EA201891975A1 - Тиазолидные соединения для лечения вирусных инфекций - Google Patents

Тиазолидные соединения для лечения вирусных инфекций

Info

Publication number
EA201891975A1
EA201891975A1 EA201891975A EA201891975A EA201891975A1 EA 201891975 A1 EA201891975 A1 EA 201891975A1 EA 201891975 A EA201891975 A EA 201891975A EA 201891975 A EA201891975 A EA 201891975A EA 201891975 A1 EA201891975 A1 EA 201891975A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
tiazolid
treatment
viral infections
tizoxanide
Prior art date
Application number
EA201891975A
Other languages
English (en)
Other versions
EA036505B1 (ru
Inventor
Жан-Франсуа Россиньоль
Мария Габриэлла Санторо
Original Assignee
Ромарк Лабораториз Л.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ромарк Лабораториз Л.С. filed Critical Ромарк Лабораториз Л.С.
Publication of EA201891975A1 publication Critical patent/EA201891975A1/ru
Publication of EA036505B1 publication Critical patent/EA036505B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Тиазолидные соединения, такие как нитазоксанид и/или тизоксанид, можно применять против вирусов, принадлежащих к семействам Picornaviridae или Paramyxoviridae.
EA201891975A 2016-03-31 2017-03-30 Способ лечения заболевания или состояния, вызванного вирусом, принадлежащим к роду enterovirus EA036505B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662316463P 2016-03-31 2016-03-31
PCT/US2017/024976 WO2017173056A1 (en) 2016-03-31 2017-03-30 Thiazolide compounds for treating viral infections

Publications (2)

Publication Number Publication Date
EA201891975A1 true EA201891975A1 (ru) 2019-03-29
EA036505B1 EA036505B1 (ru) 2020-11-18

Family

ID=58530692

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201891975A EA036505B1 (ru) 2016-03-31 2017-03-30 Способ лечения заболевания или состояния, вызванного вирусом, принадлежащим к роду enterovirus
EA202091849A EA202091849A1 (ru) 2016-03-31 2017-03-30 Тиазолидные соединения для лечения вирусных инфекций

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202091849A EA202091849A1 (ru) 2016-03-31 2017-03-30 Тиазолидные соединения для лечения вирусных инфекций

Country Status (26)

Country Link
US (2) US11135202B2 (ru)
EP (2) EP3436074B1 (ru)
JP (2) JP6567781B2 (ru)
KR (3) KR20210035339A (ru)
CN (1) CN108289961A (ru)
AU (2) AU2017244145B2 (ru)
BR (1) BR112018069974A2 (ru)
CA (2) CA3113354A1 (ru)
CY (1) CY1123221T1 (ru)
DK (1) DK3436074T3 (ru)
EA (2) EA036505B1 (ru)
ES (1) ES2810303T3 (ru)
HK (1) HK1250945A1 (ru)
HR (1) HRP20201261T1 (ru)
HU (1) HUE050601T2 (ru)
IL (2) IL262018A (ru)
LT (1) LT3436074T (ru)
MX (1) MX2021004464A (ru)
PH (1) PH12018502058A1 (ru)
PL (1) PL3436074T3 (ru)
PT (1) PT3436074T (ru)
SG (1) SG11201808453UA (ru)
SI (1) SI3436074T1 (ru)
UA (1) UA126114C2 (ru)
WO (1) WO2017173056A1 (ru)
ZA (1) ZA201806644B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111012778B (zh) * 2018-10-10 2022-06-24 北京市农林科学院 Nitazoxanide在抑制犬细小病毒中的应用
CN109536460A (zh) * 2018-12-07 2019-03-29 中国医学科学院医学生物学研究所 一种cv-a10病毒毒种及其人用灭活疫苗
CN110787161B (zh) * 2019-09-19 2022-09-27 中山大学 噻唑类化合物用于抗鱼类病毒的新用途
CN111012788B (zh) * 2019-12-12 2021-01-15 武汉职业技术学院 硝唑尼特和替唑尼特在制备抗猪繁殖与呼吸综合征病毒药物中的应用
JP2023537237A (ja) 2020-07-20 2023-08-31 ロマーク ラボラトリーズ，リミティド カンパニー チゾキサニドおよび２－ヒドロキシ－ｎ－（５－クロロ－１，３－チアゾル－２－イル）ベンズアミド（ｒｍ－４８４８）とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびｎ－メチルピペラジンの結晶塩
EP4199923A1 (en) 2020-08-24 2023-06-28 Romark Laboratories, L.C. Use of thiazolides against coronaviruses
EP4337200A1 (en) * 2021-05-28 2024-03-20 Henderson, Theodore Treatment using an antiviral compound and nitazoxanide
WO2023040990A1 (zh) 2021-09-15 2023-03-23 南京强新生物医药有限公司 治疗冠状病毒感染的新联用药物、药物组合物及其用途
CN114404439B (zh) * 2022-02-11 2023-07-11 山东农业大学 抑制不同类型猪繁殖与呼吸综合症病毒感染的阻断剂

