EP0575339A4 - Analogues du facteur de croissance acide des fibroblastes presentant une stabilite et une activite biologique ameliorees. - Google Patents

Analogues du facteur de croissance acide des fibroblastes presentant une stabilite et une activite biologique ameliorees.

Info

Publication number
EP0575339A4
EP0575339A4 EP92902895A EP92902895A EP0575339A4 EP 0575339 A4 EP0575339 A4 EP 0575339A4 EP 92902895 A EP92902895 A EP 92902895A EP 92902895 A EP92902895 A EP 92902895A EP 0575339 A4 EP0575339 A4 EP 0575339A4
Authority
EP
European Patent Office
Prior art keywords
analogs
growth factor
biological activity
fibroblast growth
enhanced stability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92902895A
Other languages
German (de)
English (en)
Other versions
EP0575339A1 (fr
Inventor
Tsutomu Arakawa
Gary Michael Fox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of EP0575339A1 publication Critical patent/EP0575339A1/fr
Publication of EP0575339A4 publication Critical patent/EP0575339A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP92902895A 1990-12-18 1992-07-17 Analogues du facteur de croissance acide des fibroblastes presentant une stabilite et une activite biologique ameliorees. Withdrawn EP0575339A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63245690A 1990-12-18 1990-12-18
US632456 1990-12-18

Publications (2)

Publication Number Publication Date
EP0575339A1 EP0575339A1 (fr) 1993-12-29
EP0575339A4 true EP0575339A4 (fr) 1995-04-05

Family

ID=24535601

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92902895A Withdrawn EP0575339A4 (fr) 1990-12-18 1992-07-17 Analogues du facteur de croissance acide des fibroblastes presentant une stabilite et une activite biologique ameliorees.

Country Status (9)

Country Link
EP (1) EP0575339A4 (fr)
JP (1) JPH06503962A (fr)
KR (1) KR930703439A (fr)
AU (1) AU663067B2 (fr)
CA (1) CA2098484A1 (fr)
IE (1) IE914393A1 (fr)
IL (1) IL100418A0 (fr)
NZ (1) NZ241021A (fr)
WO (1) WO1992011360A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717495B1 (fr) * 1994-03-18 1996-04-12 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
CZ98297A3 (cs) * 1994-10-13 1998-08-12 Amgen Inc. Způsob purifikace keratinocytových růstových faktorů
HUT77746A (hu) * 1994-10-13 1998-07-28 Amgen Inc. Fokozott stabilitással és biológiai aktivitással rendelkező savas fibroblaszt növekedési faktor analógok
JP2733207B2 (ja) * 1995-05-18 1998-03-30 工業技術院長 繊維芽細胞成長因子キメラ蛋白質を含有する医薬組成物
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
WO2000062798A2 (fr) * 1999-04-15 2000-10-26 St. Elizabeth's Medical Center, Inc. Facteurs de croissance angiogenique destines au traitement de neuropathie peripherique
US7125856B1 (en) 1999-04-15 2006-10-24 St. Elizabeth's Medical Center Of Boston, Inc. Angiogenic growth factors for treatment of peripheral neuropathy
US20070134204A1 (en) * 2005-12-09 2007-06-14 Henrich Cheng Method for treating nerve injury and vector construct for the same
US20100286042A1 (en) * 2007-10-12 2010-11-11 National Institute Of Advanced Industrial Science And Technology Medicinal Composition Containing Highly Functionalized Chimeric Protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0298723A1 (fr) * 1987-07-07 1989-01-11 California Biotechnology, Inc. Facteurs de croissance de fibroblaste recombinants

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62270597A (ja) * 1986-03-07 1987-11-24 プレジデント・アンド・フエロウズ・オブ・ハ−バ−ド・カレジ ヒト種類１ヘパリン結合性成長因子
NZ226543A (en) * 1987-10-22 1992-02-25 Merck & Co Inc Recombinant mutant acidic fibroblast growth factor
DE3909009A1 (de) * 1989-03-18 1990-09-20 Schloemann Siemag Ag Stranggiessanlage zum giessen von vorprofilen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0298723A1 (fr) * 1987-07-07 1989-01-11 California Biotechnology, Inc. Facteurs de croissance de fibroblaste recombinants

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARAKAWA, T. ET AL.: "PRODUCTION AND CHARACTERIZATION OF AN ANALOG OF ACIDIC FIBROBLAST GROWTH FACTOR WITH ENHANCED STABILITY AND BIOLOGICAL ACTIVITY.", PROTEIN ENG 6 (5). 1993. 541-546 *
BAIRD, A. ET AL.: "Receptor- and heparin-binding domains of basic fibroblast growth factor", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, April 1988 (1988-04-01), WASHINGTON US, pages 2324 - 2328 *
LESZCZYNSKI, J. & ROSE, G.: "Loops in globular proteins: a novel category of secondary structure", SCIENCE, vol. 234, 14 November 1986 (1986-11-14), LANCASTER, PA US, pages 849 - 855 *
See also references of WO9211360A1 *

Also Published As

Publication number Publication date
AU9152491A (en) 1992-07-22
AU663067B2 (en) 1995-09-28
CA2098484A1 (fr) 1992-06-19
JPH06503962A (ja) 1994-05-12
EP0575339A1 (fr) 1993-12-29
IE914393A1 (en) 1992-07-01
KR930703439A (ko) 1993-11-30
IL100418A0 (en) 1992-09-06
NZ241021A (en) 1993-12-23
WO1992011360A1 (fr) 1992-07-09

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Ipc: C12N 15/12

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Effective date: 19950215

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18D Application deemed to be withdrawn

Effective date: 19970628