EA201300817A1 - Способ улучшенного приживления гемопоэтических стволовых клеток - Google Patents

Способ улучшенного приживления гемопоэтических стволовых клеток

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Publication number
EA201300817A1
EA201300817A1 EA201300817A EA201300817A EA201300817A1 EA 201300817 A1 EA201300817 A1 EA 201300817A1 EA 201300817 A EA201300817 A EA 201300817A EA 201300817 A EA201300817 A EA 201300817A EA 201300817 A1 EA201300817 A1 EA 201300817A1
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EA
Eurasian Patent Office
Prior art keywords
stem cells
hematopoietic stem
cells
mixture
prostacyclin analog
Prior art date
Application number
EA201300817A
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English (en)
Other versions
EA033717B1 (ru
Inventor
Михаель Фрайсмут
Ева-Мария Цебедин-Брандль
Кристиан Бергмайр
Фильца Хуссайн
Original Assignee
Сифарм Сарл
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44146841&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201300817(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Сифарм Сарл filed Critical Сифарм Сарл
Publication of EA201300817A1 publication Critical patent/EA201300817A1/ru
Publication of EA033717B1 publication Critical patent/EA033717B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Настоящее изобретение представляет новый способ улучшенного приживления гемопоэтических стволовых клеток путем предварительной обработки ex vivo,включающий стадии получения образца, содержащего гемопоэтические стволовые клетки, и добавления аналога простациклина для получения смеси, стадию инкубации указанной смеси в течение периода времени, достаточного для стимуляции G альфа-пути передачи сигнала в указанных клетках, и необязательно выделения указанных стимулированных клеток. Дополнительно, представляется композиция, содержащая аналог простациклина, для использования при лечении индивидуумов, подвергающихся трансплантации гемопоэтических стволовых клеток.
EA201300817A 2011-01-13 2012-01-13 Способ ex vivo предварительной обработки гемопоэтических стволовых клеток и фармацевтическая композиция для улучшения приживления гемопоэтических стволовых клеток EA033717B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11150835 2011-01-13
PCT/EP2012/050484 WO2012095511A1 (en) 2011-01-13 2012-01-13 Method for enhancing engraftment of haematopoetic stem cells

Publications (2)

Publication Number Publication Date
EA201300817A1 true EA201300817A1 (ru) 2013-11-29
EA033717B1 EA033717B1 (ru) 2019-11-19

Family

ID=44146841

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300817A EA033717B1 (ru) 2011-01-13 2012-01-13 Способ ex vivo предварительной обработки гемопоэтических стволовых клеток и фармацевтическая композиция для улучшения приживления гемопоэтических стволовых клеток

Country Status (19)

