EA200900806A1 - Способы увеличения количества и мобилизации гемопоэтических стволовых клеток - Google Patents
Способы увеличения количества и мобилизации гемопоэтических стволовых клетокInfo
- Publication number
- EA200900806A1 EA200900806A1 EA200900806A EA200900806A EA200900806A1 EA 200900806 A1 EA200900806 A1 EA 200900806A1 EA 200900806 A EA200900806 A EA 200900806A EA 200900806 A EA200900806 A EA 200900806A EA 200900806 A1 EA200900806 A1 EA 200900806A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- increasing
- stem cells
- mobilization
- methods
- hemopoetic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
Abstract
Предложен способ увеличения числа гемопоэтических стволовых клеток в костном мозге, увеличения мобилизации этих клеток из костного мозга в кровоток и в другие ткани, а также увеличения числа дифференцирующихся гемопоэтических стволовых клеток в кровотоке.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88416207P | 2007-01-09 | 2007-01-09 | |
US88989307P | 2007-02-14 | 2007-02-14 | |
US93856407P | 2007-05-17 | 2007-05-17 | |
US1324307P | 2007-12-12 | 2007-12-12 | |
PCT/US2008/050644 WO2008086426A2 (en) | 2007-01-09 | 2008-01-09 | Methods for increasing and mobilizing hematopoietic stem cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200900806A1 true EA200900806A1 (ru) | 2010-08-30 |
EA018983B1 EA018983B1 (ru) | 2013-12-30 |
Family
ID=39609361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200900806A EA018983B1 (ru) | 2007-01-09 | 2008-01-09 | Способ усиления миграции гемопоэтических стволовых клеток, способ получения популяции указанных клеток и способы лечения с их использованием |
Country Status (15)
Country | Link |
---|---|
US (3) | US20100055077A1 (ru) |
EP (1) | EP2115124B1 (ru) |
JP (1) | JP5389666B2 (ru) |
KR (1) | KR101493474B1 (ru) |
CN (1) | CN101631850B (ru) |
BR (1) | BRPI0806557A2 (ru) |
CA (1) | CA2675032A1 (ru) |
EA (1) | EA018983B1 (ru) |
HK (1) | HK1134835A1 (ru) |
IL (1) | IL199766A (ru) |
MX (1) | MX2009007391A (ru) |
NZ (2) | NZ603805A (ru) |
SG (1) | SG177959A1 (ru) |
WO (1) | WO2008086426A2 (ru) |
ZA (1) | ZA200905378B (ru) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2539490T3 (es) | 2005-06-13 | 2015-07-01 | Cleveland Biolabs, Inc. | Métodos para proteger frente a apoptosis usando lipopéptidos |
ES2444695T3 (es) * | 2006-06-23 | 2014-02-26 | Alethia Biotherapeutics Inc. | Polinucleótidos y polipéptidos implicados en el cáncer |
CN104829714A (zh) | 2008-11-03 | 2015-08-12 | 阿莱斯亚生物疗法股份有限公司 | 特异性地阻滞肿瘤抗原的生物活性的抗体 |
WO2011053700A1 (en) * | 2009-10-28 | 2011-05-05 | Henry Ford Health System | Methods to mitigate injury from radiation exposure |
EP2338521A1 (en) * | 2009-12-28 | 2011-06-29 | Helmholtz-Zentrum für Infektionsforschung GmbH | Lipopeptide- and lipoprotein-conjugates and its use |
US20130230580A1 (en) * | 2010-09-14 | 2013-09-05 | Paul S. Frenette | Administration of SNS Neuroprotective Agents to Promote Hematopoietic Regeneration |
DK3173427T3 (da) | 2011-03-31 | 2019-08-05 | Adc Therapeutics Sa | Antistoffer mod nyre-associeret antigen 1 og antigen-bindende fragmenter deraf |
ES2731665T3 (es) | 2012-01-09 | 2019-11-18 | Adc Therapeutics Sa | Agentes para tratar cáncer de mama triple negativo |
WO2013149064A1 (en) * | 2012-03-30 | 2013-10-03 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells |
WO2013159082A1 (en) | 2012-04-20 | 2013-10-24 | Adhaere Pharmaceuticals, Inc. | Compounds and methods for regulating integrins |
CN104027791B (zh) * | 2013-03-06 | 2016-08-10 | 浙江海正药业股份有限公司 | 药物组合物 |
