MX2018005569A - Vacunas contra el virus de la hepatitis b. - Google Patents
Vacunas contra el virus de la hepatitis b.Info
- Publication number
- MX2018005569A MX2018005569A MX2018005569A MX2018005569A MX2018005569A MX 2018005569 A MX2018005569 A MX 2018005569A MX 2018005569 A MX2018005569 A MX 2018005569A MX 2018005569 A MX2018005569 A MX 2018005569A MX 2018005569 A MX2018005569 A MX 2018005569A
- Authority
- MX
- Mexico
- Prior art keywords
- virus
- hepatitis
- vaccines against
- against hepatitis
- vaccines
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/10011—Arenaviridae
- C12N2760/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/10011—Arenaviridae
- C12N2760/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/10011—Arenaviridae
- C12N2760/10041—Use of virus, viral particle or viral elements as a vector
- C12N2760/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Abstract
La presente invención proporciona inmunoterapias para infecciones por virus de la hepatitis B. Se proporcionan en la presente vectores de arenavirus genéticamente modificados adecuados como vacunas para la prevención y el tratamiento de infecciones por virus de la hepatitis B. También se proporcionan en la presente composiciones farmacéuticas y métodos para el tratamiento de infecciones por virus de la hepatitis B. Específicamente, aquí se proporcionan composiciones farmacéuticas, vacunas y métodos para tratar la infección por virus de la hepatitis B.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562250639P | 2015-11-04 | 2015-11-04 | |
PCT/EP2016/076591 WO2017076988A1 (en) | 2015-11-04 | 2016-11-03 | Vaccines against hepatitis b virus |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018005569A true MX2018005569A (es) | 2018-12-19 |
Family
ID=57249796
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018005569A MX2018005569A (es) | 2015-11-04 | 2016-11-03 | Vacunas contra el virus de la hepatitis b. |
Country Status (22)
Country | Link |
---|---|
US (2) | US11214598B2 (es) |
EP (2) | EP3371316B1 (es) |
JP (3) | JP6914950B2 (es) |
KR (1) | KR20180082485A (es) |
CN (2) | CN108779472B (es) |
AU (2) | AU2016348675B2 (es) |
BR (1) | BR112018009032A8 (es) |
CA (1) | CA3003557A1 (es) |
DK (1) | DK3371316T3 (es) |
ES (1) | ES2934698T3 (es) |
FI (1) | FI3371316T3 (es) |
HK (1) | HK1255847A1 (es) |
HR (1) | HRP20221474T1 (es) |
HU (1) | HUE060648T2 (es) |
IL (1) | IL259077A (es) |
LT (1) | LT3371316T (es) |
MX (1) | MX2018005569A (es) |
PL (1) | PL3371316T3 (es) |
PT (1) | PT3371316T (es) |
SG (1) | SG11201803474UA (es) |
SI (1) | SI3371316T1 (es) |
WO (1) | WO2017076988A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2604695T3 (pl) | 2007-12-27 | 2023-04-11 | Universität Zürich | Cząstka arenawirusa z defektem replikacji |
EP3077519B1 (en) | 2013-12-03 | 2021-03-31 | Hookipa Biotech GmbH | Cmv vaccines |
CA2967720C (en) | 2014-11-13 | 2024-01-02 | Universite De Geneve | Tri-segmented arenaviruses as vaccine vectors |
US10669315B2 (en) | 2015-06-10 | 2020-06-02 | Hookipa Biotech Gmbh | HPV vaccines |
HRP20221474T1 (hr) | 2015-11-04 | 2023-01-06 | Hookipa Biotech Gmbh | Cjepiva protiv virusa hepatitisa b |
