EA201690650A1 - Солевая форма гидрохлорида для ингибирования ezh2 - Google Patents

Солевая форма гидрохлорида для ингибирования ezh2

Info

Publication number
EA201690650A1
EA201690650A1 EA201690650A EA201690650A EA201690650A1 EA 201690650 A1 EA201690650 A1 EA 201690650A1 EA 201690650 A EA201690650 A EA 201690650A EA 201690650 A EA201690650 A EA 201690650A EA 201690650 A1 EA201690650 A1 EA 201690650A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrochloride
salt form
inhibit ezh2
methyl
ezh2
Prior art date
Application number
EA201690650A
Other languages
English (en)
Other versions
EA038869B1 (ru
Inventor
Кевин У. Кунц
Хёнг-вук Чой
Стивен Матье
Кристен Сандерс
Арани Чанда
Original Assignee
Эпизим, Инк.
Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эпизим, Инк., Эйсай Ар Энд Ди Менеджмент Ко., Лтд. filed Critical Эпизим, Инк.
Publication of EA201690650A1 publication Critical patent/EA201690650A1/ru
Publication of EA038869B1 publication Critical patent/EA038869B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В данном документе обеспечены новые твердые формы гидрохлорида N-((4,6-диметил-2-оксо-1,2-дигидропиридин-3-ил)метил)-5-(этил(тетрагидро-2Н-пиран-4-ил)амино)-4-метил-4'-(морфолинометил)-[1,1'-бифенил]-3-карбоксамида и связанные с ним композиции и способы.
EA201690650A 2013-10-16 2014-10-15 Кристаллические формы гидрохлорида n-((4,6-диметил-2-оксо-1,2-дигидропиридин-3-ил)метил)-5-(этил(тетрагидро-2h-пиран-4-ил)амино)-4-метил-4'-(морфолинометил)-[1,1'-бифенил]-3-карбоксамида, фармацевтические композиции на их основе и способы их применения EA038869B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361891786P 2013-10-16 2013-10-16
PCT/US2014/060724 WO2015057859A1 (en) 2013-10-16 2014-10-15 Hydrochloride salt form for ezh2 inhibition

Publications (2)

Publication Number Publication Date
EA201690650A1 true EA201690650A1 (ru) 2016-10-31
EA038869B1 EA038869B1 (ru) 2021-10-29

Family

ID=52828660

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690650A EA038869B1 (ru) 2013-10-16 2014-10-15 Кристаллические формы гидрохлорида n-((4,6-диметил-2-оксо-1,2-дигидропиридин-3-ил)метил)-5-(этил(тетрагидро-2h-пиран-4-ил)амино)-4-метил-4'-(морфолинометил)-[1,1'-бифенил]-3-карбоксамида, фармацевтические композиции на их основе и способы их применения

Country Status (24)

Country Link
US (3) US10040782B2 (ru)
EP (2) EP4324525A2 (ru)
JP (2) JP6608812B2 (ru)
KR (1) KR102142177B1 (ru)
CN (1) CN105829302B (ru)
AU (2) AU2014337300B2 (ru)
CA (1) CA2925889C (ru)
CL (1) CL2016000866A1 (ru)
DK (1) DK3057962T3 (ru)
EA (1) EA038869B1 (ru)
ES (1) ES2960953T3 (ru)
FI (1) FI3057962T3 (ru)
HU (1) HUE063984T2 (ru)
IL (1) IL244787B (ru)
LT (1) LT3057962T (ru)
MA (1) MA38949A1 (ru)
MX (1) MX2016004703A (ru)
MY (1) MY179802A (ru)
PE (1) PE20161273A1 (ru)
PL (1) PL3057962T3 (ru)
PT (1) PT3057962T (ru)
SG (2) SG10201901977XA (ru)
SI (1) SI3057962T1 (ru)
WO (1) WO2015057859A1 (ru)

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Also Published As

Publication number Publication date
AU2019202246A1 (en) 2019-04-18
FI3057962T3 (fi) 2023-11-03
JP2019052181A (ja) 2019-04-04
CL2016000866A1 (es) 2016-12-23
IL244787B (en) 2022-04-01
DK3057962T3 (da) 2023-11-06
IL244787A0 (en) 2016-04-21
MA38949A1 (fr) 2017-07-31
JP2016533349A (ja) 2016-10-27
PE20161273A1 (es) 2016-12-18
AU2014337300B2 (en) 2019-01-03
CN105829302B (zh) 2020-09-08
CA2925889A1 (en) 2015-04-23
PL3057962T3 (pl) 2024-01-29
AU2014337300A1 (en) 2016-04-14
ES2960953T3 (es) 2024-03-07
KR20160082993A (ko) 2016-07-11
PT3057962T (pt) 2023-11-07
EP3057962B1 (en) 2023-10-18
SI3057962T1 (sl) 2024-01-31
US10040782B2 (en) 2018-08-07
US20180282312A1 (en) 2018-10-04
LT3057962T (lt) 2023-12-11
KR102142177B1 (ko) 2020-08-07
EP4324525A2 (en) 2024-02-21
MY179802A (en) 2020-11-16
EA038869B1 (ru) 2021-10-29
JP6608812B2 (ja) 2019-11-20
US20160237068A1 (en) 2016-08-18
SG10201901977XA (en) 2019-04-29
MX2016004703A (es) 2017-02-28
NZ718201A (en) 2021-09-24
EP3057962A4 (en) 2017-05-24
HUE063984T2 (hu) 2024-02-28
US20210017163A1 (en) 2021-01-21
WO2015057859A1 (en) 2015-04-23
SG11201602269QA (en) 2016-04-28
CA2925889C (en) 2020-09-29
US10710987B2 (en) 2020-07-14
CN105829302A (zh) 2016-08-03
EP3057962A1 (en) 2016-08-24

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