SG11201404508XA - Novel morpholinyl derivatives useful as mogat-2 inhibitors - Google Patents

Novel morpholinyl derivatives useful as mogat-2 inhibitors

Info

Publication number
SG11201404508XA
SG11201404508XA SG11201404508XA SG11201404508XA SG11201404508XA SG 11201404508X A SG11201404508X A SG 11201404508XA SG 11201404508X A SG11201404508X A SG 11201404508XA SG 11201404508X A SG11201404508X A SG 11201404508XA SG 11201404508X A SG11201404508X A SG 11201404508XA
Authority
SG
Singapore
Prior art keywords
mogat
inhibitors
derivatives useful
novel
morpholinyl derivatives
Prior art date
Application number
SG11201404508XA
Inventor
Maria Rosario Gonzalez-Garcia
Maria Carmen Fernandez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48905712&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201404508X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SG11201404508XA publication Critical patent/SG11201404508XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13Dicarboxylic acids
    • C07C57/145Maleic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11201404508XA 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors SG11201404508XA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12382037 2012-01-31
US201261617093P 2012-03-29 2012-03-29
EP12382433 2012-11-06
PCT/US2013/022828 WO2013116065A1 (en) 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors

Publications (1)

Publication Number Publication Date
SG11201404508XA true SG11201404508XA (en) 2014-10-30

Family

ID=48905712

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201404508XA SG11201404508XA (en) 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors

Country Status (24)

Country Link
US (1) US8993568B2 (en)
EP (1) EP2809661B1 (en)
JP (1) JP5852269B2 (en)
KR (1) KR20140107641A (en)
CN (1) CN104080777B (en)
AP (1) AP2014007793A0 (en)
AU (1) AU2013215549B2 (en)
BR (1) BR112014018712A8 (en)
CA (1) CA2859992A1 (en)
CL (1) CL2014001862A1 (en)
CO (1) CO7020914A2 (en)
CR (1) CR20140325A (en)
DO (1) DOP2014000177A (en)
EA (1) EA024182B1 (en)
ES (1) ES2571577T3 (en)
GT (1) GT201400169A (en)
HK (1) HK1199024A1 (en)
IL (1) IL233542A0 (en)
MX (1) MX2014008604A (en)
PE (1) PE20141789A1 (en)
PH (1) PH12014501712B1 (en)
SG (1) SG11201404508XA (en)
WO (1) WO2013116065A1 (en)
ZA (1) ZA201405227B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013112323A1 (en) 2012-01-23 2013-08-01 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
TW201343629A (en) 2012-01-31 2013-11-01 Lilly Co Eli Novel benzyl sulfonamide derivatives useful as MOGAT-2 inhibitors
ES2571577T3 (en) 2012-01-31 2016-05-26 Lilly Co Eli Novel morpholinyl derivatives useful as MOGAT-2 inhibitors
AU2013341584A1 (en) 2012-11-06 2015-04-30 Eli Lilly And Company Novel benzyl sulfonamide compounds useful as MoGAT-2 inhibitors
EP3395798A4 (en) 2015-12-21 2019-07-17 Shionogi & Co., Ltd Non-aromatic heterocyclic derivative having mgat2 inhibitory activity
TWI782056B (en) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 A fused ring derivative having a mgat2 inhibitoy activity
KR20210114001A (en) 2019-01-11 2021-09-17 시오노기 앤드 컴파니, 리미티드 Dihydropyrazolopyrazinone derivatives having MGAT2 inhibitory activity

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
CA2338862A1 (en) 1998-07-31 2000-02-10 Dennis Michael Zimmerman Alkenyl sulphonamide derivatives
AU5235699A (en) 1998-07-31 2000-02-21 Eli Lilly And Company Sulfonamide derivatives
GB0408777D0 (en) 2004-04-20 2004-05-26 Glaxo Group Ltd Compounds
EP1659113A1 (en) 2004-11-08 2006-05-24 Evotec AG Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1)
EP1655283A1 (en) 2004-11-08 2006-05-10 Evotec OAI AG 11beta-HSD1 Inhibitors
EP2078719A4 (en) 2006-09-28 2009-11-11 Dainippon Sumitomo Pharma Co Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the compound
TW200831092A (en) * 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
CA2715527A1 (en) * 2007-12-05 2009-06-11 Michael Higginbottom New compounds iv
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
AU2009229860A1 (en) 2008-03-28 2009-10-01 Msd K.K. Diarylmethylamide derivative having antagonistic activity on melanin-concentrating hormone receptor
EP2313096A1 (en) * 2008-06-04 2011-04-27 AstraZeneca AB (Publ) New compounds v
CA2751244A1 (en) 2009-02-23 2010-08-26 Msd K.K. Pyrimidin-4(3h)-one derivatives
JP2014051434A (en) 2010-12-28 2014-03-20 Dainippon Sumitomo Pharma Co Ltd Bicyclic pyrimidine derivative
WO2013112323A1 (en) 2012-01-23 2013-08-01 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
ES2571577T3 (en) 2012-01-31 2016-05-26 Lilly Co Eli Novel morpholinyl derivatives useful as MOGAT-2 inhibitors
TW201343629A (en) 2012-01-31 2013-11-01 Lilly Co Eli Novel benzyl sulfonamide derivatives useful as MOGAT-2 inhibitors
AU2013341584A1 (en) 2012-11-06 2015-04-30 Eli Lilly And Company Novel benzyl sulfonamide compounds useful as MoGAT-2 inhibitors

Also Published As

Publication number Publication date
EP2809661B1 (en) 2016-04-06
HK1199024A1 (en) 2015-06-19
EP2809661A1 (en) 2014-12-10
JP5852269B2 (en) 2016-02-03
US20150005305A1 (en) 2015-01-01
CL2014001862A1 (en) 2014-11-14
BR112014018712A2 (en) 2017-06-20
DOP2014000177A (en) 2014-08-31
AU2013215549B2 (en) 2015-09-03
AU2013215549A1 (en) 2014-07-17
CA2859992A1 (en) 2013-08-08
MX2014008604A (en) 2014-08-22
IL233542A0 (en) 2014-08-31
EA201491227A1 (en) 2015-01-30
BR112014018712A8 (en) 2017-07-11
AP2014007793A0 (en) 2014-07-31
KR20140107641A (en) 2014-09-04
CR20140325A (en) 2014-08-25
CN104080777A (en) 2014-10-01
PH12014501712A1 (en) 2014-10-13
CO7020914A2 (en) 2014-08-11
CN104080777B (en) 2015-12-09
PE20141789A1 (en) 2014-11-19
US8993568B2 (en) 2015-03-31
ES2571577T3 (en) 2016-05-26
PH12014501712B1 (en) 2014-10-13
JP2015504917A (en) 2015-02-16
WO2013116065A1 (en) 2013-08-08
GT201400169A (en) 2015-08-27
EA024182B1 (en) 2016-08-31
ZA201405227B (en) 2016-05-25

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