WO2017080920A1 (en) | 2015-11-12 | 2017-05-18 | Hookipa Biotech Ag | Arenavirus particles as cancer vaccines |
SG10201914029RA (en) | 2016-10-14 | 2020-03-30 | Precision Biosciences Inc | Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome |
JP2022010188A (ja) * | 2017-02-03 | 2022-01-14 | 株式会社三洋物産 | 遊技機 |
JP2022010187A (ja) * | 2017-02-03 | 2022-01-14 | 株式会社三洋物産 | 遊技機 |
EA202091517A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и устройство для доставки вакцин против вируса гепатита b (hbv) |
EA202091516A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv) |
EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
US10870691B2 (en) | 2018-04-05 | 2020-12-22 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis B virus protein X |
US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
JP2022536850A (ja) * | 2019-06-18 | 2022-08-19 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | B型肝炎ウイルス(hbv)ワクチンおよび抗pd-1または抗pd-l1抗体の組合せ |
EP3986455A1 (en) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Company | Arenavirus vectors for hepatitis b virus (hbv) vaccines and uses thereof |
BR112021026376A2 (pt) | 2019-06-25 | 2022-05-10 | Gilead Sciences Inc | Proteínas de fusão flt3l-fc e métodos de uso |
US11497808B2 (en) * | 2019-09-30 | 2022-11-15 | Gilead Sciences, Inc. | HBV vaccines and methods treating HBV |
CN116057068A (zh) | 2019-12-06 | 2023-05-02 | 精密生物科学公司 | 对乙型肝炎病毒基因组中的识别序列具有特异性的优化的工程化大范围核酸酶 |
IL294032A (en) | 2019-12-24 | 2022-08-01 | Carna Biosciences Inc | Compounds that regulate diacylglycerol kinase |
CN115605493A (zh) | 2020-03-20 | 2023-01-13 | 吉利德科学公司(Us) | 4′-c-取代的-2-卤代-2′-脱氧腺苷核苷的前药及其制备和使用方法 |
KR102375703B1 (ko) | 2020-07-28 | 2022-03-17 | 경북대학교 산학협력단 | 사물 인터넷 환경에서 CoAP 기반의 데이터 스트리밍 방법 및 통신 시스템 |
EP4314268A2 (en) | 2021-03-23 | 2024-02-07 | Hookipa Biotech GmbH | Arenaviruses used in treatments of prostate cancer |
WO2022226242A1 (en) * | 2021-04-21 | 2022-10-27 | La Jolla Institute For Immunology | Engineered arenavirus glycoprotein compositions, methods and use thereof |
CN113201051B (zh) * | 2021-04-27 | 2022-08-02 | 复旦大学 | 一种乙肝病毒表面蛋白突变体及其在抗乙肝病毒中的应用 |
JP2024518558A (ja) | 2021-05-13 | 2024-05-01 | ギリアード サイエンシーズ, インコーポレイテッド | TLR8調節化合物と抗HBV siRNA治療薬との組合せ |
WO2022271650A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
CN117355531A (zh) | 2021-06-23 | 2024-01-05 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
KR20240025616A (ko) | 2021-06-23 | 2024-02-27 | 길리애드 사이언시즈, 인코포레이티드 | 다이아실글리세롤 키나제 조절 화합물 |
KR20240023628A (ko) | 2021-06-23 | 2024-02-22 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4722840A (en) * | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
JPH1084967A (ja) * | 1996-09-19 | 1998-04-07 | Fujirebio Inc | B型肝炎のe抗原 |
NZ512056A (en) * | 1998-12-04 | 2004-01-30 | Biogen Inc | HBV core antigen particles with multiple immunogenic components attached via peptide ligands |
FR2803599B1 (fr) * | 2000-01-06 | 2004-11-19 | Inst Nat Sante Rech Med | Nouveau virus mute de l'hepatite b, ses constituants nucleiques et proteiques et leurs applications |
EP1888622A1 (en) * | 2005-05-23 | 2008-02-20 | Oxxon Therapeutics Ltd. | Compositions for inducing an immune response against hepatitis b |
