EP0590027A4 - Mutationen in mycobakterien durch geneinbau. - Google Patents
Mutationen in mycobakterien durch geneinbau.Info
- Publication number
- EP0590027A4 EP0590027A4 EP9292913432A EP92913432A EP0590027A4 EP 0590027 A4 EP0590027 A4 EP 0590027A4 EP 9292913432 A EP9292913432 A EP 9292913432A EP 92913432 A EP92913432 A EP 92913432A EP 0590027 A4 EP0590027 A4 EP 0590027A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- mycobacteria
- insertional mutations
- insertional
- mutations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000035772 mutation Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99110251A EP0972839A1 (de) | 1991-06-13 | 1992-06-02 | Mutationen in Mycobakterien durch Geneinbau |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71465691A | 1991-06-13 | 1991-06-13 | |
US714656 | 1991-06-13 | ||
US80670691A | 1991-12-12 | 1991-12-12 | |
US806706 | 1991-12-12 | ||
PCT/US1992/004706 WO1992022326A1 (en) | 1991-06-13 | 1992-06-02 | Insertional mutations in mycobacteria |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99110251A Division EP0972839A1 (de) | 1991-06-13 | 1992-06-02 | Mutationen in Mycobakterien durch Geneinbau |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0590027A1 EP0590027A1 (de) | 1994-04-06 |
EP0590027A4 true EP0590027A4 (de) | 1994-10-19 |
Family
ID=27109189
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP9292913432A Withdrawn EP0590027A4 (de) | 1991-06-13 | 1992-06-02 | Mutationen in mycobakterien durch geneinbau. |
EP99110251A Withdrawn EP0972839A1 (de) | 1991-06-13 | 1992-06-02 | Mutationen in Mycobakterien durch Geneinbau |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99110251A Withdrawn EP0972839A1 (de) | 1991-06-13 | 1992-06-02 | Mutationen in Mycobakterien durch Geneinbau |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP0590027A4 (de) |
JP (1) | JPH06511145A (de) |
AU (2) | AU2189392A (de) |
CA (1) | CA2111217A1 (de) |
FI (1) | FI935566A0 (de) |
NO (2) | NO934515L (de) |
WO (1) | WO1992022326A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6566121B1 (en) | 1991-06-13 | 2003-05-20 | Albert Einstein College Of Medicine Of Yeshiva University | Insertional mutations in mycobacteria |
ATE407945T1 (de) | 1993-11-23 | 2008-09-15 | Univ California | Reichlich vorhandene extrazelluläre produkte und methoden zu ihrer herstellung sowie ihre verwendung |
US7300660B2 (en) | 1993-11-23 | 2007-11-27 | The Regents Of The University Of California | Abundant extracellular products and methods for their production and use |
US6752993B1 (en) | 1993-11-23 | 2004-06-22 | The Regents Of The University Of California | Abundant extracellular product vaccines and methods for their production and use |
WO1995032277A1 (en) * | 1994-05-23 | 1995-11-30 | Albert Einstein College Of Medicine Of Yeshiva University | Insertional mutations in mycobacteria |
US5843664A (en) * | 1996-06-11 | 1998-12-01 | Institut Pasteur | Method of selection of allelic exchange mutants |
US6013660A (en) * | 1996-10-02 | 2000-01-11 | The Regents Of The University Of California | Externally targeted prophylactic and chemotherapeutic method and agents |
US6221364B1 (en) * | 1996-11-12 | 2001-04-24 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacteria auxotrophic for diaminopimelate |
US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
WO1999002670A1 (en) * | 1997-07-10 | 1999-01-21 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated |
US6387694B1 (en) * | 1998-04-03 | 2002-05-14 | Albert Einstein College Of Medicine Of Yeshiva University | Mycobacterial isocitrate lyase gene and uses thereof |
US7115730B1 (en) | 1999-04-27 | 2006-10-03 | Chiron Srl | Immunogenic detoxified mutant E. coli LT-A-toxin |
AU2001230912A1 (en) | 2000-01-11 | 2001-07-24 | The Board Of Regents Of The University Of Nebraska | Identification of virulence determinants |
