EA201892278A1 - Анбитактериальные биароматические производные с оксетан-3-илокси замещением - Google Patents
Анбитактериальные биароматические производные с оксетан-3-илокси замещениемInfo
- Publication number
- EA201892278A1 EA201892278A1 EA201892278A EA201892278A EA201892278A1 EA 201892278 A1 EA201892278 A1 EA 201892278A1 EA 201892278 A EA201892278 A EA 201892278A EA 201892278 A EA201892278 A EA 201892278A EA 201892278 A1 EA201892278 A1 EA 201892278A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- anbitacterial
- oxethane
- iloxy
- substitution
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Изобретение относится к антибактериальным соединениям формулы Iв которой Uпредставляет собой N или CH, Uпредставляет собой N или CH, Uпредставляет собой N или CH, при этом понимают, что не более двух из U, U, Uмогут представлять собой N одновременно; Vпредставляет собой N или CH, Vпредставляет собой N, CH или C(OH) и Vпредставляет собой N, CH или C(OH), при этом понимают, что не более двух из V, Vи Vмогут представлять собой N одновременно; пунктирная линия "" представляет собой связь или отсутствует; X представляет собой CH или N и Q представляет собой O или S. Оно также относится к фармацевтическим композициям, содержащим эти соединения, и к применению этих соединений при изготовлении лекарственных средств для лечения бактериальных инфекций. Эти соединения представляют собой пригодные антимикробные средства, эффективные против множества патогенов у людей и животных, включая среди других грамположительные и грамотрицательные аэробные и анаэробные бактерии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2016052116 | 2016-04-14 | ||
| PCT/IB2017/052133 WO2017179002A1 (en) | 2016-04-14 | 2017-04-13 | Antibacterial biaromatic derivatives with oxetane-3-yloxy substitution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201892278A1 true EA201892278A1 (ru) | 2019-04-30 |
Family
ID=58579239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892278A EA201892278A1 (ru) | 2016-04-14 | 2017-04-13 | Анбитактериальные биароматические производные с оксетан-3-илокси замещением |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20200325154A1 (ru) |
| EP (1) | EP3442970A1 (ru) |
| JP (1) | JP2019511551A (ru) |
| KR (1) | KR20180134380A (ru) |
| CN (1) | CN108884088A (ru) |
| AR (1) | AR108108A1 (ru) |
| AU (1) | AU2017248785A1 (ru) |
| BR (1) | BR112018071101A2 (ru) |
| CA (1) | CA3020570A1 (ru) |
| EA (1) | EA201892278A1 (ru) |
| MA (1) | MA44663A (ru) |
| MX (1) | MX2018012558A (ru) |
| TW (1) | TW201738239A (ru) |
| WO (1) | WO2017179002A1 (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011003370A (es) | 2008-10-07 | 2011-04-28 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos de oxazolidinona triciclicos. |
| MA38588B1 (fr) | 2013-04-16 | 2018-04-30 | Idorsia Pharmaceuticals Ltd | Dérivés bi-aromatiques antibactériens |
| AR102256A1 (es) * | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
-
2017
- 2017-04-10 AR ARP170100914A patent/AR108108A1/es unknown
- 2017-04-13 EA EA201892278A patent/EA201892278A1/ru unknown
- 2017-04-13 JP JP2018554102A patent/JP2019511551A/ja active Pending
- 2017-04-13 CN CN201780023020.2A patent/CN108884088A/zh active Pending
- 2017-04-13 BR BR112018071101A patent/BR112018071101A2/pt not_active Application Discontinuation
- 2017-04-13 CA CA3020570A patent/CA3020570A1/en not_active Abandoned
- 2017-04-13 MX MX2018012558A patent/MX2018012558A/es unknown
- 2017-04-13 WO PCT/IB2017/052133 patent/WO2017179002A1/en active Application Filing
- 2017-04-13 MA MA044663A patent/MA44663A/fr unknown
- 2017-04-13 KR KR1020187032552A patent/KR20180134380A/ko unknown
- 2017-04-13 US US16/093,954 patent/US20200325154A1/en not_active Abandoned
- 2017-04-13 AU AU2017248785A patent/AU2017248785A1/en not_active Abandoned
- 2017-04-13 TW TW106112296A patent/TW201738239A/zh unknown
- 2017-04-13 EP EP17718618.6A patent/EP3442970A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019511551A (ja) | 2019-04-25 |
| MX2018012558A (es) | 2019-02-13 |
| KR20180134380A (ko) | 2018-12-18 |
| TW201738239A (zh) | 2017-11-01 |
| AU2017248785A1 (en) | 2018-12-06 |
| CA3020570A1 (en) | 2017-10-19 |
| BR112018071101A2 (pt) | 2019-01-29 |
| WO2017179002A1 (en) | 2017-10-19 |
| CN108884088A (zh) | 2018-11-23 |
| MA44663A (fr) | 2019-02-20 |
| US20200325154A1 (en) | 2020-10-15 |
| AR108108A1 (es) | 2018-07-18 |
| EP3442970A1 (en) | 2019-02-20 |
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