SG11201710734UA - Anti-human transferrin receptor antibody permeating blood-brain barrier - Google Patents
Anti-human transferrin receptor antibody permeating blood-brain barrierInfo
- Publication number
- SG11201710734UA SG11201710734UA SG11201710734UA SG11201710734UA SG11201710734UA SG 11201710734U A SG11201710734U A SG 11201710734UA SG 11201710734U A SG11201710734U A SG 11201710734UA SG 11201710734U A SG11201710734U A SG 11201710734UA SG 11201710734U A SG11201710734U A SG 11201710734UA
- Authority
- SG
- Singapore
- Prior art keywords
- brain barrier
- receptor antibody
- transferrin receptor
- human transferrin
- permeating
- Prior art date
Links
- 102000007238 Transferrin Receptors Human genes 0.000 title 1
- 108010033576 Transferrin Receptors Proteins 0.000 title 1
- 230000008499 blood brain barrier function Effects 0.000 title 1
- 210000001218 blood-brain barrier Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015144379 | 2015-06-24 | ||
PCT/JP2016/068738 WO2016208695A1 (en) | 2015-06-24 | 2016-06-24 | Anti-human transferrin receptor antibody permeating blood-brain barrier |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201710734UA true SG11201710734UA (en) | 2018-01-30 |
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Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114409783A (en) | 2015-06-24 | 2022-04-29 | Jcr制药股份有限公司 | Anti-human transferrin receptor antibodies across the blood brain barrier |
CN107849150B (en) | 2015-06-24 | 2021-12-14 | Jcr制药股份有限公司 | Fusion proteins comprising BDNF |
HRP20220304T1 (en) | 2015-06-24 | 2022-05-13 | F. Hoffmann - La Roche Ag | Anti-transferrin receptor antibodies with tailored affinity |
AR106189A1 (en) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE |
PE20181004A1 (en) | 2015-10-02 | 2018-06-26 | Hoffmann La Roche | BISPECIFIC ANTIBODIES AGAINST HUMAN CD20 AND THE HUMAN TRANSFERRIN RECEPTOR AND METHODS OF USE |
AU2016365834B2 (en) * | 2015-12-08 | 2023-09-28 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for internalizing enzymes |
AR110586A1 (en) * | 2016-12-26 | 2019-04-10 | Japan Chem Res | HUMAN ANTITRANSFERRINE RECEPTOR ANTIBODY THAT PENETRATES THE HEMATOENCEPHALIC BARRIER |
CN110114078B (en) | 2016-12-28 | 2024-01-30 | Jcr制药股份有限公司 | Freeze-dried preparation |
US10457717B2 (en) | 2017-02-17 | 2019-10-29 | Denali Therapeutics Inc. | Engineered polypeptides |
AU2018221731C1 (en) * | 2017-02-17 | 2021-11-18 | Denali Therapeutics Inc. | Engineered transferrin receptor binding polypeptides |
US10143187B2 (en) | 2017-02-17 | 2018-12-04 | Denali Therapeutics Inc. | Transferrin receptor transgenic models |
JP2020512836A (en) * | 2017-04-01 | 2020-04-30 | 北京韓美薬品有限公司 | Anti-PD-L1 / anti-PD-1 natural antibody structure-like heterodimer bispecific antibody and method for preparing the same |
EP3434692A1 (en) | 2017-07-24 | 2019-01-30 | Encefa | Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases |
WO2019024979A1 (en) * | 2017-07-31 | 2019-02-07 | Institute For Research In Biomedicine | Antibodies with functional domains in the elbow region |
CN111278453A (en) * | 2017-09-07 | 2020-06-12 | Jcr制药股份有限公司 | Aqueous pharmaceutical composition |
