EP0295204B1 - Multiple chamber container for separate storage and subsequent mixture - Google Patents
Multiple chamber container for separate storage and subsequent mixture Download PDFInfo
- Publication number
- EP0295204B1 EP0295204B1 EP19880810325 EP88810325A EP0295204B1 EP 0295204 B1 EP0295204 B1 EP 0295204B1 EP 19880810325 EP19880810325 EP 19880810325 EP 88810325 A EP88810325 A EP 88810325A EP 0295204 B1 EP0295204 B1 EP 0295204B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- compartment
- passage
- envelope
- container according
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
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- 239000000203 mixture Substances 0.000 title claims abstract description 21
- 238000003860 storage Methods 0.000 title claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 23
- 150000001413 amino acids Chemical class 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 8
- -1 polypropylene Polymers 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 4
- 150000002632 lipids Chemical class 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 3
- 150000008163 sugars Chemical class 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 2
- 230000010412 perfusion Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000004698 Polyethylene Substances 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 238000001802 infusion Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011365 complex material Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000002960 lipid emulsion Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3261—Flexible containers having several compartments
- B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2027—Separating means having frangible parts
Definitions
- the subject of the invention is a container for medical use, in particular a container for infusions, comprising an envelope of flexible polymerized material divided into three compartments separated from each other by sealed seals of the material of the envelope and each provided with a closed passage which can be released at will to allow the content to be transferred from one compartment to another.
- a known model of container with two compartments can be succinctly described as follows: the upper compartment, intended to contain an aqueous solution of amino acids, is provided at its top with a closable passage serving to introduce said solution and, at its base , a closed transfer passage opening into the lower compartment, intended to contain the glucose solution. After rupture of the closure, the sterile mixture of amino acids is transferred to the lower compartment, the final product then being able to flow through an evacuation passage, located at the base of the lower compartment.
- Such containers are based on flexible polymerized material, polyethylene for example.
- Such containers are not suitable, however, for the sterile storage and administration of more complex mixtures, such as ternary mixtures.
- the invention makes it possible to fill this gap. It consists of a container as defined in claim 1.
- the container 1, according to FIGS. 1 and 2 comprises an envelope of homogeneous flexible polymerized material divided into three compartments separated from one another by sealed welds of the material of the envelope and each provided with a closed passage can be released at will to allow the content to be transferred from one compartment to another.
- This container 1 is characterized in that it comprises in its upper part, two adjacent compartments 3, 4 and, in its lower part, a compartment 5, in that it is intended for separate storage and then for subsequent mixing, just before use, lipids, amino acids and sugars, in that each compartment is provided with a closable passage allowing the compound to be introduced from the outside or, respectively, to evacuate its content towards the outside and in that the material of the envelope is chemically and biologically inert with respect to each of the compounds considered and their mixtures.
- each upper compartment 3, 4 is provided with an introduction passage 7, 8 closable at its somnet and the lower compartment is provided with a closable evacuation passage 9 at its base , each of the two compartments of the upper part 3, 4 opening into the compartment of the lower part 5 by a closed passage 10, 11 located at its base.
- each upper compartment 3, 4 is provided with an introduction passage 7 ′, 8 ′ which can be closed at its top and the compartment in the lower part is provided with a closed discharge passage 9 ′ at its base, compartment 3 comprising at its base a closed transfer passage 10 ′ opening into the adjacent compartment 4, the latter being provided at its base with a closed transfer passage 11 ′ opening into the lower compartment 5.
- the introduction passages 7, 8 respectively 7 ′, 8 ′ are most generally rigid or semi-rigid and welded to the material of the envelope. They are most often closed after the introduction of the given compounds into their respective compartments, using any suitable means ensuring an absolutely tight seal resistant, preferably under the conditions of sterilization. It is the same with regard to the discharge passage 9, respectively 9 ′, the latter being able to be further either connected to a nozzle, or perforated by a hollow needle for discharging the ready-to-use mixture.
