ECSP066894A - Derivados de sulfonamida-tiazolpiridina como activadores de glucocinasa utiles en el tratamiento de diabetes de tipo 2 - Google Patents
Derivados de sulfonamida-tiazolpiridina como activadores de glucocinasa utiles en el tratamiento de diabetes de tipo 2Info
- Publication number
- ECSP066894A ECSP066894A EC2006006894A ECSP066894A ECSP066894A EC SP066894 A ECSP066894 A EC SP066894A EC 2006006894 A EC2006006894 A EC 2006006894A EC SP066894 A ECSP066894 A EC SP066894A EC SP066894 A ECSP066894 A EC SP066894A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- diabetes
- type
- thiazolpiridine
- sulfonamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invención proporciona compuestos de la fórmula (I), los cuales son activadores de la actividad de glucocinasa y, de esta manera, pueden ser empleados como agentes terapéuticos para el tratamiento de condiciones mediadas por glucocinasa. Por consiguiente, los compuestos de la fórmula (I) pueden ser empleados para la prevención y el tratamiento de tolerancia dañada a glucosa, diabetes de Tipo 2 y obesidad.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55918404P | 2004-04-02 | 2004-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066894A true ECSP066894A (es) | 2006-11-24 |
Family
ID=34963913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006894A ECSP066894A (es) | 2004-04-02 | 2006-09-29 | Derivados de sulfonamida-tiazolpiridina como activadores de glucocinasa utiles en el tratamiento de diabetes de tipo 2 |
Country Status (19)
Country | Link |
---|---|
US (1) | US7750020B2 (es) |
EP (1) | EP1735322B1 (es) |
JP (1) | JP4700684B2 (es) |
KR (1) | KR100830007B1 (es) |
CN (1) | CN1960995B (es) |
AR (1) | AR050913A1 (es) |
AT (1) | ATE524479T1 (es) |
AU (1) | AU2005229416B2 (es) |
BR (1) | BRPI0509573A (es) |
CA (1) | CA2560689C (es) |
EC (1) | ECSP066894A (es) |
IL (1) | IL178151A0 (es) |
MA (1) | MA28528B1 (es) |
NO (1) | NO20064929L (es) |
PE (1) | PE20061353A1 (es) |
PT (1) | PT1735322E (es) |
RU (1) | RU2412192C2 (es) |
TN (1) | TNSN06315A1 (es) |
WO (1) | WO2005095418A1 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
WO2004050645A1 (en) | 2002-10-03 | 2004-06-17 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
EP1737870A1 (en) * | 2004-04-02 | 2007-01-03 | Novartis AG | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
GT200600429A (es) * | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
CA2627813A1 (en) * | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Substituted pyrrolones as allosteric modulators of glucokinase |
CA2627910A1 (en) * | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Substituted cycloalkylpyrrolones as allosteric modulators of glucokinase |
CA2627892A1 (en) | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Substituted dihydroisoindolones as allosteric modulators of glucokinase |
US7531671B2 (en) * | 2005-11-01 | 2009-05-12 | Janssen Pharmaceutica N.V. | Dihydroisoindolones as allosteric modulators of glucokinase |
WO2007110449A1 (en) | 2006-03-29 | 2007-10-04 | Euro-Celtique S.A. | Benzenesulfonamide compounds and their use |
TW200815353A (en) | 2006-04-13 | 2008-04-01 | Euro Celtique Sa | Benzenesulfonamide compounds and their use |
US8937181B2 (en) | 2006-04-13 | 2015-01-20 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
EP2046755A2 (en) | 2006-07-24 | 2009-04-15 | F. Hoffmann-Roche AG | Pyrazoles as glucokinase activators |
TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
BRPI0808267A2 (pt) * | 2007-03-07 | 2014-07-22 | Kyorin Phamaceutical Co., Ltd | "composto representado pela formula geral (1) ou um sal farmeceuticamente aceitável do mesmo; método para o tratamento ou prevenção de diabetes ; uso do composto; composição farmacêutica e composto representado pela formula geral (3)". |
WO2008119734A2 (en) * | 2007-03-29 | 2008-10-09 | Novartis Ag | Process for the manufacture of organic compounds |
US8399486B2 (en) | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
US8765736B2 (en) | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
CN101827832B (zh) * | 2007-10-08 | 2014-05-07 | 阿德维纳斯治疗私人有限公司 | 作为葡糖激酶活化剂的乙酰胺衍生物、其制备方法及医药应用 |
CN101417987B (zh) * | 2007-10-24 | 2011-07-13 | 山东轩竹医药科技有限公司 | 具有磺酰胺甲酰哌嗪结构的dpp-iv抑制剂 |
TW200942239A (en) | 2008-01-18 | 2009-10-16 | Astellas Pharma Inc | Phenylacetamide derivatives |
