EA201790776A1 - Комбинированные композиции длительного действия и способы лечения гепатита с - Google Patents

Комбинированные композиции длительного действия и способы лечения гепатита с

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Publication number
EA201790776A1
EA201790776A1 EA201790776A EA201790776A EA201790776A1 EA 201790776 A1 EA201790776 A1 EA 201790776A1 EA 201790776 A EA201790776 A EA 201790776A EA 201790776 A EA201790776 A EA 201790776A EA 201790776 A1 EA201790776 A1 EA 201790776A1
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EA
Eurasian Patent Office
Prior art keywords
methods
long
treating hepatitis
combined compositions
term actions
Prior art date
Application number
EA201790776A
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English (en)
Inventor
Чжи Хун
Мартин Р. Лейверс
Original Assignee
Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54478191&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201790776(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед filed Critical Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед
Publication of EA201790776A1 publication Critical patent/EA201790776A1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

Abstract

Настоящее изобретение относится к фармацевтическим композициям, полезным в лечении, или предупреждении, либо излечении от вирусных инфекций, таких как инфекции HCV (вирус гепатита человека), и заболеваний, ассоциированных с такими инфекциями.
EA201790776A 2014-11-10 2015-10-30 Комбинированные композиции длительного действия и способы лечения гепатита с EA201790776A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077647P 2014-11-10 2014-11-10
US201462077980P 2014-11-11 2014-11-11
PCT/IB2015/058423 WO2016075584A1 (en) 2014-11-10 2015-10-30 Combination long acting compositions and methods for hepatitis c

Publications (1)

Publication Number Publication Date
EA201790776A1 true EA201790776A1 (ru) 2017-11-30

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ID=54478191

Family Applications (1)

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EA201790776A EA201790776A1 (ru) 2014-11-10 2015-10-30 Комбинированные композиции длительного действия и способы лечения гепатита с

Country Status (21)

Country Link
US (1) US10308937B2 (ru)
EP (1) EP3218486A1 (ru)
JP (1) JP2017534643A (ru)
KR (1) KR20170081257A (ru)
CN (1) CN107206089A (ru)
AU (1) AU2015344741A1 (ru)
BR (1) BR112017009504A2 (ru)
CA (1) CA2967184A1 (ru)
CL (1) CL2017001160A1 (ru)
CO (1) CO2017005767A2 (ru)
CR (1) CR20170192A (ru)
DO (1) DOP2017000116A (ru)
EA (1) EA201790776A1 (ru)
IL (1) IL252016A0 (ru)
MA (1) MA40817A (ru)
MX (1) MX2017006140A (ru)
PE (1) PE20170922A1 (ru)
PH (1) PH12017500820A1 (ru)
SG (1) SG11201703646SA (ru)
WO (1) WO2016075584A1 (ru)
ZA (1) ZA201703123B (ru)

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CN107205927A (zh) * 2014-11-10 2017-09-26 葛兰素史克知识产权第二有限公司 用于丙型肝炎的长效药物组合物
EA201890818A1 (ru) * 2015-09-29 2018-09-28 Янссен Фармасьютикалс, Инк. Режим комбинированной терапии для лечения hcv
US20190231705A1 (en) * 2018-01-29 2019-08-01 Merck Sharp & Dohme Corp. High drug load polymeric nanoparticle formulations and methods of making and using same

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US10308937B2 (en) 2019-06-04
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