CR20110484A - Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen - Google Patents

Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen

Info

Publication number
CR20110484A
CR20110484A CR20110484A CR20110484A CR20110484A CR 20110484 A CR20110484 A CR 20110484A CR 20110484 A CR20110484 A CR 20110484A CR 20110484 A CR20110484 A CR 20110484A CR 20110484 A CR20110484 A CR 20110484A
Authority
CR
Costa Rica
Prior art keywords
benzotiazepinas
derivatives
new
pharmaceutical compositions
compositions containing
Prior art date
Application number
CR20110484A
Other languages
English (en)
Inventor
Cordi Alexis
Desos Patrice
Lestage Pierre
Danober Laurence
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of CR20110484A publication Critical patent/CR20110484A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de fórmula (I) en la que: R1 y R2, Idénticos o diferentes, representan cada uno un átomo de hidrógeno o de halógeno, o un grupo alquilo, alcoxi, alquitio, acilo, alcoxicarbonilo, carboxi, hidroxi, hidroxialquilo, ciano, nitro, amino, aminocarbonilo sustituido o no, aminosulfonilo.
CR20110484A 2009-03-20 2011-09-12 Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen CR20110484A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901300A FR2943342B1 (fr) 2009-03-20 2009-03-20 Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
CR20110484A true CR20110484A (es) 2011-10-24

Family

ID=40863576

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110484A CR20110484A (es) 2009-03-20 2011-09-12 Nuevos derivados de benzotiazepinas su procedimiento de preparacion y composiciones farmaceuticas que los contienen

Country Status (45)

