EA201491083A1 - Фармацевтические композиции 7-(6-(2-гидроксипропан-2-ил)пиридин-3-ил)-1-((транс)-4-метоксициклогексил)-3,4-дигидропиразино[2,3-b]пиразин-2(1н)-она, их твердые формы и способы их применения - Google Patents

Фармацевтические композиции 7-(6-(2-гидроксипропан-2-ил)пиридин-3-ил)-1-((транс)-4-метоксициклогексил)-3,4-дигидропиразино[2,3-b]пиразин-2(1н)-она, их твердые формы и способы их применения

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Publication number
EA201491083A1
EA201491083A1 EA201491083A EA201491083A EA201491083A1 EA 201491083 A1 EA201491083 A1 EA 201491083A1 EA 201491083 A EA201491083 A EA 201491083A EA 201491083 A EA201491083 A EA 201491083A EA 201491083 A1 EA201491083 A1 EA 201491083A1
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EA
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Prior art keywords
pyridin
trans
methods
pirazrazin
methoxycyclogexil
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EA201491083A
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English (en)
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EA026390B1 (ru
EA201491083A8 (ru
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Махмуд С. Ассаф
Терренс Джозеф Коннолли
Энджела Жубер Джеймс
Кевин Джозеф Клопфер
Уилльям Вэй-Хва Леонг
Анил Менон
Аманда Николь Миклос
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СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Publication of EA201491083A1 publication Critical patent/EA201491083A1/ru
Publication of EA201491083A8 publication Critical patent/EA201491083A8/ru
Publication of EA026390B1 publication Critical patent/EA026390B1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract

Представлены композиции 7-(6-(2-гидроксипропан-2-ил)пиридин-3-ил)-1-((транс)-4-метоксициклогексил)-3,4-дигидропиразино[2,3-b]пиразин-2(1Н)-она, его твердые формы, изотопологи и метаболиты и способы их применения для лечения заболевания, расстройства или состояния.
EA201491083A 2011-12-02 2012-11-30 ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ 7-(6-(2-ГИДРОКСИПРОПАН-2-ИЛ)ПИРИДИН-3-ИЛ)-1-((ТРАНС)-4-МЕТОКСИЦИКЛОГЕКСИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА, ИХ ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ EA026390B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161566109P 2011-12-02 2011-12-02
US201261647288P 2012-05-15 2012-05-15
US201261653439P 2012-05-31 2012-05-31
US201261670419P 2012-07-11 2012-07-11
PCT/US2012/067172 WO2013082344A1 (en) 2011-12-02 2012-11-30 Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use

Publications (3)

Publication Number Publication Date
EA201491083A1 true EA201491083A1 (ru) 2014-11-28
EA201491083A8 EA201491083A8 (ru) 2015-02-27
EA026390B1 EA026390B1 (ru) 2017-04-28

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EA201491083A EA026390B1 (ru) 2011-12-02 2012-11-30 ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ 7-(6-(2-ГИДРОКСИПРОПАН-2-ИЛ)ПИРИДИН-3-ИЛ)-1-((ТРАНС)-4-МЕТОКСИЦИКЛОГЕКСИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА, ИХ ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ

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US (1) US9403829B2 (ru)
EP (1) EP2785325B1 (ru)
JP (2) JP6076370B2 (ru)
KR (1) KR102040997B1 (ru)
CN (1) CN104093398B (ru)
AU (1) AU2012304276B2 (ru)
BR (1) BR112014013332B1 (ru)
CA (2) CA3125862A1 (ru)
CO (1) CO6990726A2 (ru)
EA (1) EA026390B1 (ru)
EC (1) ECSP14007473A (ru)
ES (1) ES2694413T3 (ru)
HK (1) HK1202052A1 (ru)
IL (1) IL232827B (ru)
IN (1) IN2014CN04037A (ru)
MX (1) MX363034B (ru)
MY (1) MY169749A (ru)
NI (1) NI201400052A (ru)
PE (1) PE20141696A1 (ru)
PH (2) PH12014501230B1 (ru)
SG (2) SG11201402766UA (ru)
UA (1) UA114496C2 (ru)
WO (1) WO2013082344A1 (ru)
ZA (1) ZA201403865B (ru)

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