ECSP13012928A - Derivados de fluoro-piridinona útiles como agentes antibacterianos - Google Patents

Derivados de fluoro-piridinona útiles como agentes antibacterianos

Info

Publication number
ECSP13012928A
ECSP13012928A ECSP13012928A ECSP13012928A EC SP13012928 A ECSP13012928 A EC SP13012928A EC SP13012928 A ECSP13012928 A EC SP13012928A EC SP13012928 A ECSP13012928 A EC SP13012928A
Authority
EC
Ecuador
Prior art keywords
derivatives
piridinone
antibacterial agents
fluoro
useful
Prior art date
Application number
Other languages
English (en)
Inventor
Matthew Frank Brown
Mark Stephen Plummer
Usa Reilly
Ye Che
Justin Ian Montgomery
Loren Michael Price
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP13012928A publication Critical patent/ECSP13012928A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención se refiere a una nueva clase de derivados de ácido hidroxámico, su uso como inhibidores de LpxC y, más específicamente, a su uso para tratar infecciones bacterianas.
ECSP13012928 2011-03-07 2013-10-07 Derivados de fluoro-piridinona útiles como agentes antibacterianos ECSP13012928A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161449825P 2011-03-07 2011-03-07

Publications (1)

Publication Number Publication Date
ECSP13012928A true ECSP13012928A (es) 2013-11-29

Family

ID=45841548

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012928 ECSP13012928A (es) 2011-03-07 2013-10-07 Derivados de fluoro-piridinona útiles como agentes antibacterianos

Country Status (33)