- the transfer passages 10, 11 respectively 10 ′, 11 ′ may include rigid or semi-rigid parts depending on the circumstances. They can consist of a manually breakable tip, a tearable weld under the effect of lateral pressure or a ball tightened in a flexible tube and which can be expelled manually. Such passages use known techniques and can ensure, if necessary, the sterile transfer of the contents from one compartment to another. As a rule, they are welded to the material of the envelope.
- the material of the envelope must meet several conditions. Essentially, it must be flexible, of homogeneous composition and chemically and biologically inert with respect to each of the compounds considered and their mixtures. It must also be weldable using the usual techniques such as hot welding, ultrasonic or high frequency and compatible with the common materials used to make the passages mentioned above. It must also be impermeable to liquids, gases and vapors and preferably transparent, although the latter condition is not essential.
- the envelope 2 may consist of a single sheet of a polymerized material meeting the conditions listed above. Envelope 2 can also be made up of a composite sheet, double or even triple depending on the case, only the material in contact with the given compounds then having to be chemically inert with respect to these or their mixtures.
- polystyrene-ethylene-butyl examples include polyethylene, polypropylene, blocked polyether polyamide or mixtures of polyethylene and styrene-ethylene-butyl, polyethylene and ethylene-vinyl acetate , linear polyethylene, polypropylene and styrene-ethylene-butyl.
- a single sheet or, as the case may be, the inner layer of a composite sheet is preferably formed.
- complex materials constituting composite sheets the following may be mentioned: polyamide-polypropylene (PA / PP), linear polyamide-polyethylene, low density or high density (PA / PE) for example.
- the container of the invention can be used as follows.
- compartment 3 of the container according to FIG. 1 an emulsion based on lipids (essentially triglycerides) assimilated by the human body is introduced.
- compartment 4 an aqueous solution of essential amino acids is introduced and, in the lower container 5, an aqueous solution of glucose, for example at 40% in H2O.
- the introduction of these liquids is carried out according to the usual techniques, through the passages 7, 8 and 9 respectively, which are then closed in a sealed manner, after introduction.
- the container thus filled can then be sterilized in an autoclave (temperature> 100 ° C) and stored as is for several months, even several years.
- the procedure is as follows: the breakable passage 11 is broken manually and the amino acid solution is passed into the lower compartment 5.
- the mixture can be activated by trituration of the compartment 5.
- the procedure is identical with the breakable passage 10, passing the lipid emulsion into compartment 5.
- the resulting mixture ready for use, can be administered after the nozzle 9 would have been connected to an infusion probe for example.
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Package Specialized In Special Use (AREA)
- Packages (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
L'invention a pour objet un récipient à usage médical, en particulier un récipient pour perfusions, comprenant une enveloppe en matière souple polymérisée divisée en trois compartiments séparés l'un de l'autre par des soudures étanches de la matière de l'enveloppe et pourvus chacun d'un passage obturé pouvant être dégagé à volonté pour permettre de transférer le contenu d'un compartiment dans un autre.The subject of the invention is a container for medical use, in particular a container for infusions, comprising an envelope of flexible polymerized material divided into three compartments separated from each other by sealed seals of the material of the envelope and each provided with a closed passage which can be released at will to allow the content to be transferred from one compartment to another.
Dans le domaine pharmaceutique, et plus précisément dans le domaine des solutions pour perfusions, on utilise depuis quelque temps déjà des sachets souples pour l'administration de mélanges d'acides aminés et de glucose. De tels mélanges ne pouvant être soumis comme tels à la stérilisation (possibilité de réactions de Maillard), il convient de stériliser et de stocker séparément les acides aminés et la solution de glucose. Afin d'en assurer le mélange, puis l'administration de ce dernier dans des conditions de stérilité absolues on utilise avantageusement un récipient tel un sachet souple à deux compartiments.In the pharmaceutical field, and more precisely in the field of solutions for infusions, flexible bags have been used for some time for the administration of mixtures of amino acids and glucose. Since such mixtures cannot be subjected as such to sterilization (possibility of Maillard reactions), the amino acids and the glucose solution should be sterilized and stored separately. In order to ensure mixing, then administration of the latter under conditions of absolute sterility, a container such as a flexible bag with two compartments is advantageously used.
