches moment
DE3935257A1 (de) * 1989-10-23 1991-04-25 Langhals Heinz Mit antikoerpern verknuepfte liposomen als traeger fuer einen gezielten transport von wirkstoffen und reagenzien - fluoreszenzmarkierung der transportwege und des wirkorts
US5036861A (en) * 1990-01-11 1991-08-06 Sembrowich Walter L Method and apparatus for non-invasively monitoring plasma glucose levels
US5200891A (en) * 1990-01-17 1993-04-06 Bruce A. Kehr Electronic medication dispensing method
DK0613652T3 (da) * 1990-02-15 1997-08-25 Hewlett Packard Gmbh Apparat og fremgangsmåde til ikke invasiv måling af oxygenmåling
GB9103752D0 (en) 1991-02-22 1991-04-10 Pa Consulting Services Detection of species
US5318023A (en) * 1991-04-03 1994-06-07 Cedars-Sinai Medical Center Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle
DE4137934A1 (de) 1991-11-18 1993-05-19 Boehringer Mannheim Gmbh Neue pentacyklische verbindungen und ihre verwendung als absorptions- oder fluoreszenzfarbstoffe
WO1994000602A1 (fr) * 1992-06-29 1994-01-06 Sensor Technologies, Inc. Procede et dispositif de detection et de quantification de substances dans des liquides organiques
US5487384A (en) * 1993-02-25 1996-01-30 Blue Marble Research, Inc. Kinematic assay of plasma glucose concentration without blood sampling
DE4417639A1 (de) * 1994-05-19 1995-11-23 Boehringer Mannheim Gmbh Verfahren zur Bestimmung eines Analyten in einer biologischen Probe
EP0760091B1 (fr) 1994-05-19 1999-11-03 Roche Diagnostics GmbH Procede et dispositif pour la determination d'un analyte dans un echantillon biologique
FR2721521B1 (fr) * 1994-06-27 1996-12-13 Commissariat Energie Atomique Dispositif microdoseur pulvérisateur automatique de médicament et ensemble doseur intelligent utilisant ce dispositif.
CA2195752C (fr) 1994-07-25 2010-10-26 Hans-Peter Josel Molecules oligomeres de support presentant des groupes marqueurs integres determines et des haptenes
US5981286A (en) 1994-07-25 1999-11-09 Roche Diagnostics, Gmbh Hydrophilic metal complexes
WO1996003423A1 (fr) * 1994-07-25 1996-02-08 Boehringer Mannheim Gmbh Peptides marques par un haptene
US5572996A (en) * 1994-09-19 1996-11-12 Pdt Systems, Inc. In vivo pharmacokinetics of photosensitive drugs and method
GB9601186D0 (en) * 1996-01-20 1996-03-20 Cleansharp Ltd Administration of Drugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9807364A1 *

Also Published As

Publication number Publication date
US6081734A (en) 2000-06-27
DE19780856D2 (de) 1999-09-23
WO1998007364A1 (fr) 1998-02-26
JP2000516504A (ja) 2000-12-12

Similar Documents

Publication Publication Date Title
WO1998007364A1 (fr) Systeme de controle pour la prise reguliere d'un medicament
DE10027100C2 (de) Verfahren und Vorrichtung zum Nachweisen von Substanzen in Körperflüssigkeiten
DE69032535T2 (de) Verfahren und Vorrichtung zur Bestimmung der Ähnlichkeit eines biologischen Analyts, ausgehend von einem aus bekannten biologischen Fluiden hergestellten Modell
DE10011284B4 (de) Vorrichtung für eine In-vivo Messung der Konzentration eines Inhaltsstoffs einer Körperflüssigkeit
DE60023162T2 (de) Stethoskop
DE19612425C2 (de) Apparat zur Messung von Hämoglobinkonzentration
EP0707826B1 (fr) Procédé et appareil pour la détermination du glucose contenu dans un milieu biologique
EP0726729B1 (fr) Procede et dispositif permettant de determiner la concentration de glucose dans une matrice biologique
DE68923941T2 (de) Verfahren und Gerät zur Messung der Eigenschaften einer Substanz mittels Lichtstreuung.
DE10213692B4 (de) Verfahren zur Steuerung einer Vorrichtung und Vorrichtung zur Messung von Inhaltsstoffen im Blut
EP1518495B1 (fr) Procédé et dispositif de surveillance continue de la concentration d'un analyte
EP0728440B1 (fr) Procédé et appareil pour la détection non-invasive, profonde et sélective de l'activité musculaire
DE69837425T2 (de) Verfahren und Vorrichtung zur nichtinvasiven photoakustischen Messung von Blutglukose
DE69432869T2 (de) Glukose Fluoreszenzmonitor und Verfahren
DE69933717T2 (de) Optischer Sensor zur in situ Messung von Analyten
DE3031249A1 (de) Verfahren und vorrichtung zum entdecken von karies.
DE69728525T2 (de) Mittels vakuum verbesserter transdermaler flüssigkeitstransport
DE102010014775A1 (de) Vorrichtung und Verfahren zur Bestimmen eines biologischen, chemischen und/oder physikalischen Parameters in lebendem biologischem Gewebe
DE602004001794T2 (de) Verfahren und Vorrichtung zur in vitro oder in vivo Messung der Konzentration einer Substanz
WO2001028414A2 (fr) Dispositif pour determiner $m(f)i$m(g)in vivo$m(f)/i$m(g) de maniere non invasive la concentration de composants dans le sang ou dans des tissus organiques et pour etablir d'autres grandeurs pertinentes sur le plan medical
CH640350A5 (en) Instrument for the quantitative determination of optically active substances
DE69122506T2 (de) Nichtinvasiver medizinischer sensor
EP1273904A2 (fr) Procédé et appareil pour la détection d'une substance dans un tissu vivant
DE19629342C2 (de) Verfahren und Anordnung zur nicht-invasiven, transkutanen Bestimmung von Stoffkonzentrationen in Körpergeweben
DE102020119026A1 (de) Messsystem und Messverfahren

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990220

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT CH DE ES FR GB IT LI NL

17Q First examination report despatched

Effective date: 20030213

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20030726