JP2016518415A (ja) * | 2013-10-21 | 2016-06-23 | アドバンスド ニューロリジェネレイティブ セラピーズ エルエルシー | 加齢と疾患免疫機能障害と細胞老化とをリンパ球系幹細胞で修復する方法、及び治療使用のためのそれらの再適用する方法 |
CN104744563B (zh) * | 2013-12-27 | 2019-02-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 端基具有亲脂性结构的线性脂肽、其制备方法及用途 |
WO2016073733A1 (en) * | 2014-11-06 | 2016-05-12 | Cleveland Biolabs, Inc. | Methods of treating cancer using lipopeptides |
US20210189344A1 (en) * | 2018-08-30 | 2021-06-24 | The Regents Of The University Of California | Mobilization and collection of peripheral blood hematopoietic stem cells from deceased donors |
CN112851755B (zh) * | 2021-01-13 | 2023-09-01 | 中国人民解放军军事科学院军事医学研究院 | 一种线性脂肽化合物及其制备方法与应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
DE19822820A1 (de) * | 1998-05-20 | 1999-11-25 | Biotechnolog Forschung Gmbh | Pharmazeutisches Präparat zur Wundbehandlung |
ES2539490T3 (es) * | 2005-06-13 | 2015-07-01 | Cleveland Biolabs, Inc. | Métodos para proteger frente a apoptosis usando lipopéptidos |
RU2009108289A (ru) * | 2006-08-07 | 2010-09-20 | Джензим Корпорейшн (Us) | Комбинированная терапия |
-
2008
- 2008-01-09 BR BRPI0806557-8A2A patent/BRPI0806557A2/pt active Search and Examination
- 2008-01-09 MX MX2009007391A patent/MX2009007391A/es active IP Right Grant
- 2008-01-09 CN CN2008800077612A patent/CN101631850B/zh not_active Expired - Fee Related
- 2008-01-09 CA CA002675032A patent/CA2675032A1/en not_active Abandoned
- 2008-01-09 EA EA200900806A patent/EA018983B1/ru not_active IP Right Cessation
- 2008-01-09 NZ NZ603805A patent/NZ603805A/en not_active IP Right Cessation
- 2008-01-09 EP EP08705809.5A patent/EP2115124B1/en not_active Not-in-force
- 2008-01-09 JP JP2009545662A patent/JP5389666B2/ja not_active Expired - Fee Related
- 2008-01-09 WO PCT/US2008/050644 patent/WO2008086426A2/en active Search and Examination
- 2008-01-09 KR KR20097016496A patent/KR101493474B1/ko not_active IP Right Cessation
- 2008-01-09 US US12/522,606 patent/US20100055077A1/en not_active Abandoned
- 2008-01-09 SG SG2012001392A patent/SG177959A1/en unknown
- 2008-01-09 NZ NZ578928A patent/NZ578928A/xx not_active IP Right Cessation
-
2009
- 2009-07-08 IL IL199766A patent/IL199766A/en not_active IP Right Cessation
- 2009-07-31 ZA ZA200905378A patent/ZA200905378B/xx unknown
-
2010
- 2010-03-23 HK HK10103026.0A patent/HK1134835A1/xx not_active IP Right Cessation
-
2013
- 2013-07-02 US US13/933,954 patent/US20140045747A1/en not_active Abandoned
-
2015
- 2015-03-04 US US14/638,888 patent/US20150174195A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20100055077A1 (en) | 2010-03-04 |
ZA200905378B (en) | 2010-05-26 |
WO2008086426A8 (en) | 2009-07-30 |
EP2115124A4 (en) | 2012-05-30 |
SG177959A1 (en) | 2012-02-28 |
US20150174195A1 (en) | 2015-06-25 |
HK1134835A1 (en) | 2010-05-14 |
NZ578928A (en) | 2013-03-28 |
WO2008086426A2 (en) | 2008-07-17 |
MX2009007391A (es) | 2009-08-13 |
NZ603805A (en) | 2014-03-28 |
AU2008204836A1 (en) | 2008-07-17 |
EP2115124A2 (en) | 2009-11-11 |
KR20090108703A (ko) | 2009-10-16 |
IL199766A (en) | 2015-01-29 |
BRPI0806557A2 (pt) | 2014-04-15 |
KR101493474B1 (ko) | 2015-02-16 |
JP5389666B2 (ja) | 2014-01-15 |
EA018983B1 (ru) | 2013-12-30 |
US20140045747A1 (en) | 2014-02-13 |
JP2010515748A (ja) | 2010-05-13 |
CN101631850B (zh) | 2013-12-04 |
CA2675032A1 (en) | 2008-07-17 |
CN101631850A (zh) | 2010-01-20 |
EP2115124B1 (en) | 2016-03-16 |
WO2008086426A3 (en) | 2008-12-18 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG MD TJ TM |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ RU |