Un modèle connu de récipient à deux compartiments peut être succinctement décrit comme suit: le compartiment supérieur, destiné à contenir une solution aqueuse d'acides aminés, est pourvu à son sommet d'un passage obturable servant à introduire ladite solution et, à sa base, d'un passage de transfert obturé débouchant dans le compartiment inférieur, destiné à contenir la solution de glucose. Après rupture de l'obturation, le mélange stérile d'acides aminés est transféré dans le compartiment inférieur, le produit final pouvant alors s'écouler par un passage d'évacuation, situé à la base du compartiment inférieur. De tels récipients sont à base de matière souple polymérisée, le polyéthylène par exemple.A known model of container with two compartments can be succinctly described as follows: the upper compartment, intended to contain an aqueous solution of amino acids, is provided at its top with a closable passage serving to introduce said solution and, at its base , a closed transfer passage opening into the lower compartment, intended to contain the glucose solution. After rupture of the closure, the sterile mixture of amino acids is transferred to the lower compartment, the final product then being able to flow through an evacuation passage, located at the base of the lower compartment. Such containers are based on flexible polymerized material, polyethylene for example.
De tels récipients ne conviennent pas, cependant, au stockage et à l'administration stérile de mélanges plus complexes, tels des mélanges ternaires.Such containers are not suitable, however, for the sterile storage and administration of more complex mixtures, such as ternary mixtures.
Dans le fascicule de brevet WO-A-8.301.569, on décrit un sachet souple à trois compartiments, et permettant de stocker séparément trois solutions. Cependant, de par sa géométrie, ce récipient ne permet pas la réalisation d'un mélange ternaire parfaitement homogène. De plus, les compartiments sont superposés et celui du milieu n'est pas pourvu d'un passage obturable permettant d'y introduire, de l'extérieur, une des trois solutions. De ce fait, un transit par le compartiment du haut (ou du bas) est obligatoire pour remplir le compartiment du milieu.In patent specification WO-A-8,301,569, a flexible bag with three compartments is described, allowing three solutions to be stored separately. However, due to its geometry, this container does not allow the production of a perfectly homogeneous ternary mixture. In addition, the compartments are superimposed and that of the middle is not provided with a closable passage allowing to introduce, from the outside, one of the three solutions. Therefore, a transit through the top (or bottom) compartment is mandatory to fill the middle compartment.
Bien qu'il existe des matériaux polymères présentant toutes les qualités voulues, notamment inertie chimique via à vis des acides aminés et du glucose et de leur mélange, il n'a cependant pas été possible de réaliser, jusqu'à la présente invention, un récipient à trois compartiments permettant de stocker et stériliser séparément des solutions d'acides aminés, de lipides et de sucres tels que le glucose, puis à en administrer le mélange résultant sous forme de solution pour perfusion.Although there are polymeric materials having all the desired qualities, in particular chemical inertness via with respect to amino acids and glucose and their mixture, it has not however been possible, until the present invention, to produce a container with three compartments for separately storing and sterilizing solutions of amino acids, lipids and sugars such as glucose, then administering the resulting mixture in the form of a solution for infusion.
L'invention permet de combler cette lacune. Elle consiste en un récipient tel que défini à la revendication 1.The invention makes it possible to fill this gap. It consists of a container as defined in
Les dessins annexés illustrent à titre d'exemple, deux formes d'exécutions du récipient selon l'invention.
- La figure 1 représente, vue en plan, la première forme d'exécution.
- La figure 2 représente, vue en plan, la deuxième forme d'exécution.
- Figure 1 shows, in plan view, the first embodiment.
- Figure 2 shows, in plan view, the second embodiment.