Country Link
US (2) US8624034B2 (es)
EP (1) EP2683689B1 (es)
JP (1) JP5620020B2 (es)
KR (1) KR101593288B1 (es)
CN (2) CN104529883A (es)
AP (1) AP3336A (es)
AR (1) AR085615A1 (es)
AU (1) AU2012226473B8 (es)
BR (1) BR112013022536B1 (es)
CA (1) CA2828337C (es)
CL (1) CL2013002417A1 (es)
CO (1) CO6761338A2 (es)
CR (1) CR20130403A (es)
CU (1) CU20130117A7 (es)
DO (1) DOP2013000200A (es)
EA (1) EA024782B1 (es)
EC (1) ECSP13012928A (es)
ES (1) ES2626457T3 (es)
GE (1) GEP20156370B (es)
GT (1) GT201300213A (es)
HK (2) HK1191951A1 (es)
IL (1) IL228100A0 (es)
MA (1) MA34963B1 (es)
MX (1) MX341977B (es)
NI (1) NI201300077A (es)
PE (1) PE20140397A1 (es)
SG (1) SG192766A1 (es)
TN (1) TN2013000353A1 (es)
TW (1) TWI453197B (es)
UA (1) UA107423C2 (es)
UY (1) UY33936A (es)
WO (1) WO2012120397A1 (es)
ZA (1) ZA201306515B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8722686B2 (en) 2008-09-19 2014-05-13 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
WO2011073845A1 (en) 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
UA107423C2 (en) 2011-03-07 2014-12-25 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
KR20130140164A (ko) 2011-04-08 2013-12-23 화이자 인코포레이티드 항박테리아제로서 유용한 이미다졸, 피라졸 및 트라이아졸 유도체
DK2694488T3 (en) 2011-04-08 2014-12-15 Pfizer Isoxazole derivatives useful as antibacterial SUBSTANCES
AR097617A1 (es) * 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
WO2015085238A1 (en) * 2013-12-05 2015-06-11 The Regents Of The University Of California, A California Corporation Inhibitors of lpxc
JP6407288B2 (ja) 2013-12-19 2018-10-17 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性１ｈ−インダゾール及び１ｈ−インドール誘導体
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
ES2687393T3 (es) 2014-04-22 2018-10-25 Novartis Ag Derivados del ácido hidroxámico de isoxazolina como inhibidores de LpxC
EP3143007B1 (en) * 2014-05-16 2018-07-11 Idorsia Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
PE20170129A1 (es) 2014-06-03 2017-03-30 Actelion Pharmaceuticals Ltd Compuestos de pirazol y su uso como bloqueadores de los canales de calcio tipo t
CA2963875A1 (en) 2014-11-19 2016-05-26 Actelion Pharmaceuticals Ltd Antibacterial benzothiazole derivatives
US9549916B2 (en) 2014-12-16 2017-01-24 Novartis Ag Isoxazole hydroxamic acid compounds as LpxC inhibitors
CN104876883B (zh) * 2015-06-05 2017-11-28 安徽联创生物医药股份有限公司 抗失眠药物苏沃雷生中间体的合成方法
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
US10071973B2 (en) 2016-06-14 2018-09-11 Novartis Ag Crystalline isoxazole hydroxamic acid compounds
JP6931701B2 (ja) 2016-12-16 2021-09-08 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｔ型カルシウムチャンネルブロッカーを含有する薬学的合剤
CN110234622B (zh) 2017-02-06 2023-07-04 爱杜西亚药品有限公司 用于合成1-芳基-1-三氟甲基环丙烷的新颖方法
AU2019235870A1 (en) * 2018-03-15 2020-09-03 Pfizer Inc. Pyridinone and pyrimidinone phosphates and boronates useful as antibacterial agents
WO2019175828A1 (en) * 2018-03-15 2019-09-19 Pfizer Inc. Fluoro-pyridinone phosphates and boronates useful as antibacterial agents
CN110699312B (zh) * 2019-11-28 2022-08-12 西北农林科技大学 一种猪种布鲁氏菌bi-1基因缺失菌株及其构建方法和应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769461A (en) 1986-09-16 1988-09-06 American Home Products Corporation Quinolinyl benzene hydroxamic acids as anti-inflammatory/antiallergic agents
US5110831A (en) 1990-11-30 1992-05-05 Du Pont Merck Pharmaceutical Company Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors
BR9907689A (pt) 1998-02-07 2000-11-14 British Biotech Pharm Agentes antibacterianos
GB9925470D0 (en) 1999-10-27 1999-12-29 Smithkline Beecham Plc Novel compounds
US20050119305A1 (en) 2001-03-21 2005-06-02 Masao Naka Il-6 production inhibitors
ES2180456B1 (es) 2001-07-20 2004-05-01 Laboratorios S.A.L.V.A.T., S.A. Isoxazoles sustituidos y su utilizacion como antibioticos.
GEP20063937B (en) * 2002-02-14 2006-10-10 Pharmacia Corp Substituted pyridinones as modulators of p38 map kinase
CN102267924A (zh) 2003-01-08 2011-12-07 诺华疫苗和诊断公司 抗菌剂
GB0302431D0 (en) 2003-01-30 2003-03-05 Glaxo Group Ltd Novel compounds
EP1828145A4 (en) 2004-12-10 2009-08-19 Univ Emory 2'- AND 3'-SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGUE FOR THE TREATMENT OF VIRAL INFECTIONS AND ANORMAL CELL PROLIFERATION
WO2006118155A1 (ja) 2005-04-27 2006-11-09 Ishihara Sangyo Kaisha, Ltd. ビフェニル誘導体又はその塩、並びにそれらを有効成分として含有する農園芸用殺菌剤
WO2006124897A2 (en) 2005-05-13 2006-11-23 Lexicon Genetics Incorporated Methods and compositions for improving cognition
CA2634005C (en) * 2005-12-15 2012-01-03 Vicuron Pharmaceuticals Inc. N-hydroxyamide derivatives possessing antibacterial activity
WO2008045671A1 (en) 2006-10-06 2008-04-17 Janssen Pharmaceutica, N.V. Matrix metalloprotease inhibitors
WO2009008905A1 (en) 2007-02-01 2009-01-15 Panthera Biopharma, Llc. Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning
WO2008105515A1 (ja) 2007-02-28 2008-09-04 Taisho Pharmaceutical Co., Ltd. 新規なヒドロキサム酸誘導体
WO2008115262A2 (en) 2007-03-20 2008-09-25 Curis, Inc. Hsp90 inhibitors containing a zinc binding moiety
CN101239978A (zh) * 2008-03-05 2008-08-13 南方医科大学 一种咪唑并吡啶类化合物
EP2315746A1 (en) * 2008-08-04 2011-05-04 Schering Corporation Urea derivatives as antibacterial agents
JP5455913B2 (ja) 2008-08-27 2014-03-26 大正製薬株式会社 ナフチリジン−ｎ−オキシドを有する新規ヒドロキサム酸誘導体
US8372885B2 (en) 2008-09-17 2013-02-12 Novartis Ag Organic compounds and their uses
US8722686B2 (en) 2008-09-19 2014-05-13 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
EP2443119A1 (en) * 2009-06-16 2012-04-25 Schering Corporation Gamma secretase modulators
US20120238546A1 (en) * 2009-06-16 2012-09-20 Zhaoning Zhu Gamma secretase modulators
WO2011073845A1 (en) * 2009-12-16 2011-06-23 Pfizer Inc. N-linked hydroxamic acid derivatives useful as antibacterial agents
UA107423C2 (en) 2011-03-07 2014-12-25 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
KR20130140164A (ko) 2011-04-08 2013-12-23 화이자 인코포레이티드 항박테리아제로서 유용한 이미다졸, 피라졸 및 트라이아졸 유도체
DK2694488T3 (en) 2011-04-08 2014-12-15 Pfizer Isoxazole derivatives useful as antibacterial SUBSTANCES

