ECSP055575A - Uso de derivados de tio-oxindol en el tratamiento de enfermedades de la piel. - Google Patents
Uso de derivados de tio-oxindol en el tratamiento de enfermedades de la piel.Info
- Publication number
- ECSP055575A ECSP055575A EC2005005575A ECSP055575A ECSP055575A EC SP055575 A ECSP055575 A EC SP055575A EC 2005005575 A EC2005005575 A EC 2005005575A EC SP055575 A ECSP055575 A EC SP055575A EC SP055575 A ECSP055575 A EC SP055575A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- skin diseases
- thio
- oxindol derivatives
- oxindol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona métodos para el tratamiento de enfermedades de la piel, el cual incluye la administración a un mamífero de una composición que contiene un compuesto de fórmula I, o tautómeros del mismo, en un régimen donde la fórmula I es como se muestra y donde R1-R5 y Q1 son definidos como se describe aquí. Específicamente se describen métodos para el tratamiento del acné, el hirsutismo y una composición para acondicionar la piel.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39191302P | 2002-06-25 | 2002-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP055575A true ECSP055575A (es) | 2005-04-18 |
Family
ID=30000776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2005005575A ECSP055575A (es) | 2002-06-25 | 2005-01-25 | Uso de derivados de tio-oxindol en el tratamiento de enfermedades de la piel. |
Country Status (17)
Country | Link |
---|---|
US (1) | US7115649B2 (es) |
EP (1) | EP1515680A4 (es) |
JP (1) | JP2005535625A (es) |
KR (1) | KR20050012831A (es) |
CN (1) | CN1662206A (es) |
AR (1) | AR040338A1 (es) |
AU (1) | AU2003258952A1 (es) |
BR (1) | BR0312092A (es) |
CA (1) | CA2489810A1 (es) |
EC (1) | ECSP055575A (es) |
IL (1) | IL165394A0 (es) |
MX (1) | MXPA04012418A (es) |
NO (1) | NO20045215L (es) |
RU (1) | RU2005101624A (es) |
TW (1) | TW200401637A (es) |
WO (1) | WO2004000227A2 (es) |
ZA (1) | ZA200410401B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
CA2489813A1 (en) * | 2002-06-25 | 2003-12-31 | Wyeth | Use of thio-oxindole derivatives in treatment of hormone-related conditions |
WO2005100346A1 (en) | 2004-04-08 | 2005-10-27 | Wyeth | Thioamide derivatives as progesterone receptor modulators |
ATE409699T1 (de) * | 2004-04-08 | 2008-10-15 | Wyeth Corp | Verfahren zur minimierung von thioamidverunreinigungen |
AU2005237520B2 (en) | 2004-04-27 | 2012-01-19 | Wyeth | Purification of progesterone receptor modulators |
GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
MY158766A (en) | 2005-04-11 | 2016-11-15 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
WO2008060789A2 (en) | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
WO2008088771A2 (en) * | 2007-01-12 | 2008-07-24 | Cornell Research Foundation, Inc. | Adenylyl cyclases as novel targets for the treatment of infection by eukaryotic pathogens |
CN101636157A (zh) * | 2007-01-12 | 2010-01-27 | 康乃尔研究基金会有限公司 | 作为抗菌干预的新型靶的腺苷酰环化酶 |
EP2350091B1 (en) | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
US8263606B2 (en) | 2008-10-17 | 2012-09-11 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
RU2015103694A (ru) | 2009-10-14 | 2015-06-27 | Ксенон Фармасьютикалз Инк. | Способы синтеза спиро-оксиндольных соединений |
MX343215B (es) | 2010-02-26 | 2016-10-27 | Xenon Pharmaceuticals Inc | Composiciones farmacéuticas del compuesto espiro-oxindol para administración tópica y sus usos como agentes terapéuticos. |
KR101278271B1 (ko) * | 2011-08-02 | 2013-06-25 | 충남대학교산학협력단 | 인돌린-2-티온 유사체를 함유한 미백용 조성물 |