US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
CA2722733C (en) | 2008-04-28 | 2016-02-23 | Kyorin Pharmaceutical Co., Ltd. | Cyclopentylacrylamide derivative |
BRPI0912802A2 (pt) | 2008-05-16 | 2015-10-13 | Takeda San Diego Inc | ativadores de glicoquinase |
EP2344458A1 (en) | 2008-09-11 | 2011-07-20 | Pfizer Inc. | Heteroaryls amide derivatives and their use as glucokinase activators |
EA018894B1 (ru) | 2009-03-11 | 2013-11-29 | Пфайзер Инк. | N,n-диметил-5-(2-метил-6-((5-метилпиразин-2-ил)карбамоил)бензо-фуран-4-илокси)пиримидин-2-карбоксамид, используемый в качестве активатора глюкокиназы, и содержащая его фармацев-тическая композиция |
US8765747B2 (en) | 2009-06-12 | 2014-07-01 | Dana-Farber Cancer Institute, Inc. | Fused 2-aminothiazole compounds |
US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
EP2519517B1 (en) | 2009-12-29 | 2015-03-25 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
EP3936608A1 (en) | 2010-03-31 | 2022-01-12 | The Scripps Research Institute | Reprogramming cells |
EP2822935B1 (en) | 2011-11-17 | 2019-05-15 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
WO2013173382A1 (en) * | 2012-05-15 | 2013-11-21 | Amgen Inc. | Benzothiophene sulfonamides and other compounds that interact with glucokinase regulatory protein |
EP2909194A1 (en) | 2012-10-18 | 2015-08-26 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
WO2014063061A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
US10000483B2 (en) | 2012-10-19 | 2018-06-19 | Dana-Farber Cancer Institute, Inc. | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof |
EP3057956B1 (en) | 2013-10-18 | 2021-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7) |
US20160264551A1 (en) | 2013-10-18 | 2016-09-15 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of prolferative diseases |
WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
WO2015164604A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
WO2016105528A2 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
US10550121B2 (en) | 2015-03-27 | 2020-02-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
EP4019515A1 (en) | 2015-09-09 | 2022-06-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2242469C2 (ru) * | 1999-03-29 | 2004-12-20 | Ф.Хоффманн-Ля Рош Аг | Активаторы глюкокиназы |
US6320050B1 (en) * | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
US6610846B1 (en) | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
DK1169312T3 (da) | 1999-03-29 | 2005-01-31 | Hoffmann La Roche | Glucokinaseaktivatorer |
US6353111B1 (en) | 1999-12-15 | 2002-03-05 | Hoffmann-La Roche Inc. | Trans olefinic glucokinase activators |
AU7049401A (en) * | 2000-05-03 | 2001-11-12 | Hoffmann La Roche | Alkynyl phenyl heteroaromatic glucokinase activators |
BR0110492A (pt) * | 2000-05-03 | 2003-04-08 | Hoffmann La Roche | Composto, composição farmacêutica que compreende esse composto, processo para a preparação de composição farmacêutica, utilização do composto e processo para a preparação do composto |
DE60106599T2 (de) * | 2000-05-08 | 2006-02-09 | F. Hoffmann-La Roche Ag | Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren |
WO2001085707A1 (en) | 2000-05-08 | 2001-11-15 | F. Hoffmann-La Roche Ag | Para-amine substituted phenylamide glucokinase activators |
US6489485B2 (en) * | 2000-05-08 | 2002-12-03 | Hoffmann-La Roche Inc. | Para-amine substituted phenylamide glucokinase activators |
WO2002008209A1 (en) | 2000-07-20 | 2002-01-31 | F. Hoffmann-La Roche Ag | Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators |
US6369232B1 (en) * | 2000-08-15 | 2002-04-09 | Hoffmann-La Roche Inc. | Tetrazolyl-phenyl acetamide glucokinase activators |
US6433188B1 (en) * | 2000-12-06 | 2002-08-13 | Wendy Lea Corbett | Fused heteroaromatic glucokinase activators |
PT1341774E (pt) * | 2000-12-06 | 2006-05-31 | Hoffmann La Roche | Activadores heteroaromaticos, fundidos de glicocinase |
US6482951B2 (en) | 2000-12-13 | 2002-11-19 | Hoffmann-La Roche Inc. | Isoindolin-1-one glucokinase activators |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
US6911545B2 (en) | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
BR0215212A (pt) | 2001-12-21 | 2004-12-07 | Novo Nordisk As | Ativador de carboxamida ou sulfonamida de glicoquinase, composto, composição farmacêutica, e, uso de um composto |