ES2536426T3 (es) | 2006-03-23 | 2015-05-25 | Novartis Ag | Compuestos de imidazoquinoxalina como inmunomoduladores |
WO2007109812A2 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
NZ594510A (en) * | 2006-12-27 | 2012-06-29 | Harvard College | Compositions and methods for the treatment of infections and tumors |
PL2604695T3 (pl) | 2007-12-27 | 2023-04-11 | Universität Zürich | Cząstka arenawirusa z defektem replikacji |
SG178254A1 (en) * | 2009-08-07 | 2012-03-29 | Transgene Sa | Composition for treating hbv infection |
US10076570B2 (en) * | 2009-08-07 | 2018-09-18 | Transgene S.A. | Composition for treating HBV infection |
WO2012162428A1 (en) | 2011-05-23 | 2012-11-29 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Prime-boost vaccination for viral infection |
KR102195196B1 (ko) | 2012-01-24 | 2020-12-28 | 샌포드 헬스 | 종양원성 바이러스성 폴리펩티드 양성 종양 치료용 폴리뉴클레오티드 |
EP2968506B1 (en) | 2013-03-15 | 2019-07-31 | Université de Genève | Anti-mycobacterial vaccines |
GB201305361D0 (en) | 2013-03-25 | 2013-05-08 | Univ Edinburgh | Enhanced expression |
EP3077519B1 (en) | 2013-12-03 | 2021-03-31 | Hookipa Biotech GmbH | Cmv vaccines |
WO2015183895A1 (en) | 2014-05-27 | 2015-12-03 | University Of Rochester | Novel arenavirus vaccine |
US9943585B2 (en) | 2014-07-30 | 2018-04-17 | University Of Rochester | Methods and compositions related to reorganization of arenavirus genome for development of novel arenavirus live-attenuated vaccines (LAV) |
MX2017003694A (es) | 2014-09-22 | 2017-10-12 | Univ Minnesota | Sistema de genética inversa del virus pichindé y métodos de uso. |
GB201419572D0 (en) | 2014-11-03 | 2014-12-17 | Pirbright Inst The | Virus |
CA2967720C (en) * | 2014-11-13 | 2024-01-02 | Universite De Geneve | Tri-segmented arenaviruses as vaccine vectors |
DE102015207036A1 (de) | 2015-04-17 | 2016-10-20 | Karl Sebastian Lang | Arenaviren zur Anwendung bei der Behandlung und/oder Vorbeugung von Tumoren sowie Verfahren zur Herstellung von Arenaviren mit (verbesserten) tumorregressiven Eigenschaften |
US10669315B2 (en) | 2015-06-10 | 2020-06-02 | Hookipa Biotech Gmbh | HPV vaccines |
US10849969B2 (en) | 2015-10-23 | 2020-12-01 | Institut Pasteur | Recombinant attenuated Mopeia virus comprising a modified nucleoprotein with reduced exonuclease activity |
HRP20221474T1 (hr) | 2015-11-04 | 2023-01-06 | Hookipa Biotech Gmbh | Cjepiva protiv virusa hepatitisa b |
WO2017080920A1 (en) | 2015-11-12 | 2017-05-18 | Hookipa Biotech Ag | Arenavirus particles as cancer vaccines |
WO2017190074A1 (en) | 2016-04-28 | 2017-11-02 | The University Of Chicago | Lymphangiogenesis for therapeutic immunomodulation |
CN109804074B (zh) | 2016-05-18 | 2023-10-10 | 巴塞尔大学 | 作为疫苗载体的三区段pichinde病毒 |
EP3534943A2 (en) | 2016-11-04 | 2019-09-11 | Hookipa Biotech GmbH | Replication-deficient arenavirus particles and tri-segmented arenavirus particles as cancer vaccines |
CN110719788A (zh) | 2017-04-07 | 2020-01-21 | 霍欧奇帕生物科技有限公司 | 治疗实体瘤的沙粒病毒颗粒 |
-
2016
- 2016-11-03 HR HRP20221474TT patent/HRP20221474T1/hr unknown
- 2016-11-03 PT PT167915735T patent/PT3371316T/pt unknown
- 2016-11-03 AU AU2016348675A patent/AU2016348675B2/en active Active
- 2016-11-03 PL PL16791573.5T patent/PL3371316T3/pl unknown
- 2016-11-03 ES ES16791573T patent/ES2934698T3/es active Active