US9737522B2 (en) | 2012-08-09 | 2017-08-22 | Emory University | NMDA receptor modulators and uses related thereto |
TW201636017A (zh) | 2015-02-05 | 2016-10-16 | 梯瓦製藥國際有限責任公司 | 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US169198A (en) * | 1875-10-26 | Improvement in treating quicksilver-ore | ||
US92711A (en) * | 1869-07-20 | e d w a r d s | ||
WO1985000519A1 (en) * | 1983-07-29 | 1985-02-14 | Duke University | Method of treating androgen-related disorders |
DE4335876A1 (de) * | 1993-10-17 | 1995-04-20 | Schering Ag | Kombination von Progesteronantagonisten und Antiöstrogenen mit partialer agonistischer Wirkung für die Hormonsubstitutions-Therapie für peri- und postmenopausale Frauen |
IL142598A0 (en) * | 1998-10-23 | 2002-03-10 | Aventis Pharma Gmbh | Preparations for topical application of substances having antiandrogenic effect |
AU760964B2 (en) * | 1998-12-31 | 2003-05-22 | Sugen, Inc. | 3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activityand for use in cancer chemotherapy |
US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
EP1206761B1 (en) | 1999-08-26 | 2007-10-03 | Automotive Systems Laboratory Inc. | Magnetic sensor |
US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
US7119207B2 (en) * | 2000-04-10 | 2006-10-10 | Pfizer Inc | Benzoamide piperidine containing compounds and related compounds |
YU73902A (sh) | 2000-04-10 | 2005-09-19 | Pfizer Products Inc. | Jedinjenja koja sadrže benzoamid-piperidin i srodna jedinjenja |
UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
JP4976849B2 (ja) * | 2004-07-12 | 2012-07-18 | ローム株式会社 | 半導体発光素子 |
-
2003
- 2003-06-23 RU RU2005101624/04A patent/RU2005101624A/ru not_active Application Discontinuation
- 2003-06-23 AU AU2003258952A patent/AU2003258952A1/en not_active Abandoned
- 2003-06-23 CA CA002489810A patent/CA2489810A1/en not_active Abandoned
- 2003-06-23 CN CN038147823A patent/CN1662206A/zh active Pending
- 2003-06-23 MX MXPA04012418A patent/MXPA04012418A/es unknown
- 2003-06-23 JP JP2004516162A patent/JP2005535625A/ja active Pending
- 2003-06-23 WO PCT/US2003/019791 patent/WO2004000227A2/en not_active Application Discontinuation
- 2003-06-23 US US10/601,442 patent/US7115649B2/en not_active Expired - Fee Related
- 2003-06-23 BR BR0312092-9A patent/BR0312092A/pt not_active IP Right Cessation
- 2003-06-23 TW TW092116985A patent/TW200401637A/zh unknown
- 2003-06-23 KR KR10-2004-7021067A patent/KR20050012831A/ko not_active Application Discontinuation
- 2003-06-23 EP EP03761271A patent/EP1515680A4/en not_active Withdrawn
- 2003-06-24 AR ARP030102254A patent/AR040338A1/es unknown
-
2004
- 2004-11-25 IL IL16539404A patent/IL165394A0/xx unknown
- 2004-11-29 NO NO20045215A patent/NO20045215L/no not_active Application Discontinuation
- 2004-12-23 ZA ZA200410401A patent/ZA200410401B/xx unknown
-
2005
- 2005-01-25 EC EC2005005575A patent/ECSP055575A/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20040006122A1 (en) | 2004-01-08 |
US7115649B2 (en) | 2006-10-03 |
TW200401637A (en) | 2004-02-01 |
RU2005101624A (ru) | 2005-06-27 |
WO2004000227A2 (en) | 2003-12-31 |
NO20045215L (no) | 2005-03-17 |
JP2005535625A (ja) | 2005-11-24 |
BR0312092A (pt) | 2005-03-22 |
IL165394A0 (en) | 2006-01-15 |
EP1515680A2 (en) | 2005-03-23 |
ZA200410401B (en) | 2006-05-31 |
KR20050012831A (ko) | 2005-02-02 |
AR040338A1 (es) | 2005-03-30 |
MXPA04012418A (es) | 2005-04-19 |
WO2004000227A3 (en) | 2004-04-08 |
CN1662206A (zh) | 2005-08-31 |
CA2489810A1 (en) | 2003-12-31 |
EP1515680A4 (en) | 2005-09-21 |
AU2003258952A1 (en) | 2004-01-06 |
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