EP0570378A1 - Dispositif doseur de solutions steriles et/ou pharmaceutiques - Google Patents

Dispositif doseur de solutions steriles et/ou pharmaceutiques

Info

Publication number
EP0570378A1
EP0570378A1 EP19920900409 EP92900409A EP0570378A1 EP 0570378 A1 EP0570378 A1 EP 0570378A1 EP 19920900409 EP19920900409 EP 19920900409 EP 92900409 A EP92900409 A EP 92900409A EP 0570378 A1 EP0570378 A1 EP 0570378A1
Authority
EP
European Patent Office
Prior art keywords
nozzle
sterile
wall
ring
cylindrical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920900409
Other languages
German (de)
English (en)
Spanish (es)
Inventor
Pedro Casamira Camps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Medical SA
Original Assignee
Industrias Palex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industrias Palex SA filed Critical Industrias Palex SA
Publication of EP0570378A1 publication Critical patent/EP0570378A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/08—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the diaphragm or bellows type
    • G01F11/082—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the diaphragm or bellows type of the squeeze container type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps

Definitions

  • the present invention concerns a sterile and / or pharmaceutical solutions dosing device, formed by a single-use container containing the solution, provided with a nozzle and a cap covering it, a ring in function of closure and a rigid support for its support, which in turn, facilitates the use and handling of the device.
  • the dosing device object of the present invention of sterile and / or pharmaceutical solutions is of medical or surgical application, for use in human or veterinary functions.
  • Container devices of pharmaceutical and veterinary liquid solutions such as ampoules, cartridges or vials, which are provided with needles are known or means for its coupling, which allows its direct use in its administration.
  • Such a device is described in Spanish Patent No. 8801006, formed by a container of flexible synthetic material, being emptied by pressure exerted against the walls thereof.
  • part of the solution is spilled on the flat surface where the assembly rests, by principles of capillarity.
  • container cartridge systems of solutions that can be coupled to rigid structures are also known, such as that described in PCT Patent WO 89/02286, of Wolke, in which a device formed by a sealed container can be described. inside a hollow rigid structure, with one of its ends provided with a needle that pierces and communicates with the outside the solution contained in the container, dosable through a plunger located at the other end of the indicated hollow rigid structure.
  • the device according to the present invention eliminates the aforementioned drawbacks, managing to dose and supply a sterile solution in optimal conditions, easy to use and high precision, as well as with a low cost in the industrial manufacturing process.
  • the current device comprises a container containing the solution, consisting of: - a cylindrical general flexible laminar body with its wall in accordion bellows, with a blind base and the other axially extended in a cylindrical duct, which ends with an outer ring, - a cylindrical tubular nozzle, which has a relief external surrounding, flat, and presenting a bevel-like end, and its outer diameter being slightly smaller than that of the bore of the cylindrical duct that extends the bellows, c) a cap that covers a part of the nozzle, presenting on its wall a weakened surrounding line, and its mouth being extended in a wall, attached to the surrounding relief of the nozzle, and, d) a grooved ring that determines a circular race capable of perimetrically trapping the extension ring in the body a) with the wall of the cap, and laterally extending this ribbed ring into at least one fin.
  • the coupling between the flexible laminar body and the tubular nozzle is carried out at the end of the latter with the hole in the cylindrical duct that extends the bellows.
  • the cap covers the other end of the nozzle, resting its wall with the outer ring of the flexible laminar body.
  • the described elements placed are secured by the grooved ring that perimetrically catches the ring of the extension of the flexible laminar body with the wall of the cap.
  • the set described is bearable in a rigid structure, as a support, formed by:
  • a circular base comprising a central recess, with a lateral extension that has a hole that the it passes, the perpendicular axis being tightly adjustable, and with a lower extension provided with perpendicular pressure means on said axis.
  • the axis perpendicular to the base of the rigid structure is capable of presenting a graduated scale.
  • Figure 1 is a perspective view of the flexible laminar body, the tubular nozzle and the cap, in preassembly position,
  • Figure 2 is a cross-sectional view of the elements shown in Figure 1, coupled with each other and with the grooved ring joining them,
  • Figure 3 is a double view of a valve in section and in perspective with the three elements that compose it
  • Figure 4 is a perspective view of the support structure of the assembly shown in Figure 2
  • Figure 5 is a cross-sectional view of the support structure
  • FIG. 6 is a perspective view of the support structure to which the assembly shown in Figure 2 has been attached.
  • the elements designated with numbers in the drawings correspond to the parts indicated below.
  • Figure 1 shows a device according to the present invention, formed by a laminar body 10, a nozzle 20 and a cap 30, represented in a preassembly position, on the same ideal axis.
  • the laminar body 10 has a generally cylindrical configuration inferiorly, with its side wall 11 in accordion bellows and its blind base. By its other base it extends axially in a cylindrical duct 12, which ends with an outer ring 13 defining a central hole 14 that communicates the inside of the body 10 with the outside.
  • the nozzle 20 is tubular, with a longitudinal hole 21 that passes through it, presenting a general cylindrical configuration, with an external and flat surrounding relief 22.
  • the nozzle 20 of Figure 1 has an upper end 23 as a bevel. As will be described later, this end may have different shapes depending on applications.
  • the overall diameter of the nozzle 20, both above and below relative to the surrounding relief 22 has a diameter slightly less than that of the orifice 'of the core 14 and cylindrical conduit 12 of the laminar body 10.
  • the nozzle 20 is preferably realizable of plastic material.
  • the thickness of the same must have a rigidity that eliminates any possible flexibility in its use.
  • the cap 30 is of elongated general configuration, with a central and hollow cylindrical section from which two diametrically opposed fins 31 and 32 emerge laterally, with their upper ends slightly inclined to finish off against their upper end. Inwardly, the cap 30 provides a blind cylindrical cavity, not shown in Figure 1, of a diameter substantially greater than that of the upper section of the nozzle 20. Lowerly, the cap 30 comprises on its outer wall a surrounding weakened line 31, prolonged rubbing its mouth on a wall 34 that determines a flat ring.
  • the internal cavity of the cap 30 is capable of receiving the upper section of the nozzle 20, thereby coinciding with the upper surface of the surrounding relief 22 against the lower surface of the wall 34 that determines the mouth of the cap 30.
