MX370389B - Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. - Google Patents

Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona.

Info

Publication number
MX370389B
MX370389B MX2015015010A MX2015015010A MX370389B MX 370389 B MX370389 B MX 370389B MX 2015015010 A MX2015015010 A MX 2015015010A MX 2015015010 A MX2015015010 A MX 2015015010A MX 370389 B MX370389 B MX 370389B
Authority
MX
Mexico
Prior art keywords
dihydro
compounds
isoindol
isoquinoline
new
Prior art date
Application number
MX2015015010A
Other languages
English (en)
Other versions
MX2015015010A (es
Inventor
E Martin Rainer
Liu Yongfu
Wang Lisha
Aebi Johannes
Amrein Kurt
Hornsperger Benoit
Kuhn Bernd
P Maerki Hans
V Mayweg Alexander
Tan Xuefei
Zhou Mingwei
Chen Wenming
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015015010A publication Critical patent/MX2015015010A/es
Publication of MX370389B publication Critical patent/MX370389B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La invención proporciona nuevos compuestos que tienen la fórmula general (I) en donde R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, A, m, n y p son tal como se describe en el presente documento, composiciones que incluyen los compuestos y métodos de uso de los compuestos.
MX2015015010A 2013-05-27 2014-05-26 Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. MX370389B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013076281 2013-05-27
PCT/EP2014/060790 WO2014191338A1 (en) 2013-05-27 2014-05-26 New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds

Publications (2)

Publication Number Publication Date
MX2015015010A MX2015015010A (es) 2016-03-09
MX370389B true MX370389B (es) 2019-12-11

Family

ID=50884887

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015010A MX370389B (es) 2013-05-27 2014-05-26 Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona.

Country Status (22)

Country Link
US (1) US9695151B2 (es)
EP (1) EP3004077B1 (es)
JP (2) JP6416229B2 (es)
KR (1) KR102436885B1 (es)
CN (1) CN105143204B (es)
AR (1) AR096424A1 (es)
BR (1) BR112015028871B1 (es)
CA (1) CA2903180C (es)
DK (1) DK3004077T3 (es)
ES (1) ES2763338T3 (es)
HK (1) HK1213564A1 (es)
HR (1) HRP20192275T1 (es)
HU (1) HUE046773T2 (es)
LT (1) LT3004077T (es)
MX (1) MX370389B (es)
PL (1) PL3004077T3 (es)
PT (1) PT3004077T (es)
RS (1) RS59739B1 (es)
RU (1) RU2695524C2 (es)
SI (1) SI3004077T1 (es)
TW (1) TWI651317B (es)
WO (1) WO2014191338A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE046773T2 (hu) * 2013-05-27 2020-03-30 Hoffmann La Roche Új 3,4-dihidro-2H-izokinolin-1-on és 2,3-dihidro-izoindol-1-on vegyületek
JP6338658B2 (ja) 2013-10-07 2018-06-06 アンタレス・ファーマ・インコーポレーテッド テストステロンの針補助ジェット注射を通じたヘマトクリット調節
EA035185B1 (ru) * 2014-10-08 2020-05-12 Ф. Хоффманн-Ля Рош Аг Производные спиродиамина в качестве ингибиторов альдостеронсинтазы
WO2019126559A1 (en) 2017-12-20 2019-06-27 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
RU2717310C1 (ru) * 2019-06-04 2020-03-20 Общество с ограниченной ответственностью "Таргет Медикалс" Ингибиторы альдостеронсинтазы на основе производных 2-амино-4H-пиран-3-карбонитрила

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
CN85100796A (zh) * 1985-04-01 1986-10-01 辉瑞公司 喹啉酮衍生物的制备方法
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
US8541404B2 (en) * 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
WO2012035078A1 (en) * 2010-09-16 2012-03-22 Novartis Ag 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
CA2832996C (en) * 2011-04-26 2019-05-07 Merck Sharp & Dohme Corp. Tricyclic triazole compounds and their use as aldosterone synthase inhibitors
AU2012307509B2 (en) * 2011-09-15 2017-06-29 F. Hoffmann-La Roche Ag New dihydroquinoline-2-one derivatives
US9353081B2 (en) * 2011-09-23 2016-05-31 Hoffmann-La Roche Inc. Bicyclic dihydroquinoline-2-one derivatives
PL3004076T3 (pl) * 2013-05-27 2020-04-30 F.Hoffmann-La Roche Ag Nowe związki 3,4-dihydro-2h-izochinolin-1-onowe i 2,3-dihydroizoindol-1-onowe
HUE046773T2 (hu) * 2013-05-27 2020-03-30 Hoffmann La Roche Új 3,4-dihidro-2H-izokinolin-1-on és 2,3-dihidro-izoindol-1-on vegyületek

Also Published As

Publication number Publication date
KR102436885B1 (ko) 2022-08-26
CA2903180A1 (en) 2014-12-04
JP6670906B2 (ja) 2020-03-25
EP3004077B1 (en) 2019-10-30
TWI651317B (zh) 2019-02-21
TW201533037A (zh) 2015-09-01
US20160075687A1 (en) 2016-03-17
PL3004077T3 (pl) 2020-04-30
HK1213564A1 (zh) 2016-07-08
RU2015150287A (ru) 2017-06-28
WO2014191338A1 (en) 2014-12-04
CN105143204A (zh) 2015-12-09
DK3004077T3 (da) 2020-01-13
SI3004077T1 (sl) 2020-01-31
HUE046773T2 (hu) 2020-03-30
JP2016520601A (ja) 2016-07-14
AR096424A1 (es) 2015-12-30
BR112015028871B1 (pt) 2022-02-01
LT3004077T (lt) 2020-01-27
RU2695524C2 (ru) 2019-07-23
BR112015028871A2 (pt) 2017-07-25
HRP20192275T1 (hr) 2020-03-06
US9695151B2 (en) 2017-07-04
ES2763338T3 (es) 2020-05-28
PT3004077T (pt) 2019-12-19
CN105143204B (zh) 2018-02-02
MX2015015010A (es) 2016-03-09
RS59739B1 (sr) 2020-02-28
JP2019023212A (ja) 2019-02-14
JP6416229B2 (ja) 2018-10-31
CA2903180C (en) 2022-03-15
KR20160012145A (ko) 2016-02-02
EP3004077A1 (en) 2016-04-13

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