Also Published As

Publication number Publication date
AP2013007074A0 (en) 2013-08-31
AU2012226473B2 (en) 2015-06-11
MX2013010276A (es) 2013-10-01
CO6761338A2 (es) 2013-09-30
US8624034B2 (en) 2014-01-07
TW201249798A (en) 2012-12-16
MA34963B1 (fr) 2014-03-01
TN2013000353A1 (fr) 2015-01-20
NI201300077A (es) 2014-01-07
CN103443079B (zh) 2015-06-03
AU2012226473B8 (en) 2015-10-15
GT201300213A (es) 2014-06-06
SG192766A1 (en) 2013-09-30
JP2014507464A (ja) 2014-03-27
MX341977B (es) 2016-09-07
UA107423C2 (en) 2014-12-25
DOP2013000200A (es) 2014-06-15
CA2828337A1 (en) 2012-09-13
US8779148B2 (en) 2014-07-15
AR085615A1 (es) 2013-10-16
CN104529883A (zh) 2015-04-22
JP5620020B2 (ja) 2014-11-05
AU2012226473A1 (en) 2013-09-05
BR112013022536A2 (pt) 2016-11-29
NZ614205A (en) 2014-06-27
US20120232083A1 (en) 2012-09-13
EP2683689B1 (en) 2017-04-12
CR20130403A (es) 2013-09-18
HK1191951A1 (en) 2014-08-08
EP2683689A1 (en) 2014-01-15
GEP20156370B (en) 2015-09-25
BR112013022536B1 (pt) 2020-05-26
WO2012120397A1 (en) 2012-09-13
EA201391072A1 (ru) 2014-02-28
KR20130131459A (ko) 2013-12-03
UY33936A (es) 2012-10-31
CA2828337C (en) 2016-05-03
ZA201306515B (en) 2014-05-28
CN103443079A (zh) 2013-12-11
CL2013002417A1 (es) 2013-12-13
AP3336A (en) 2015-07-31
ES2626457T3 (es) 2017-07-25
US20140057919A1 (en) 2014-02-27
IL228100A0 (en) 2013-09-30
CU20130117A7 (es) 2013-10-29
KR101593288B1 (ko) 2016-02-11
HK1209734A1 (en) 2016-04-08
TWI453197B (zh) 2014-09-21
EA024782B1 (ru) 2016-10-31
PE20140397A1 (es) 2014-03-28

Similar Documents

Publication Publication Date Title
ECSP13012928A (es) Derivados de fluoro-piridinona útiles como agentes antibacterianos
UY33754A (es) Monobactamas
CR20140231A (es) Derivados de ácido benzotiazol-6-il acético y su uso para tratar una infección por vih
CU20160006A7 (es) Derivados de piperidinil-indol como inhibidores de factor de complemento b
MX2013011526A (es) Derivados de isoxazol utiles como agentes antibacteriales .
CL2012003385A1 (es) Tratamiento para la incontinencia.
WO2011045703A3 (en) C-linked hydroxamic acid derivatives useful as antibacterial agents
UY34472A (es) Derivados modificados de 4-fenil-piridina
UY34414A (es) Composiciones hemostáticas
CR20140166A (es) Compuestos de (hetero)arilciclopropilamina como inhibidores de lsd1
UY33925A (es) Inhibidores tricíclicos de quinasas
UY33958A (es) Inhibidores de la glucosilceramida sintasa
CY1117163T1 (el) Ιμιδαζοπυριδαζινες ως αναστολεις κινασης ακτ
TN2015000519A1 (en) Small molecule inhibitors of fibrosis
UY34541A (es) ?derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina?.
CO7091177A2 (es) Inhibidores de la beta-secretasa
UY34545A (es) Novedosas dihidropirimidinoisoquinolinonas y composiciones farmacéuticas de las mismas para el tratamiento de trastornos inflamatorios.
CR20140079A (es) Aminoquinazolinas como inhibidores de quinasa
UY33930A (es) Inhibidores novedosos de quinasas
CL2014000470A1 (es) Compuestos derivados del acido 2-oxo-piridin-3-carboxilico; composicion farmaceutica; combinacion; y su uso para tratar o mejorar una infeccion bacteriana.
UY34415A (es) Composiciones hemostáticas
UY35274A (es) Compuestos y métodos para tratar infecciones bacterianas
BR112014003027A2 (pt) formulação herbicida melhorada
EA201500931A1 (ru) Производные пиридин-4-ила
CL2014003059A1 (es) Uso de seaprose para eliminar biopelículas bacterianas; composicion de seaprose.