Country Link
US (1) US10213464B2 (ru)
EP (1) EP2663313B1 (ru)
JP (2) JP6110309B2 (ru)
KR (1) KR101950526B1 (ru)
CN (1) CN103379907B (ru)
AU (1) AU2012206517B2 (ru)
BR (1) BR112013017878B1 (ru)
CA (1) CA2824113C (ru)
CL (1) CL2013002034A1 (ru)
DK (1) DK2663313T3 (ru)
EA (1) EA033717B1 (ru)
ES (1) ES2693622T3 (ru)
IL (1) IL227331A (ru)
PL (1) PL2663313T3 (ru)
PT (1) PT2663313T (ru)
SG (1) SG191908A1 (ru)
UA (1) UA113284C2 (ru)
WO (1) WO2012095511A1 (ru)
ZA (1) ZA201304743B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6901823B2 (ja) * 2012-08-01 2021-07-14 ユナイテッド セラピューティクス コーポレイション 間葉系幹細胞による肺動脈性高血圧症の処置
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
ES2927844T3 (es) 2013-01-11 2022-11-11 Corsair Pharma Inc Profármacos de treprostinil
AU2015217142B2 (en) * 2014-02-12 2020-04-09 7 Hills Pharma LLC Compositions and methods to improve the homing and grafting of hematopoetic stem cells
AU2015249751A1 (en) * 2014-04-23 2016-11-10 Texas Heart Institute Methods of enhancing stem cell engraftment
LT3250202T (lt) * 2015-01-27 2021-06-25 SciPharm S.à r.l. Kompozicija, skirta naudoti kraujodaros kamieninių ląstelių po transplantacijos prigijimo pagerinimui
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US10898494B2 (en) 2016-05-05 2021-01-26 Liquidia Technologies, Inc. Dry powder treprostinil for the treatment of pulmonary hypertension
CN109727671B (zh) * 2018-12-28 2021-07-09 广东省心血管病研究所 一种鉴定造血干细胞移植术效果的信息分析***及方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
US6242482B1 (en) * 2000-06-05 2001-06-05 United Therapeutics Corporation Prostaglandin compounds and derivatives thereof, compositions containing the same and method of using the same for the treatment of congestive heart failure
US8696564B2 (en) 2004-07-09 2014-04-15 Cardiac Pacemakers, Inc. Implantable sensor with biocompatible coating for controlling or inhibiting tissue growth
US20070065414A1 (en) * 2005-09-16 2007-03-22 Boston Scientific Scimed, Inc. Enhanced delivery of cells
EP3424507A1 (en) * 2006-03-24 2019-01-09 Children's Medical Center Corporation Method to modulate hematopoietic stem cell growth
JP5426389B2 (ja) * 2006-10-20 2014-02-26 チルドレンズ メディカル センター コーポレーション 組織の再生を亢進するための方法
KR101587071B1 (ko) * 2008-07-23 2016-01-20 도레이 카부시키가이샤 만성 신부전 처치제
CN102164487A (zh) * 2008-09-25 2011-08-24 阿拉迪姆公司 曲前列素的深肺部递送
AU2009313290B2 (en) 2008-11-06 2016-04-21 Indiana University Research & Technology Corporation Materials and methods to enhance hematopoietic stem cells engraftment procedures
JP5836262B2 (ja) * 2009-03-19 2015-12-24 フェイト セラピューティクス， インコーポレイテッド サイクリックａｍｐエンハンサーおよび／またはｅｐリガンドを含む組成物、ならびにこれを調製および使用する方法
CA2770066C (en) * 2009-08-07 2018-10-23 Scipharm Sarl Prostacyclin, analogue or derivative thereof for the treatment of cystic fibrosis

Also Published As

Publication number Publication date
CN103379907A (zh) 2013-10-30
US10213464B2 (en) 2019-02-26
EP2663313B1 (en) 2018-08-08
IL227331A (en) 2017-12-31
KR20140005956A (ko) 2014-01-15
ES2693622T3 (es) 2018-12-13
DK2663313T3 (en) 2018-11-26
JP2014507409A (ja) 2014-03-27
EA033717B1 (ru) 2019-11-19
BR112013017878B1 (pt) 2021-08-31
EP2663313A1 (en) 2013-11-20
CN103379907B (zh) 2018-01-09
JP6110309B2 (ja) 2017-04-05
AU2012206517B2 (en) 2016-12-01
CL2013002034A1 (es) 2014-03-21
CA2824113C (en) 2020-04-14
IL227331A0 (en) 2013-09-30
KR101950526B1 (ko) 2019-02-20
NZ612450A (en) 2015-03-27
CA2824113A1 (en) 2012-07-19
SG191908A1 (en) 2013-08-30
BR112013017878A8 (pt) 2018-01-09
PT2663313T (pt) 2018-10-23
BR112013017878A2 (ru) 2017-08-15
AU2012206517A1 (en) 2013-08-01
UA113284C2 (xx) 2017-01-10
US20130344038A1 (en) 2013-12-26
JP2017046707A (ja) 2017-03-09
WO2012095511A1 (en) 2012-07-19
PL2663313T3 (pl) 2019-01-31
ZA201304743B (en) 2014-09-25

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