EA201692227A1 - Производные сложных аминоэфиров - Google Patents

Производные сложных аминоэфиров

Info

Publication number
EA201692227A1
EA201692227A1 EA201692227A EA201692227A EA201692227A1 EA 201692227 A1 EA201692227 A1 EA 201692227A1 EA 201692227 A EA201692227 A EA 201692227A EA 201692227 A EA201692227 A EA 201692227A EA 201692227 A1 EA201692227 A1 EA 201692227A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aminoesters
derivatives
complex
compounds
pde4
Prior art date
Application number
EA201692227A
Other languages
English (en)
Other versions
EA032761B1 (ru
Inventor
Элизабетта Армани
Габриэле Амари
Кармелида Капальди
Уэсли Блэкэби
Йен Линней
Эрве Ван Де Поэль
Чарльз Бэйкер-Гленн
Наймиша Триведи
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Publication of EA201692227A1 publication Critical patent/EA201692227A1/ru
Publication of EA032761B1 publication Critical patent/EA032761B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Изобретение относится к новым соединениям, представляющим собой как ингибиторы фермента фосфодиэстераза 4 (PDE4), так и антагонисты мускаринового рецептора М3, к способам получения таких соединений, содержащим их композициям и их терапевтическому применению.
EA201692227A 2014-06-05 2015-06-03 Производные сложных аминоэфиров EA032761B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14171266 2014-06-05
PCT/EP2015/062417 WO2015185649A1 (en) 2014-06-05 2015-06-03 Aminoester derivatives

Publications (2)

Publication Number Publication Date
EA201692227A1 true EA201692227A1 (ru) 2017-05-31
EA032761B1 EA032761B1 (ru) 2019-07-31

Family

ID=50884281

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692227A EA032761B1 (ru) 2014-06-05 2015-06-03 Производные сложных аминоэфиров

Country Status (32)

Country Link
US (2) US9763924B2 (ru)
EP (1) EP3152201B1 (ru)
JP (1) JP2017516824A (ru)
KR (1) KR102420323B1 (ru)
CN (1) CN106459020B (ru)
AR (1) AR100732A1 (ru)
AU (1) AU2015270539B2 (ru)
BR (1) BR112016026725B1 (ru)
CA (1) CA2953198C (ru)
CL (1) CL2016003117A1 (ru)
CY (1) CY1120698T1 (ru)
DK (1) DK3152201T3 (ru)
EA (1) EA032761B1 (ru)
ES (1) ES2688826T3 (ru)
GE (1) GEP20186922B (ru)
HR (1) HRP20181967T1 (ru)
HU (1) HUE042119T2 (ru)
IL (1) IL249325B (ru)
LT (1) LT3152201T (ru)
MA (1) MA39947B1 (ru)
MX (1) MX2016015958A (ru)
PE (1) PE20161557A1 (ru)
PH (1) PH12016502221A1 (ru)
PL (1) PL3152201T3 (ru)
PT (1) PT3152201T (ru)
RS (1) RS57787B1 (ru)
SG (1) SG11201610132RA (ru)
SI (1) SI3152201T1 (ru)
TN (1) TN2016000546A1 (ru)
TW (1) TW201625600A (ru)
WO (1) WO2015185649A1 (ru)
ZA (1) ZA201608331B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA42048A (fr) 2015-05-07 2018-03-14 Chiesi Farm Spa Dérivés d'aminoesters
AR104822A1 (es) * 2015-06-01 2017-08-16 Chiesi Farm Spa Derivado de aminoésteres
TW201710254A (zh) * 2015-06-01 2017-03-16 吉斯藥品公司 胺基酯衍生物
CN106866474B (zh) * 2017-02-16 2018-12-28 陕西师范大学 一种手性α-芳基甘氨酸酯衍生物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2022783A1 (en) * 2007-08-08 2009-02-11 CHIESI FARMACEUTICI S.p.A. "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors"
PE20091552A1 (es) 2008-02-06 2009-10-25 Glaxo Group Ltd Farmacoforos duales - antagonistas muscarinicos de pde4
EP2216327A1 (en) 2009-02-06 2010-08-11 CHIESI FARMACEUTICI S.p.A. Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors
BR112015012716A2 (pt) * 2012-12-05 2017-07-11 Chiesi Farm Spa derivados de feniletilpiridina como inibidores de pde4
CN104822671B (zh) 2012-12-05 2017-10-31 奇斯药制品公司 作为pde4抑制剂的苯乙基吡啶衍生物
TW201439089A (zh) 2012-12-05 2014-10-16 Chiesi Farma Spa 新穎化合物
RU2016121852A (ru) 2013-12-05 2017-12-07 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные бензгидрила для лечения респираторных заболеваний
CA2932487A1 (en) * 2013-12-05 2015-06-11 Chiesi Farmaceutici S.P.A. Heteroaryl derivatives for the treatment of respiratory diseases

Also Published As

Publication number Publication date
ES2688826T3 (es) 2018-11-07
ZA201608331B (en) 2018-05-30
MA39947B1 (fr) 2018-10-31
AU2015270539B2 (en) 2018-11-08
KR102420323B1 (ko) 2022-07-13
AU2015270539A1 (en) 2016-12-22
PL3152201T3 (pl) 2019-02-28
GEP20186922B (en) 2018-11-12
HRP20181967T1 (hr) 2019-02-08
AR100732A1 (es) 2016-10-26
KR20170015294A (ko) 2017-02-08
CL2016003117A1 (es) 2017-06-23
SG11201610132RA (en) 2017-01-27
RS57787B1 (sr) 2018-12-31
LT3152201T (lt) 2018-10-10
PT3152201T (pt) 2018-10-26
US20170340616A1 (en) 2017-11-30
US10117860B2 (en) 2018-11-06
IL249325A0 (en) 2017-02-28
CA2953198A1 (en) 2015-12-10
EP3152201A1 (en) 2017-04-12
PH12016502221A1 (en) 2017-02-06
BR112016026725A2 (pt) 2017-08-15
MX2016015958A (es) 2017-04-10
TW201625600A (zh) 2016-07-16
WO2015185649A9 (en) 2017-01-05
EP3152201B1 (en) 2018-08-29
TN2016000546A1 (en) 2018-04-04
US20150352091A1 (en) 2015-12-10
CY1120698T1 (el) 2019-12-11
WO2015185649A1 (en) 2015-12-10
BR112016026725B1 (pt) 2024-02-27
SI3152201T1 (sl) 2018-10-30
US9763924B2 (en) 2017-09-19
JP2017516824A (ja) 2017-06-22
MA39947A (fr) 2017-04-12
IL249325B (en) 2018-12-31
BR112016026725A8 (pt) 2021-06-29
CA2953198C (en) 2023-06-13
CN106459020A (zh) 2017-02-22
CN106459020B (zh) 2019-06-18
HUE042119T2 (hu) 2019-06-28
EA032761B1 (ru) 2019-07-31
DK3152201T3 (en) 2018-11-19
PE20161557A1 (es) 2017-02-07

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM