EP0590027A4 - Insertional mutations in mycobacteria. - Google Patents

Insertional mutations in mycobacteria.

Info

Publication number: EP0590027A4
Authority: EP; European Patent Office
Prior art keywords: mycobacteria; insertional mutations; insertional; mutations
Prior art date: 1991-06-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP9292913432A

Other languages

German (de)

French (fr)

Other versions

EP0590027A1 (en

Inventor

William R Jacobs

Barry Bloom

Ganjam V Kalpana

Jeffrey D Cirillo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Albert Einstein College of Medicine

Original Assignee

Albert Einstein College of Medicine

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-13

Filing date

1992-06-02

Publication date

1994-10-19

1992-06-02 Application filed by Albert Einstein College of Medicine filed Critical Albert Einstein College of Medicine

1992-06-02 Priority to EP99110251A priority Critical patent/EP0972839A1/en

1994-04-06 Publication of EP0590027A1 publication Critical patent/EP0590027A1/en

1994-10-19 Publication of EP0590027A4 publication Critical patent/EP0590027A4/en

Status Withdrawn legal-status Critical Current

Links

230000035772 mutation Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pulmonology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Orthopedics, Nursing, And Contraception (AREA)

EP9292913432A 1991-06-13 1992-06-02 Insertional mutations in mycobacteria. Withdrawn EP0590027A4 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP99110251A EP0972839A1 (en)	1991-06-13	1992-06-02	Insertional mutations in mycobacteria

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US71465691A	1991-06-13	1991-06-13
US714656		1991-06-13
US80670691A	1991-12-12	1991-12-12
US806706		1991-12-12
PCT/US1992/004706 WO1992022326A1 (en)	1991-06-13	1992-06-02	Insertional mutations in mycobacteria

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99110251A Division EP0972839A1 (en)	1991-06-13	1992-06-02	Insertional mutations in mycobacteria

Publications (2)

Publication Number	Publication Date
EP0590027A1 EP0590027A1 (en)	1994-04-06
EP0590027A4 true EP0590027A4 (en)	1994-10-19

Family

ID=27109189

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP9292913432A Withdrawn EP0590027A4 (en)	1991-06-13	1992-06-02	Insertional mutations in mycobacteria.
EP99110251A Withdrawn EP0972839A1 (en)	1991-06-13	1992-06-02	Insertional mutations in mycobacteria

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP99110251A Withdrawn EP0972839A1 (en)	1991-06-13	1992-06-02	Insertional mutations in mycobacteria

Country Status (7)

Country	Link
EP (2)	EP0590027A4 (en)
JP (1)	JPH06511145A (en)
AU (2)	AU2189392A (en)
CA (1)	CA2111217A1 (en)
FI (1)	FI935566A0 (en)
NO (2)	NO934515L (en)
WO (1)	WO1992022326A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6566121B1 (en)	1991-06-13	2003-05-20	Albert Einstein College Of Medicine Of Yeshiva University	Insertional mutations in mycobacteria
WO1995014713A2 (en)	1993-11-23	1995-06-01	The Regents Of The University Of California	Abundant extracellular products and methods for their production and use
US6752993B1 (en)	1993-11-23	2004-06-22	The Regents Of The University Of California	Abundant extracellular product vaccines and methods for their production and use
US7300660B2 (en)	1993-11-23	2007-11-27	The Regents Of The University Of California	Abundant extracellular products and methods for their production and use
WO1995032277A1 (en) *	1994-05-23	1995-11-30	Albert Einstein College Of Medicine Of Yeshiva University	Insertional mutations in mycobacteria
US5843664A (en) *	1996-06-11	1998-12-01	Institut Pasteur	Method of selection of allelic exchange mutants
US6013660A (en) *	1996-10-02	2000-01-11	The Regents Of The University Of California	Externally targeted prophylactic and chemotherapeutic method and agents
US6221364B1 (en) *	1996-11-12	2001-04-24	Albert Einstein College Of Medicine Of Yeshiva University	Recombinant mycobacteria auxotrophic for diaminopimelate
US6818222B1 (en)	1997-03-21	2004-11-16	Chiron Corporation	Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
WO1999002670A1 (en) *	1997-07-10	1999-01-21	The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services	Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated
US6387694B1 (en)	1998-04-03	2002-05-14	Albert Einstein College Of Medicine Of Yeshiva University	Mycobacterial isocitrate lyase gene and uses thereof
US7115730B1 (en)	1999-04-27	2006-10-03	Chiron Srl	Immunogenic detoxified mutant E. coli LT-A-toxin
WO2001051649A2 (en) *	2000-01-11	2001-07-19	The Board Of Regents Of The University Of Nebraska	Identification of virulence determinants
CL2007002710A1 (en) *	2007-09-20	2008-01-04	Univ Pontificia Catolica Chile	Immunogenic formulation that confers protection against infection or pathology caused by the respiratory syncytial virus (vrs) comprising an attenuated recombinant strain of mycobacterium; and use of the immunogenic formulation to prepare a vaccine to prevent, treat or attenuate infections of vrs.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990000594A2 (en) *	1988-07-07	1990-01-25	Whitehead Institute For Biomedical Research	Recombinant mycobacterial expression vehicles and uses therefor
WO1992001783A1 (en) *	1990-07-16	1992-02-06	Albert Einstein College Of Medicine Of Yeshiva University	Dna capable of site-specific integration into mycobacteria

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0347425B1 (en) *	1987-03-02	1995-12-27	Whitehead Institute For Biomedical Research	Recombinant mycobacterial vaccine
CA2063414A1 (en) *	1989-06-19	1990-12-20	Richard A. Young	Vector-mediated genomic insertion and expression of dna in bcg

1992
- 1992-06-02 AU AU21893/92A patent/AU2189392A/en not_active Abandoned
- 1992-06-02 EP EP9292913432A patent/EP0590027A4/en not_active Withdrawn
- 1992-06-02 JP JP5500932A patent/JPH06511145A/en active Pending
- 1992-06-02 CA CA002111217A patent/CA2111217A1/en not_active Abandoned
- 1992-06-02 WO PCT/US1992/004706 patent/WO1992022326A1/en not_active Application Discontinuation
- 1992-06-02 EP EP99110251A patent/EP0972839A1/en not_active Withdrawn
1993
- 1993-12-09 NO NO934515A patent/NO934515L/en unknown
- 1993-12-09 NO NO934515D patent/NO934515D0/en unknown
- 1993-12-10 FI FI935566A patent/FI935566A0/en unknown
1997
- 1997-03-17 AU AU16357/97A patent/AU1635797A/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990000594A2 (en) *	1988-07-07	1990-01-25	Whitehead Institute For Biomedical Research	Recombinant mycobacterial expression vehicles and uses therefor
WO1992001783A1 (en) *	1990-07-16	1992-02-06	Albert Einstein College Of Medicine Of Yeshiva University	Dna capable of site-specific integration into mycobacteria

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CARLOS MARTIN ET AL.: "Transposition of an antibiotic resistance element in mycobacteria", NATURE, vol. 345, no. 6277, 21 June 1990 (1990-06-21), LONDON GB, pages 739 - 743 *
GANJAM V. KALPANA ET AL.: "Insertional mutagenesis and illegitimate recombination in mycobacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, no. 12, 15 June 1991 (1991-06-15), WASHINGTON US, pages 5433 - 5437 *
JEFFREY D. CIRILLO ET AL.: "A novel transposon Trap for mycobacteria: Isolation and characterization of IS1096", JOURNAL OF BACTERIOLOGY, vol. 173, no. 24, December 1991 (1991-12-01), pages 7772 - 7780 *
P.M. ENGLAND ET AL.: "IS900-promoted stable integration of a foreign gene into mycobacteria", MOLECULAR MICROBIOLOGY, vol. 5, no. 8, August 1991 (1991-08-01), pages 2047 - 2052 *
See also references of WO9222326A1 *
W.R.JACOBS JR. ET AL.: "Development of BCG as a recombinant vaccine vehicle", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 155, 1990, pages 153 - 160 *
WILLIAM R. JACOBS, JR. ET AL.: "Genetic systems for mycobacteria", METHODS IN ENZYMOLOGY, vol. 204, 1991, pages 537 - 555 *

Also Published As

Publication number	Publication date
WO1992022326A1 (en)	1992-12-23
CA2111217A1 (en)	1992-12-23
NO934515D0 (en)	1993-12-09
AU1635797A (en)	1997-06-12
FI935566A (en)	1993-12-10
EP0972839A1 (en)	2000-01-19
JPH06511145A (en)	1994-12-15
EP0590027A1 (en)	1994-04-06
NO934515L (en)	1994-02-02
AU2189392A (en)	1993-01-12
FI935566A0 (en)	1993-12-10

Legal Events

Date	Code	Title	Description
1994-02-18	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1994-04-06	17P	Request for examination filed	Effective date: 19940107
1994-04-06	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1994-10-05	RHK1	Main classification (correction)	Ipc: C12N 15/74
1994-10-19	A4	Supplementary search report drawn up and despatched	Effective date: 19940901
1994-10-19	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE
1995-08-30	17Q	First examination report despatched	Effective date: 19950714
2000-05-12	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2000-06-28	18D	Application deemed to be withdrawn	Effective date: 19991014

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