EA202090995A1 - Полициклические амиды в качестве положительных аллостерических модуляторов мускариновых рецепторов м1 - Google Patents

Полициклические амиды в качестве положительных аллостерических модуляторов мускариновых рецепторов м1

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Publication number
EA202090995A1
EA202090995A1 EA202090995A EA202090995A EA202090995A1 EA 202090995 A1 EA202090995 A1 EA 202090995A1 EA 202090995 A EA202090995 A EA 202090995A EA 202090995 A EA202090995 A EA 202090995A EA 202090995 A1 EA202090995 A1 EA 202090995A1
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EA
Eurasian Patent Office
Prior art keywords
positive allosteric
allosteric modulators
receptors
muscarine receptors
polycyclic
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EA202090995A
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English (en)
Inventor
Рамакришна Нироджи
Абдул Рашид Мохаммед
Анил Карбхари Схинде
Шанкар Редди Гаггинапалли
Дурга Маллешвари Канчарла
Сантош Кумар Пандей
Ренни Абрахам
Венкатесварлу Джасти
Original Assignee
Сувен Лайф Сайенсиз Лимитед
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Application filed by Сувен Лайф Сайенсиз Лимитед filed Critical Сувен Лайф Сайенсиз Лимитед
Publication of EA202090995A1 publication Critical patent/EA202090995A1/ru

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Chemical & Material Sciences (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к соединениям формулы (I) или к их изотопным формам, стереоизомерам, таутомерам или фармацевтически приемлемой соли (солям) в качестве положительных аллостерических модуляторов мускариновых рецепторов M1 (M1 PAM). Настоящее изобретение описывает получение, фармацевтическую композицию и применение соединения формулы (I)
EA202090995A 2017-10-27 2018-10-26 Полициклические амиды в качестве положительных аллостерических модуляторов мускариновых рецепторов м1 EA202090995A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741038173 2017-10-27
PCT/IB2018/058372 WO2019082140A1 (en) 2017-10-27 2018-10-26 POLYCYCLIC AMIDES AS POSITIVE ALLOSTERIC MODULATORS OF M1 MUSCARINIC RECEPTOR

Publications (1)

Publication Number Publication Date
EA202090995A1 true EA202090995A1 (ru) 2020-07-15

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EA202090995A EA202090995A1 (ru) 2017-10-27 2018-10-26 Полициклические амиды в качестве положительных аллостерических модуляторов мускариновых рецепторов м1

Country Status (16)

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US (1) US11278530B2 (ru)
EP (1) EP3700895B1 (ru)
JP (1) JP7110338B2 (ru)
KR (1) KR102406885B1 (ru)
CN (1) CN111278814B (ru)
AU (1) AU2018354969B2 (ru)
BR (1) BR112020008050A2 (ru)
CA (1) CA3078164C (ru)
EA (1) EA202090995A1 (ru)
IL (1) IL273885B (ru)
MA (1) MA50464A (ru)
MX (1) MX2020004339A (ru)
NZ (1) NZ763341A (ru)
SG (1) SG11202003471XA (ru)
WO (1) WO2019082140A1 (ru)
ZA (1) ZA202002058B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017220539A1 (de) 2017-11-17 2019-05-23 Zf Friedrichshafen Ag Verfahren zum Betreiben eines Systems aus einem landwirtschaftlichen Arbeitsfahrzeug und zumindest einem an diesem angeordneten Arbeitsgerät
WO2020067456A1 (ja) * 2018-09-28 2020-04-02 武田薬品工業株式会社 複素環化合物
EP3858823A4 (en) * 2018-09-28 2022-07-06 Takeda Pharmaceutical Company Limited CONDENSED CYCLIC COMPOUND

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8754220B2 (en) * 2009-11-20 2014-06-17 Merck Sharp & Dohme Corp. Quinolizidinone carboxamide M1 receptor positive allosteric modulators
PL2512243T3 (pl) 2009-12-17 2016-09-30 Pozytywne modulatory allosteryczne receptora amidu chinoliny m1
WO2011149801A1 (en) * 2010-05-28 2011-12-01 Merck Sharp & Dohme Corp. Naphthalene carboxamide m1 receptor positive allosteric modulators
US8815902B2 (en) * 2010-06-15 2014-08-26 Merck Sharp & Dohme Corp. Tetrahydroquinoline amide M1 receptor positive allosteric modulators
JP6211509B2 (ja) * 2012-03-02 2017-10-11 武田薬品工業株式会社 複素環化合物およびその用途
TW201512197A (zh) * 2013-08-30 2015-04-01 Hoffmann La Roche 吡咯并吡啶或吡唑并吡啶衍生物
GB201317363D0 (en) * 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
WO2015080904A1 (en) * 2013-11-27 2015-06-04 Vanderbilt University Substituted 4-benzyl-3,4-dihydro-2h-benzo[b][1,4]oxazine-2carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor m1
CA2930961A1 (en) * 2014-01-22 2015-07-30 F. Hoffmann-La Roche Ag Fluoro-naphthyl derivatives
WO2016009297A1 (en) 2014-07-18 2016-01-21 Pfizer Inc. Pyridine derivatives as muscarinic m1 receptor positive allosteric modulators
DK3303331T3 (en) 2015-06-08 2019-04-23 Suven Life Sciences Ltd MUSCARIN M1 RECEPTOR-POSITIVE ALLOSTER MODULATORS
DK3347349T3 (da) 2015-09-10 2019-10-28 Suven Life Sciences Ltd Fluorindolderivater som muskarin m1-receptor-positive allosteriske modulatorer
WO2017123482A1 (en) 2016-01-14 2017-07-20 Merck Sharp & Dohme Corp. Dihydropyrido quinazoline m1 receptor positive allosteric modulators
EP3416639B1 (en) * 2016-02-16 2022-06-08 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1
WO2017155816A1 (en) * 2016-03-09 2017-09-14 Merck Sharp & Dohme Corp. Quinazoline compounds useful as m1 receptor positive allosteric modulators
JP6860551B2 (ja) 2016-03-11 2021-04-14 武田薬品工業株式会社 芳香環化合物
ES2824495T3 (es) * 2016-09-02 2021-05-12 Suven Life Sciences Ltd Moduladores alostéricos positivos del receptor muscarínico M1
US10899759B2 (en) * 2016-09-30 2021-01-26 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M1
PT3643718T (pt) * 2017-06-20 2023-10-26 Takeda Pharmaceuticals Co Composto heterocíclico e seu uso como modulador alostérico positivo do recetor muscarínico colinérgico m1
BR112020007606A2 (pt) * 2017-10-18 2020-09-29 Suven Life Sciences Limited composto, composição farmacêutica, uso do composto e da composição farmacêutica e combinação
EA202191046A1 (ru) * 2018-10-17 2021-07-12 Сувен Лайф Сайенсиз Лимитед Производные пирролопиридазина, как позитивные аллостерические модуляторы мускаринового рецептора m1
US20200131180A1 (en) * 2018-10-24 2020-04-30 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1
US20200131159A1 (en) * 2018-10-24 2020-04-30 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m1

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