EP3833691A4 - Anticorps anti-pd-l1 humains - Google Patents

Anticorps anti-pd-l1 humains Download PDF

Info

Publication number
EP3833691A4
EP3833691A4 EP20796021.2A EP20796021A EP3833691A4 EP 3833691 A4 EP3833691 A4 EP 3833691A4 EP 20796021 A EP20796021 A EP 20796021A EP 3833691 A4 EP3833691 A4 EP 3833691A4
Authority
EP
European Patent Office
Prior art keywords
antibodies
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20796021.2A
Other languages
German (de)
English (en)
Other versions
EP3833691A1 (fr
Inventor
Lei Fang
Yuanyuan Yang
Zhengyi WANG
Bingshi GUO
Feifei CUI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
I Mab Biopharma Co Ltd
Original Assignee
I Mab Biopharma US Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I Mab Biopharma US Ltd filed Critical I Mab Biopharma US Ltd
Publication of EP3833691A1 publication Critical patent/EP3833691A1/fr
Publication of EP3833691A4 publication Critical patent/EP3833691A4/fr
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
EP20796021.2A 2019-04-26 2020-04-26 Anticorps anti-pd-l1 humains Pending EP3833691A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2019084468 2019-04-26
PCT/CN2020/087019 WO2020216379A1 (fr) 2019-04-26 2020-04-26 Anticorps anti-pd-l1 humains

Publications (2)

Publication Number Publication Date
EP3833691A1 EP3833691A1 (fr) 2021-06-16
EP3833691A4 true EP3833691A4 (fr) 2022-05-18

Family

ID=72940614

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20796021.2A Pending EP3833691A4 (fr) 2019-04-26 2020-04-26 Anticorps anti-pd-l1 humains

Country Status (14)

Country Link
US (1) US11208486B2 (fr)
EP (1) EP3833691A4 (fr)
JP (1) JP7212990B2 (fr)
KR (1) KR20210070323A (fr)
CN (1) CN112996815B (fr)
AU (1) AU2020261961B2 (fr)
BR (1) BR112021005365A2 (fr)
CA (1) CA3112681A1 (fr)
EA (1) EA202190495A1 (fr)
IL (1) IL281397B (fr)
MX (1) MX2021004897A (fr)
SG (1) SG11202103000WA (fr)
WO (1) WO2020216379A1 (fr)
ZA (1) ZA202101523B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023187460A1 (fr) * 2022-04-01 2023-10-05 Mabtree Biologics Ag Anticorps humain ou fragment de liaison à l'antigène de celui-ci spécifique contre pd-l1 pour améliorer la fonction des lymphocytes t

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010077634A1 (fr) * 2008-12-09 2010-07-08 Genentech, Inc. Anticorps anti-pd-l1 et leur utilisation pour améliorer la fonction des lymphocytes t
WO2013079174A1 (fr) * 2011-11-28 2013-06-06 Merck Patent Gmbh Anticorps anti-pd-l1 et utilisations associées
WO2018178122A1 (fr) * 2017-03-29 2018-10-04 Glycotope Gmbh Anticorps pd-l1 et ta-muc1

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6420140B1 (en) 1996-10-11 2002-07-16 Abgenix, Inc. Production of multimeric protein by cell fusion method
CN115093480A (zh) 2012-05-31 2022-09-23 索伦托药业有限公司 与pd-l1结合的抗原结合蛋白
WO2014055897A2 (fr) * 2012-10-04 2014-04-10 Dana-Farber Cancer Institute, Inc. Anticorps monoclonaux humains anti pd-l1 et procédés d'utilisation
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
CN105777906B (zh) * 2014-12-19 2019-04-23 苏州丁孚靶点生物技术有限公司 抗pd-l1全人抗体及其应用
JP6983371B2 (ja) * 2015-11-17 2021-12-17 スーヂョウ サンケイディア バイオファーマスーティカルズ カンパニー リミテッド 抗ｐｄ−ｌ１抗体、その抗原結合フラグメントおよびその医療用途
CN106939047B (zh) * 2016-01-04 2021-08-31 江苏怀瑜药业有限公司 一种pd-l1抗体及其制备方法
US10590199B2 (en) 2016-06-29 2020-03-17 Checkpoint Therapeutics, Inc. PD-L1-specific antibodies and methods of using the same
TWI829628B (zh) * 2016-12-19 2024-01-21 瑞士商赫孚孟拉羅股份公司 與靶向4-1bb (cd137)促效劑併用之組合療法
CN110856446A (zh) * 2017-04-18 2020-02-28 阿法姆海外股份有限公司 抗pd-l1抗体及其用途
EP3649154A1 (fr) * 2017-07-06 2020-05-13 Merus N.V. Molécules de liaison permettant de moduler l'activité biologique exprimée par une cellule
CN111225926A (zh) * 2017-10-10 2020-06-02 努玛治疗有限公司 靶向pdl1的抗体及其使用方法
CA3092421A1 (fr) * 2018-03-01 2019-09-06 Vrije Universiteit Brussel Immunoglobulines se liant au pd-l1 humain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010077634A1 (fr) * 2008-12-09 2010-07-08 Genentech, Inc. Anticorps anti-pd-l1 et leur utilisation pour améliorer la fonction des lymphocytes t
WO2013079174A1 (fr) * 2011-11-28 2013-06-06 Merck Patent Gmbh Anticorps anti-pd-l1 et utilisations associées
WO2018178122A1 (fr) * 2017-03-29 2018-10-04 Glycotope Gmbh Anticorps pd-l1 et ta-muc1