Country Link
US (1) US8236790B2 (es)
EP (1) EP2246339B1 (es)
JP (1) JP5437473B2 (es)
KR (1) KR101431504B1 (es)
CN (1) CN102361860B (es)
AP (1) AP3050A (es)
AR (1) AR075892A1 (es)
AT (1) ATE513822T1 (es)
AU (1) AU2010200815B2 (es)
BR (1) BRPI1009200A2 (es)
CA (1) CA2696705C (es)
CL (1) CL2011002287A1 (es)
CO (1) CO6361956A2 (es)
CR (1) CR20110484A (es)
CU (1) CU24030B1 (es)
CY (1) CY1111807T1 (es)
DK (1) DK2246339T3 (es)
EA (1) EA020259B1 (es)
EC (1) ECSP11011340A (es)
ES (1) ES2368691T3 (es)
FR (1) FR2943342B1 (es)
GE (1) GEP20135862B (es)
HK (1) HK1167404A1 (es)
HN (1) HN2011002458A (es)
HR (1) HRP20110626T1 (es)
IL (1) IL215016A (es)
JO (1) JO2780B1 (es)
MA (1) MA33131B1 (es)
MX (1) MX2011009638A (es)
MY (1) MY154001A (es)
NI (1) NI201100169A (es)
NZ (1) NZ595082A (es)
PE (1) PE20120113A1 (es)
PL (1) PL2246339T3 (es)
PT (1) PT2246339E (es)
RS (1) RS51919B (es)
SA (1) SA110310217B1 (es)
SG (1) SG174274A1 (es)
SI (1) SI2246339T1 (es)
TN (1) TN2011000469A1 (es)
TW (1) TWI388326B (es)
UA (1) UA100477C2 (es)
UY (1) UY32475A (es)
WO (1) WO2010106249A1 (es)
ZA (1) ZA201001905B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2774715C (en) 2009-07-27 2018-04-03 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
NZ604478A (en) 2010-07-02 2014-12-24 Gilead Sciences Inc Fused heterocyclic compounds as ion channel modulators
UY33551A (es) 2010-08-10 2012-03-30 Takeda Pharmaceutical Compuesto heterocíclico y su uso
EA028156B9 (ru) 2011-05-10 2018-01-31 Джилид Сайэнс, Инк. Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов
TWI478908B (zh) * 2011-07-01 2015-04-01 Gilead Sciences Inc 作為離子通道調節劑之稠合雜環化合物
AU2015224425B2 (en) * 2011-07-01 2017-02-09 Gilead Sciences, Inc. Fused benzoxazepinones as ion channel modulators
NO3175985T3 (es) 2011-07-01 2018-04-28
EP2813508B1 (en) 2012-02-08 2018-01-31 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111574475B (zh) * 2020-06-03 2022-09-20 西安都创医药科技有限公司 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
CN115368363B (zh) * 2021-05-17 2024-02-20 中山大学 一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2130096A1 (fr) * 1992-04-15 1993-10-28 Jean-Claude Aloup Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant
CA2319173A1 (en) * 1998-02-11 1999-08-19 Jingwu Duan Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
ZA991301B (en) * 1998-02-18 1999-09-13 Neurosearch As Glutamate receptor modulators.
US6156746A (en) * 1998-08-25 2000-12-05 Bristol-Myers Squibb Company 1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
GB0209467D0 (en) * 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
DE10300973A1 (de) * 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2877338B1 (fr) * 2004-11-03 2007-01-26 Servier Lab Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2879201B1 (fr) * 2004-12-10 2007-02-16 Servier Lab Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
UY32475A (es) 2010-09-30
KR101431504B1 (ko) 2014-08-20
IL215016A0 (en) 2011-11-30
UA100477C2 (uk) 2012-12-25
TWI388326B (zh) 2013-03-11
TW201036615A (en) 2010-10-16
NZ595082A (en) 2013-12-20
SA110310217B1 (ar) 2013-06-15
DK2246339T3 (da) 2011-10-10
SI2246339T1 (sl) 2011-09-30
PT2246339E (pt) 2011-08-01
RS51919B (en) 2012-02-29
CA2696705A1 (fr) 2010-09-20
ZA201001905B (en) 2010-11-24
NI201100169A (es) 2012-01-11
MA33131B1 (fr) 2012-03-01
CN102361860B (zh) 2014-09-10
FR2943342A1 (fr) 2010-09-24
ATE513822T1 (de) 2011-07-15
ECSP11011340A (es) 2011-10-31
CU24030B1 (es) 2014-10-02
TN2011000469A1 (fr) 2013-03-27
EA020259B1 (ru) 2014-09-30
BRPI1009200A2 (pt) 2017-06-13
KR20110128209A (ko) 2011-11-28
US8236790B2 (en) 2012-08-07
CU20110169A7 (es) 2012-02-15
MX2011009638A (es) 2011-09-28
HRP20110626T1 (hr) 2011-10-31
GEP20135862B (en) 2013-06-25
AU2010200815B2 (en) 2015-05-07
CN102361860A (zh) 2012-02-22
EP2246339A1 (fr) 2010-11-03
AP2011005935A0 (en) 2011-10-31
HN2011002458A (es) 2014-05-19
IL215016A (en) 2013-08-29
WO2010106249A1 (fr) 2010-09-23
US20100240635A1 (en) 2010-09-23
MY154001A (en) 2015-04-30
JP2012520858A (ja) 2012-09-10
AR075892A1 (es) 2011-05-04
AU2010200815A1 (en) 2010-10-07
CY1111807T1 (el) 2015-10-07
PL2246339T3 (pl) 2011-11-30
HK1167404A1 (en) 2012-11-30
CL2011002287A1 (es) 2012-02-03
JO2780B1 (en) 2014-03-15
ES2368691T3 (es) 2011-11-21
JP5437473B2 (ja) 2014-03-12
EA201101334A1 (ru) 2012-04-30
FR2943342B1 (fr) 2011-03-04
CA2696705C (fr) 2013-02-12
AP3050A (en) 2014-11-30
SG174274A1 (en) 2011-10-28
CO6361956A2 (es) 2012-01-20
PE20120113A1 (es) 2012-02-24
EP2246339B1 (fr) 2011-06-22

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