ECSP088127A - Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents

Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Info

Publication number
ECSP088127A
ECSP088127A EC2008008127A ECSP088127A ECSP088127A EC SP088127 A ECSP088127 A EC SP088127A EC 2008008127 A EC2008008127 A EC 2008008127A EC SP088127 A ECSP088127 A EC SP088127A EC SP088127 A ECSP088127 A EC SP088127A
Authority
EC
Ecuador
Prior art keywords
pyridinylamine
cyclopropanamine
composites
new
pharmaceutical compositions
Prior art date
Application number
EC2008008127A
Other languages
English (en)
Inventor
Solo Goldstein
Claude Guillonneau
Yves Charton
Brian Lockhart
Pierre Lestage
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ECSP088127A publication Critical patent/ECSP088127A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compuesto de Fórmula I en la que:n representa un número entero comprendido entre 1 y 6 inclusive,R1 y R2 representan un átomo de hidrógeno, un grupo alquilo (C1-C6) o arilalquilo (C1-C6), R3 y R4 representan un átomo de hidrógeno, un grupo alquilo (C1-C6)R5 y R6 representan un átomo de hidrógeno, un grupo alquilo (C1-C6) halógeno, hidroxi, alcoxi, (C1-C6), ciano, nitro, acilo (C2-C6), alcoxicarbonilo (C1-C6), trihalógenoalquilo (C1-C6) trihalógenoalcoxi (C1-C6) o amino sustituidos opcionalmente,R7 representa un átomo de hidrógeno, un grupo alquilo (C1-C6) o arialquilo.Medicamentos
EC2008008127A 2005-07-28 2008-01-21 Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen ECSP088127A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0508032A FR2889188B1 (fr) 2005-07-28 2005-07-28 Nouveaux composes 1,1-pyridinylaminocyclopropanamines polysubstitues, leur procede de preparation et les compositions phamaceutiques qui les contiennent
PCT/FR2006/001831 WO2007012761A1 (fr) 2005-07-28 2006-07-27 Nouveaux composes 1,1-pyridinyl aminocyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ECSP088127A true ECSP088127A (es) 2008-02-20

Family

ID=36169157

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008127A ECSP088127A (es) 2005-07-28 2008-01-21 Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen

Country Status (32)

Country Link
US (2) US7388022B2 (es)
EP (1) EP1757586B1 (es)
JP (1) JP2007031439A (es)
KR (1) KR100824831B1 (es)
CN (1) CN100448848C (es)
AR (1) AR055589A1 (es)
AT (1) ATE416166T1 (es)
AU (1) AU2006203237A1 (es)
BR (1) BRPI0603027A (es)
CA (1) CA2552831A1 (es)
CR (1) CR9679A (es)
DE (1) DE602006003956D1 (es)
DK (1) DK1757586T3 (es)
EA (1) EA011124B1 (es)
EC (1) ECSP088127A (es)
ES (1) ES2318700T3 (es)
FR (1) FR2889188B1 (es)
GE (1) GEP20084506B (es)
GT (1) GT200800005A (es)
HK (1) HK1098146A1 (es)
HR (1) HRP20090090T3 (es)
MA (1) MA28425B1 (es)
MX (1) MXPA06008541A (es)
NO (1) NO20063462L (es)
NZ (1) NZ548746A (es)
PL (1) PL1757586T3 (es)
PT (1) PT1757586E (es)
SG (1) SG129412A1 (es)
SI (1) SI1757586T1 (es)
TN (1) TNSN08023A1 (es)
WO (1) WO2007012761A1 (es)
ZA (1) ZA200606276B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2896800B1 (fr) * 2006-01-30 2008-04-11 Servier Lab Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US10288289B2 (en) * 2014-12-12 2019-05-14 United Technologies Corporation Gas turbine engine diffuser-combustor assembly inner casing