Le récipient 1, selon les figures 1 et 2, comprend une enveloppe en matière souple homogène polymérisée divisée en trois compartiments séparés l'un de l'autre par des soudures étanches de la matière de l'enveloppe et pourvus chacun d'un passage obturé pouvant être dégagé à volonté pour permettre de transférer le contenu d'un compartiment dans un autre.The
Ce récipient 1 se caractérise par le fait qu'il comporte dans sa partie supérieure, deux compartinents adjacents 3, 4 et, dans sa partie inférieure, un conpartiment 5, en ce qu'il est destiné au stockage séparé puis au mélange subséquent, juste avant utilisation, de lipides, d'acides aminés et de sucres, en ce que chaque conpartiment est pourvu d'un passage obturable permettant d'y introduire de l'extérieur le composé ou, respectivement d'en évacuer son contenu vers l'extérieur et en ce que la matière de l'enveloppe est chimiquenent et biologiquement inerte vis à vis de chacun des composés considérés et de leurs mélanges.This
Dans l'exemple préféré selon la figure 1, chaque compartinent supérieur 3, 4 est pourvu d'un passage d'introduction 7, 8 obturable à son somnet et le compartiment inférieur est pourvu d'un passage d'évacuation obturable 9 à sa base, chacun des deux compartiments de la partie supérieure 3, 4 débouchant dans le compartiment de la partie inférieure 5 par un passage obturé 10, 11 situé à sa base.In the preferred example according to Figure 1, each
Dans l'exécution selon la figure 2, chaque compartiment supérieur 3, 4 est pourvu d'un passage d'introduction 7′, 8′ obturable à son sommet et le compartiment de la partie inférieure est pourvu d'un passage d'évacuation obturable 9′ à sa base, le compartiment 3 comportant à sa base un passage de transfert obturé 10′ débouchant dans le compartiment adjacent 4, ce dernier étant pourvu à sa base d'un passage de transfert obturé 11′ débouchant dans le compartiment inférieur 5.In the embodiment according to FIG. 2, each
Les passages d'introduction 7, 8 respectivement 7′, 8′ sont le plus généralenent rigides ou semi-rigides et soudés à la matière de l'enveloppe. Ils sont le plus souvent obturés après l'introduction des composés donnés dans leurs compartiments respectifs, à l'aide de tout moyen adéquat assurant une obturation absolument étanche résistant de, préférence aux conditions de la stérilisation. Il en est de même pour ce qui concerne le passage d'évacuation 9, respectivement 9′, ce dernier pouvant être en outre soit connecté a un embout, soit perforé par une aiguille creuse pour l'évacuation du mélange prêt à l'emploi.The
Les passages de transfert 10, 11 respectivement 10′, 11′ peuvent comporter des parties rigides ou semi-rigides selon les circonstances. Ils peuvent consister en un embout cassable manuellement, en une soudure déchirable sous l'effet d'une pression latérale ou en une bille serrée dans un tube souple et que l'on peut expulser manuellement. De tels passages font appel à des techniques connues et peuvent assurer, si besoin est, le transfert stérile du contenu d'un compartiment dans un autre. Dans la règle, ils sont soudés à la matière de l'enveloppe.The
Pour parvenir aux buts visés, la matière de l'enveloppe doit réunir plusieurs conditions. Pour l'essentiel, elle doit être souple, de composition homogène et chimiquement et biologiquement inerte vis-à-vis de chacun des composés considérés et de leurs mélanges. Elle doit être en outre soudable à l'aide des techniques usuelles telles que le soudage à chaud, à ultra-sons ou à haute fréquence et compatible avec les matériaux courants utilisés pour réaliser les passages mentionnés plus haut. Elle doit être également étanche aux liquides, aux gaz et aux vapeurs et de préférence transparente, bien que cette dernière condition ne soit pas indispensable.To achieve the intended goals, the material of the envelope must meet several conditions. Essentially, it must be flexible, of homogeneous composition and chemically and biologically inert with respect to each of the compounds considered and their mixtures. It must also be weldable using the usual techniques such as hot welding, ultrasonic or high frequency and compatible with the common materials used to make the passages mentioned above. It must also be impermeable to liquids, gases and vapors and preferably transparent, although the latter condition is not essential.