MA50746A (en) | 2017-10-02 | 2020-08-12 | Denali Therapeutics Inc | FUSION PROTEINS INCLUDING SUBSTITUTIVE ENZYMOTHERAPY ENZYMES |
BR112020013921A2 (en) * | 2018-01-10 | 2020-12-01 | Denali Therapeutics Inc. | transferrin receptor binding polypeptides and uses of these |
SG11202006433PA (en) * | 2018-02-05 | 2020-08-28 | Jcr Pharmaceuticals Co Ltd | Method for delivering drug to muscle |
CN112312922A (en) | 2018-06-21 | 2021-02-02 | 诺和诺德股份有限公司 | Novel compounds for the treatment of obesity |
WO2020022499A1 (en) | 2018-07-27 | 2020-01-30 | 国立大学法人大阪大学 | Composition for inhibiting aging, preventing, improving, or treating age-related diseases, or extending lifespan |
WO2020037150A2 (en) | 2018-08-16 | 2020-02-20 | Denali Therapeutics Inc. | Engineered bispecific proteins |
JP2022501319A (en) * | 2018-09-25 | 2022-01-06 | アカデミア シニカAcademia Sinica | Anti-Siglec antibody, pharmaceutical composition comprising it and its use |
KR20200047937A (en) * | 2018-10-26 | 2020-05-08 | 재단법인 목암생명과학연구소 | Fusion protein comprising ids and use thereof |
TW202029980A (en) * | 2018-10-26 | 2020-08-16 | 美商免疫遺傳股份有限公司 | Epcam antibodies, activatable antibodies, and immunoconjugates, and uses thereof |
US20220332838A1 (en) * | 2018-11-20 | 2022-10-20 | Perseus Proteomics Inc. | Agent for inhibiting iron uptake into cells |
CN111518791B (en) * | 2018-11-27 | 2021-11-23 | 江南大学 | Sucrose hydrolase mutant and preparation method and application thereof |
JP2022516660A (en) * | 2019-01-08 | 2022-03-01 | アーマジェン・インコーポレイテッド | Methods and compositions for increasing galactosidase β-1 activity in CNS |
CN113474369A (en) | 2019-01-09 | 2021-10-01 | 维克塔-霍洛斯公司 | Transferrin receptor binding molecules, conjugates thereof, and uses thereof |
BR112021014574A2 (en) | 2019-01-23 | 2021-10-05 | Encefa | CD31 COMPETITORS AND USES THEREOF |
KR20220130678A (en) | 2019-12-23 | 2022-09-27 | 데날리 테라퓨틱스 인크. | progranulin variants |
JPWO2021167107A1 (en) | 2020-02-22 | 2021-08-26 | ||
PE20231931A1 (en) | 2020-10-14 | 2023-12-01 | Denali Therapeutics Inc | FUSION PROTEINS COMPRISING SULFOGLUCOSAMINE SULFOHYDROLASE ENZYMES AND METHODS THEREOF |
WO2022153957A1 (en) | 2021-01-12 | 2022-07-21 | Jcrファーマ株式会社 | Nucleic acid molecule containing incorporated gene encoding fused protein of ligand and protein having physiological activity |
EP4298132A1 (en) * | 2021-02-23 | 2024-01-03 | Ichilov Tech Ltd. | Fusion proteins for treating cns diseases |
CN117279665A (en) * | 2021-05-12 | 2023-12-22 | Jcr制药股份有限公司 | Pharmaceutical composition for treating mucopolysaccharidosis type I |
WO2023287238A1 (en) * | 2021-07-15 | 2023-01-19 | 한양대학교 산학협력단 | Anti-human transferrin receptor antibody having improved blood-brain-barrier permeability, and multi-specific antibody and pharmaceutical composition which use same |
WO2023004156A1 (en) | 2021-07-23 | 2023-01-26 | Denali Therapeutics Inc. | Methods for the treatment of hunter syndrome |
TW202321274A (en) | 2021-08-19 | 2023-06-01 | 日商Jcr製藥股份有限公司 | Human transferrin receptor-binding peptide |
JPWO2023026994A1 (en) * | 2021-08-21 | 2023-03-02 | ||
WO2023027125A1 (en) | 2021-08-24 | 2023-03-02 | ペプチドリーム株式会社 | Human transferrin receptor-binding antibody-peptide conjugate |
