EA202090800A1 - Новые анти-cd3-эпсилон антитела - Google Patents
Новые анти-cd3-эпсилон антителаInfo
- Publication number
- EA202090800A1 EA202090800A1 EA202090800A EA202090800A EA202090800A1 EA 202090800 A1 EA202090800 A1 EA 202090800A1 EA 202090800 A EA202090800 A EA 202090800A EA 202090800 A EA202090800 A EA 202090800A EA 202090800 A1 EA202090800 A1 EA 202090800A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- new anti
- epsilon antibodies
- seq
- group
- cdr sequences
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/7051—T-cell receptor (TcR)-CD3 complex
Abstract
Представлены выделенные моноклональные анти-CD3-эпсилон антитела или их антигенсвязывающие фрагменты, включающие одну или несколько последовательностей CDR тяжелой цепи, выбранных из группы, состоящей из SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45 и 47, и/или одну или несколько последовательностей CDR каппа-легкой цепи, выбранных из группы, состоящей из SEQ ID NO: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46 и 48. Также представлены кодирующие их выделенные полинуклеотиды, включающие их фармацевтические композиции и их применение.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2017102622 | 2017-09-21 | ||
PCT/CN2018/106618 WO2019057099A1 (en) | 2017-09-21 | 2018-09-20 | NOVEL ANTI-CD3EPSILON ANTIBODIES |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090800A1 true EA202090800A1 (ru) | 2020-08-11 |
Family
ID=65811028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090800A EA202090800A1 (ru) | 2017-09-21 | 2018-09-20 | Новые анти-cd3-эпсилон антитела |
Country Status (15)
Country | Link |
---|---|
US (2) | US11440962B2 (ru) |
EP (1) | EP3684806A4 (ru) |
JP (2) | JP7305624B2 (ru) |
KR (1) | KR20200055052A (ru) |
CN (2) | CN115991777A (ru) |
AU (1) | AU2018336519A1 (ru) |
BR (1) | BR112020004992A2 (ru) |
CA (1) | CA3074130A1 (ru) |
EA (1) | EA202090800A1 (ru) |
IL (1) | IL273393A (ru) |
MX (1) | MX2020003087A (ru) |
SG (1) | SG11202001358RA (ru) |
TW (1) | TWI820041B (ru) |
WO (1) | WO2019057099A1 (ru) |
ZA (1) | ZA202001314B (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020005676A2 (pt) | 2017-09-22 | 2020-10-20 | WuXi Biologics Ireland Limited | novos complexos polipeptídicos biespecíficos |
MX2020003144A (es) | 2017-09-22 | 2020-07-28 | Wuxi Biologics Ireland Ltd | Nuevos complejos de polipeptidos biespecificos cd3/cd19. |
CN114174339A (zh) * | 2019-06-07 | 2022-03-11 | 阿迪马布有限责任公司 | 高亲和力抗cd3抗体及其产生和使用方法 |
US20230067182A1 (en) * | 2019-11-29 | 2023-03-02 | Boe Technology Group Co., Ltd. | Data Processing Device and Method, and Computer Readable Storage Medium |
PE20230389A1 (es) * | 2020-05-27 | 2023-03-06 | Janssen Biotech Inc | Proteinas que comprenden dominios de union al antigeno de cd3 y usos de estas |
US20230279138A1 (en) * | 2020-07-27 | 2023-09-07 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Novel bispecific anti-cd3/cd20 polypeptide complex formulation |
US11795224B2 (en) * | 2021-03-24 | 2023-10-24 | China Medical University Hospital | Anti-T-cell nanobody and nucleic acid encoding sequence thereof, and uses of the same |
CN115536740A (zh) * | 2021-06-30 | 2022-12-30 | 苏州方德门达新药开发有限公司 | 介导细胞内有效滞留cd3的空间构象表位及其应用 |
CN115558023A (zh) * | 2021-07-02 | 2023-01-03 | 安源医药科技(上海)有限公司 | 抗cd3抗体及其用途 |
WO2023173258A1 (zh) * | 2022-03-14 | 2023-09-21 | 成都盛世君联生物技术有限公司 | 一种抗cd3抗体及其制备方法和用途 |
CN115286715B (zh) * | 2022-05-18 | 2023-05-23 | 上海百英生物科技股份有限公司 | 一种抗cd3的纳米抗体或其抗原结合部分及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020142000A1 (en) | 1999-01-15 | 2002-10-03 | Digan Mary Ellen | Anti-CD3 immunotoxins and therapeutic uses therefor |
CA2625440C (en) | 2005-10-11 | 2023-06-13 | Micromet Ag | Compositions comprising cross-species-specific antibodies and uses thereof |
CA2682626A1 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific bispecific binders |
JP2010524851A (ja) * | 2007-04-03 | 2010-07-22 | マイクロメット アーゲー | 種間特異的結合ドメイン |
WO2011109588A1 (en) | 2010-03-03 | 2011-09-09 | Health Research Inc. | Novel cd3 epsilon immunogens and antibodies |
SG11201509361TA (en) | 2013-05-28 | 2015-12-30 | Numab Ag | Novel antibodies |
PL3192812T3 (pl) | 2013-12-17 | 2020-10-19 | Genentech, Inc. | Przeciwciała anty-CD3 i sposoby ich zastosowania |
CN106459201A (zh) | 2014-05-28 | 2017-02-22 | 豪夫迈·罗氏有限公司 | 结合人和食蟹猴CD3ε的抗体 |
