EA201591675A1 - Замещенные 7-азабициклы и их применение в качестве модуляторов рецепторов орексина - Google Patents

Замещенные 7-азабициклы и их применение в качестве модуляторов рецепторов орексина

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Publication number
EA201591675A1
EA201591675A1 EA201591675A EA201591675A EA201591675A1 EA 201591675 A1 EA201591675 A1 EA 201591675A1 EA 201591675 A EA201591675 A EA 201591675A EA 201591675 A EA201591675 A EA 201591675A EA 201591675 A1 EA201591675 A1 EA 201591675A1
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Eurasian Patent Office
Prior art keywords
pyrazinyl
pyrazidinyl
pyrazolyl
alkyl
compounds
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EA201591675A
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English (en)
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EA028386B1 (ru
Inventor
Хитер Р. Коут
Курт А. Дворак
Энн Е. Фитцджералд
Терри П. Леболд
Кэти Превилл
Брок Т. Шайрман
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Янссен Фармацевтика Нв
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Publication of EA201591675A1 publication Critical patent/EA201591675A1/ru
Publication of EA028386B1 publication Critical patent/EA028386B1/ru

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Abstract

Изобретение относится к соединениям формулы Iгде кольцо А представляет собой фенил, нафталинил, пиридил, хинолинил, изохинолинил, имидазопиридил, фуранил, тиазолил, изоксазолил, пиразолил, имидазотиазолил, бензимидазолил или индазолил; Rпредставляет собой Н, алкил, алкокси, гидроксиалкилен, ОН, галоген, фенил, триазолил, оксазолил, изоксазолил, пиридил, пиримидинил, пиразинил, пиридазинил, пиперазинил, пиразолил, оксадиазолил, пирролидинил, тиофенил, морфолинил или диалкиламино; Rпредставляет собой Н, алкил, алкокси, гидроксиалкилен или галоген; Z представляет собой NH, N-алкил или О; Rпредставляет собой пиридил, пиримидинил, пиразинил, пиридазинил, хиназолинил, хиноксалинил, пиразолил, бензоксазолил, имидазопиразинил, триазолопиразинил, необязательно замещенный одним или двумя заместителями, независимо выбранными из группы, состоящей из алкила, алкокси или галогена, при этом n равно 0 или 1. Способы получения соединений формулы I также описаны здесь. Изобретение также относится к фармацевтическим композициям, содержащим соединения формулы I. Способы применения соединений данного изобретения также входят в объем содержания настоящего изобретения.
EA201591675A 2013-03-13 2014-03-12 Замещенные 7-азабициклы и их применение в качестве модуляторов рецепторов орексина EA028386B1 (ru)

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US201361780428P 2013-03-13 2013-03-13
PCT/US2014/024322 WO2014159591A1 (en) 2013-03-13 2014-03-12 Substituted 7-azabicycles and their use as orexin receptor modulators

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EA201591675A1 true EA201591675A1 (ru) 2016-01-29
EA028386B1 EA028386B1 (ru) 2017-11-30

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