WO2009124086A3 - Antibacterial drug for treatment of staphylococcus aureus and other gram-positive bacterial infections - Google Patents

Antibacterial drug for treatment of staphylococcus aureus and other gram-positive bacterial infections Download PDF

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Publication number
WO2009124086A3
WO2009124086A3 PCT/US2009/039023 US2009039023W WO2009124086A3 WO 2009124086 A3 WO2009124086 A3 WO 2009124086A3 US 2009039023 W US2009039023 W US 2009039023W WO 2009124086 A3 WO2009124086 A3 WO 2009124086A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacterial infections
treatment
staphylococcus aureus
gram
positive bacterial
Prior art date
Application number
PCT/US2009/039023
Other languages
French (fr)
Other versions
WO2009124086A2 (en
Inventor
Dongcheng Dai
Dennis E. Hruby
Tove C. Bolken
Rebecca L. Wilson
Kevin F. Jones
Robert Jordon
Original Assignee
Siga Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siga Technologies, Inc. filed Critical Siga Technologies, Inc.
Publication of WO2009124086A2 publication Critical patent/WO2009124086A2/en
Publication of WO2009124086A3 publication Critical patent/WO2009124086A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds, methods and pharmaceutical compositions for treating bacterial infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of bacterial infections such as caused by the Staphylococcus aureus family is disclosed.
PCT/US2009/039023 2008-04-04 2009-03-31 Antibacterial drug for treatment of staphylococcus aureus and other gram-positive bacterial infections WO2009124086A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4239708P 2008-04-04 2008-04-04
US61/042,397 2008-04-04

Publications (2)

Publication Number Publication Date
WO2009124086A2 WO2009124086A2 (en) 2009-10-08
WO2009124086A3 true WO2009124086A3 (en) 2010-02-25

Family

ID=41136091

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/039023 WO2009124086A2 (en) 2008-04-04 2009-03-31 Antibacterial drug for treatment of staphylococcus aureus and other gram-positive bacterial infections

Country Status (1)

Country Link
WO (1) WO2009124086A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012149452A1 (en) * 2011-04-29 2012-11-01 Regents Of The University Of Michigan Compounds, formulations, and methods of protein kinase c inhibition
WO2013016653A1 (en) 2011-07-28 2013-01-31 Cell Signaling Technology, Inc. Multi component detection
WO2023101556A1 (en) * 2021-12-02 2023-06-08 Rijksuniversiteit Groningen Novel inhibitors of aspartate transcarbamoylase (atcase) and compositions, methods and uses related thereto.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958910A (en) * 1996-07-19 1999-09-28 Hoffmann-La Roche Inc. Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
US20070275962A1 (en) * 2003-09-10 2007-11-29 Gpc Biotech Ag Heterobicyclic Compounds as Pharmaceutically Active Agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958910A (en) * 1996-07-19 1999-09-28 Hoffmann-La Roche Inc. Use of N-(4-aryl-thiazol-2-yl)-sulfonamides
US20070275962A1 (en) * 2003-09-10 2007-11-29 Gpc Biotech Ag Heterobicyclic Compounds as Pharmaceutically Active Agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
OCHSNER ET AL.: "Mode of Action and Biochemical Characterization of REP8839, a Novel Inhibitor of Methionyl-tRNA Synthetase.", ANTIMICROB. AGENTS CHEMOTHER., vol. 49, no. 10, 2005, pages 4253 - 4262 *

Also Published As

Publication number Publication date
WO2009124086A2 (en) 2009-10-08

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