EA201890130A1 - Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер - Google Patents

Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер

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Publication number
EA201890130A1
EA201890130A1 EA201890130A EA201890130A EA201890130A1 EA 201890130 A1 EA201890130 A1 EA 201890130A1 EA 201890130 A EA201890130 A EA 201890130A EA 201890130 A EA201890130 A EA 201890130A EA 201890130 A1 EA201890130 A1 EA 201890130A1
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EA
Eurasian Patent Office
Prior art keywords
antibody
transferrin receptor
human transferrin
compounds
penetrating
Prior art date
Application number
EA201890130A
Other languages
English (en)
Other versions
EA039366B1 (ru
Inventor
Хироюки Сонода
Кенити Такахаси
Original Assignee
Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57585554&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201890130(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. filed Critical Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД.
Publication of EA201890130A1 publication Critical patent/EA201890130A1/ru
Publication of EA039366B1 publication Critical patent/EA039366B1/ru

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    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Abstract

Раскрыты средства для того, чтобы превращать соединения, обладающие физиологической или фармакологической активностью и неспособные проходить через гематоэнцефалический барьер, в форму, которая позволяет им проходить через гематоэнцефалический барьер, и соединения, превращенные таким образом. Средством является антитело к рецептору трансферрина человека, и превращенными соединениями являются молекулярные конъюгаты между физиологически активным белком или фармакологически активными низкомолекулярными соединениями и антителом к рецептору трансферрина человека.
EA201890130A 2015-06-24 2016-06-24 Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер EA039366B1 (ru)

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PCT/JP2016/068738 WO2016208695A1 (ja) 2015-06-24 2016-06-24 血液脳関門を通過する抗ヒトトランスフェリン受容体抗体

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