CL2007002710A1 (es) * | 2007-09-20 | 2008-01-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que confiere proteccion contra la infeccion o patologia causada por el virus respiratorio sincicial (vrs) que comprende una cepa recombinante atenuada de mycobacterium; y uso de la formulacion inmunogenica para preparar una vacuna para prevenir, tratar o atenuar infecciones del vrs. |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990000594A2 (en) * | 1988-07-07 | 1990-01-25 | Whitehead Institute For Biomedical Research | Recombinant mycobacterial expression vehicles and uses therefor |
WO1992001783A1 (en) * | 1990-07-16 | 1992-02-06 | Albert Einstein College Of Medicine Of Yeshiva University | Dna capable of site-specific integration into mycobacteria |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3011939B2 (ja) * | 1987-03-02 | 2000-02-21 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 組換えミコバクテリア・ワクチン |
DE69034100T2 (de) * | 1989-06-19 | 2004-06-09 | Whitehead Institute For Biomedical Research, Cambridge | Verktorvermittelte genominsertion und expression von dna in bcg |
-
1992
- 1992-06-02 EP EP9292913432A patent/EP0590027A4/de not_active Withdrawn
- 1992-06-02 JP JP5500932A patent/JPH06511145A/ja active Pending
- 1992-06-02 AU AU21893/92A patent/AU2189392A/en not_active Abandoned
- 1992-06-02 WO PCT/US1992/004706 patent/WO1992022326A1/en not_active Application Discontinuation
- 1992-06-02 EP EP99110251A patent/EP0972839A1/de not_active Withdrawn
- 1992-06-02 CA CA002111217A patent/CA2111217A1/en not_active Abandoned
-
1993
- 1993-12-09 NO NO934515A patent/NO934515L/no unknown
- 1993-12-09 NO NO934515D patent/NO934515D0/no unknown
- 1993-12-10 FI FI935566A patent/FI935566A0/fi unknown
-
1997
- 1997-03-17 AU AU16357/97A patent/AU1635797A/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990000594A2 (en) * | 1988-07-07 | 1990-01-25 | Whitehead Institute For Biomedical Research | Recombinant mycobacterial expression vehicles and uses therefor |
WO1992001783A1 (en) * | 1990-07-16 | 1992-02-06 | Albert Einstein College Of Medicine Of Yeshiva University | Dna capable of site-specific integration into mycobacteria |
Non-Patent Citations (7)
Title |
---|
CARLOS MARTIN ET AL.: "Transposition of an antibiotic resistance element in mycobacteria", NATURE, vol. 345, no. 6277, 21 June 1990 (1990-06-21), LONDON GB, pages 739 - 743 * |
GANJAM V. KALPANA ET AL.: "Insertional mutagenesis and illegitimate recombination in mycobacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, no. 12, 15 June 1991 (1991-06-15), WASHINGTON US, pages 5433 - 5437 * |
JEFFREY D. CIRILLO ET AL.: "A novel transposon Trap for mycobacteria: Isolation and characterization of IS1096", JOURNAL OF BACTERIOLOGY, vol. 173, no. 24, December 1991 (1991-12-01), pages 7772 - 7780 * |
P.M. ENGLAND ET AL.: "IS900-promoted stable integration of a foreign gene into mycobacteria", MOLECULAR MICROBIOLOGY, vol. 5, no. 8, August 1991 (1991-08-01), pages 2047 - 2052 * |
See also references of WO9222326A1 * |
W.R.JACOBS JR. ET AL.: "Development of BCG as a recombinant vaccine vehicle", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 155, 1990, pages 153 - 160 * |
WILLIAM R. JACOBS, JR. ET AL.: "Genetic systems for mycobacteria", METHODS IN ENZYMOLOGY, vol. 204, 1991, pages 537 - 555 * |
Also Published As
Publication number | Publication date |
---|---|
CA2111217A1 (en) | 1992-12-23 |
FI935566A (fi) | 1993-12-10 |
EP0972839A1 (de) | 2000-01-19 |
JPH06511145A (ja) | 1994-12-15 |
NO934515D0 (no) | 1993-12-09 |
FI935566A0 (fi) | 1993-12-10 |
AU1635797A (en) | 1997-06-12 |
EP0590027A1 (de) | 1994-04-06 |
WO1992022326A1 (en) | 1992-12-23 |
NO934515L (no) | 1994-02-02 |
AU2189392A (en) | 1993-01-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19940107 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
|
RHK1 | Main classification (correction) |
Ipc: C12N 15/74 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19940901 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE |
|
17Q | First examination report despatched |
Effective date: 19950714 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19991014 |