ECSP17019103A - Alfa-glucosidasa ácida muy potente con hidratos de carbono potenciados - Google Patents
Alfa-glucosidasa ácida muy potente con hidratos de carbono potenciadosInfo
- Publication number
- ECSP17019103A ECSP17019103A ECIEPI201719103A ECPI201719103A ECSP17019103A EC SP17019103 A ECSP17019103 A EC SP17019103A EC IEPI201719103 A ECIEPI201719103 A EC IEPI201719103A EC PI201719103 A ECPI201719103 A EC PI201719103A EC SP17019103 A ECSP17019103 A EC SP17019103A
- Authority
- EC
- Ecuador
- Prior art keywords
- glucosidase
- rhgaa
- acid alpha
- enhanced carbon
- carbon hydrates
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0102—Alpha-glucosidase (3.2.1.20)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Composición de alfa glucosidasa humana recombinante (rhGAA) derivada de células CHO que contiene una composición de glicano más optimizada que consiste en una cantidad de rhGAA que contiene N-glicanos que llevan manosa-6-fosfato (M6P) o bis-M6P mayor que las rhGAAs convencionales, junto con una baja cantidad de glicanos de alto contenido en manosa no fosforilados y una baja cantidad de galactosa terminal en oligosacáridos complejos. Se describen composiciones que contienen la rhGAA y métodos de uso.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462057842P | 2014-09-30 | 2014-09-30 | |
US201462057847P | 2014-09-30 | 2014-09-30 | |
US201562112463P | 2015-02-05 | 2015-02-05 | |
US201562135345P | 2015-03-19 | 2015-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP17019103A true ECSP17019103A (es) | 2017-06-30 |
Family
ID=55631441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECIEPI201719103A ECSP17019103A (es) | 2014-09-30 | 2017-03-28 | Alfa-glucosidasa ácida muy potente con hidratos de carbono potenciados |
Country Status (36)
Country | Link |
---|---|
US (5) | US10208299B2 (es) |
EP (2) | EP4273241A3 (es) |
JP (3) | JP6851964B2 (es) |
KR (3) | KR20220146662A (es) |
CN (2) | CN107075468B (es) |
AU (2) | AU2015325028B2 (es) |
BR (1) | BR112017005810A2 (es) |
CA (2) | CA3228032A1 (es) |
CL (1) | CL2017000722A1 (es) |
CO (1) | CO2017002776A2 (es) |
CR (1) | CR20170107A (es) |
DK (1) | DK3201320T3 (es) |
DO (1) | DOP2017000079A (es) |
EA (1) | EA038986B1 (es) |
EC (1) | ECSP17019103A (es) |
ES (1) | ES2967620T3 (es) |
FI (2) | FI3201320T3 (es) |
FR (1) | FR24C1012I1 (es) |
HR (1) | HRP20240041T1 (es) |
HU (2) | HUE064629T2 (es) |
IL (4) | IL307587A (es) |
LT (1) | LT3201320T (es) |
MX (2) | MX2017003989A (es) |
MY (1) | MY186336A (es) |
NI (1) | NI201700039A (es) |
PE (1) | PE20170906A1 (es) |
PH (1) | PH12017500455A1 (es) |
PL (1) | PL3201320T3 (es) |
PT (1) | PT3201320T (es) |
RS (1) | RS65066B1 (es) |
SG (2) | SG11201702114TA (es) |
SI (1) | SI3201320T1 (es) |
SV (1) | SV2017005416A (es) |
TN (1) | TN2017000082A1 (es) |
WO (1) | WO2016054231A1 (es) |
ZA (2) | ZA201701945B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US10208299B2 (en) | 2014-09-30 | 2019-02-19 | Amicus Therapeutics, Inc. | Highly potent acid alpha-glucosidase with enhanced carbohydrates |
BR112018013151A2 (pt) * | 2015-12-30 | 2018-12-18 | Amicus Therapeutics Inc | alfa-glicosidase ácida aumentada para o tratamento da doença de pompe |
PT3957320T (pt) * | 2015-12-30 | 2023-11-23 | Amicus Therapeutics Inc | Alfa-glicosidase ácida aumentada para o tratamento da doença de pompe |
TWI759291B (zh) * | 2016-03-30 | 2022-04-01 | 美商阿米庫斯醫療股份有限公司 | 用於選擇高m6p重組蛋白之方法 |
KR102455821B1 (ko) * | 2016-03-30 | 2022-10-18 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 고 m6p 재조합 단백질의 선택 방법 |
KR20240001291A (ko) | 2016-03-30 | 2024-01-03 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 재조합 산 알파-글루코시다제를 포함하는 제형 |
US11357834B2 (en) | 2017-01-10 | 2022-06-14 | Amicus Therapeutics, Inc. | Recombinant α-galactosidase A for treatment of Fabry disease |
EA039750B1 (ru) * | 2017-03-30 | 2022-03-10 | Амикус Терапьютикс, Инк. | Способ отбора рекомбинантных белков с высоким содержанием m6p |
MX2019013624A (es) * | 2017-05-15 | 2020-01-13 | Amicus Therapeutics Inc | Alfa-glucosidasa acida humana recombinante. |
JP2022546587A (ja) | 2019-09-06 | 2022-11-04 | アミカス セラピューティックス インコーポレイテッド | 生物製剤の捕捉及び精製のための方法 |
TW202245830A (zh) * | 2021-02-11 | 2022-12-01 | 美商阿米庫斯醫療股份有限公司 | 重組人類酸性α-葡萄糖苷酶及其用途 |
WO2023150387A1 (en) * | 2022-02-07 | 2023-08-10 | M6P Therapeutics, Inc. | Compositions comprising acid alpha glucosidase and methods of use thereof |
TW202400212A (zh) * | 2022-05-05 | 2024-01-01 | 美商阿米庫斯醫療股份有限公司 | 用於治療龐貝氏病之方法 |
WO2024119091A1 (en) * | 2022-12-02 | 2024-06-06 | Amicus Therapeutics, Inc. | Fexamethods for treating infantile-onset pompe disease in pediatric patients |
WO2024119070A1 (en) * | 2022-12-02 | 2024-06-06 | Amicus Therapeutics, Inc. | Methods for treating late onset pompe disease in pediatric patients |
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2015
- 2015-09-30 US US15/515,808 patent/US10208299B2/en active Active
- 2015-09-30 CR CR20170107A patent/CR20170107A/es unknown
- 2015-09-30 SG SG11201702114TA patent/SG11201702114TA/en unknown
- 2015-09-30 IL IL307587A patent/IL307587A/en unknown
- 2015-09-30 BR BR112017005810A patent/BR112017005810A2/pt not_active Application Discontinuation
- 2015-09-30 PL PL15845664.0T patent/PL3201320T3/pl unknown
- 2015-09-30 CA CA3228032A patent/CA3228032A1/en active Pending
- 2015-09-30 LT LTEPPCT/US2015/053252T patent/LT3201320T/lt unknown
- 2015-09-30 CN CN201580052512.5A patent/CN107075468B/zh active Active
- 2015-09-30 HU HUE15845664A patent/HUE064629T2/hu unknown
- 2015-09-30 DK DK15845664.0T patent/DK3201320T3/da active
- 2015-09-30 EP EP23191307.0A patent/EP4273241A3/en active Pending
- 2015-09-30 HR HRP20240041TT patent/HRP20240041T1/hr unknown
- 2015-09-30 KR KR1020227035610A patent/KR20220146662A/ko not_active Application Discontinuation
- 2015-09-30 SG SG10202003753PA patent/SG10202003753PA/en unknown
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