EA201291436A1 - Производные гексафторизопропил карбамата, их получение и их терапевтическое применение - Google Patents

Производные гексафторизопропил карбамата, их получение и их терапевтическое применение

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Publication number
EA201291436A1
EA201291436A1 EA201291436A EA201291436A EA201291436A1 EA 201291436 A1 EA201291436 A1 EA 201291436A1 EA 201291436 A EA201291436 A EA 201291436A EA 201291436 A EA201291436 A EA 201291436A EA 201291436 A1 EA201291436 A1 EA 201291436A1
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EA
Eurasian Patent Office
Prior art keywords
derivatives
carbamate
hexafluoropiropil
receiving
therapeutic application
Prior art date
Application number
EA201291436A
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English (en)
Other versions
EA022076B1 (ru
Inventor
Режин Барч
Дороте Шере
Люк Эвен
Кристиан Хорнарт
Жан Женесс
Франк Марге
Original Assignee
Санофи
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Application filed by Санофи filed Critical Санофи
Publication of EA201291436A1 publication Critical patent/EA201291436A1/ru
Publication of EA022076B1 publication Critical patent/EA022076B1/ru

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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Abstract

Изобретение относится к производным гексафторизопропил карбамата общей формулы (I)в которой R, Z, А, m и n имеют значения, определенные в описании, в форме основания или соли присоединения с кислотой. Эти соединения могут использоваться в качестве ингибиторов фермента MGL (моноацил глицерин липазы).
EA201291436A 2010-06-04 2011-06-06 Производные гексафторизопропил карбамата, их получение и их терапевтическое применение EA022076B1 (ru)

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FR1054411A FR2960875B1 (fr) 2010-06-04 2010-06-04 Derives de carbamates d'hexafluoroisopropyle, leur preparation et leur application en therapeutique
PCT/IB2011/052458 WO2011151808A1 (en) 2010-06-04 2011-06-06 Hexafluoroisopropyl carbamate derivatives, their preparation and their therapeutic application

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