  • the lower section of the nozzle 20 is capable of being inserted inside the central hole 14 and penetrating the cylindrical conduit 12, thereby coinciding with the lower surface of the surrounding relief 22 with the upper surface of the outer ring 13 of the body 10.
  • Figure 2 shows in section the body 10 and the cap 30 with the nozzle 20 inserted inside the cylindrical duct 12, and in turn inside the cap 30.
  • the grooved ring 40 determines a circular race 41 capable of perimetrically trapping the outer ring 13 of the body 10, with the wall 34 of the cap 30, and consequently the surrounding relief 22 of the nozzle 20.
  • the grooved ring 40 extends laterally in the example illustrated on a fin 42.
  • the grooved ring 40 allows the body 10, the nozzle 20 and the cap 30 to be held together in a stable manner. In an industrial application of the device according to the present invention, it is preferable to fill the solution inside the body 10 before proceed to the assembly of the parts that compose it.
  • the described device consists of a closed single-use container that allows solutions to be supplied. To be able to practice its opening and proceed to dose it is necessary to hold the device with one hand by its fin 42 and with the other hand hold the cap 30, to proceed to tear it by axial rotation. In this operation the fins 31 and 32 of the cap 30 cooperate effectively, preventing the fingers from slipping during the opening of the device.
  • the contained solution can be dosed by holding the cylindrical duct 12 with two consecutive fingers of the hand and pressing the blind base of the body 10 with the thumb.
  • the lateral wall 11 of the body 10 will yield, allowing to be dosed by slight weakening of the accordion bellows, and / or to suction for its recovery.
  • the upper end 23 of the nozzle 20 has a beveled shape, for specific applications in terms of the use of the device. As indicated previously, the nozzle 20 may have different upper ends 23, such as that illustrated in Figure 3. Likewise, the inner duct that passes the nozzle 20 can provide elements that allow maintaining a unidirectional passage of the contained solutions. inside the body 10. In Fig. 3 a nozzle 20 is illustrated which has a cylindrical end 23.
  • the represented nozzle 20 is formed by the union of two halves, one upper and the other lower, comprising a hole 21 that communicates in an inner tubular duct 28 that passes it longitudinally, with a disc 29 which is located inside a cavity 27, exercising the valve functions, allowing with This is a unidirectional solution step.
  • the described valve is conventional, oblivious to the present invention in terms of the particularities that it presents, and valves of different types can be used.
  • the ends 23 of the nozzle 20 may have different shapes according to the specific application to which the solution to be dosed is intended. Independently, valves or direct conduits can be used inside the nozzle 20.
  • a non-return valve as described will allow to extract the air that may exist inside the body 10 and maintain this position in a stable manner. Similarly, the indicated valve will prevent any suction, and in turn, penetration of other liquid or gaseous materials inside the body 10.
  • the nozzle 20 may also present the convenient forms to be able to receive conventional tubes or fittings tightly against its outer surface and to ensure its retention. In all cases, the blind cavity of the cap 30 will have the appropriate shapes to be able to receive these ends and in turn keep the device in general tight.
  • the ribbed ring 40 extends laterally on a fin 42.
  • the number of fins that the device can comprise are multiple.
  • This fin has clear functional applications, allowing to adhere a label with the identification of the solution contained in the device, such as a description, formula, expiration date or similar data.
  • a label with the identification of the solution contained in the device, such as a description, formula, expiration date or similar data.
  • the utility of a fin allows to protect the fingers of the hand at the time of dosing the solution avoiding the contact of those with the element receiving the solution.
  • the flap prevents the device from rolling on surfaces
  • FIGs 4 and 5 illustrate a rigid support 50.
  • Figure 6 the rigid support 50 is shown in which the dosing device has been engaged.
  • a flat area 51 is provided with one of its sides presenting a recess 54, and with two non-contiguous and parallel ends provided with a shoulder 52 and 53 in L / , which determine two longitudinal guides.
  • the rigid support 50 comprises a lower axis 55 and perpendicular to the flat area 51, arranged symmetrically thereon.
  • the support 50 comprises a base 56 that has a circular zone with a central recess 57 and a side hole 58 that passes through it.
  • the side hole 58 of the base 56 is substantially larger in diameter than that of the shaft 55.
  • the base 56 has an extension inferiorly provided with an inner hole 65 perpendicular to the side hole 58 and communicated therewith, with pressure means constituted by a screw 59 that controls a spring 61 and in turn it collaborates on the cylinder 60.
  • the cylinder 60 exerts pressure by collaboration of the means indicated in the previous paragraph on the surface of the shaft 55.
  • the base 56 is only movable to will along axis 55.
  • the base 56 on the axis 55 is limited superiorly by the flat area 51, and inferiorly by the recess 62, which has at its last end a slight step against which the cylinder 60 collaborates.
  • the external surface of the shaft 55 has a graduated scale 63, whose usefulness will be described later.
  • the different parts that make up the rigid support can also be obtained by molding, of plastic or metallic materials.
  • the dosing device is attachable in the rigid support 50.
  • the fin 42 must be placed on the flat area 51 with the guided collaboration of the 'L' projections 52 and 53 upon receiving the sides of the fin 42 itself.
  • the neck 12 of the body 10 and the ring 40 are located in the recess 54.
  • the blind base of the body 10 is located in the central recess 57 of the base 56 of the rigid support.
  • Figure 6 illustrates the final positioning of the device on the rigid support.
  • the application of the rigid support has clear advantages that allow dosing with greater precision, by collaborating with a greater rigidity of the whole device, and by understanding the graduated scale 63 on the axis 55. With this, it is possible to dose concrete amounts of solution.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Le dispotif doseur de solutions stériles et/ou pharmaceutiques de la présente invention est constitué d'un corps laminaire (10) qui contient la solution, présentant un col supérieur à l'intérieur duquel peut être introduit un ajutage tubulaire (20) qui est recouvert par un capuchon (30) présentant une zone d'affaiblissement, avec un anneau cannelé (40) qui relie entre elles lesdites parties. Le dispositif peut être couplé à un support rigide (50) qui comprend une base pouvant coulisser sur un axe afin de permettre l'application de la solution en pressant manuellement sur la base dudit support.
EP19920900409 1991-11-22 1991-11-22 Dispositif doseur de solutions steriles et/ou pharmaceutiques Withdrawn EP0570378A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES1991/000081 WO1993010422A1 (fr) 1991-11-22 1991-11-22 Dispositif doseur de solutions steriles et/ou pharmaceutiques