JP4419571B2 (ja) * | 2002-03-26 | 2010-02-24 | 萬有製薬株式会社 | 新規アミノベンズアミド誘導体 |
JP4091600B2 (ja) | 2002-04-26 | 2008-05-28 | エフ.ホフマン−ラ ロシュ アーゲー | 置換フェニルアセトアミド及びグルコキナーゼ活性化物質としてのその使用 |
JPWO2003097824A1 (ja) | 2002-05-16 | 2005-09-15 | 萬有製薬株式会社 | グルコキナーゼタンパク質の結晶、及びその結晶を用いたドラッグデザイン方法 |
KR101116627B1 (ko) | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
WO2004050645A1 (en) * | 2002-10-03 | 2004-06-17 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
WO2004031179A1 (en) | 2002-10-03 | 2004-04-15 | F. Hoffmann-La Roche Ag | Indole-3-carboxamides as glucokinase (gk) activators |
MY141521A (en) | 2002-12-12 | 2010-05-14 | Hoffmann La Roche | 5-substituted-six-membered heteroaromatic glucokinase activators |
ES2362656T3 (es) | 2003-01-06 | 2011-07-11 | Eli Lilly And Company | Arilciclopropilacetamidas sustituidas como activadores de glucoquinasa. |
WO2004063194A1 (en) | 2003-01-06 | 2004-07-29 | Eli Lilly And Company | Heteroaryl compounds |
PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
WO2004072066A1 (en) | 2003-02-11 | 2004-08-26 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
NZ540791A (en) | 2003-02-13 | 2009-09-25 | Banyu Pharma Co Ltd | Novel 2-pyridinecarboxamide derivatives |
MXPA05009059A (es) | 2003-02-26 | 2005-10-19 | Banyu Pharma Co Ltd | Derivados de heteroarilcarbamoilbenceno. |
EP1737870A1 (en) * | 2004-04-02 | 2007-01-03 | Novartis AG | Thiazolopyridine derivates, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
JP2007533722A (ja) | 2004-04-21 | 2007-11-22 | プロシディオン・リミテッド | トリ(シクロ)置換アミド化合物 |
MX2007001650A (es) | 2004-08-12 | 2007-07-13 | Prosidion Ltd | Fenilacetamidas substituidas y su uso como activadores de glucocinasa. |
CA2590720A1 (en) | 2004-12-03 | 2006-06-08 | Lone Jeppesen | Heteroaromatic glucokinase activators |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos |
-
2005
- 2005-04-01 JP JP2007505512A patent/JP4700684B2/ja not_active Expired - Fee Related
- 2005-04-01 CN CN2005800178910A patent/CN1960995B/zh not_active Expired - Fee Related
- 2005-04-01 AT AT05731007T patent/ATE524479T1/de not_active IP Right Cessation
- 2005-04-01 BR BRPI0509573-5A patent/BRPI0509573A/pt not_active IP Right Cessation
- 2005-04-01 KR KR1020067020441A patent/KR100830007B1/ko not_active IP Right Cessation
- 2005-04-01 EP EP05731007A patent/EP1735322B1/en active Active
- 2005-04-01 PT PT05731007T patent/PT1735322E/pt unknown
- 2005-04-01 AU AU2005229416A patent/AU2005229416B2/en not_active Ceased
- 2005-04-01 CA CA2560689A patent/CA2560689C/en not_active Expired - Fee Related
- 2005-04-01 US US11/547,046 patent/US7750020B2/en not_active Expired - Fee Related
- 2005-04-01 WO PCT/EP2005/003456 patent/WO2005095418A1/en active Application Filing
- 2005-04-01 RU RU2006138433/04A patent/RU2412192C2/ru not_active IP Right Cessation
- 2005-08-09 AR ARP050103320A patent/AR050913A1/es not_active Application Discontinuation
-
2006
- 2006-03-29 PE PE2006000347A patent/PE20061353A1/es not_active Application Discontinuation
- 2006-09-18 IL IL178151A patent/IL178151A0/en unknown
- 2006-09-29 TN TNP2006000315A patent/TNSN06315A1/en unknown
- 2006-09-29 EC EC2006006894A patent/ECSP066894A/es unknown
- 2006-10-11 MA MA29381A patent/MA28528B1/fr unknown
- 2006-10-27 NO NO20064929A patent/NO20064929L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA28528B1 (fr) | 2007-04-03 |
CN1960995B (zh) | 2010-12-08 |
AU2005229416B2 (en) | 2009-03-26 |
CA2560689A1 (en) | 2005-10-13 |
TNSN06315A1 (en) | 2007-12-03 |
BRPI0509573A (pt) | 2007-09-25 |
US20080103167A1 (en) | 2008-05-01 |
WO2005095418A1 (en) | 2005-10-13 |
PE20061353A1 (es) | 2006-12-29 |
EP1735322A1 (en) | 2006-12-27 |
ATE524479T1 (de) | 2011-09-15 |
AU2005229416A1 (en) | 2005-10-13 |
KR20060131955A (ko) | 2006-12-20 |
JP4700684B2 (ja) | 2011-06-15 |
NO20064929L (no) | 2006-12-20 |
JP2007530632A (ja) | 2007-11-01 |
US7750020B2 (en) | 2010-07-06 |
CN1960995A (zh) | 2007-05-09 |
EP1735322B1 (en) | 2011-09-14 |
CA2560689C (en) | 2011-03-01 |
AR050913A1 (es) | 2006-12-06 |
IL178151A0 (en) | 2006-12-31 |
PT1735322E (pt) | 2012-01-12 |
RU2412192C2 (ru) | 2011-02-20 |
RU2006138433A (ru) | 2008-05-10 |
KR100830007B1 (ko) | 2008-05-15 |
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