EA201490516A1 - Бифенилкарбоксиамиды в качестве ингибиторов rock-киназ - Google Patents

Бифенилкарбоксиамиды в качестве ингибиторов rock-киназ

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Publication number
EA201490516A1
EA201490516A1 EA201490516A EA201490516A EA201490516A1 EA 201490516 A1 EA201490516 A1 EA 201490516A1 EA 201490516 A EA201490516 A EA 201490516A EA 201490516 A EA201490516 A EA 201490516A EA 201490516 A1 EA201490516 A1 EA 201490516A1
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Eurasian Patent Office
Prior art keywords
inhibitors
diseases
rock
relates
present
Prior art date
Application number
EA201490516A
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English (en)
Inventor
Йо Ален
Сандро Боланд
Арно Пьер Жан Бурен
Оливье Дефер
Дирк Лейзен
Original Assignee
Амакем Нв
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Application filed by Амакем Нв filed Critical Амакем Нв
Publication of EA201490516A1 publication Critical patent/EA201490516A1/ru

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Настоящее изобретение относится к новым ингибиторам киназ, а именно к ингибиторам ROCK, к композициям, в частности фармацевтическим препаратам, содержащим такие ингибиторы, и к применениям таких ингибиторов в лечении и профилактике заболеваний. В частности, настоящее изобретение относится к новым ингибиторам ROCK, к композициям, в частности фармацевтическим препаратам, содержащим такие ингибиторы, и к применениям таких ингибиторов в лечении и профилактике заболеваний. Помимо этого, настоящее изобретение относится к способам лечения и использованию указанных соединений в производстве лекарственного препарата для применения при ряде терапевтических показаний, включая сексуальную дисфункцию, воспалительные заболевания, глазные заболевания, желудочно-кишечные заболевания и респираторные заболевания.
EA201490516A 2011-08-31 2012-08-31 Бифенилкарбоксиамиды в качестве ингибиторов rock-киназ EA201490516A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11179491 2011-08-31
PCT/EP2012/067018 WO2013030367A1 (en) 2011-08-31 2012-08-31 Biphenylcarboxamides as rock kinase inhibitors

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EA201490516A1 true EA201490516A1 (ru) 2014-07-30

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EA201490516A EA201490516A1 (ru) 2011-08-31 2012-08-31 Бифенилкарбоксиамиды в качестве ингибиторов rock-киназ
EA201490495A EA024232B1 (ru) 2011-08-31 2012-08-31 Новые легкоразрушающиеся ингибиторы rock
EA201490515A EA201490515A1 (ru) 2011-08-31 2012-08-31 Новые ингибиторы rock-киназ

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EA201490495A EA024232B1 (ru) 2011-08-31 2012-08-31 Новые легкоразрушающиеся ингибиторы rock
EA201490515A EA201490515A1 (ru) 2011-08-31 2012-08-31 Новые ингибиторы rock-киназ

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US (3) US9067889B2 (ru)
EP (3) EP2751078A1 (ru)
JP (3) JP2014525427A (ru)
KR (2) KR20140072879A (ru)
CN (3) CN103874684A (ru)
AU (3) AU2012300832A1 (ru)
BR (3) BR112014004447A2 (ru)
CA (3) CA2846694A1 (ru)
EA (3) EA201490516A1 (ru)
ES (1) ES2560830T3 (ru)
IL (2) IL231122A0 (ru)
MX (3) MX2014002395A (ru)
PT (1) PT2751080E (ru)
SG (2) SG11201400058PA (ru)
WO (3) WO2013030365A1 (ru)
ZA (3) ZA201401418B (ru)

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US10842669B2 (en) * 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
WO2013030365A1 (en) * 2011-08-31 2013-03-07 Amakem Nv Novel rock kinase inhibitors
EP2903618B1 (en) 2012-10-05 2022-06-01 Kadmon Corporation, LLC Rho kinase inhibitors
CA2898674C (en) * 2013-01-29 2021-01-26 Amakem Nv Pyridine derivatives as soft rock inhibitors
US10092537B2 (en) 2013-04-15 2018-10-09 Renascience Co., Ltd. Use for PAI-1 inhibitor
PT3083554T (pt) * 2013-12-17 2019-06-11 Lilly Co Eli Compostos de ácido dimetilbenzóico
CA3110661A1 (en) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition of protein kinases to treat friedreich ataxia
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