EA202090925A1 - Гетероарильные соединения в качестве позитивных аллостерических модуляторов мускаринового рецептора m1 - Google Patents
Гетероарильные соединения в качестве позитивных аллостерических модуляторов мускаринового рецептора m1Info
- Publication number
- EA202090925A1 EA202090925A1 EA202090925A EA202090925A EA202090925A1 EA 202090925 A1 EA202090925 A1 EA 202090925A1 EA 202090925 A EA202090925 A EA 202090925A EA 202090925 A EA202090925 A EA 202090925A EA 202090925 A1 EA202090925 A1 EA 202090925A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- positive allosteric
- allosteric modulators
- heteroaryl compounds
- muscarine receptor
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Настоящее изобретение относится к соединениям формулы (I) или их изотопным формам, стереоизомерам, таутомерам или фармацевтически приемлемой соли (солям) в качестве позитивных аллостерических модуляторов мускаринового рецептора M1 (M1 PAMs). В настоящем изобретении описаны получение, фармацевтическая композиция и применение соединения формулы (I)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201741037090 | 2017-10-18 | ||
PCT/IB2018/058047 WO2019077517A1 (en) | 2017-10-18 | 2018-10-17 | HETEROARYL COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF M1 MUSCARINIC RECEPTOR |
Publications (2)
Publication Number | Publication Date |
---|---|
EA202090925A1 true EA202090925A1 (ru) | 2020-07-13 |
EA039781B1 EA039781B1 (ru) | 2022-03-14 |
Family
ID=64277732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090925A EA039781B1 (ru) | 2017-10-18 | 2018-10-17 | Гетероарильные соединения в качестве позитивных аллостерических модуляторов мускаринового рецептора m1 |
Country Status (16)
Country | Link |
---|---|
US (1) | US11234979B2 (ru) |
EP (1) | EP3697790B1 (ru) |
JP (1) | JP7104783B2 (ru) |
KR (1) | KR102438588B1 (ru) |
CN (1) | CN111212840B (ru) |
AU (1) | AU2018353544B2 (ru) |
BR (1) | BR112020007606A2 (ru) |
CA (1) | CA3076757C (ru) |
EA (1) | EA039781B1 (ru) |
IL (1) | IL273748B (ru) |
MA (1) | MA50402A (ru) |
MX (1) | MX2020003832A (ru) |
NZ (1) | NZ764004A (ru) |
SG (1) | SG11202003284RA (ru) |
WO (1) | WO2019077517A1 (ru) |
ZA (1) | ZA202002034B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020008050A2 (pt) | 2017-10-27 | 2020-11-03 | Suven Life Sciences Limited | composto modulador alostérico positivo de receptor muscarínico m1, composição farmacêutica compreendendo o referido composto, uso dos mesmos e combinação |
EA202191046A1 (ru) * | 2018-10-17 | 2021-07-12 | Сувен Лайф Сайенсиз Лимитед | Производные пирролопиридазина, как позитивные аллостерические модуляторы мускаринового рецептора m1 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8754220B2 (en) | 2009-11-20 | 2014-06-17 | Merck Sharp & Dohme Corp. | Quinolizidinone carboxamide M1 receptor positive allosteric modulators |
TW201512197A (zh) | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | 吡咯并吡啶或吡唑并吡啶衍生物 |
WO2015044072A1 (en) * | 2013-09-27 | 2015-04-02 | F. Hoffmann-La Roche Ag | Indol and indazol derivatives |
GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
US10221175B2 (en) | 2015-04-24 | 2019-03-05 | Vanderbilt University | Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1 |
DK3303331T3 (en) | 2015-06-08 | 2019-04-23 | Suven Life Sciences Ltd | MUSCARIN M1 RECEPTOR-POSITIVE ALLOSTER MODULATORS |
DK3347349T3 (da) | 2015-09-10 | 2019-10-28 | Suven Life Sciences Ltd | Fluorindolderivater som muskarin m1-receptor-positive allosteriske modulatorer |
-
2018
- 2018-10-17 BR BR112020007606-6A patent/BR112020007606A2/pt unknown
- 2018-10-17 EA EA202090925A patent/EA039781B1/ru unknown
- 2018-10-17 KR KR1020207013222A patent/KR102438588B1/ko active IP Right Grant
- 2018-10-17 US US16/753,183 patent/US11234979B2/en active Active
- 2018-10-17 CA CA3076757A patent/CA3076757C/en active Active
- 2018-10-17 WO PCT/IB2018/058047 patent/WO2019077517A1/en unknown
- 2018-10-17 AU AU2018353544A patent/AU2018353544B2/en active Active
- 2018-10-17 MA MA050402A patent/MA50402A/fr unknown
- 2018-10-17 JP JP2020520490A patent/JP7104783B2/ja active Active
- 2018-10-17 MX MX2020003832A patent/MX2020003832A/es unknown
- 2018-10-17 CN CN201880066720.4A patent/CN111212840B/zh active Active
- 2018-10-17 NZ NZ764004A patent/NZ764004A/en unknown
- 2018-10-17 SG SG11202003284RA patent/SG11202003284RA/en unknown
- 2018-10-17 EP EP18801031.8A patent/EP3697790B1/en active Active
-
2020
- 2020-04-01 IL IL273748A patent/IL273748B/en unknown
- 2020-05-04 ZA ZA2020/02034A patent/ZA202002034B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2021500323A (ja) | 2021-01-07 |
MA50402A (fr) | 2021-05-19 |
CA3076757A1 (en) | 2019-04-25 |
IL273748B (en) | 2022-06-01 |
NZ764004A (en) | 2023-03-31 |
MX2020003832A (es) | 2020-08-06 |
BR112020007606A2 (pt) | 2020-09-29 |
WO2019077517A1 (en) | 2019-04-25 |
AU2018353544B2 (en) | 2020-09-17 |
KR102438588B1 (ko) | 2022-08-31 |
JP7104783B2 (ja) | 2022-07-21 |
US11234979B2 (en) | 2022-02-01 |
EP3697790A1 (en) | 2020-08-26 |
CN111212840A (zh) | 2020-05-29 |
US20200237761A1 (en) | 2020-07-30 |
KR20200069330A (ko) | 2020-06-16 |
CN111212840B (zh) | 2022-07-22 |
EA039781B1 (ru) | 2022-03-14 |
AU2018353544A1 (en) | 2020-04-16 |
CA3076757C (en) | 2022-10-11 |
SG11202003284RA (en) | 2020-05-28 |
ZA202002034B (en) | 2021-05-26 |
EP3697790B1 (en) | 2023-01-18 |
IL273748A (en) | 2020-05-31 |
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