EA201691600A1 - Дигидропиридиноновые ингибиторы mgat2 для применения в лечении метаболических нарушений - Google Patents

Дигидропиридиноновые ингибиторы mgat2 для применения в лечении метаболических нарушений

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Publication number
EA201691600A1
EA201691600A1 EA201691600A EA201691600A EA201691600A1 EA 201691600 A1 EA201691600 A1 EA 201691600A1 EA 201691600 A EA201691600 A EA 201691600A EA 201691600 A EA201691600 A EA 201691600A EA 201691600 A1 EA201691600 A1 EA 201691600A1
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EA
Eurasian Patent Office
Prior art keywords
mgat2
inhibitors
dihydropyridinous
treatment
metabolic disorders
Prior art date
Application number
EA201691600A
Other languages
English (en)
Inventor
Вэй Мэн
Гуохуа Чжао
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201691600A1 publication Critical patent/EA201691600A1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

В настоящем изобретении предусматриваются соединения формулы (I)или их стереоизомеры или фармацевтически приемлемые соли, где все переменные (заместители) имеют значение по определению в данной заявке. Эти соединения представляют собой ингибиторы моноацилглицерол-ацилтрансферазы типа 2 (MGAT2), которые можно применять в качестве лекарственных средств.
EA201691600A 2014-03-07 2015-03-05 Дигидропиридиноновые ингибиторы mgat2 для применения в лечении метаболических нарушений EA201691600A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461949506P 2014-03-07 2014-03-07
PCT/US2015/018874 WO2015134701A1 (en) 2014-03-07 2015-03-05 Dihydropyridinone mgat2 inhibitors for use in the treatment of metabolic disorders

Publications (1)

Publication Number Publication Date
EA201691600A1 true EA201691600A1 (ru) 2017-01-30

Family

ID=52686514

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691600A EA201691600A1 (ru) 2014-03-07 2015-03-05 Дигидропиридиноновые ингибиторы mgat2 для применения в лечении метаболических нарушений

Country Status (13)

Country Link
US (2) US9701672B2 (ru)
EP (1) EP3114121B1 (ru)
JP (1) JP6498705B2 (ru)
KR (1) KR20160120790A (ru)
CN (1) CN106068265B (ru)
AU (1) AU2015227142A1 (ru)
CA (1) CA2941955A1 (ru)
EA (1) EA201691600A1 (ru)
ES (1) ES2700574T3 (ru)
IL (1) IL247589A0 (ru)
MX (1) MX2016011105A (ru)
SG (1) SG11201607392SA (ru)
WO (1) WO2015134701A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8791091B2 (en) 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
PT3114120T (pt) 2014-03-07 2019-05-08 Bristol Myers Squibb Co Inibidores de mgat2 di-hidropiridinona tetrazolonasubstituída
US9974778B2 (en) 2014-06-11 2018-05-22 Bristol-Myers Squibb Company Substituted pyridinones as MGAT2 inhibitors
WO2017069224A1 (ja) * 2015-10-22 2017-04-27 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有するスピロ環誘導体
EP3395798A4 (en) 2015-12-21 2019-07-17 Shionogi & Co., Ltd NON-AROMATIC HETEROCYCLIC DERIVATIVE HAVING MGAT2 INHIBITORY ACTIVITY
KR102375929B1 (ko) 2016-03-31 2022-03-16 온크터널 테라퓨틱스, 인코포레이티드. 인돌린 유사체 및 이의 용도
JP2020158390A (ja) * 2017-06-20 2020-10-01 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する非芳香族複素環誘導体およびそれらを含有する医薬組成物
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
JP7068743B2 (ja) * 2019-01-11 2022-05-17 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する縮合環誘導体を含有する医薬組成物
MX2021008050A (es) * 2019-01-11 2021-08-05 Shionogi & Co Derivado de dihidropirazolopirazinona que tiene actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat2).
CN112194659A (zh) 2019-07-08 2021-01-08 浙江海正药业股份有限公司 炔类衍生物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
ATE396731T1 (de) 2003-03-25 2008-06-15 Vertex Pharma Thiazole zur verwendung als inhibitoren von protein-kinasen
JPWO2008038768A1 (ja) 2006-09-28 2010-01-28 大日本住友製薬株式会社 二環性ピリミジン構造を有する化合物及びそれを含有する医薬組成物
US8791091B2 (en) 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
WO2013112323A1 (en) 2012-01-23 2013-08-01 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
EP3004059B1 (en) 2013-05-29 2017-09-20 Bristol-Myers Squibb Company Dihydropyridinone mgat2 inhibitors

Also Published As

Publication number Publication date
MX2016011105A (es) 2016-12-12
US20170267666A1 (en) 2017-09-21
AU2015227142A1 (en) 2016-10-20
EP3114121A1 (en) 2017-01-11
CA2941955A1 (en) 2015-09-11
JP2017508795A (ja) 2017-03-30
US9701672B2 (en) 2017-07-11
JP6498705B2 (ja) 2019-04-10
SG11201607392SA (en) 2016-10-28
KR20160120790A (ko) 2016-10-18
IL247589A0 (en) 2016-11-30
WO2015134701A1 (en) 2015-09-11
ES2700574T3 (es) 2019-02-18
US20170015653A1 (en) 2017-01-19
CN106068265B (zh) 2020-05-22
EP3114121B1 (en) 2018-09-26
CN106068265A (zh) 2016-11-02
US9856244B2 (en) 2018-01-02

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