L'enveloppe 2 peut être constituée d'une feuille simple d'une matière polymérisée répondant aux conditions énumérées ci-dessus. L'enveloppe 2 peut être aussi constituée d'une feuille composite, double voire triple selon les cas, seule la matière au contact des composés donnés devant alors être chimiquement inerte vis-à-vis de ceux-ci ou de leurs mélanges.The
Parmi les matières polymérisées répondant avantageusement aux conditions énumérées ci-dessus, on peut citer les matériaux suivants: le polyéthylène haute densité, le polypropylène, le polyéther-polyamide bloqué ou les mélanges de polyéthylène et styrène-éthylène-butyle, polyéthylène et éthylène-vinylacétate, polyéthylène linéaire, polypropylène et styrène-éthylène-butyle. A l'aide de tels matériaux on constitue de préférence une feuille simple ou, selon les cas, la couche interne d'une feuille composite. A titre de matériaux complexes constituant des feuilles composites, on peut citer les suivants: le polyamide-polypropylène (PA/PP), le polyamide-polyéthylène linéaire, basse densité ou haute densité (PA/PE) par exemple.Among the polymerized materials advantageously meeting the conditions listed above, mention may be made of the following materials: high density polyethylene, polypropylene, blocked polyether polyamide or mixtures of polyethylene and styrene-ethylene-butyl, polyethylene and ethylene-vinyl acetate , linear polyethylene, polypropylene and styrene-ethylene-butyl. Using such materials, a single sheet or, as the case may be, the inner layer of a composite sheet is preferably formed. As complex materials constituting composite sheets, the following may be mentioned: polyamide-polypropylene (PA / PP), linear polyamide-polyethylene, low density or high density (PA / PE) for example.
De tels matériaux se sont avérés particulièrement bien adaptés à la fabrication du récipient selon l'invention.Such materials have proven to be particularly well suited to the manufacture of the container according to the invention.
Dans l'une de ses exécutions préférentielles, le récipient de l'invention peut être utilisé comme suit. Dans le compartiment 3 du récipient selon Figure 1, on introduit une émulsion à base de lipides (essentiellement des triglycérides) assimilables par l'organisme humain. Dans le compartiment 4, on introduit une solution aqueuse d'acides aminés essentiels et, dans le récipient inférieur 5, une solution aqueuse de glucose, par exemple à 40% dans H₂O. L'introduction de ces liquides s'effectue selon les techniques usuelles, par les passages 7, 8 et 9 respectivement, qui sont ensuite obturés de façon étanche, après introduction. Le récipient ainsi rempli peut être alors stérilisé dans un autoclave (temp. > 100°C) et stocké en l'état durant plusieurs mois, voire plusieurs années.In one of its preferred embodiments, the container of the invention can be used as follows. In
Avant utilisation sous forme de perfusion, on procède de la façon suivante: le passage cassable 11 est rompu manuellement et l'on fait passer la solution d'acides aminés dans le compartient inférieur 5. Le mélange peut être activé par trituration du compartient 5. On opère de façon identique avec le passage cassable 10, faisant passer l'émulsion de lipides dans le compartiment 5. Après un nouveau mélange des composants en présence, le mélange résultant, prêt à l'emploi, peut être administré après que l'embout 9 eût été connecté à une sonde à perfusion par exemple.Before use in the form of an infusion, the procedure is as follows: the
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT88810325T ATE65473T1 (en) | 1987-05-29 | 1988-05-24 | MULTI-CHAMBER VESSEL FOR STORAGE AND SUBSEQUENT MIXING OF ACTIVE COMPONENTS. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH02066/87A CH686778A5 (en) | 1987-05-29 | 1987-05-29 | Container for separate storage of active compounds and their subsequent mixing. |
CH2066/87 | 1987-05-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0295204A1 EP0295204A1 (en) | 1988-12-14 |
