EA201690602A1 - Способы и системы для обработки клеточной культуры - Google Patents

Способы и системы для обработки клеточной культуры

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Publication number
EA201690602A1
EA201690602A1 EA201690602A EA201690602A EA201690602A1 EA 201690602 A1 EA201690602 A1 EA 201690602A1 EA 201690602 A EA201690602 A EA 201690602A EA 201690602 A EA201690602 A EA 201690602A EA 201690602 A1 EA201690602 A1 EA 201690602A1
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EA
Eurasian Patent Office
Prior art keywords
systems
methods
filtration
cellular culture
processing cellular
Prior art date
Application number
EA201690602A
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English (en)
Other versions
EA031652B1 (ru
Inventor
Хан Чжоу
Бенджамин Райт
Марчелла Юй
Цзинь Инь
Константин Константинов
Original Assignee
Джензим Корпорейшн
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51660627&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201690602(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джензим Корпорейшн filed Critical Джензим Корпорейшн
Publication of EA201690602A1 publication Critical patent/EA201690602A1/ru
Publication of EA031652B1 publication Critical patent/EA031652B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Water Supply & Treatment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Настоящее изобретение предлагает способы обработки клеточной культуры и незамкнутые фильтрационные системы. Фильтрационные системы включают блок тангенциальной проточной фильтрации (ТПФ), имеющий независимые впускные и выпускные отверстия, присоединенные к биореактору с клеточной культурой, и насос, предназначенный для обращения потока текучей среды через блок фильтрации.
EA201690602A 2013-09-16 2014-09-16 Способ и система для обработки клеточной культуры EA031652B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361878502P 2013-09-16 2013-09-16
PCT/US2014/055897 WO2015039115A1 (en) 2013-09-16 2014-09-16 Methods and systems for processing a cell culture

Publications (2)

Publication Number Publication Date
EA201690602A1 true EA201690602A1 (ru) 2016-07-29
EA031652B1 EA031652B1 (ru) 2019-02-28

Family

ID=51660627

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201690602A EA031652B1 (ru) 2013-09-16 2014-09-16 Способ и система для обработки клеточной культуры
EA201892084A EA035665B1 (ru) 2013-09-16 2014-09-16 Способ и система для обработки клеточной культуры

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201892084A EA035665B1 (ru) 2013-09-16 2014-09-16 Способ и система для обработки клеточной культуры

Country Status (18)

Country Link
US (2) US20150158907A1 (ru)
EP (1) EP3047013B1 (ru)
JP (4) JP6925127B2 (ru)
KR (3) KR20220031937A (ru)
CN (2) CN113444620B (ru)
AU (3) AU2014318420B2 (ru)
BR (2) BR112016005545B1 (ru)
CA (1) CA2924332C (ru)
CY (1) CY1124684T1 (ru)
DK (1) DK3047013T3 (ru)
EA (2) EA031652B1 (ru)
ES (1) ES2891728T3 (ru)
HK (1) HK1222672A1 (ru)
HU (1) HUE055888T2 (ru)
IL (1) IL244552B (ru)
MX (2) MX2016003440A (ru)
SG (2) SG10201803601SA (ru)
WO (1) WO2015039115A1 (ru)

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Publication number Priority date Publication date Assignee Title
CN110241012A (zh) * 2018-03-09 2019-09-17 嘉和生物药业有限公司 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用
CN110241012B (zh) * 2018-03-09 2022-11-01 嘉和生物药业有限公司 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用

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JP2016530893A (ja) 2016-10-06
MX2021007792A (es) 2021-08-11
JP2020124204A (ja) 2020-08-20
CY1124684T1 (el) 2022-07-22
SG11201601899TA (en) 2016-04-28
KR20230142653A (ko) 2023-10-11
KR20220031937A (ko) 2022-03-14
EA035665B1 (ru) 2020-07-23
HK1222672A1 (zh) 2017-07-07
BR122021001466B1 (pt) 2021-10-13
AU2020202568B2 (en) 2022-06-02
IL244552A0 (en) 2016-04-21
JP2023058588A (ja) 2023-04-25
CN105722967B (zh) 2021-03-19
SG10201803601SA (en) 2018-06-28
US20150158907A1 (en) 2015-06-11
JP6925127B2 (ja) 2021-08-25
AU2014318420A1 (en) 2016-04-14
CA2924332C (en) 2023-03-14
CA2924332A1 (en) 2015-03-19
JP7227406B2 (ja) 2023-02-21
ES2891728T3 (es) 2022-01-31
HUE055888T2 (hu) 2022-01-28
EA031652B1 (ru) 2019-02-28
EP3047013B1 (en) 2021-08-18
CN113444620A (zh) 2021-09-28
MX2016003440A (es) 2016-11-11
DK3047013T3 (da) 2021-11-15
CN113444620B (zh) 2024-03-29
US20210269477A1 (en) 2021-09-02
IL244552B (en) 2020-04-30
EA201892084A1 (ru) 2019-02-28
WO2015039115A1 (en) 2015-03-19
AU2014318420B2 (en) 2020-01-16
JP2022050549A (ja) 2022-03-30
AU2022221495A1 (en) 2022-09-22
KR102369211B1 (ko) 2022-03-03
KR20160055866A (ko) 2016-05-18
EP3047013A1 (en) 2016-07-27
JP7008746B2 (ja) 2022-01-25
CN105722967A (zh) 2016-06-29
BR112016005545B1 (pt) 2021-06-01
AU2020202568A1 (en) 2020-05-07

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