EA201791578A1 - Панель биомаркеров для обнаружения рака - Google Patents

Панель биомаркеров для обнаружения рака

Info

Publication number
EA201791578A1
EA201791578A1 EA201791578A EA201791578A EA201791578A1 EA 201791578 A1 EA201791578 A1 EA 201791578A1 EA 201791578 A EA201791578 A EA 201791578A EA 201791578 A EA201791578 A EA 201791578A EA 201791578 A1 EA201791578 A1 EA 201791578A1
Authority
EA
Eurasian Patent Office
Prior art keywords
panel
biomarkers
cancer detection
markers
mirna
Prior art date
Application number
EA201791578A
Other languages
English (en)
Other versions
EA037995B1 (ru
Inventor
Барбара Бурвинкель
Жунси Ян
Андреас Шнеевайсс
Original Assignee
Рупрехт-Карлс-Университет Гейдельберг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рупрехт-Карлс-Университет Гейдельберг filed Critical Рупрехт-Карлс-Университет Гейдельберг
Publication of EA201791578A1 publication Critical patent/EA201791578A1/ru
Publication of EA037995B1 publication Critical patent/EA037995B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

В изобретении предложены панели маркеров метилирования и микроРНК, а также применение указанной панели для прогнозирования, диагностики и/или лечения рака и средства для обнаружения указанных маркеров, наборы, содержащие указанные средства, и устройства для анализа указанной панели маркеров.
EA201791578A 2015-02-24 2016-02-24 Панель биомаркеров для обнаружения рака EA037995B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15156389 2015-02-24
PCT/EP2016/053813 WO2016135168A1 (en) 2015-02-24 2016-02-24 Biomarker panel for the detection of cancer

Publications (2)

Publication Number Publication Date
EA201791578A1 true EA201791578A1 (ru) 2018-02-28
EA037995B1 EA037995B1 (ru) 2021-06-21

Family

ID=52589264

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791578A EA037995B1 (ru) 2015-02-24 2016-02-24 Панель биомаркеров для обнаружения рака

Country Status (17)

Country Link
US (1) US10941451B2 (ru)
EP (1) EP3262190B1 (ru)
JP (2) JP6807873B2 (ru)
KR (1) KR20170120124A (ru)
CN (1) CN107406880A (ru)
AU (1) AU2016223532B2 (ru)
BR (1) BR112017018008A2 (ru)
CA (1) CA2975952A1 (ru)
DK (1) DK3262190T3 (ru)
EA (1) EA037995B1 (ru)
ES (1) ES2893297T3 (ru)
HK (1) HK1246828A1 (ru)
IL (1) IL253756B (ru)
MX (1) MX2017010836A (ru)
PL (1) PL3262190T3 (ru)
UA (1) UA124612C2 (ru)
WO (1) WO2016135168A1 (ru)

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KR102100557B1 (ko) * 2017-06-21 2020-04-14 사회복지법인 삼성생명공익재단 대장암 환자의 항암제 치료 반응성 예측용 마커
WO2018236065A1 (ko) * 2017-06-21 2018-12-27 사회복지법인 삼성생명공익재단 대장암 환자의 항암제 치료 반응성 예측용 마커
CN110997915A (zh) * 2017-08-23 2020-04-10 国立研究开发法人国立癌研究中心 肝细胞癌的风险评价方法
WO2019081507A1 (en) 2017-10-23 2019-05-02 Universität Heidelberg NEW MARKERS DERIVED FROM BLOOD FOR CANCER DETECTION
JP7326764B2 (ja) * 2018-03-09 2023-08-16 東ソー株式会社 腫瘍マーカーならびに腫瘍細胞を夾雑細胞と区別して回収および検出する方法
WO2020169826A1 (en) * 2019-02-21 2020-08-27 Universität Heidelberg Biomarker panel for diagnosis and prognosis of cancer
CN110136776B (zh) * 2019-05-15 2021-04-20 深圳大学 一种从低质量核糖体印迹数据预测基因编码框的方法和***
CN110269869B (zh) * 2019-07-30 2023-03-31 宁夏医科大学 一种以蜥蜴为主的抗肿瘤药物及验证方法
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
CN113186279A (zh) * 2020-01-14 2021-07-30 南京腾辰生物科技有限公司 用于辅助诊断癌症的透明质酸酶甲基化标志物及试剂盒
CN113136428B (zh) * 2020-01-19 2024-04-19 腾辰生物科技(上海)有限公司 一种甲基化标志物在辅助诊断癌症中的应用
CN113528635A (zh) * 2020-04-16 2021-10-22 南京腾辰生物科技有限公司 一种印记基因的甲基化作为心脑血管疾病早期诊断的标志物
US20230340607A1 (en) * 2020-07-13 2023-10-26 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compositions and methods for detecting gene fusions of rad51ap1 and dyrk4 and for diagnosing and treating cancer
CN114480630A (zh) * 2020-10-26 2022-05-13 南京腾辰生物科技有限公司 用于辅助诊断癌症的一种甲基化标志物
WO2022170133A1 (en) * 2021-02-04 2022-08-11 The Cleveland Clinic Foundation Micro rna liver cancer markers and uses thereof
JP7143480B1 (ja) * 2021-06-10 2022-09-28 株式会社大一商会 遊技機

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US20030211606A1 (en) * 2002-05-10 2003-11-13 Isis Pharmaceuticals Inc. Antisense modulation of DYRK4 expression
DE602004024539D1 (de) * 2003-07-03 2010-01-21 Gentron Llc Verfahren und systeme zur diagnose von nicht das zentrale nervensystem (zns) betreffenden krankheiten in zns-proben
KR20070004725A (ko) * 2004-02-20 2007-01-09 더 리전츠 오브 더 유니버시티 오브 캘리포니아 타액 ｍＲＮＡ 프로파일링, 생물 마커 및 관련 방법 및부품 키트
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JP2011097833A (ja) * 2009-11-04 2011-05-19 Takeshi Zama 特定の遺伝子のメチル化の頻度を、頭頸部腫瘍のバイオマーカーとして使用する方法
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Also Published As

Publication number Publication date
UA124612C2 (uk) 2021-10-20
CA2975952A1 (en) 2016-09-01
ES2893297T3 (es) 2022-02-08
IL253756B (en) 2021-04-29
US20180245159A1 (en) 2018-08-30
HK1246828A1 (zh) 2018-09-14
CN107406880A (zh) 2017-11-28
JP2021052777A (ja) 2021-04-08
EP3262190A1 (en) 2018-01-03
MX2017010836A (es) 2018-02-09
JP6807873B2 (ja) 2021-01-13
EP3262190B1 (en) 2021-09-01
PL3262190T3 (pl) 2021-12-20
DK3262190T3 (da) 2021-10-11
AU2016223532B2 (en) 2021-07-01
IL253756A0 (en) 2017-09-28
AU2016223532A1 (en) 2017-08-17
EA037995B1 (ru) 2021-06-21
KR20170120124A (ko) 2017-10-30
JP2018509934A (ja) 2018-04-12
WO2016135168A1 (en) 2016-09-01
BR112017018008A2 (pt) 2018-04-10
US10941451B2 (en) 2021-03-09

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