IL311175A (en) | 2021-09-01 | 2024-04-01 | Biogen Ma Inc | Anti-transferrin receptor antibodies and uses thereof |
WO2023090409A1 (en) * | 2021-11-19 | 2023-05-25 | Jcrファーマ株式会社 | Peptide having affinity for human transferrin receptor |
AR128003A1 (en) * | 2021-12-17 | 2024-03-20 | Denali Therapeutics Inc | FUSION PROTEINS COMPRISING α-L-IDURONIDASE ENZYMES AND METHODS THEREOF |
JP2023159049A (en) * | 2022-04-19 | 2023-10-31 | Jcrファーマ株式会社 | Glycoproteins with reduced number of mannose-6-phosphate |
WO2023207574A1 (en) * | 2022-04-28 | 2023-11-02 | 领诺(上海)医药科技有限公司 | Recombinant harsa for crossing blood-brain barrier |
WO2024010067A1 (en) * | 2022-07-08 | 2024-01-11 | Jcrファーマ株式会社 | Nuecleic acid molecule, vector, recombinant cells, and drug for treating central nervous system diseases |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672683A (en) | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
WO1993010819A1 (en) | 1991-11-26 | 1993-06-10 | Alkermes, Inc. | Process for the preparation of transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
US5154924A (en) * | 1989-09-07 | 1992-10-13 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
EP0599303A3 (en) | 1992-11-27 | 1998-07-29 | Takeda Chemical Industries, Ltd. | Peptide conjugate |
JPH06228199A (en) | 1992-11-27 | 1994-08-16 | Takeda Chem Ind Ltd | Peptide binding body capable of passing through blood brain barrier |
US6472147B1 (en) * | 1999-05-25 | 2002-10-29 | The Scripps Research Institute | Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries |
EP1197755A1 (en) | 2000-10-11 | 2002-04-17 | Pepscan Systems B.V. | Identification of protein binding sites |
MXPA03003690A (en) * | 2000-10-27 | 2004-05-05 | Chiron Spa | Nucleic acids and proteins from streptococcus groups a b. |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US7388079B2 (en) | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
US20050026823A1 (en) | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
US7442372B2 (en) | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
US8142781B2 (en) | 2005-10-07 | 2012-03-27 | Armagen Technologies, Inc. | Fusion proteins for blood-brain barrier delivery |
AR059089A1 (en) | 2006-01-20 | 2008-03-12 | Genzyme Corp | INTRAVENTRICULAR ADMINISTRATION OF AN ENZYME FOR LISOSOMAL STORAGE DISEASES |
GB0624500D0 (en) * | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
CN101245107B (en) * | 2007-02-14 | 2010-10-13 | 中国人民解放军军事医学科学院生物工程研究所 | Antihuman transferrin acceptor human source antibody and uses thereof |
CA2607771A1 (en) | 2007-11-01 | 2009-05-01 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence | Humanized anti-venezuelan equine encephalitis virus recombinant antibody |
US20100077498A1 (en) | 2008-09-11 | 2010-03-25 | Pardridge William M | Compositions and methods for blood-brain barrier delivery in the mouse |
US20110318380A1 (en) * | 2008-10-01 | 2011-12-29 | Dako Denmark A/S | MHC Multimers in Cancer Vaccines and Immune Monitoring |
RU2595379C2 (en) | 2009-04-16 | 2016-08-27 | АббВай Биотерапеутикс Инк. | ANTIBODIES AGAINST TNF-α AND USE THEREOF |
WO2011044542A1 (en) * | 2009-10-09 | 2011-04-14 | Armagen Technologies, Inc. | Methods and compositions for increasing iduronate 2-sulfatase activity in the cns |
