EA202190495A1 - Антитела против pd-l1 человека - Google Patents

Антитела против pd-l1 человека

Info

Publication number
EA202190495A1
EA202190495A1 EA202190495A EA202190495A EA202190495A1 EA 202190495 A1 EA202190495 A1 EA 202190495A1 EA 202190495 A EA202190495 A EA 202190495A EA 202190495 A EA202190495 A EA 202190495A EA 202190495 A1 EA202190495 A1 EA 202190495A1
Authority
EA
Eurasian Patent Office
Prior art keywords
seq
against human
fragments
antibodies against
antibodies
Prior art date
Application number
EA202190495A
Other languages
English (en)
Russian (ru)
Inventor
Лэй Фан
Юаньюань Ян
Чжэнъи Ван
Бинши Гуо
Фэйфэй Цуй
Original Assignee
Ай-Маб Биофарма Юэс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ай-Маб Биофарма Юэс Лимитед filed Critical Ай-Маб Биофарма Юэс Лимитед
Publication of EA202190495A1 publication Critical patent/EA202190495A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
EA202190495A 2019-04-26 2020-04-26 Антитела против pd-l1 человека EA202190495A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2019084468 2019-04-26
PCT/CN2020/087019 WO2020216379A1 (fr) 2019-04-26 2020-04-26 Anticorps anti-pd-l1 humains

Publications (1)

Publication Number Publication Date
EA202190495A1 true EA202190495A1 (ru) 2022-02-03

Family

ID=72940614

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190495A EA202190495A1 (ru) 2019-04-26 2020-04-26 Антитела против pd-l1 человека

Country Status (14)

Country Link
US (1) US11208486B2 (fr)
EP (1) EP3833691A4 (fr)
JP (1) JP7212990B2 (fr)
KR (1) KR20210070323A (fr)
CN (1) CN112996815B (fr)
AU (1) AU2020261961B2 (fr)
BR (1) BR112021005365A2 (fr)
CA (1) CA3112681A1 (fr)
EA (1) EA202190495A1 (fr)
IL (1) IL281397B (fr)
MX (1) MX2021004897A (fr)
SG (1) SG11202103000WA (fr)
WO (1) WO2020216379A1 (fr)
ZA (1) ZA202101523B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023187460A1 (fr) * 2022-04-01 2023-10-05 Mabtree Biologics Ag Anticorps humain ou fragment de liaison à l'antigène de celui-ci spécifique contre pd-l1 pour améliorer la fonction des lymphocytes t

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6420140B1 (en) 1996-10-11 2002-07-16 Abgenix, Inc. Production of multimeric protein by cell fusion method
PE20120341A1 (es) * 2008-12-09 2012-04-24 Genentech Inc Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t
LT2785375T (lt) 2011-11-28 2020-11-10 Merck Patent Gmbh Anti-pd-l1 antikūnai ir jų panaudojimas
CN115093480A (zh) 2012-05-31 2022-09-23 索伦托药业有限公司 与pd-l1结合的抗原结合蛋白
WO2014055897A2 (fr) * 2012-10-04 2014-04-10 Dana-Farber Cancer Institute, Inc. Anticorps monoclonaux humains anti pd-l1 et procédés d'utilisation
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
CN105777906B (zh) * 2014-12-19 2019-04-23 苏州丁孚靶点生物技术有限公司 抗pd-l1全人抗体及其应用
JP6983371B2 (ja) * 2015-11-17 2021-12-17 スーヂョウ サンケイディア バイオファーマスーティカルズ カンパニー リミテッド 抗ｐｄ−ｌ１抗体、その抗原結合フラグメントおよびその医療用途
CN106939047B (zh) * 2016-01-04 2021-08-31 江苏怀瑜药业有限公司 一种pd-l1抗体及其制备方法
US10590199B2 (en) 2016-06-29 2020-03-17 Checkpoint Therapeutics, Inc. PD-L1-specific antibodies and methods of using the same
TWI829628B (zh) * 2016-12-19 2024-01-21 瑞士商赫孚孟拉羅股份公司 與靶向4-1bb (cd137)促效劑併用之組合療法
CN111315776A (zh) 2017-03-29 2020-06-19 葛莱高托普有限公司 Pd-l1和ta-muc1抗体
CN110856446A (zh) * 2017-04-18 2020-02-28 阿法姆海外股份有限公司 抗pd-l1抗体及其用途
EP3649154A1 (fr) * 2017-07-06 2020-05-13 Merus N.V. Molécules de liaison permettant de moduler l'activité biologique exprimée par une cellule
CN111225926A (zh) * 2017-10-10 2020-06-02 努玛治疗有限公司 靶向pdl1的抗体及其使用方法
CA3092421A1 (fr) * 2018-03-01 2019-09-06 Vrije Universiteit Brussel Immunoglobulines se liant au pd-l1 humain

Also Published As

Publication number Publication date
CN112996815A (zh) 2021-06-18
US20210309747A1 (en) 2021-10-07
JP7212990B2 (ja) 2023-01-26
CN112996815B (zh) 2024-02-20
WO2020216379A1 (fr) 2020-10-29
US11208486B2 (en) 2021-12-28
ZA202101523B (en) 2022-06-29
AU2020261961A1 (en) 2021-04-22
IL281397B (en) 2022-04-01
EP3833691A1 (fr) 2021-06-16
JP2022511311A (ja) 2022-01-31
MX2021004897A (es) 2021-06-18
KR20210070323A (ko) 2021-06-14
IL281397A (en) 2021-04-29
EP3833691A4 (fr) 2022-05-18
CA3112681A1 (fr) 2020-10-29
AU2020261961B2 (en) 2022-07-07
BR112021005365A2 (pt) 2021-11-16
SG11202103000WA (en) 2021-04-29

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