Publications (1)

Publication Number Publication Date
EP0570378A1 true EP0570378A1 (fr) 1993-11-24

Family

ID=8270758

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920900409 Withdrawn EP0570378A1 (fr) 1991-11-22 1991-11-22 Dispositif doseur de solutions steriles et/ou pharmaceutiques

Country Status (3)

Country Link
EP (1) EP0570378A1 (fr)
CA (1) CA2101049A1 (fr)
WO (1) WO1993010422A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9311892D0 (en) * 1993-06-09 1993-07-28 Glaxo Wellcome Australia Ltd Device
US6820770B2 (en) * 2002-12-06 2004-11-23 The Dial Corporation Dispenser holder for vehicles
GB0309354D0 (en) 2003-04-24 2003-06-04 Glaxo Group Ltd Nozzle for a nasal inhaler
CN104602737B (zh) 2013-03-15 2017-09-29 泰尔茂株式会社 注射器用组装体、其组装方法及其组装装置、使用所述注射器用组装体的预灌封注射器及其组装方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1407945A (fr) * 1964-09-07 1965-08-06 Behringwerke Ag Dispositif pour le prélèvement de liquides organiques dans des conditions de stérilité
US4244366A (en) * 1979-10-30 1981-01-13 Burron Medical, Inc. Syringe stroke controlling mechanism
US4327782A (en) * 1980-04-03 1982-05-04 The Procter & Gamble Company Dispensing apparatus having portable means for dispensing predetermined quantity of liquid from a bulk container
US4671330A (en) * 1984-10-26 1987-06-09 Gilbert Miles Container with removable transfer flask
AU6400986A (en) * 1985-10-01 1987-04-24 Axipac Ltd. Disposable syringe
US4955871A (en) * 1987-04-29 1990-09-11 Path Single-use disposable syringe

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9310422A1 *

Also Published As

Publication number Publication date
CA2101049A1 (fr) 1993-05-23
WO1993010422A1 (fr) 1993-05-27

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