- 2016-11-03 EP EP16791573.5A patent/EP3371316B1/en active Active
- 2016-11-03 US US15/773,512 patent/US11214598B2/en active Active
- 2016-11-03 SG SG11201803474UA patent/SG11201803474UA/en unknown
- 2016-11-03 BR BR112018009032A patent/BR112018009032A8/pt active Search and Examination
- 2016-11-03 SI SI201631654T patent/SI3371316T1/sl unknown
- 2016-11-03 CN CN201680077751.0A patent/CN108779472B/zh active Active
- 2016-11-03 JP JP2018541546A patent/JP6914950B2/ja active Active
- 2016-11-03 KR KR1020187015548A patent/KR20180082485A/ko not_active Application Discontinuation
- 2016-11-03 MX MX2018005569A patent/MX2018005569A/es unknown
- 2016-11-03 LT LTEPPCT/EP2016/076591T patent/LT3371316T/lt unknown
- 2016-11-03 CN CN202211051785.6A patent/CN115948467A/zh active Pending
- 2016-11-03 DK DK16791573.5T patent/DK3371316T3/da active
- 2016-11-03 FI FIEP16791573.5T patent/FI3371316T3/fi active
- 2016-11-03 HU HUE16791573A patent/HUE060648T2/hu unknown
- 2016-11-03 EP EP22201924.2A patent/EP4177348A1/en active Pending
- 2016-11-03 CA CA3003557A patent/CA3003557A1/en active Pending
- 2016-11-03 WO PCT/EP2016/076591 patent/WO2017076988A1/en active Application Filing
-
2018
- 2018-05-01 IL IL259077A patent/IL259077A/en unknown
- 2018-11-22 HK HK18114923.3A patent/HK1255847A1/zh unknown
-
2021
- 2021-07-14 JP JP2021116562A patent/JP2021182922A/ja active Pending
- 2021-11-24 US US17/535,121 patent/US20220073568A1/en active Pending
-
2023
- 2023-01-10 AU AU2023200108A patent/AU2023200108A1/en active Pending
- 2023-10-19 JP JP2023180121A patent/JP2024010027A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2018005569A (es) | Vacunas contra el virus de la hepatitis b. | |
HK1251219A1 (zh) | 用於治療和預防乙型肝炎病毒感染的新的6,7-二氫吡啶並[2,1-a]酞嗪-2-酮類化合物 | |
PH12018500573A1 (en) | Hepatitis b core protein modulators | |
CY1124288T1 (el) | Cmv εμβολια | |
MX2017008720A (es) | Derivados y metodos para tratamiento de las infecciones por hepatitis b. | |
MX2019003525A (es) | Moduladores alostericos de proteina nucleo de hepatitis b. | |
JOP20180008A1 (ar) | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b | |
PH12016501379A1 (en) | Azepane derivatives and methods of treating hepatitis b infections | |
PH12016501254A1 (en) | Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection | |
EA030115B9 (ru) | Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b | |
EA201791460A1 (ru) | N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения | |
PH12017550022A1 (en) | Phosphoramidates for the treatment of hepatitis b virus | |
MX2017005252A (es) | Metodos para la preparacion de ribosidos. | |
EP3505620A4 (en) | 2D ORGANOID FOR INFECTIONS AND GROWTH OF HUMAN DIARRHOEVIRUS AND USE OF THE TWO-DIMENSIONAL ORGANOID | |
EA201792069A1 (ru) | Производные азокана и азонана и способы лечения инфекций гепатита в | |
MX2017000312A (es) | Derivados de isoindolina para usarse en el tratamiento de una infeccion viral. | |
PH12017500816A1 (en) | Long acting pharmaceutical compositions for hepatitis c | |
PH12017500820A1 (en) | Combination long acting compositions and methods for hepatitis c | |
EA201691835A1 (ru) | Аллостерические модуляторы капсидного белка гепатита в |