JP5500944B2 (en) | 2009-10-29 | 2014-05-21 | 三菱電機株式会社 | Cooker |
JP2012062312A (en) | 2010-08-19 | 2012-03-29 | Yoshikatsu Eto | Agent for treatment of hunter syndrome |
KR102099462B1 (en) | 2010-11-30 | 2020-04-10 | 제넨테크, 인크. | Low affinity blood brain barrier receptor antibodies and uses therefor |
US20120231023A1 (en) * | 2011-03-08 | 2012-09-13 | Baylor Research Institute | Novel Vaccine Adjuvants Based on Targeting Adjuvants to Antibodies Directly to Antigen-Presenting Cells |
CA2828662A1 (en) | 2011-04-20 | 2012-10-26 | Roche Glycart Ag | Method and constructs for the ph dependent passage of the blood-brain-barrier |
US9598496B2 (en) | 2011-05-09 | 2017-03-21 | Perseus Proteomics Inc. | Antibody capable of specifically recognizing transferrin receptor |
TWI450727B (en) | 2011-12-29 | 2014-09-01 | Ind Tech Res Inst | Single-domain anti-human transferrin receptor antibody and uses thereof |
JP6419068B2 (en) * | 2012-05-21 | 2018-11-07 | ジェネンテック, インコーポレイテッド | Methods for improving the safety of blood-brain barrier transport |
RS57259B1 (en) | 2012-12-24 | 2018-08-31 | Abbvie Inc | Prolactin receptor binding proteins and uses thereof |
WO2014189973A2 (en) | 2013-05-20 | 2014-11-27 | Genentech, Inc. | Anti-transferrin receptor antibodies and methods of use |
US10364288B2 (en) | 2013-05-24 | 2019-07-30 | Biogen Ma Inc. | Anti-GPIIB/IIIA antibodies or uses thereof |
TW201536811A (en) | 2013-05-31 | 2015-10-01 | Biogen Idec Inc | Chimeric FVII-XTEN molecules and uses thereof |
WO2015009961A1 (en) * | 2013-07-19 | 2015-01-22 | Armagen Technologies, Inc. | Compositions and methods related to structures that cross the blood brain barrier |
KR20160037173A (en) | 2013-08-02 | 2016-04-05 | 에프. 호프만-라 로슈 아게 | Therapeutic fusion protein |
US9994641B2 (en) | 2013-12-25 | 2018-06-12 | Jcr Pharmaceuticals Co., Ltd. | Anti-human transferrin receptor antibody that passes through blood-brain barrier |
BR112016015589A2 (en) | 2014-01-06 | 2017-10-31 | Hoffmann La Roche | monovalent transit modules for the blood-brain barrier |
CA2874083C (en) * | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
CN107849150B (en) | 2015-06-24 | 2021-12-14 | Jcr制药股份有限公司 | Fusion proteins comprising BDNF |
CN114409783A (en) | 2015-06-24 | 2022-04-29 | Jcr制药股份有限公司 | Anti-human transferrin receptor antibodies across the blood brain barrier |
EP3322732A2 (en) | 2015-07-13 | 2018-05-23 | Cytomx Therapeutics Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
HUE054726T2 (en) * | 2016-03-02 | 2021-09-28 | Eisai R&D Man Co Ltd | Eribulin-based antibody-drug conjugates and methods of use |
AU2017316955B2 (en) | 2016-08-25 | 2022-03-03 | Jcr Pharmaceuticals Co., Ltd. | Method for producing antibody fusion protein |
AR110586A1 (en) | 2016-12-26 | 2019-04-10 | Japan Chem Res | HUMAN ANTITRANSFERRINE RECEPTOR ANTIBODY THAT PENETRATES THE HEMATOENCEPHALIC BARRIER |
CN110114078B (en) | 2016-12-28 | 2024-01-30 | Jcr制药股份有限公司 | Freeze-dried preparation |
CN111278453A (en) | 2017-09-07 | 2020-06-12 | Jcr制药股份有限公司 | Aqueous pharmaceutical composition |
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