Also Published As

Publication number Publication date
CN112996815A (zh) 2021-06-18
US20210309747A1 (en) 2021-10-07
JP7212990B2 (ja) 2023-01-26
EA202190495A1 (ru) 2022-02-03
CN112996815B (zh) 2024-02-20
WO2020216379A1 (fr) 2020-10-29
US11208486B2 (en) 2021-12-28
ZA202101523B (en) 2022-06-29
AU2020261961A1 (en) 2021-04-22
IL281397B (en) 2022-04-01
EP3833691A1 (fr) 2021-06-16
JP2022511311A (ja) 2022-01-31
MX2021004897A (es) 2021-06-18
KR20210070323A (ko) 2021-06-14
IL281397A (en) 2021-04-29
CA3112681A1 (fr) 2020-10-29
AU2020261961B2 (en) 2022-07-07
BR112021005365A2 (pt) 2021-11-16
SG11202103000WA (en) 2021-04-29

Similar Documents

Publication Publication Date Title
EP3986936A4 (fr) Anticorps anti-tigit
EP3880239A4 (fr) ANTICORPS SIRPalpha THÉRAPEUTIQUES
EP3824096A4 (fr) Nouveaux anticorps et leurs procédés de préparation et d'utilisation
EP3918323A4 (fr) Anticorps anti-gal3 et leurs utilisations
EP3997127A4 (fr) Anticorps ciblant la dll3 et leurs utilisations
EP3746120A4 (fr) Anticorps anti-pd-1
EP3962956A4 (fr) Anticorps anti-hvem et leur utilisation
AU2019361253A1 (en) Anti-synuclein antibodies
EP3962954A4 (fr) Anticorps anti-galectine-9 et leurs utilisations
EP4025609A4 (fr) Anticorps anti-steap1 et leurs utilisations
EP4001308A4 (fr) Anticorps anti-tigit et leur application
EP3768724A4 (fr) Nouveaux anticorps anti-pd-1
EP3986462A4 (fr) Anticorps anti-tim-3
EP4029878A4 (fr) Anticorps monoclonal humain ciblant ykl-40
EP3995582A4 (fr) Anticorps anti-epha4
EP4018998A4 (fr) Produit cosmétique
EP3852779A4 (fr) Anticorps anti-klrg1
EP3870222A4 (fr) Anticorps anti-vih
EP3837286A4 (fr) Anticorps dirigés contre znt8 humain
EP4010368A4 (fr) Anticorps anti-nampt et leurs utilisations
EP4037703A4 (fr) Formulations d'anticorps anti-connexine
EP3947462A4 (fr) Anticorps anti-galectine-9 et leurs utilisations
EP3917965A4 (fr) Nouveaux anticorps anti-ifnar1
EP3949801A4 (fr) Ensemble cosmétique
EP3829606A4 (fr) Anticorps anti-cd79 et leurs utilisations

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210312

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

A4 Supplementary search report drawn up and despatched

Effective date: 20220420

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 39/00 20060101ALI20220412BHEP

Ipc: A61K 39/395 20060101ALI20220412BHEP

Ipc: G01N 33/68 20060101ALI20220412BHEP

Ipc: C12P 21/02 20060101ALI20220412BHEP

Ipc: C12N 15/13 20060101ALI20220412BHEP

Ipc: C07K 16/28 20060101AFI20220412BHEP

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230418

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: I-MAB BIOPHARMA CO., LTD.

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20240409