Family Cites Families (24)

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GB1437800A (en) 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
US5387598A (en) 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
US5965590A (en) 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
US5856348A (en) 1994-09-08 1999-01-05 Romark Laboratories, L.C. Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide
MX9604483A (es) 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
US5859038A (en) 1994-09-08 1999-01-12 Romark Laboratories, L.C. Method for treatment of helicobacter pylori infections
US5968961A (en) 1997-05-07 1999-10-19 Romark Laboratories, L.C. Pharmaceutical compositions of tizoxanide and nitazoxanide
US5935591A (en) 1998-01-15 1999-08-10 Romark Laboratories, L.C. Method for treatment of equine protozoal myeloencephalitis with thiazolides
US7582297B2 (en) 2003-04-11 2009-09-01 Medimmune, Llc Methods of treating respiratory conditions
UA90864C2 (en) 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
BRPI0706379A2 (pt) 2006-01-09 2011-03-22 Romark Lab Lc tratamento de hepatite viral
BRPI0815057B8 (pt) 2007-08-03 2021-05-25 Romark Laboratories Lc composto, composição farmacêutica, e, uso de um composto
GB0716292D0 (en) * 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
PL2395840T3 (pl) 2009-02-13 2020-09-07 Romark Laboratories, L.C. Preparaty farmaceutyczne nitazoksanidu o kontrolowanym uwalnianiu
SG10201402281WA (en) 2009-05-12 2014-07-30 Romark Lab Lc Haloalkyl heteroaryl benzamide compounds
CN108042535A (zh) * 2009-06-26 2018-05-18 罗马克实验室有限公司 用于治疗流感的化合物和方法
EP2585067B1 (en) * 2010-06-25 2017-08-09 Biota Scientific Management Pty Ltd Compound for the treatment of enteroviruses
JP5837936B2 (ja) 2010-11-01 2015-12-24 ロマーク ラボラトリース，エル．シー． アルキルスルフィニル置換チアゾリド化合物
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JP5904270B2 (ja) 2012-03-15 2016-04-13 トヨタ自動車株式会社 車両走行制御装置
WO2015054465A1 (en) * 2013-10-11 2015-04-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
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US10100023B2 (en) 2014-11-11 2018-10-16 Romark Laboratories, L.C. Compositions and methods of treatment with prodrugs of tizoxanide, an analogue or salt thereof

Also Published As

Publication number Publication date
JP6567781B2 (ja) 2019-08-28
KR20210035339A (ko) 2021-03-31
US11135202B2 (en) 2021-10-05
DK3436074T3 (da) 2020-08-03
LT3436074T (lt) 2020-09-25
UA126114C2 (uk) 2022-08-17
US20220125767A1 (en) 2022-04-28
ES2810303T3 (es) 2021-03-08
EP3677282A1 (en) 2020-07-08
CA3113354A1 (en) 2017-10-05
WO2017173056A1 (en) 2017-10-05
KR20180125552A (ko) 2018-11-23
US20170281603A1 (en) 2017-10-05
IL280327A (en) 2021-03-01
JP2019203014A (ja) 2019-11-28
KR20180124970A (ko) 2018-11-21
CY1123221T1 (el) 2021-10-29
HRP20201261T1 (hr) 2021-02-05
EP3436074B1 (en) 2020-06-10
IL262018A (en) 2018-10-31
AU2017244145B2 (en) 2019-08-01
AU2019236602A1 (en) 2019-10-17
EP3436074A1 (en) 2019-02-06
PH12018502058A1 (en) 2019-06-24
EA036505B1 (ru) 2020-11-18
PT3436074T (pt) 2020-08-21
PL3436074T3 (pl) 2020-11-02
KR102136803B1 (ko) 2020-07-22
HK1250945A1 (zh) 2019-01-18
BR112018069974A2 (pt) 2019-01-29
MX2021004464A (es) 2021-06-04
ZA201806644B (en) 2021-02-24
SG11201808453UA (en) 2018-10-30
HUE050601T2 (hu) 2020-12-28
KR102233826B1 (ko) 2021-03-31
EA202091849A1 (ru) 2020-12-11
CA3019326A1 (en) 2017-10-05
CN108289961A (zh) 2018-07-17
AU2017244145A1 (en) 2018-11-15
CA3019326C (en) 2021-05-25
JP2019510044A (ja) 2019-04-11
SI3436074T1 (sl) 2020-09-30

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