EA201990410A1 - Производные имидазола и их применение в лечении аутоиммунных или воспалительных заболеваний или раковых заболеваний - Google Patents

Производные имидазола и их применение в лечении аутоиммунных или воспалительных заболеваний или раковых заболеваний

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Publication number
EA201990410A1
EA201990410A1 EA201990410A EA201990410A EA201990410A1 EA 201990410 A1 EA201990410 A1 EA 201990410A1 EA 201990410 A EA201990410 A EA 201990410A EA 201990410 A EA201990410 A EA 201990410A EA 201990410 A1 EA201990410 A1 EA 201990410A1
Authority
EA
Eurasian Patent Office
Prior art keywords
autoimmune
treatment
diseases
application
imidazole derivatives
Prior art date
Application number
EA201990410A
Other languages
English (en)
Inventor
Эндрю Бакстер
Джон Александер Браун
Дэвид Хёрст
Филип Хамфрис
Кэтрин Луис Джонс
Випулкумар Кантибхай Пател
Original Assignee
Глаксосмитклайн Интеллекчуал Проперти (№ 2) Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Глаксосмитклайн Интеллекчуал Проперти (№ 2) Лимитед filed Critical Глаксосмитклайн Интеллекчуал Проперти (№ 2) Лимитед
Publication of EA201990410A1 publication Critical patent/EA201990410A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

Соединения формулы (I) и их соли:где R, R, Rи a являются такими, как определено в настоящей заявке. Соединения формулы (I) и их соли, как было обнаружено, ингибируют связывание содержащих бромодомены белков BET семейства, например, с ацетилированными остатками лизина и поэтому могут иметь применение в терапии, например в лечении аутоиммунных и воспалительных заболеваний, таких как ревматоидный артрит; и раковых заболеваний.
EA201990410A 2016-09-02 2017-08-31 Производные имидазола и их применение в лечении аутоиммунных или воспалительных заболеваний или раковых заболеваний EA201990410A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1614934.6A GB201614934D0 (en) 2016-09-02 2016-09-02 Chemical compounds
PCT/EP2017/071868 WO2018041947A1 (en) 2016-09-02 2017-08-31 Imidazole derivatives and their use in the treatment of autoimmune or inflammatory diseases or cancers

Publications (1)

Publication Number Publication Date
EA201990410A1 true EA201990410A1 (ru) 2019-09-30

Family

ID=57140084

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990410A EA201990410A1 (ru) 2016-09-02 2017-08-31 Производные имидазола и их применение в лечении аутоиммунных или воспалительных заболеваний или раковых заболеваний

Country Status (24)

Country Link
US (1) US20190175571A1 (ru)
EP (1) EP3507283A1 (ru)
JP (1) JP2019526577A (ru)
KR (1) KR20190042701A (ru)
CN (1) CN109790147A (ru)
AR (1) AR109487A1 (ru)
AU (1) AU2017317724A1 (ru)
BR (1) BR112019004241A2 (ru)
CA (1) CA3035312A1 (ru)
CL (1) CL2019000538A1 (ru)
CO (1) CO2019001871A2 (ru)
CR (1) CR20190106A (ru)
DO (1) DOP2019000047A (ru)
EA (1) EA201990410A1 (ru)
GB (1) GB201614934D0 (ru)
JO (1) JOP20190029A1 (ru)
MA (1) MA46085A (ru)
MX (1) MX2019002491A (ru)
PE (1) PE20190478A1 (ru)
PH (1) PH12019500460A1 (ru)
SG (1) SG11201901673SA (ru)
TW (1) TW201817724A (ru)
UY (1) UY37393A (ru)
WO (1) WO2018041947A1 (ru)

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CR20190101A (es) 2016-09-02 2019-07-04 Ironwood Pharmaceuticals Inc Estimuladores de sgc
CN111686107B (zh) * 2020-07-16 2021-06-08 中国农业科学院兰州兽医研究所 化合物plx51107用于制备预防或治疗非洲猪瘟药物的新用途
CN111588725B (zh) * 2020-07-16 2021-06-08 中国农业科学院兰州兽医研究所 化合物arv-825用于制备预防或治疗非洲猪瘟药物的新用途
CN111588721B (zh) * 2020-07-16 2021-06-08 中国农业科学院兰州兽医研究所 化合物zl0580用于制备预防或治疗非洲猪瘟药物的新用途
CN111686114B (zh) * 2020-07-16 2021-06-08 中国农业科学院兰州兽医研究所 化合物i-bet-762用于制备预防或治疗非洲猪瘟药物的新用途
WO2024018423A1 (en) * 2022-07-21 2024-01-25 Tay Therapeutics Limited Pyrroles and imidazoles as bet protein inhibitors
CN117257964B (zh) * 2023-10-25 2024-04-02 苏州大学 基于碳酸氢铵的微波诱导吲哚美辛原位无定形化增溶技术

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Also Published As

Publication number Publication date
TW201817724A (zh) 2018-05-16
PH12019500460A1 (en) 2019-12-16
WO2018041947A1 (en) 2018-03-08
UY37393A (es) 2018-03-23
JOP20190029A1 (ar) 2019-02-25
JP2019526577A (ja) 2019-09-19
EP3507283A1 (en) 2019-07-10
PE20190478A1 (es) 2019-04-04
US20190175571A1 (en) 2019-06-13
CL2019000538A1 (es) 2019-05-17
CO2019001871A2 (es) 2019-03-08
CA3035312A1 (en) 2018-03-08
MX2019002491A (es) 2019-07-08
SG11201901673SA (en) 2019-03-28
DOP2019000047A (es) 2019-03-15
GB201614934D0 (en) 2016-10-19
CN109790147A (zh) 2019-05-21
KR20190042701A (ko) 2019-04-24
AR109487A1 (es) 2018-12-12
CR20190106A (es) 2019-05-02
BR112019004241A2 (pt) 2019-06-04
MA46085A (fr) 2019-07-10
AU2017317724A1 (en) 2019-03-21

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