EP3204415B1 (en) * | 2014-10-09 | 2020-06-17 | EngMab Sàrl | Bispecific antibodies against cd3epsilon and ror1 |
EP4039710A3 (en) | 2015-01-23 | 2022-10-19 | Sanofi | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
-
2018
- 2018-09-20 MX MX2020003087A patent/MX2020003087A/es unknown
- 2018-09-20 EA EA202090800A patent/EA202090800A1/ru unknown
- 2018-09-20 KR KR1020207011016A patent/KR20200055052A/ko not_active Application Discontinuation
- 2018-09-20 US US16/649,149 patent/US11440962B2/en active Active
- 2018-09-20 SG SG11202001358RA patent/SG11202001358RA/en unknown
- 2018-09-20 WO PCT/CN2018/106618 patent/WO2019057099A1/en active Application Filing
- 2018-09-20 CN CN202211326811.1A patent/CN115991777A/zh active Pending
- 2018-09-20 CN CN201880056557.3A patent/CN111108119B/zh active Active
- 2018-09-20 EP EP18859373.5A patent/EP3684806A4/en active Pending
- 2018-09-20 CA CA3074130A patent/CA3074130A1/en active Pending
- 2018-09-20 AU AU2018336519A patent/AU2018336519A1/en active Pending
- 2018-09-20 JP JP2020516462A patent/JP7305624B2/ja active Active
- 2018-09-20 BR BR112020004992-1A patent/BR112020004992A2/pt unknown
- 2018-09-20 TW TW107133192A patent/TWI820041B/zh active
-
2020
- 2020-02-28 ZA ZA2020/01314A patent/ZA202001314B/en unknown
- 2020-03-18 IL IL273393A patent/IL273393A/en unknown
-
2022
- 2022-08-02 US US17/816,732 patent/US20230192850A1/en active Pending
-
2023
- 2023-06-28 JP JP2023105809A patent/JP2023126851A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2018336519A1 (en) | 2020-03-05 |
US11440962B2 (en) | 2022-09-13 |
IL273393A (en) | 2020-05-31 |
US20230192850A1 (en) | 2023-06-22 |
EP3684806A4 (en) | 2021-09-22 |
CN111108119B (zh) | 2022-11-15 |
NZ762170A (en) | 2023-10-27 |
KR20200055052A (ko) | 2020-05-20 |
WO2019057099A1 (en) | 2019-03-28 |
BR112020004992A2 (pt) | 2020-10-06 |
CN115991777A (zh) | 2023-04-21 |
US20200299384A1 (en) | 2020-09-24 |
ZA202001314B (en) | 2021-08-25 |
CA3074130A1 (en) | 2019-03-28 |
EP3684806A1 (en) | 2020-07-29 |
SG11202001358RA (en) | 2020-03-30 |
TWI820041B (zh) | 2023-11-01 |
TW201922787A (zh) | 2019-06-16 |
MX2020003087A (es) | 2020-08-17 |
JP2023126851A (ja) | 2023-09-12 |
CN111108119A (zh) | 2020-05-05 |
JP2020534830A (ja) | 2020-12-03 |
JP7305624B2 (ja) | 2023-07-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA202090800A1 (ru) | Новые анти-cd3-эпсилон антитела | |
AR111630A1 (es) | ANTICUERPOS ANTI-SIRPa | |
EA201991577A1 (ru) | Новые антитела против рецептора трансферрина человека, способные преодолевать гематоэнцефалический барьер | |
NZ630610A (en) | Tau peptides, anti-tau antibodies, and methods of use thereof | |
EA201792184A1 (ru) | Антитела, направленные против т-клеточного иммуноглобулина и белка муцина 3 (tim-3) | |
AR106184A1 (es) | Proteínas de unión a pd-1 y sus métodos de uso | |
AR052959A1 (es) | Anticuerpos anti- ccr5 y usos de los mismos | |
EA034770B8 (ru) | Человеческие антитела к pd-1 | |
NZ628528A (en) | Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof | |
PE20190737A1 (es) | Anticuerpos anti-cd27 | |
MX2022002111A (es) | Novedosos anticuerpos anti-cldn18.2. | |
RS54452B1 (en) | INGREDIENTS AND PROCEDURES FOR DIAGNOSIS AND TREATMENT OF CANCER | |
EA201490053A1 (ru) | Антитела, которые связываются с ox40, и их применение | |
EA202091130A1 (ru) | Лиофилизованный препарат моноклонального антитела к транстиретину | |
WO2020014473A8 (en) | TGFβ1 INHIBITORS AND USE THEREOF | |
CY1123275T1 (el) | Μορια συνδεσης ειδικα για il-21 και χρησεις αυτων | |
AR096601A1 (es) | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso | |
CL2018003608A1 (es) | Anticuerpo aislado o fragmento de unión a antígeno del mismo que se une específicamente interleucina-25 hjumana (il-2525); composición farmacéutica que lo comprende; uso de dicha composición farmacéutica para tratar una enfermedad o trastorno asociado con la actividad o expresión de il-25. (divisional solicitud 201700703) | |
NZ728981A (en) | Anti-ceramide antibodies | |
MX2021002690A (es) | Anticuerpos anti-avb8 y composiciones y usos de los mismos. | |
PH12021550244A1 (en) | Anti-btla antibody | |
MX2020003093A (es) | Anticuerpos anti-cd19 novedosos. | |
PH12017500699A1 (en) | Antibodies that bind to ccr6 and their uses | |
EA201792561A1 (ru) | Антитела, нацеленные на морфогенетический белок кости 9 (bmp9), и способы их применения | |
MX2019009498A (es) | Anticuerpos mimeticos de fgf21 y usos de los mismos. |