EP0295204B1 true EP0295204B1 (en) | 1991-07-24 |
Family
ID=4225101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19880810325 Revoked EP0295204B1 (en) | 1987-05-29 | 1988-05-24 | Multiple chamber container for separate storage and subsequent mixture |
Country Status (7)
Country | Link |
---|---|
US (1) | US4997083A (en) |
EP (1) | EP0295204B1 (en) |
JP (1) | JPH07106755B2 (en) |
AT (1) | ATE65473T1 (en) |
CH (1) | CH686778A5 (en) |
DE (1) | DE3863849D1 (en) |
ES (1) | ES2024048B3 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992010100A1 (en) * | 1990-12-13 | 1992-06-25 | Heden-Team Ag | Automatic baking apparatus and mixbag therefor |
US5146840A (en) * | 1989-11-22 | 1992-09-15 | Heden-Team Ag | Automatic baking apparatus and mixbag therefore |
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- 1988-05-24 AT AT88810325T patent/ATE65473T1/en active
- 1988-05-24 ES ES88810325T patent/ES2024048B3/en not_active Expired - Lifetime
- 1988-05-24 DE DE8888810325T patent/DE3863849D1/en not_active Revoked
- 1988-05-24 EP EP19880810325 patent/EP0295204B1/en not_active Revoked
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Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5146840A (en) * | 1989-11-22 | 1992-09-15 | Heden-Team Ag | Automatic baking apparatus and mixbag therefore |
WO1992010100A1 (en) * | 1990-12-13 | 1992-06-25 | Heden-Team Ag | Automatic baking apparatus and mixbag therefor |
WO1993023093A1 (en) * | 1992-05-14 | 1993-11-25 | Baxter International Inc. | Non-pvc coextruded medical grade port tubing |
EP0642550A1 (en) * | 1992-05-29 | 1995-03-15 | Ferro Corporation | Radio frequency weldable polymer articles |
US5601889A (en) * | 1992-05-29 | 1997-02-11 | Ferro Corporation | Radio frequency weldable polymer articles |
EP0623045A1 (en) * | 1992-11-06 | 1994-11-09 | Baxter Int | Method for filtering a body fluid using rinse chamber bag. |
US5431174A (en) * | 1994-04-04 | 1995-07-11 | Via Medical Corporation | Method of fluid delivery and collection |
DE19605357A1 (en) * | 1996-02-14 | 1997-08-21 | Braun Melsungen Ag | Flexible plastic container |
EP0790051A2 (en) | 1996-02-14 | 1997-08-20 | B. Braun Melsungen Ag | Flexible plastic container |
US6231559B1 (en) | 1996-10-11 | 2001-05-15 | B. Braun Melsungen Ag | Flexible plastic container with three chambers |
AU742793B2 (en) * | 1997-11-28 | 2002-01-10 | Gambro A.B. | Multiple compartment container for medical solution |
EP2386286A1 (en) | 2010-05-10 | 2011-11-16 | B. Braun Melsungen AG | Handling |
EP2386284A1 (en) | 2010-05-10 | 2011-11-16 | B. Braun Melsungen AG | Shape |
EP2386283A1 (en) | 2010-05-10 | 2011-11-16 | B. Braun Melsungen AG | Filling |
WO2011141315A1 (en) | 2010-05-10 | 2011-11-17 | B. Braun Melsungen Ag | Filling |
WO2011141317A1 (en) | 2010-05-10 | 2011-11-17 | B. Braun Melsungen Ag | Handling |
WO2011141318A1 (en) | 2010-05-10 | 2011-11-17 | B. Braun Melsungen Ag | Shape |
US9022653B2 (en) | 2010-05-10 | 2015-05-05 | B. Braun Melsungen Ag | Flexible multichamber bag |
Also Published As
Publication number | Publication date |
---|---|
JPH07106755B2 (en) | 1995-11-15 |
US4997083A (en) | 1991-03-05 |
DE3863849D1 (en) | 1991-08-29 |
CH686778A5 (en) | 1996-06-28 |
ATE65473T1 (en) | 1991-08-15 |
EP0295204A1 (en) | 1988-12-14 |
ES2024048B3 (en) | 1992-02-16 |
JPS63317481A (en) | 1988-12-26 |
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Opponent name: FRESENIUS AG * 920421 KABI PHARMACIA AB, UPPSALA Effective date: 19920408 |
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Opponent name: KABI PHARMACIA AB. Opponent name: FRESENIUS AG |
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Owner name: VIFOR MEDICAL AG TE EMMENBRUECKE, ZWITSERLAND. |
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Opponent name: FRESENIUS AG * 920421 PHARMACIA AKTIEBOLAG Effective date: 19920408 |
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Opponent name: FRESENIUS AG * 920421 PHARMACIA AKTIEBOLAG Effective date: 19920408 |
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