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2095350C1 (ru) * 1993-10-13 1997-11-10 Центр по химии лекарственных средств (ЦХЛС-ВНИХФИ) 3-(n,n-диметилкарбамоилокси)-2-этил-6-метилпиридина сукцинат, обладающий антигипоксической активностью
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
EP1491532B1 (en) * 1997-10-27 2010-12-15 NeuroSearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetyloholine receptors
JP2003501416A (ja) * 1999-06-07 2003-01-14 ターガセプト，インコーポレイテッド 医薬組成物およびその使用法
JP2001261652A (ja) * 2000-03-21 2001-09-26 Suntory Ltd 二置換イミノヘテロサイクリック化合物
US6448276B1 (en) * 2000-05-17 2002-09-10 Inspire Pharmaceuticals, Inc. Method for treating vaginal dryness with nicotinic acetylcholine receptor agonists
FR2810664B1 (fr) * 2000-06-27 2004-12-24 Adir Nouveaux composes cyclopropaniques 1,1 et 1,2-dissubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
FR2889188B1 (fr) 2007-09-07
WO2007012761A8 (fr) 2007-12-21
EP1757586B1 (fr) 2008-12-03
GEP20084506B (en) 2008-10-10
HRP20090090T3 (en) 2009-03-31
MXPA06008541A (es) 2007-01-29
CA2552831A1 (fr) 2007-01-28
US20080146621A1 (en) 2008-06-19
DE602006003956D1 (en) 2009-01-15
EP1757586A1 (fr) 2007-02-28
FR2889188A1 (fr) 2007-02-02
SG129412A1 (en) 2007-02-26
US7388022B2 (en) 2008-06-17
CN1903844A (zh) 2007-01-31
PL1757586T3 (pl) 2009-04-30
GT200800005A (es) 2008-09-24
CR9679A (es) 2008-02-20
ES2318700T3 (es) 2009-05-01
EA011124B1 (ru) 2008-12-30
WO2007012761A1 (fr) 2007-02-01
CN100448848C (zh) 2009-01-07
HK1098146A1 (en) 2007-07-13
PT1757586E (pt) 2009-02-17
BRPI0603027A (pt) 2007-03-13
EA200601247A1 (ru) 2007-04-27
NO20063462L (no) 2007-01-29
AU2006203237A1 (en) 2007-02-15
ATE416166T1 (de) 2008-12-15
JP2007031439A (ja) 2007-02-08
NZ548746A (en) 2007-06-29
US20070027192A1 (en) 2007-02-01
DK1757586T3 (da) 2009-03-09
ZA200606276B (en) 2007-12-27
KR100824831B1 (ko) 2008-04-23
KR20070015012A (ko) 2007-02-01
SI1757586T1 (sl) 2009-04-30
MA28425B1 (fr) 2007-02-01
AR055589A1 (es) 2007-08-29
TNSN08023A1 (en) 2009-07-14

Similar Documents

Publication Publication Date Title
UY29886A1 (es) Derivados de pirazol novedosos, composiciones farmaccuticas que los contienen, procedimientos para la preparacinn de los mismos y aplicaciones
UY29742A1 (es) Procedimiento para la preparación de betamimeticos
UY28342A1 (es) Nuevos compuestos
DOP2006000045A (es) Derivados del (1,5-difenil-1h-pirazol-3-il oxadiazol, su preparacion y su aplicacion en terapeutica
CO6280399A2 (es) Peptidil nitrilos y uso de los mismos como inhibidores de peptidil peptidasa i
UY28572A1 (es) Compuestos novedosos
CO6160235A2 (es) Isoxazolinas insecticidas
AR069531A1 (es) Derivados de indolinona y procedimiento para su fabricacion
UY29234A1 (es) Derivados de adamantano, composiciones farmacéuticas que los contienen, procedimientos de preparación de ambos y aplicaciones.
NO20061317L (no) Imidazopyridinderivater som induserbare NO-syntaseinhibatorer
BR0305767A (pt) Métodos e composições para a preparação de derivados de ácido 4-substituìdo 3-hidroxibutìrico
NO20054787L (no) Indenderivater som farmasotiske midler
ECSP066304A (es) Compuestos
CU23761B7 (es) Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
CR20110484A (es) Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen
PA8575601A1 (es) Procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso
CR9391A (es) Derivados de indanil-piperazinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
PA8768301A1 (es) Nuevos derivados tricíclicos, su procedimiento de preparación y las composiciones farmacéuticas que lo contienen
UY28694A1 (es) Nuevos compuestos
UY30801A1 (es) Compuestos calciliticos
NO20061344L (no) Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer
CO6311082A2 (es) Derivados de sulfonil-quinolina, procesos para su preparación y composiciones farmacéuticas que los contienen
AR068372A1 (es) Derivados de n-fenilacetamida, inhibidores de la enzima soat1, y composiciones farmaceuticas y cosmeticas que los contienen
ECSP088127A (es) Nuevos compuestos 1,1-piridinilamino-ciclopropanaminas polisustituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
AR046768A1 (es) Derivados de piridin-tetrazol, metodos de obtencion y composiciones farmaceuticas